ライフサイエンスコーパス: fold

1 so greatly stimulate TNF secretion (by 4,500-fold).

2 imilar manner as integrin subunit beta3 (>50 fold).

3 well as the AMPA receptor subunit GluA1i (5-fold).

4 the structure without distorting native RNA fold.

5 inf) varied among these strains by 33.7-56.6-fold.

6 Taxol towards cancer cell lines by over 200-fold.

7 thermostability and increased affinity by 60-fold.

8 gA, which reduced channel activity up to 10-fold.

9 2 was significantly decreased by 2.8 +/- 1.0-fold.

10 ues (Ser/Thr(296/297)) may perturb the local fold.

11 al that there are few commonalities in their folds.

12 between spontaneous and chaperonin-mediated folding.

13 nin), a complex known to function in protein folding.

14 dulate ribosome speed and facilitate protein folding.

15 with Zika virus impairs cortical growth and folding.

16 tein reach the transition state and continue folding.

17 e relative with cancer ( P < .001), with 3.3-fold, 2.1-fold, and 1.8-fold differences shown for lung,

18 orting (45.9 per 1000 patient-days) were 1.2-fold (95% CI, 1.1-1.2) higher than rates without family

19 increased iron absorption from FePP by 2.55-fold (95% CI: 1.48-, 4.37-fold; P = 0.001) but not from

20 meal, which did not reach significance (1.21-fold; 95% CI: 0.92-, 1.61-fold; P = 0.060).

21 Within 30 days, CABG patients had a 25-fold, a 26-fold, and a 18-fold higher risk of dying from

22 h a KD of 170 nM, which corresponds to a 120-fold affinity improvement compared to the parent molecul

23 odeling predicts that this protease adopts a fold and a catalytic site characteristic of minimal PLP

24 orms a bilobal structure consisting of an OB-fold and a holiday junction resolvase domain.

25 that POT1C contains two domains, a third OB fold and a Holliday junction resolvase-like domain.

26 Although the overall fold and catalytic center are conserved relative to othe

27 site(s) existing on the surface of any GLTP-fold and delineate new differences between GLTP superfam

28 increases its polarity by approximately 1000-fold and reduces the toxicity of Taxol towards cancer ce

29 e Bmal1(fx/fx);Tek-Cre mice decreased by 1.5-fold and was accompanied by a profound decrease in proli

30 t of stacking, significantly affect tertiary folding and appear to largely explain previously observe

31 control sequences to probe contributions to folding and binding, and identified 2,618 high-affinity

32 ained by the consequent challenge to protein folding and function.

33 binding of proteins and modulate the global folding and interactions of double helices with hundreds

34 d diverse scaffold libraries with verifiable folding and stability.

35 nteractions (for example, cleavage, binding, folding and unfolding) and biological targets in in vitr

36 nvestigate the biophysical mechanisms of RNA folding and unfolding, its interactions with ligands, an

37 nks are absolutely required to allow protein folding and, conversely, that protein folding occurs pri

38 I domains are one of the most common protein folds and are present in 2% of animal proteins.

39 with cancer ( P < .001), with 3.3-fold, 2.1-fold, and 1.8-fold differences shown for lung, colorecta

40 n 30 days, CABG patients had a 25-fold, a 26-fold, and a 18-fold higher risk of dying from myocardial

41 n by 50%, impedes salivary gland invasion 10-fold, and causes a complete absence of liver invasion as

42 ein found to possess the RNase A superfamily fold, and homologs of this toxin are associated with sec

43 PrgU has an RNA-binding fold, and prgB-prgU gene pairs are widely distributed am

44 CyRPA has a six-bladed beta-propeller fold, and we identify the region that interacts with PfR

45 of KaiB, a protein that adopts two distinct folds, and the post-adenosine triphosphate hydrolysis st

46 However, the effects of folded anisotropic fabrics, widespread in orogenic setti

47 uction was realized to be approximately four-fold as compared to the corresponding electrode modified

48 re found to be highly abundant in leaves (16-fold) as compared to flower tissues.

49 luK3a (59-fold), GluK2a (15-fold), GluK1b (5-fold), as well as the AMPA receptor subunit GluA1i (5-fo

50 on show that these mutations perturb protein folding, assembly or polarity of secretion of C1QTNF5 an

51 der mechanical force during co-translational folding at the ribosome.

52 d -825 have nanomolar beta1-AR affinity >500-fold beta1-AR vs beta2-AR selectivity and no agonism.

53 10-2 VF univariable model showed an almost 2-fold better fit to the data (R2 = 9.2% vs 4.9%).

54 tative genital protrusion varied more than 3-fold between species ranging from 0.5% of somatosensory

55 While tipping in a fold bifurcation of an equilibrium is well understood, m

56 Optimal constructs conferred 10(3)-fold binding enhancements with only two ligands.

57 f-assembly of defects such as scars, pleats, folds, blisters, and liquid crystal ripples.

58 drimer nanoparticle uptake significantly ( 2-fold both 2 and 6h following treatment).

59 catalysts that contain a shared core protein fold but whose active sites are located in entirely diff

60 2 differentially expressed regions with >|2| fold change and p </= 0.05.

61 el of nuclear Smad3 varied across cells, the fold change in the level of nuclear Smad3 was a more pre

62 d Poly(I:C), respectively, with at least a 1-fold change relative to unexposed thrombocytes.

63 entified and 740 proteins that presented a 4-fold change were considered a CRC proteomic signature.

64 cross diseases for statistical significance (fold change>/=1.5 and false discovery rate</=0.05), to i

65 in vitro (false discovery rate, </=0.001; 2-fold change) with 557 showing decreased and 329 showing

66 r expressed in PET false-negative cases (5.3-fold change, P < .001) which provides a mechanistic expl

67 = .045) and CD38+HLA-DR+ CD8+ T cells (1.40 fold-change in integrated HIV DNA per 1-unit increase in

68 grated HIV DNA with PD-1+ CD4+ T-cells (1.44 fold-change in integrated HIV DNA per 10-unit increase i

69 The precision of the fold-change response was observed throughout the signali

70 n skin accounted for 54% of the variation in fold changes of urinary PAH metabolites (p < 0.002).

71 st estimating protein fold-changes from mRNA fold-changes between different cell-types, and highlight

72 e results caution against estimating protein fold-changes from mRNA fold-changes between different ce

73 nant mIFN (rmIFN) exhibited an alpha-helical fold characteristic of type I IFNs and bound to IFNalpha

74 cal gyrification of the brain represents the folding characteristic of the cerebral cortex.

75 nvaded erythrocytes by an increase of 10-300 fold compared to wild-type (WT) merozoites.

76 lysine acetylation in Cpt2M(-/-) hearts 2.3-fold compared with littermate control mice fed a ketogen

77 Toc75 is predicted to have a beta-barrel fold consisting of an N-terminal intermembrane space (IM

78 : six samples (four to approximately 1- to 4-fold coverage) from a 3,500 year temporal transect ( app

79 During 10-fold cross validation, we increased the accuracy of the

80 benchmarking experiments based on both five-fold cross-validation and independent tests indicated th

81 d the performance of our method using both 5-fold cross-validation and independent tests.

82 teristic curve) that reaches 0.65 both in 10-fold cross-validation and on an independent test set.

83 ities was assessed and validated by using 10-fold cross-validation to limit the effect of optimistic

84 erformance was internally validated using 10-fold cross-validation.

85 ecific tissues for (18)F-4FMFES, notably a 4-fold decrease in blood-pool activity as compared with (1

86 ood at different larval masses produced a 10-fold difference in mass between smallest and largest adu

87 We identified 764 genes with at least a 2-fold difference in TL1A-mediated expression between IFNG

88 P < .001), with 3.3-fold, 2.1-fold, and 1.8-fold differences shown for lung, colorectal, and breast

89 ion with acetonitrile/water/formic acid, ten-fold dilution and analysis by LC-MS/MS using a pH 10 car

90 owed by screening for variants whose in vivo folding displays increased or decreased GroEL dependence

91 The amino-terminal domain with a fold distinct among known TRP structures, together with

92 73 N-terminal 111 residues form a globularly folded domain (hCDC73-NTD).

93 Runx2 was up-regulated by 6.4-fold during IL-13-induced goblet cell differentiation of

94 These clones possess 100-140 fold enhanced catalytic efficiency compared to hASNase1.

95 ion angle and polarization, and achieved 10-fold enhancement in fluorescence intensity compared to a

96 hed at the vegetal pole and six were over 10-fold enriched at the animal pole.

97 Ninety were novel mRNAs over 4-fold enriched at the vegetal pole and six were over 10-f

98 ork to dissect the coupling of synthesis and folding essential for riboswitch function, revealing the

99 ators, and not significantly affected by 100-fold excess sulfate, which reduced selenate uptake by 10

100 vaccination, we observed an approximately 70-fold expansion of the plasmablast population.

101 tion of the second nucleotide (kobs2) is 700-fold faster for tCfTP than tCTP due the increased effect

102 reased, the rate of binding, particularly to folded FN, and stability of the bound FN-alphavbeta3 com

103 Signal was amplified nearly 25-fold for DON, 90-fold for ZEA and 12-fold for T-2 toxin

104 arly 25-fold for DON, 90-fold for ZEA and 12-fold for T-2 toxin assay using Ab2-AuNPs.

105 nal was amplified nearly 25-fold for DON, 90-fold for ZEA and 12-fold for T-2 toxin assay using Ab2-A

106 Macrodomain is a conserved protein fold found in several plus-strand RNA viruses that binds

107 The diagnosis rate of OUD increased nearly 6-fold from 2001 to 2014 (from 0.26 per 100000 person-year

108 olecules captured by the nanopore can freely fold from the unstructured state without constraint and

109 n applied to the human genome, we achieve 55-fold genome coverage, allowing us to map autonomous prom

110 of KAR subunits GluK3a (59-fold), GluK2a (15-fold), GluK1b (5-fold), as well as the AMPA receptor sub

111 current amplitude of KAR subunits GluK3a (59-fold), GluK2a (15-fold), GluK1b (5-fold), as well as the

112 Strikingly, nanodiscs elicited up to 47-fold greater frequencies of neoantigen-specific CTLs tha

113 y and systolic dysfunction, evidenced by a 5-fold greater heart mass, 60-90% reduction in blood eject

114 Indeed, Ru-thio-chrysin displayed a 4-fold greater inhibition of platelet function and thrombu

115 ntervention period was associated with a 4.5-fold greater odds of receiving preferred beta-lactam the

116 Step count was at least 2-fold greater on POD1 [mean difference 843.3 steps (95% C

117 cific CTLs than soluble vaccines and even 31-fold greater than perhaps the strongest adjuvant in clin

118 ecific IgG and IgA with the IgA responses 30-fold greater than systemic levels.

119 carrier in vivo jetPEI, siRNA-L2 achieved 19-fold greater tumor accumulation and 46-fold increase in

120 FP group, cells from BMP group showed >1,000-fold higher BMP-2 release, and the majority of them stai

121 ed Th17 induction and the correspondingly 10-fold higher CT B subunit-specific serum IgG response in

122 erial lysis typically requires at least a 10-fold higher electric field ( approximately 10 kV/cm), re

123 The risk of all second cancers was 1.3-fold higher for HL survivors with a first-degree relativ

124 d not (95% CI, 3.1-5.7); risk of IBS was 2.3-fold higher in individuals who had infectious enteritis

125 tistically significant, rates of BPAR were 2-fold higher in patients administered belatacept every 8

126 Risk of IBS was 4.2-fold higher in patients who had infectious enteritis in

127 alpha-tocopherol concentration was over 3.5-fold higher in supplemented samples than in control lamb

128 ared to those from IL5tg mice, including 800-fold higher levels of eotaxin-1.

129 late from the roots constitutively and had 2-fold higher malate concentrations in the xylem sap than

130 versus lowest TMAO quartile had a crude 1.86-fold higher mortality risk (Ptrend < 0.001).

131 patients had a 25-fold, a 26-fold, and a 18-fold higher risk of dying from myocardial infarction, he

132 rate for S. pinnata (1 h) was three- to four-fold higher than for nonhyperaccumulators, and not signi

133 (2) The retention of E. coli O157:H7 was 3.3 fold higher than that of E. coli K12 in all biochar-amen

134 gher than that of Pol mu and approximately 2-fold higher than that of Pol lambda.

135 searching ability of Pol beta is at least 4-fold higher than that of Pol mu and approximately 2-fold

136 able to those of known oncogenes and are ten-fold higher than those of random genes.

137 ss than 0.2 to greater than 0.7 IU/ml had 10-fold higher tuberculosis incidence rates than those who

138 ination over intramuscular delivery of a two-fold higher vaccine dose.

139 The 28-day all-cause mortality was two-fold higher when procalcitonin did not show a decrease o

140 ostsynaptic currents (sEPSCs) three- and two-fold higher, respectively, than those of adapting neuron

141 ts show that the as-prepared biosensor has 7 folds higher catalytic activity with lower oxidation pot

142 Secondary effects on protein folding homeostasis likely contribute to UPR activation,

143 retains full metabolic activity, but is 100-fold impaired in its ability to activate APJ.

144 ITP-based immunoassay and demonstrate a 1300-fold improvement in limit of detection compared to a sta

145 bility, the resolution of which yielded a 25-fold improvement in taxadiene production.

146 ediated intracellular delivery results in 10-fold improvement of its cancer cell-killing efficacy.

147 ificantly larger (all P < 0.04) by up to 8.5-fold in +DD compared to -DD subjects.

148 called foldons and that a number of proteins fold in a reproducible pathway one foldon unit at a time

149 ting galectin-3, which is increased up to 30-fold in cancer patients, promotes blood-borne metastasis

150 and total cardiovascular risk were nearly 2-fold in comparison with subjects who remained below CAC5

151 to an additional increase of more than five-fold in imaging contrast in vivo.

152 -mediated inhibition of FXa approximately 12-fold in the presence of protein S.

153 y enhance microtubule growth rate by several-fold in vitro.

154 Protein folding in the cell was originally assumed to be a spont

155 Proper gp160 folding in the ER requires core glycosylation, disulfide

156 a number of compound families by 18- to 210-fold, including the silent virulence factor malleilacton

157 ns of cooperativity and stability in protein folding, including the balance between solvent and polyp

158 meta-analysis of four studies estimated a 10-fold increase (in other words, times 10) in PBDE exposur

159 ion-inhibition antibody titer geometric mean fold increase against influenza B and (2) lower seroconv

160 mutant bound to the DNA consensus with a 30-fold increase in affinity (100 nm).

161 es of over 9 mAh cm(-2)areal , which is a 35-fold increase in capacity compared to without phenol.

162 he Janus catalyst exhibits a more than three-fold increase in catalytic efficiency compared to the Pt

163 reference genome, our assembly features a 52-fold increase in contig length and notable improvements

164 This corresponds to an unprecedented 7.8-fold increase in crossover frequency.

165 evaluated for seroconversion, defined as a 4-fold increase in immunoglobulin G directed against Crypt

166 in 0.2cm(2) area of nail permitting a 10(3)-fold increase in initial drug uptake.

167 n after injection of the tracer showed a 2.5-fold increase in metabolic stability of (18)F-4FMFES ove

168 mine, whereas one atpE mutant exhibited a 50-fold increase in MIC for BDQ.

169 gnificantly rescued dye visual function ( 58 fold increase in OKR, p < 0.001, 3 fold increase in VMR

170 ed 19-fold greater tumor accumulation and 46-fold increase in per-tumor-cell uptake in a mouse orthot

171 n PAL-RNAi transgenic plants resulted in 1.6-fold increase in phenylacetaldehyde emission.

172 by the use of the coatings, which led to a 2-fold increase in plum storability.

173 lows a 30-fold longer reaction time and a 40-fold increase in pressure compared to standard PTR-TOF-M

174 contrast, S. melilutra models exhibit a six-fold increase in stiffness from expected stiffness-volum

175 rived mesenchymal stem cells, displayed a 55-fold increase in the expression of hepatocyte growth fac

176 ardiac arrhythmia and is associated with a 5-fold increase in the risk for stroke.

177 efore pregnancy and was associated with a >2-fold increase in the risk of offspring obesity at ages 6

178 offers high sensitivities, achieving a four-fold increase in the supported number of subscribers and

179 ion ( 58 fold increase in OKR, p < 0.001, 3 fold increase in VMR, p < 0.05).

180 A threefold to 32-fold increase occurred within 15 minutes after initiatio

181 rimary teeth from 3 GACI subjects revealed 4-fold increased cervical cementum thickness ( P = 0.00007

182 t quartile of a 127-variant score had a 2.49-fold increased odds of cardioembolic stroke (95% confide

183 ring with PTEN germline mutations confer a 2-fold increased prevalence (OR 2.7) of thyroid cancer com

184 22q11.2DS) is associated with a more than 20-fold increased risk for developing schizophrenia.

185 risk-increasing foods is associated with a 2-fold increased risk of all-cause mortality.Selecting spe

186 -, approximately 5.1-, and approximately 6.7-fold increases in col Ialpha 1, sox 9, and aggrecan gene

187 mutations are associated with modest 2- to 8-fold increases in MICs for BDQ and clofazimine, whereas

188 , URMC-099 activation of autophagy led to 50-fold increases in the plasma drug concentration of the v

189 We observed 3-fold increases in tumor mass and levels of angiogenesis

190 The covalently connected strands folded into hyperstable collagen triple helices (Tm appr

191 hat SFTI-1 and the albumin are independently folded into well-defined domains separated by a flexible

192 e C-terminal extension of capsid protein VP3 folds into a globular protruding (P) domain, exposed on

193 ray scattering analyses show that the Zf-GRF fold is typified by a crescent-shaped ssDNA binding claw

194 Protein folding is a complex process that can lead to disease wh

195 In many cases, folding is associated with myosin accumulation at the ap

196 riflate in facilitating this reaction is two-fold: it enables "ate" complex formation and overcomes c

197 e central subunit of the BAM complex, on the folding kinetics of a model OMP (tOmpA) using fluorescen

198 d to cross the energy barrier that dominates folding kinetics, known as the transition path time.

199 developed massive albuminuria (controls: 35-fold; KO: 5400-fold versus baseline), hypoalbuminemia, r

200 al dendrites, these inputs produce a 5- to 6-fold larger EPSP at the soma of CA2 compared with CA1 PN

201 ome of closely related cyanobacteria, but 10-fold larger than most plastid genomes.

202 though viruses from the tenofovir arm were 2-fold less infectious, they replicated at rates similar t

203 etween the target protein and entries in the fold library to generate models.

204 Therefore, the new design allows a 30-fold longer reaction time and a 40-fold increase in pres

205 latitudes (8% vs. 11% of genera), despite 11-fold lower abundance (1.2% vs. 12.7% of basal area).

206 sites, inhibits Angpt1 signalling at seventy-fold lower concentrations.

207 in response to IL4 treatment resulting in 4-fold lower PPARgamma expression in knock-out cells than

208 riant and isoform dependent, with a 5- to 11-fold lower sensitivity to Cav1.3 variants during SN DA-l

209 sitively related to aqueous zinc, but were 7-fold lower than larvae.

210 ough the amount of HT in the biscuit was 100-fold lower than the biscuit formulated with HT.

211 tructural information for this vital protein-folding machine in humans.

212 gested pull and release approach to graphene folding may find applications in the theoretical studies

213 A 4-fold modified risk was found with ADRA1A rs17426222 and

214 ssembly of the dephosphorylated filaments to folded monomers, dimers, and small oligomers, followed b

215 g E. coli K-12 in pure cultures, PEf1 was 20-fold more effective in suppressing E. coli under simulat

216 set of repurposable drugs is approximately 6-fold more enriched with drugs having published evidence

217 We now show that ANI-7 is up to 263-fold more potent at inhibiting the growth of breast canc

218 utated) immunocytokines that are up to 1,000-fold more potent on target cells, allowing specific sign

219 optimization led to compound 28, which was 4-fold more potent than its parent 3.

220 cells that expressed MAN2A1-FER were about 2-fold more sensitive to the FER kinase inhibitor crizotin

221 We found that the residues making up the folding nucleus tend to interact in the denatured state

222 ing incomplete and distorted versions of the folding nucleus.

223 ding nonnative interactions, and most of the folding occurs after the initial binding event.

224 rotein folding and, conversely, that protein folding occurs prior to disulfide formation.

225 act information to determine the topological fold of RNA.

226 he apparent surface uniformity and conserved fold of SH3 domains, they display different binding mech

227 The P-loop phosphotransferase fold of the kinase is embellished by a unique 'G-loop' e

228 ty of co-replicational or co-transcriptional folding of G-quadruplex inside the polymerase machinery

229 d anaerobic electron acceptors for oxidative folding of periplasmic proteins.

230 BG have been implicated in the expansion and folding of the cerebrum and cerebellum, respectively.

231 n identity-could coordinate co-translational folding of the encoded protein.

232 rocyclization proceeds efficiently, inducing folding of the o-phenylenes.

233 analysis mainly detects selection for proper folding of the TCR receptor protein.

234 in the oligosaccharide-oligonucleotide (OB) folds of POT1 have been identified in many human cancers

235 An arabinose-inducible, rapidly folding OmpA-GFP chimera was utilized to jam the SecYEG

236 ried significantly among sites, more than 36-fold on a mass basis.

237 insen's discovery that purified proteins can fold on their own after removal from denaturant.

238 id not affect the ability of beta-tubulin to fold or become assembled into the alpha/beta-heterodimer

239 exposed hydrophobic regions of incompletely folded or aggregated proteins.

240 rate, but found that stabilizing either the folded or unfolded TL conformation decreased termination

241 Fold outgrowth was superior from LL explants compared to

242 ion than their parental AAV vectors (2- to 9-fold over AAV2), with the highest of these being the hap

243 sition rate can be as high as [{n(n + 1)}/2]-fold over conventional EEM spectrometers.

244 ntary and balanced subdesigns analogous to a fold-over in two-level reduced factorial designs.

245 In these structures, folding overcomes intramolecular electrostatic repulsion

246 ubsequent airway smooth muscle growth by 1.5-fold (P < 0.05), which was dependent on MMP-1 activation

247 hese, 176 proteins were altered at least 1.5-fold (p-value < 0.05) in abundance during hypochlorite s

248 from FePP by 2.55-fold (95% CI: 1.48-, 4.37-fold; P = 0.001) but not from FeSO4 There was a trend to

249 significance (1.21-fold; 95% CI: 0.92-, 1.61-fold; P = 0.060).

250 The strategy is based on a three-fold, partially intermolecular [2+2+n] (n = 1 or 2) cycl

251 This is an example of a well-folded partner of NUPR1, because its other interacting p

252 This finding suggests that the folding path of twister RNA requires proper orientation

253 Here, we effectively map part of the folding pathway for the model large multidomain protein,

254 Long folding pathways are interesting, because they demonstra

255 ic G4 structures, correctly assessing the G4 folding potential of over 700,000 such sequences in the

256 ion with a combinatorial approach to the RNA folding problem in order to compute all possible non-pse

257 int and can be programmed to terminate their folding process at different intermediates.

258 ones, notably involved in the gluten-protein folding process, were up-regulated in superior (SP) and

259 Exploring the tertiary structure folding processes of RNA enables us to understand and co

260 in windowed calculation along the sequence: fold propensity, and net segment charge.

261 mutant of an extensively studied flavodoxin fold protein CheY.

262 otein interactions (PPIs), those involving a folded protein and an intrinsically disordered protein (

263 tness landscapes in the context of a protein fold provides a strategy for elucidating the sequence-st

264 gM with synonymous alternates produced a 600-fold range in FlgM activity.

265 e population varied over an approximately 15-fold range, from 57 for IGF1 to 872 for IGF2R, although

266 diction, secondary structure prediction, and fold recognition.

267 typical of type I IFNs, albeit with 100-1000-fold reduced potency compared with rmIFNalpha1 and rmIFN

268 mples analyzed, with SERS demonstrating a 60-fold reduction in acquisition time compared with HPLC.

269 010 in South Asian forests and increased 3.5-fold relative to 1850.

270 easured by gpELISA (estimated geometric mean fold rise from baseline [GMFR] = 1.6 [95% confidence int

271 (8)]-gamma-MSH-NH2 (compound 5), which is 16-fold selective for the hMC1R (EC50 = 4.5 nM) versus othe

272 1beta-HSD1) enzyme (IC50 3.0 nM) with >10000-fold selectivity over human 11beta-hydroxysteroid dehydr

273 ents were combined, the current increased 12-fold, showing the two effects are due to independent mec

274 stasis of breast cancer was approximately 10-fold smaller than glioma vasculature.

275 We found that when Spy0125 was in a folded state, its thioester bond could be cleaved with t

276 he Dumbbell structure to maintain an overall folded state.

277 ronger H-bonds, and increased entropy in the folded state.

278 e dynamically controllable via switching the folding state of Miura-ori split-ring resonators.

279 el wherein DDX1 can act as an RNA chaperone, folding stem IIB into a proper Rev binding conformation.

280 fy clusters corresponding to known tetraloop folds such as GGUG, RNYA, AGNN, and CUUG.

281 Substrate binding breaks the six-fold symmetry of the complex, allowing five of the six V

282 nected metal helix slat structures with four-fold symmetry, which exhibits nonresonant Drude-like res

283 xic solanine and chaconine, exceeding by 2-5-fold the recommended limit, and ranging from 2578+/-86mg

284 the ADAMTS13 cleavage site through A2-domain-fold thermodynamic destabilization.

285 defining the functions of CTCF in chromosome folding, these results provide new fundamental insights

286 By making a direct connection to protein folding, this analysis provides strong evidence that man

287 h SP (1 microM), markedly increase (by 1,000-fold) TNF gene expression in cultured human LAD2 and pri

288 Several different strand-folding topologies have been reported for Q-quadruplexes

289 for several physiological processes.Proteins fold under mechanical force during co-translational fold

290 ighlight connections between protein/peptide folding, unfolding and aggregation mechanisms, with the

291 ive albuminuria (controls: 35-fold; KO: 5400-fold versus baseline), hypoalbuminemia, reduced GFR, and

292 s are decorated by large spikes around the 5-fold vertices.

293 response of the cellular metamaterial during folding were studied to investigate the underlying mecha

294 tionary phase and boosts heat resistance 100-fold when expressed in Escherichia coli This qualifies C

295 active model of chaperonin-mediated protein folding, where partial unfolding of misfolded intermedia

296 The second domain has a known SWIB/MDM2 fold, which was not observed before in other translation

297 erstood are the very early stages of protein folding, which are likely defined by intrinsic local int

298 sion of AF markers was upregulated with 5-30 folds within the equiaxially loaded biphasic scaffolds c

299 tion, and invasiveness and formed larger (>2-fold) xenograft tumors in mice, with more metastases, th

300 om the extended unfolded state to the native fold, yielded nearly 120 mus of cumulative sampling time