ライフサイエンスコーパス: foldamer

1 even in solvents that normally denature the foldamer.

2 ked geometry characteristic of this class of foldamer.

3 al-centered reduction of a Cu(II)-containing foldamer.

4 , detectable by (13)C NMR, is induced in the foldamer.

5 abilize the folding in a variety of peptidic foldamers.

6 us allowing the rational design of new short foldamers.

7 formations and expands the repertoire of the foldamers.

8 secondary structures formed by beta-peptide foldamers.

9 , the released SWCNTs appeared to be free of foldamers.

10 ve a strong interfacial interaction with the foldamers.

11 omposed of either alpha-peptides or peptidic foldamers.

12 udy the secondary structures of these hybrid foldamers.

13 /beta-peptides") are intriguing as potential foldamers.

14 atic conformational studies of gamma-peptide foldamers.

15 zation of short o-phenylene ethynylene (oPE) foldamers.

16 irector of absolute helicity in nickel-salen foldamers.

17 nd oligomers and synthetic biological hybrid foldamers.

18 s prompting the design of new peptidomimetic foldamers.

19 ly described, solvent-driven folding of m-PE foldamers.

20 reated based on the folding of these helical foldamers.

21 ons, including the synthesis of beta-peptide foldamers.

22 rocesses ("effect") in these oligoazobenzene foldamers.

23 on mechanism across nanosized, rigid helical foldamers.

24 ntimicrobial helical sulfono-gamma-AApeptide foldamers.

25 mers in the synthesis of aromatic oligoamide foldamers.

26 conformational transition of the pentameric foldamer 105 is reflected in distinct spectral character

27 Helical foldamer 2 was synthesized and bound to human carbonic a

28 rption bands compared to the monomer M (tau4,foldamer = 20 ps, tau4,monomer = 9 ps).

29 etic details of donor-acceptor oligorotaxane foldamers, a class of molecular switches.

30 In water, this foldamer adopts a right-handed helical conformation with

31 vibrational features of the monomer and the foldamer after photoexcitation, with an additional time

32 ral role, on the basis of comparisons with a foldamer analogue that shows much-reduced binding.

33 sed in various shape persistent macrocycles, foldamers and "molecular machines".

34 The conformations of three cholate foldamers and one molecular basket were studied by fluor

35 e important building blocks for designing of foldamers and other biomimetic structures.

36 a series of structurally related amphiphilic foldamers and present a more refined model of their conf

37 inhibitors, including constrained peptides, foldamers and proteomimetic-derived ligands.

38 to photoinduced charge transfer between the foldamers and SWCNTs.

39 Foldamer architectures dictate the unfolding and refoldi

40 Foldamers are an intriguing family of biomimetic oligome

41 The designed foldamers are highly active against S. aureus in an anim

42 Synthetic foldamers are particularly attractive systems for develo

43 In this respect, peptidic foldamers are perhaps the best-characterized systems, as

44 Foldamers are synthetic and designable oligomers that ad

45 thus far formed by the folding of unnatural foldamers, are generated.

46 The studies revealed that a QPY foldamer as a stator can reversibly control the intermes

47 d NMR confirm left-handedness of the helical foldamers as well as HCA dimerization.

48 Forty-eight copies of the foldamer assemble into a 5-nm cage-like structure, an om

49 d to the backbone of a quinquepyridine (QPY) foldamer at the second and fourth pyridine rings, respec

50 ization of azobenzene moieties embedded in a foldamer backbone and the resulting conformational helix

51 t among several alpha/beta- and beta-peptide foldamer backbones only alpha/beta-peptides intended to

52 nstructing rotamer libraries for non-natural foldamer backbones.

53 ical secondary structures available to these foldamer backbones.

54 alysis of the EPR spectra shows that the L,D foldamers bear two types of complexation sites that are

55 The trans-dominated helical foldamer becomes less stable upon photoisomerization to

56 d the 14-helicity of a well-studied class of foldamers, beta(3)-peptides, in water.

57 d conformational behavior of photoresponsive foldamers bound in a phospholipid bilayer akin to a biol

58 Glutamate-functionalized oligocholate foldamers bound Zn(OAc)(2), guanidine, and even amine co

59 re comprised of a central helical oligoamide foldamer bridge with 9, 14, 18, 19, or 34 8-amino-2-quin

60 re has revealed several key requirements for foldamer bundle formation in aqueous conditions, and pro

61 helical diastereomers of nickel-salen-based foldamers can be observed on a NMR time scale.

62 mational studies of the basic units of these foldamers can be of invaluable assistance in designing n

63 f bioinspired unnatural backbones leading to foldamers can provide effective peptide mimics with impr

64 These helical foldamers can serve as novel platforms for the systemati

65 oligomers with well-defined conformations ("foldamers") can mimic protein secondary structural eleme

66 lene ethynylene)s, which are single-stranded foldamers, can be made to reversibly disperse and releas

67 uted glycine, represent a versatile class of foldamers capable of folding into defined secondary and

68 gress has been reported within this context, foldamer capsules reported thus far are largely restrict

69 An achiral but helical foldamer carrying a basic binding site interacts selecti

70 Such foldamer catalysts are shown to form an autocatalytic se

71 centers, promising a generation of synthetic foldamer catalysts for enantioselective transformations

72 he binding site, and reversibly switches the foldamer chain between its left and right-handed conform

73 tatistical mechanical partition functions of foldamer chain molecules.

74 Two epimeric series of foldamers characterized by the presence of a repeating a

75 series of oligomers forms ordered beta-turn foldamers, characterized by a 311 pattern.

76 development of a new class of antimicrobial foldamers combating emerging antibiotic-resistant pathog

77 mational ordering of this important class of foldamer compounds.

78 studied as important examples of biomimetic "foldamer" compounds, as they exhibit a capacity to popul

79 creasingly important class of peptidomimetic foldamers comprised of N-alkylglycine units that have be

80 Synthetic foldamers consisting of beta-amino acids offer excellent

81 Peptidic foldamers, consisting of various amino acid based backbo

82 between molecules, as the three amphiphilic foldamer constitutional isomers that formed hydrogels up

83 alpha/gamma-Peptide foldamers containing either gamma(4)-amino acid residues

84 characterization of new alpha/gamma-peptide foldamers containing the cyclically constrained gamma-am

85 ructure formed from an amphiphilic arylamide foldamer crystallized from aqueous solution.

86 It is not yet evident if foldamer design can be extended to reliably create terti

87 elated to diverse building blocks and modern foldamer design principles, such as the stereochemical p

88 s expand the scope of heterogeneous-backbone foldamer design to a new tertiary structure class and sh

89 Previously we described a foldamer (designated 1 here) that was generated from GCN

90 The first step in foldamer development is to identify synthetic oligomers

91 lectrical measurements, we observed that the foldamer-dispersed SWCNTs are individually well-disperse

92 Under illumination, transistors based on the foldamer-dispersed SWCNTs demonstrated significant photo

93 Non-natural folded polymers (foldamers) display considerable versatility, and the des

94 The potential of foldamer drug candidates reaching the clinic is still a

95 r, we describe that rational designed hybrid foldamers exhibit potential in the detection of polynucl

96 Presented herein is a foldamer for strand mimicry in which dipolar repulsion i

97 toids, have emerged as an important class of foldamers for the study of biomolecular interactions and

98 ense of an otherwise achiral helical peptide foldamer formed from the achiral quaternary amino acids

99 ay during which the hole migrates across the foldamer from the acceptor to the donor.

100 These facially amphiphilic foldamers have a relatively rigid intramolecular hydroge

101 therapeutic perspective, while polyaromatic foldamers have barely evolved from their nascency and re

102 ion to regulate chloride, aryltriazole-based foldamers have been created to "catch and release" chlor

103 Nonnatural foldamers have been developed to emulate these protein s

104 Over the past decade, foldamers have progressively emerged as useful architect

105 ctures comparable to those found in nature ("foldamers") have considerable potential for use in a ran

106 adopt well-defined compact conformations, or foldamers, have been attained utilizing hydrogen bonding

107 Nonnatural folded polymers, or foldamers, have the potential for similar versatility, a

108 Using foldamers having controlled sequences, structures, and w

109 the H-bonding pattern and the handedness of foldamer helices are rare so far.

110 Several foldamer helices featuring topologically distinct H-bond

111 cently reported water-soluble self-assembled foldamer helix bundle to encapsulate simple guest molecu

112 ping mechanism of hole transport through the foldamer helix, with individual hops occurring on the su

113 Foldamers, however, have not been explored as platforms

114 lation of guests by a complex self-assembled foldamer in aqueous conditions is possible.

115 The middle foldamer in the stack can be replaced by alternate seque

116 ies for achieving stable folding among short foldamers in aqueous solution.

117 s expected to prove useful for this class of foldamers in general.

118 The behavior of the foldamers in the membrane phase is similar to that of an

119 ort o-phenylenes, a simple class of aromatic foldamers, into twisted macrocycles.

120 However, the charge density of the foldamer is one-half that of the natural polymer.

121 Screw-sense inversion in these helical foldamers is coupled with cyclohexane ring-flipping, and

122 his study, a new set of chirality controlled foldamers is provided to probe as biocompatible biopolym

123 n this perspective, the current knowledge of foldamers is reviewed in a drug discovery context.

124 was used to probe the inter-relationship of foldamer length, self-association strength, and ionophor

125 charge transfer is very fast considering the foldamer length.

126 injection rate is largely invariant for all foldamer lengths (ca. 60 ps), the subsequent hole transf

127 As a result, the foldamer-ligand mixture behaves as a biomimetic chemical

128 tetracarboxylic diimide (PTDI) units: linear foldamers lin2 and lin4, monocyclic complement cyc2, and

129 s in the main chain of N,N'-linked oligourea foldamers locally impairs the characteristic three cente

130 Small changes in the structure of a foldamer may lead to gross changes in conformational pre

131 Based on these findings, chain-centered foldamers might find use as models to investigate the fu

132 fined and predictable folding propensities ('foldamers') might lead to molecules with useful function

133 ong these are synthetic oligomeric peptide ("foldamer") mimics, which can display conformational orde

134 Prior to heating, all foldamers of the series exhibited spectral characteristi

135 Many foldamers, oligomers that adopt well-defined secondary s

136 s between n = 1 on one side and longer chain foldamers on the other side.

137 future biomedical development of urea-based foldamer peptide mimics.

138 Analysis of the biological activity of the foldamer peptides showed that four anginex derivatives d

139 Foldamers present a particularly difficult challenge for

140 Foldamers provide an attractive medium to test the mecha

141 deciphering the dynamics of photoswitchable foldamers provides a detailed understanding of their pho

142 s valuable insight toward the development of foldamer quaternary assemblies with improved (bio)physic

143 A synthetic helical aromatic oligoamide foldamer receptor with high affinity and selectivity for

144 tly, the secondary structure of this minimal foldamer regulates its ability to dimerize dihydrofolate

145 opt well-defined secondary structures (i.e., foldamers) represent appealing components for the fabric

146 The foldamers retained the beta-sheet tendency, though with

147 Linear, cyclic, and concatenated foldamers reveal that photoabsorption and excitation ind

148 olecule fluorescence studies on chromophoric foldamers reveal that the maximum domain length is deloc

149 lease using light-dependent control over the foldamer's degree of helix stabilization.

150 The predictability of the foldamer secondary structure coupled to the high level o

151 permit both rational and modular control of foldamer secondary structure, while maintaining the capa

152 Although foldamer self-association in nonpolar chloroform increas

153 arginine and glutamic acid residues into the foldamer sequence.

154 ign approach that exploits the modularity of foldamer sequences and, in the case of aromatic amide fo

155 mains challenging to design these so-called 'foldamers' so that they are capable of inducing or contr

156 ce of photoinduced structural changes in the foldamer, starting from the initial ultrafast isomerizat

157 B[n] family, it is possible to fold a single foldamer strand (3) into the CB[8].(a,a,a,s)-3 conformer

158 e linkage may be introduced into Aib peptide foldamer structures by standard coupling methods and pho

159 the way for its use in the design of future foldamer structures.

160 However, examples of foldamer subunits within larger architectures remain rar

161 Non-hydrogen bonded foldamers such as those generated from 2,2-disubstituted

162 quid crystals, molecular switches, polymers, foldamers, supramolecular materials, molecular recogniti

163 The dynamic properties of foldamers, synthetic molecules that mimic folded biomole

164 ptoids", are a prototypical example of these foldamer systems and are known to form a helix resemblin

165 opology is seen in few natural and unnatural foldamer systems.

166 Along with other "foldamer" systems, peptoid oligomer sequences can be pre

167 on, with an additional time constant for the foldamer (tau = 150 ps), indicating the initial steps of

168 These results demonstrate the application of foldamer templates as therapeutics.

169 e crystal structure of an alpha/beta-peptide foldamer that adopts a tetrameric helix-bundle quaternar

170 synthesis, and structural analysis of a new foldamer that mimics an extended beta-sheet are presente

171 eviously, we reported an abiotic amphiphilic foldamer that, upon heating, undergoes an irreversible c

172 ve been exploited in the design of aedamers--foldamers that adopt a novel, pleated secondary structur

173 ilding blocks to prepare alpha/gamma-peptide foldamers that adopt a specific helical conformation in

174 ic N,N'-linked oligoureas are peptidomimetic foldamers that adopt a well-defined helical secondary st

175 cation and analysis of helical peptide-based foldamers that bind to a specific cleft on the anti-apop

176 We describe efforts to develop peptidic foldamers that bind to the irregular receptor-recognitio

177 tal structures of six new alpha/beta-peptide foldamers that have a regular alpha-residue/alpha-residu

178 lected stereoisomers, most of them being new foldamers that have been synthesized and characterized f

179 Two photoswitchable foldamers that incorporate azobenzene moieties as the en

180 n the achiral domain of the maleamide-linked foldamers that is absent from the fumaramides.

181 d small (molecular mass <1,000 Da) arylamide foldamers that mimic antimicrobial peptides.

182 The ability to design foldamers that mimic the defined structural motifs of na

183 Here we report heterogeneous-backbone foldamers that mimic the zinc finger domain, a ubiquitou

184 is to design unnatural backbone oligomers ("foldamers") that fold like natural peptides.

185 sequences and, in the case of aromatic amide foldamers, their amenability to structural elucidation,

186 Termed "foldamers," these agents have diverse potential applicat

187 e rise in predictable designs of abiological foldamers, this water-assisted strategy can, in principl

188 e we demonstrate the capacity of a synthetic foldamer to capture structure in a disease relevant pept

189 to both ends of an mPE dodecamer induce the foldamer to collapse into a presumed helical conformatio

190 organizing and stabilizing an aryl-triazole foldamer to help extract hydrophilic chloride ions from

191 mbling guests exemplifies the amenability of foldamers to outstanding achievements in molecular recog

192 ray to cooperatively interlock the ends of a foldamer together with its helical core.

193 micking the properties of biomacromolecules, foldamers using solvophobic driving forces must be tempe

194 The most stable foldamer was composed of a total of 6 residues beginning

195 bis-hexameric oligo(m-phenylene ethynylene) foldamer was examined in 30 solvents to correlate the un

196 tion relations of beta-amino-acid-containing foldamers, we followed a top-down approach to study a se

197 e mechanism of action of these antimicrobial foldamers, we have investigated the lipid interaction, d

198 All of these foldamers were crystallized from aqueous solution, and a

199 The conformations of these foldamers were studied by fluorescence spectroscopy in h

200 The conformations of the foldamers were studied by UV, fluorescence, fluorescence

201 es, we studied oligo(m-phenylene ethynylene) foldamers, where the introduction of an endo-methyl grou

202 nce in a helical oligo(aminoisobutyric acid) foldamer, which is relayed to a reporter group at the re

203 library of homologous rigid-rod 310-helical foldamers, which have incrementally increasing lengths a

204 add to the growing evidence that nonnatural foldamers will emerge as an important class of therapeut

205 A chiral aryl-triazole foldamer with two azobenzene end groups has been synthes

206 rongest ionophoric activity was observed for foldamers with >10 Aib residues, which have end-to-end d

207 he design and construction of nanostructured foldamers with actuator and sensory properties, which ma

208 In contrast, foldamers with aryl rings in their main chains possess d

209 o folded nanostructures and hence are hybrid foldamers with biological sequences and synthetic proper

210 Oligocholate foldamers with different numbers and locations of guanid

211 ultraviolet spectra of three model synthetic foldamers with heterogeneous backbones, alpha/beta-pepti

212 as are the first examples of hydrogen-bonded foldamers with reversible hydrogen-bond directionality.

213 The development of foldamers with the ability to bind and encapsulate "gues

214 The ortho-phenylenes are a simple class of foldamers, with the formation of helices driven by offse

215 two such principles in the design of peptoid foldamers yields a new and unique secondary structure th