ライフサイエンスコーパス: folate receptor

1 re known to express high levels of the alpha-folate receptor).

2 ylphosphatidylinositol-anchored protein (the folate receptor).

3 y GPI-anchored proteins (5' nucleotidase and folate receptor).

4 nanosensors with cancer cells expressing the folate receptor.

5 t to target tumor cells that overexpress the folate receptor.

6 cells were transfected with the GPI-anchored folate receptor.

7 in cultured tumor cells that overexpress the folate receptor.

8 selectively taken up by tumor cells via the folate receptor.

9 r the imaging of tumors that overexpress the folate receptor.

10 ecific killing of cells that overexpress the folate receptor.

11 idant to renal proximal tubule cells via the folate receptor.

12 and an assay was designed for screening the folate receptor.

13 lic acid as a drug-delivery system targeting folate receptors.

14 G alpha4 subunit in mediating responses from folate receptors.

15 tive delivery to cancer cells overexpressing folate receptors.

16 not be related to the very low expression of folate receptors.

17 ne delivery to cancer cells that overexpress folate receptors.

18 ED27 cells, and KB cells, which express the folate receptors.

19 from that of the reduced folate carrier and folate receptors.

20 rigid ligand-binding site of these bona fide folate receptors.

21 harmaceutical for targeting tumor-associated folate receptors.

22 harmaceutical for targeting tumor-associated folate receptors.

23 ing targeting efficiency to cells expressing folate receptors.

24 e to the kidney and other tissues expressing folate receptors.

25 folates, the reduced folate carrier and the folate receptors.

26 ake by the malignant cells that over-express folate-receptors.

27 specificity for integrin alpha(4)beta(1) or folate receptor 1 (FOLR1), and common specificity for CD

28 nstrated its selectivity and potency against folate receptor 1 (FOLR1)-expressing ovarian cancer cell

29 njury-related induction of the high-affinity folate receptor 1 (Folr1).

30 We show that knockdown of folate receptor 1 (Folr1; also known as FRalpha) impairs

31 in, tissue inhibitor of metalloproteinase 3, folate receptor 1, S100A2, signal transducer and activat

32 We show that the folate-receptor 1 (FolR1), a GPI-anchored cell surface m

33 Despite the isolation of placental folate receptors 25 y ago and progress in defining the m

34 Here we identify folate receptor 4 (Folr4) as the receptor for Izumo1 on

35 al antibodies against OX40, CTLA4, GITR, and folate receptor 4 (FR4).

36 nd instead caused those T cells to develop a Folate receptor 4(hi)CD73(hi) anergic phenotype.

37 ed markers of suppressive function (CD73 and folate receptor 4), and delayed disease after adoptive t

38 traits-including the expression of CD73 and folate receptor 4, and the epigenetic modification of Tr

39 tracellular distributions; some (such as the folate receptor) accumulate in transferrin-containing co

40 Recently, folate receptor alpha (FR alpha), a glycosylphosphatidyl

41 cosyl phosphatidylinositol-anchored protein, folate receptor alpha (FR alpha).

42 In this work we examined the hypothesis that folate receptor alpha (FRalpha) acts as a transcription

43 Folate receptor alpha (FRalpha) autoantibodies have been

44 Folate receptor alpha (FRalpha) has been described as a

45 rug conjugate consisting of a humanized anti-folate receptor alpha (FRalpha) monoclonal antibody link

46 Folate receptor alpha (FRalpha) mRNA was shown by RT-PCR

47 MOv18IgE, which targets folate receptor alpha (FRalpha), is a novel system to mo

48 or the three known folate transport proteins folate receptor alpha (FRalpha), proton-coupled folate t

49 the reduced- folate transporter (RFT-1) and folate receptor alpha (FRalpha), the two proteins involv

50 A candidate antigen is the folate receptor alpha (FRalpha), which is overexpressed

51 microscopy revealed the distribution of the folate receptor alpha along the basolateral region of th

52 y using MTX(R)-ZR-75-1 cells showed that the folate receptor alpha cDNA obtained by RT-PCR from the R

53 nt work represents the first analysis of the folate receptor alpha expression in intact mammalian ret

54 the reduced-folate transporter but also the folate receptor alpha in mediating this transport.

55 The expression of the folate receptor alpha in mouse RPE was analyzed by rever

56 In situ hybridization localized the folate receptor alpha mRNA to the mouse RPE cells and to

57 , and subsequent sequencing established that folate receptor alpha mRNA transcripts are expressed in

58 n enhanced generation of high-avidity murine folate receptor alpha T cells that persisted in vivo and

59 The folate receptor alpha was detected immunohistochemically

60 e present study was to determine whether the folate receptor alpha was present in the RPE and, if so,

61 A model epitope derived from the murine folate receptor alpha, a self- and tumor Ag, was modifie

62 s specific for the cancer-associated antigen folate receptor alpha.

63 The human KB cell or alpha folate receptor (alpha hFR) is a membrane glycoprotein o

64 ive intracellular accumulation through alpha-folate receptor (alpha-FR) transport.

65 nhibitor specifically transported into alpha-folate receptor (alpha-FR)-overexpressing tumors.

66 A cDNA encoding the folate receptor-alpha (FR-alpha) was recovered from cell

67 chimeric antigen receptor (CAR) specific for folate receptor-alpha (FRalpha) have shown robust antitu

68 Children were subtyped by glutathione and folate receptor-alpha autoantibody (FRAA) status.

69 g of liposomes enhanced the sensitization of folate receptor-alpha(+) ovarian tumor cells in vitro, t

70 An mAb directed against the folate receptor also shifted approximately 50% of the ca

71 We now show by cell fractionation that folate receptors also must be clustered in caveolae for

72 llular uptake levels were independent of the folate receptor and did not require a pH-sensitive lipid

73 , nanoceria identified the expression of the folate receptor and EpCAM on lung carcinoma and breast a

74 pic cancer biomarkers at pH 7.0, such as the folate receptor and EpCAM.

75 unctionally by transfection the cloned human folate receptor and the human reduced-folate transporter

76 The expression of the folate receptor and the reduced-folate transporter in th

77 defect contains autoantibodies that bind to folate receptors and can block the cellular uptake of fo

78 tion between maternal autoantibodies against folate receptors and neural-tube defects reflects a caus

79 explain the high folate-binding affinity of folate receptors and provide a template for designing mo

80 r cell targeting and internalization via the folate receptor, and induces significant cancer cell dea

81 Cell membrane-associated folate receptors are selectively overexpressed in certai

82 cid acted as both a targeting ligand for the folate receptor as well as a quencher for doxorubicin's

83 adenoviral infection of target cells via the folate receptor at a high efficiency.

84 rodevelopmental disorder typically caused by folate receptor autoantibodies (FRAs) that interfere wit

85 Additional studies of folate receptor autoimmunity and leucovorin calcium trea

86 Folate receptor beta (FR-beta) is present on activated m

87 Folate receptor beta (FRbeta) is a myeloid-lineage antig

88 ized in a receptor-specific manner into both folate receptor beta-expressing macrophage cell lines an

89 Activated macrophages express folate receptor-beta (FR-beta), which can be targeted by

90 FA-HSA-ATO could specifically recognize folate receptor-beta-positive (FRbeta+) chronic myeloid

91 folate receptors in mice, and knock-down of folate receptors by delivery of antisense oligonucleotid

92 To investigate the folate receptor dependence of gene transfer with the fil

93 h lipid to DNA ratios (e.g. 10 and 12), were folate receptor-dependent and required a pH-sensitive li

94 -rapa inhibited mTOR activity in a dose- and folate receptor-dependent manner.

95 ion of murine breast cancer cells (4T1) in a folate receptor-dependent manner.

96 xpressed at very low levels in most tissues, folate receptors, especially FRalpha, are expressed at h

97 se cells expressed very small amounts of the folate receptor evidenced from the binding of folate and

98 ogressed to clinical trials for detection of folate receptor-expressing gynecological tumors.

99 a portion of the excised specimens assessed folate receptor expression in 49 patients.

100 U appears to be a function of a cell's alpha-folate receptor expression.

101 d mice lacking Folbp2, another member of the folate receptor family that is GPI anchored but binds fo

102 eta, a GPI-anchored protein belonging to the folate receptor family.

103 methylation and with expression of both the folate receptor Folr1 and the de novo DNA methyltransfer

104 Finally, binding to the folate receptor (FOLR1) overexpressed in a cancer cell l

105 nclear how Juno - which was previously named folate receptor (FR) 4, based on sequence similarity con

106 carbon atoms) were synthesized as selective folate receptor (FR) alpha and beta substrates and as an

107 eyl pyrrolo[2,3-d]pyrimidines 2c and 2d with folate receptor (FR) alpha and proton-coupled folate tra

108 and 10-13 were selectively inhibitory toward folate receptor (FR) alpha-expressing Chinese hamster ov

109 ogue and potently inhibited proliferation of folate receptor (FR) alpha-expressing Chinese hamster ov

110 e system was characterized by detecting free folate receptor (FR) and an FR+ cancer cell line (KB) in

111 its distribution in the neighborhood of the folate receptor (FR) and beta-globin genes by using high

112 everal transporters and receptors, including folate receptor (FR) beta, a GPI-anchored protein belong

113 Folate receptor (FR) can be used as a therapeutic target

114 am to provide targeted antitumor agents with folate receptor (FR) cellular uptake specificity and gly

115 The folate receptor (FR) has proven a valuable target for nu

116 The folate receptor (FR) is a valuable therapeutic target th

117 Folate receptor (FR) is highly expressed in many types o

118 The membrane-bound high-affinity folate receptor (FR) is highly expressed on a wide range

119 the expression and functional competence of folate receptor (FR) isoforms on human hematopoietic cel

120 The glycosyl-phosphatidylinositol anchored folate receptor (FR) mediates selective delivery of a br

121 different positions to folic acid (FA), the folate receptor (FR) targeting unit.

122 ted that a subset of macrophages expresses a folate receptor (FR) that can mediate internalization of

123 The folate receptor (FR) type alpha is a promising target fo

124 The folate receptor (FR) type alpha may be distinguished fro

125 phobic domain of the GPI signal in the human folate receptor (FR) type alpha was substituted with the

126 The utility of the folate receptor (FR) type alpha, in a broad range of tar

127 e characterized using a truncated version of folate receptor (FR) type beta (FR-beta delta 5) in whic

128 The folate receptor (FR) type beta is a promising target for

129 Folate receptor (FR) type beta is a promising target for

130 Folate receptor (FR) type beta is expressed in the myelo

131 When the GPI-anchored folate receptor (FR) type beta was expressed transiently

132 Up-regulation of folate receptor (FR) type-beta in acute myelogenous leuk

133 The homologous folate receptor (FR) types alpha and beta from both huma

134 Folate receptor (FR), a serum protein indicative of vari

135 cetylvinblastine conjugate that binds to the folate receptor (FR), which is expressed on the majority

136 tine hydrazide (DAVLBH), is a ligand for the folate receptor (FR), with activity against FR-positive

137 ement in the 5'-untranslated region of human folate receptor (FR)-alpha mRNA with a cytosolic trans-f

138 Repression of the folate receptor (FR)-alpha P4 core promoter by ER is enh

139 (99m)Tc, termed (99m)Tc-EC20, for imaging of folate receptor (FR)-expressing macrophages that accumul

140 CFT might play in another transport pathway, folate receptor (FR)-mediated endocytosis.

141 ly into the BALB/c athymic nude mice bearing folate receptor (FR)-overexpressing KB xenograft, the ta

142 ate FITC-specific CAR-T cell activity toward folate receptor (FR)-overexpressing tumor cells.

143 This agent was found to bind folate receptor (FR)-positive cells and tissues with hig

144 e DOTA-folate conjugate cm09, which binds to folate receptor (FR)-positive KB tumor cells.

145 f-PCN(DXR)) demonstrated enhanced potency to folate receptor (FR)-positive tumor cells such as KB and

146 epared a low-density lipoprotein (LDL)-based folate receptor (FR)-targeted agent by conjugating folic

147 EC131, a new folate receptor (FR)-targeted drug conjugate, was prepar

148 99mTc-EC20 is a folate receptor (FR)-targeted imaging agent consisting o

149 very and ultrasound-stimulated activation of folate receptor (FR)-targeted phase-change contrast agen

150 ting human cells that highly overexpress the folate receptor (FR).

151 orter/heme carrier protein 1 (PCFT/HCP1) and folate receptor (FR).

152 des and drugs into tumors overexpressing the folate receptor (FR).

153 third of human cancers that overexpress the folate receptor (FR).

154 0A and L1210JF) overexpress the cell surface folate receptor (FR).

155 t attached drugs to cells that overexpress a folate receptor (FR).

156 roton-coupled folate transporter (PCFT), and folate receptors (FR) are folate-specific transporters.

157 Folate receptors (FR) are inversely regulated by the ext

158 Glycosyl-phosphatidylinositol-anchored folate receptors (FR) have physiologic and pharmacologic

159 e through the translational up-regulation of folate receptors (FR) is unclear.

160 Folate receptors (FR) may be of use for targeted deliver

161 a 'database mining' strategy to detect novel folate receptors (FR), we identified two potential novel

162 The folate receptor (FRalpha) was significantly overexpresse

163 erated rat IgE and IgG mAbs specific for the folate receptor (FRalpha), which is expressed widely on

164 Folate receptors (FRalpha, FRbeta and FRgamma) are cyste

165 nese hamster ovary (CHO) sublines expressing folate receptors (FRs) alpha or beta (IC50s < 1 nM) or t

166 unds 1-3) were synthesized as substrates for folate receptors (FRs) and the proton-coupled folate tra

167 3b was completely selective for transport by folate receptors (FRs) and the proton-coupled folate tra

168 The expression of folate receptors (FRs) in cervical carcinoma (HeLa-IU1)

169 ellular acquisition of folate is mediated by folate receptors (FRs) in many malignant and normal huma

170 the intracellular trafficking of endocytosed folate receptors (FRs) labeled with fluorescent folate c

171 More recently, human folate receptors (FRs), high affinity receptors that tra

172 s study, the importance of sphingolipids for folate receptor function was investigated in Caco-2 cell

173 Our data suggest that the folate receptor gene and the beta-globin locus are regul

174 region between the beta-globin locus and the folate receptor gene is fully methylated and condensed a

175 ow that a 3.3 kbp DNA region upstream of the folate receptor gene is sufficient to induce strong expr

176 We have identified a folate receptor gene upstream of the chicken beta-globin

177 These include a folate receptor gene, a 16 kb condensed chromatin region

178 The human folate receptor (hFR) type gamma and gamma' are constitu

179 The human folate receptor (hFR) type gamma gene is driven by a TAT

180 The folate receptor homolog FOLR-1 is required for the stimu

181 t renal cyst-lining cells highly express the folate receptor in ADPKD and mouse models.

182 The involvement of the folate receptor in mediating tumor uptake of (111)In-DTP

183 n induction of expression of the human alpha folate receptor in nasopharyngeal epidermoid carcinoma c

184 Although a critical role of placental folate receptors in maternal-to-fetal folate transport w

185 Knockout of folate receptors in mice, and knock-down of folate recep

186 s study was to evaluate the in vivo assay of folate receptors in nonfunctional pituitary adenomas usi

187 ta-globin genes, consistent with the role of folate receptors in proliferation.

188 )Tc-folate is an accurate method of assaying folate receptors in vivo and may provide a quantitative

189 we hypothesized that autoantibodies against folate receptors in women may be associated with pregnan

190 Since antiserum to folate receptors induces embryo resorption and malformat

191 Our findings support a model in which the folate receptor interacts with cell adhesion molecules,

192 The cell membrane folate receptor is a potential molecular target for tumo

193 The cell-membrane folate receptor is a potential molecular target for tumo

194 The folate receptor is expressed at negligible levels in the

195 The folate receptor is overexpressed in a wide variety of hu

196 The folate receptor, like many glycosylphosphatidylinositol-

197 LM are taken up by activated macrophages via folate receptor mediated endocytosis and that their hydr

198 asily internalized by cancer cells through a folate receptor-mediated endocytic pathway.

199 m of rapamycin (FC-rapa) that is taken up by folate receptor-mediated endocytosis and cleaved intrace

200 t can significantly facilitate "scale up" of folate receptor-mediated liposomal cancer therapy to the

201 nhibition of thymidylate synthase with alpha-folate receptor-mediated targeting of tumor cells.

202 ith the (111)In-1 complex, consistent with a folate receptor-mediated targeting process.

203 It is likely that folate receptor-mediated transport is not sufficient to

204 The folate receptor-mediated transport of 5-methyltetrahydro

205 The (111)In-DTPA-folate also shows folate receptor-mediated uptake and retention in the kid

206 The folate receptor-mediated uptake of 99mTc-HYNIC-folate by

207 t of sphingolipid depletion was specific for folate receptor-mediated vitamin uptake.

208 could effectively target cancer cells, where folate-receptor-mediated endocytosis of QDs into living

209 he vitamin B9-binding pocket of an ancestral folate receptor molecule.

210 arison with the uptake of these particles in folate-receptor-negative cell lines such as A549.

211 ed, suggesting a causal relationship between folate receptor number and vitamin uptake.

212 ttachment of folic acid ligand recognized by folate receptors of cancer cells is described).

213 presumably reflecting radiotracer binding to folate receptors of the proximal tubules.

214 ies blocked the binding of [3H]folic acid to folate receptors on placental membranes and on ED27 and

215 gent), folic acid (FA, targets overexpressed folate receptors on specific cancer cells), and methotre

216 JQ-FT is recognized by folate receptors on the plasma membrane and delivered in

217 ents and conjugated with tumor cells through folate receptors over-expressed on cancer cells.

218 ol subjects contained autoantibodies against folate receptors (P<0.001).

219 tidylinositol-anchored hydrophobic placental folate receptors (PFRs), which have an important functio

220 ex of 1 was found to selectively localize in folate receptor-positive human KB tumor xenografts and t

221 of nude mice bearing approximately 100 mm(3) folate receptor-positive human xenografts led to complet

222 ted following the treatment of an aggressive folate receptor-positive J6456 lymphoma model.

223 ly inoculated with approximately 1.8 x 10(6) folate receptor-positive KB (human nasopharyngeal carcin

224 (44)Sc-cm09 was investigated in vitro using folate receptor-positive KB tumor cells and in vivo by P

225 (47)Sc-labeled cm10 was tested on folate receptor-positive KB tumor cells in vitro.

226 57BL/6 mice bearing subcutaneously implanted folate receptor-positive syngeneic tumors.

227 rovide a quantitative marker for identifying folate receptor-positive tumors.

228 y of folic acid conjugated quantum dots into folate-receptor-positive cell lines such as KB cells.

229 neous inoculation of approximately 4 X 10(6) folate-receptor-positive KB (human nasopharyngeal carcin

230 glycosylphosphatidylinositol (GPI) anchored folate receptor protein alpha (FR alpha) and thereby can

231 The high affinity of folic acid for folate receptors provides a unique opportunity to use fo

232 ntibodies by incubation with human placental folate receptors radiolabeled with [3H]folic acid.

233 element separating the globin locus from the folate receptor region, which suggests that this insulat

234 leotides at gestation day 8 or antibodies to folate receptor, results in profound developmental abnor

235 In vitro (47)Sc-cm10 showed folate receptor-specific binding and uptake into KB tumo

236 r the whole time of investigation and showed folate receptor-specific binding to KB tumor cells.

237 f folate and from the detectable presence of folate receptor-specific transcript, but there was no ev

238 ed upon a combination of cell doubling time, folate receptor status, S phase percentage, and TSase ex

239 designing more specific drugs targeting the folate receptor system.

240 study model, we hypothesized that IMI with a folate receptor targeted near-infrared contrast agent (O

241 However, the potencies of all folate-receptor targeted therapies depend on 1) the rate

242 Folate receptor-targeted cancer therapies constitute a p

243 ary nodule were intravenously administered a folate receptor-targeted fluorescent contrast agent spec

244 t-inducible NF-kappaB downregulation through folate receptor-targeted hollow gold nanospheres carryin

245 mize both the potencies and specificities of folate receptor-targeted therapies in vivo.

246 cally active agents covalently attached to a folate receptor targeting ligand unit via two disulfide-

247 To probe structural requirements for folate receptor targeting with low molecular weight radi

248 ere carried out to show that combined pH and folate-receptor targeting reduces off-target accumulatio

249 In this research, we have developed a folate receptor-targeting multifunctional dual drug-load

250 data does not support a contribution of the folate receptor to cytotoxicity.

251 alization of SWNTs inside cells labeled with folate receptor tumor markers, and NIR-triggered cell de

252 The folate receptor type alpha (FR-alpha) is a promising tum

253 a cell line overexpressing the tumor marker folate receptor, was affected by both the lipid to DNA r

254 To test this concept, we chose to target the folate receptor, which is overexpressed on the surface o

255 te 4-hydroxy-Tempo (tempol)-folate to target folate receptors, which are highly expressed in the prox

256 f ligand-mediated drug delivery by targeting folate receptors, which are overexpressed in most ovaria