ライフサイエンスコーパス: folded structure

1 ucture less than 5 A (fraction of completely folded structures).

2 e known to confer structural rigidity to the folded structure.

3 ropagating local chirality via a dynamically folded structure.

4 dicating that it results from a higher order folded structure.

5 d three single T loops also adopt a parallel folded structure.

6 eriments demonstrated that p58C forms a well folded structure.

7 ugh it is well protected from solvent in the folded structure.

8 otein binding was affected by sR6's distinct folded structure.

9 s can be functional even in the absence of a folded structure.

10 structured in the transition state as in the folded structure.

11 l causes Hmg2p to undergo a change to a less folded structure.

12 denaturation, to probe the stability of the folded structure.

13 olecules likely adopt a co-transcriptionally folded structure.

14 pentapeptide derived from Hsp90 stabilises a folded structure.

15 tially different under conditions that favor folded structure.

16 ior of the barrel, thereby destabilizing its folded structure.

17 associated with the C-terminal domain in the folded structure.

18 in the unfolded state, as well as the native folded structure.

19 milar to the native fold than any individual folded structure.

20 beta-amino acids that adopts a cooperatively folded structure.

21 d(GGTTGGTGTGGTTGG), inducing a unimolecular folded structure.

22 rmation of the third disulfide and the final folded structure.

23 extensive network of interactions across the folded structure.

24 hancement in the formation of the N-terminal folded structure.

25 rther increased selection for the N-terminal folded structure.

26 the fluorescence properties of the resulting folded structure.

27 he forces that maintain the integrity of the folded structure.

28 ide is random coil-like and lacks a dominant folded structure.

29 onformational change from a random coil to a folded structure.

30 to determine dynamic features related to the folded structure.

31 y of each other (d approximately 3 A) in the folded structure.

32 amics of hydrated tRNA while stabilizing its folded structure.

33 nfolding of an i-motif through the partially folded structure.

34 from H/D exchange, implying an intrinsically folded structure.

35 called LoopA, LoopB, and LoopC, adopt stable folded structures.

36 mino acids and their microenvironment in the folded structures.

37 of sequence space most likely to yield well folded structures.

38 only the desired fold but also alternatively folded structures.

39 he presence of a heterogeneous population of folded structures.

40 llow native proteins to acquire their unique folded structures.

41 generate de novo proteins with cooperatively folded structures.

42 odel (GNM) recently introduced for analyzing folded structures.

43 ificant differences were detectable in their folded structures.

44 n the solid state, revealing compact, highly folded structures.

45 he S-S bridge as a natural building block in folded structures.

46 ying membrane proteins and determining their folded structures.

47 rmal and chemical stability of the resultant folded structures.

48 ange, consistent with the NTDs having formed folded structures.

49 tion results in the formation of a partially folded structure, a stable core comprising the C-termina

50 rally occurring proteins sample the space of folded structures accessible to the polypeptide chain.

51 e PUA domain bind RNA molecules with complex folded structures, adding to the growing collection of n

52 The folded structure agrees excellently with the NMR NOE dat

53 tch: loss of the bound zinc ion disrupts the folded structure, allowing the ligand cysteine residues

54 ide oligomers have been shown to form stable folded structures analogous to those encountered in natu

55 amolecular interactions that favor the final folded structure and a less specific set of intermolecul

56 m half-life in vivo without compromising its folded structure and activity.

57 erefore, protein models that encode only the folded structure and are energetically unfrustrated (Go-

58 We have experimentally deduced the folded structure and characterized the ssDNA promoter pr

59 ally disordered proteins lack a well-defined folded structure and contain a high degree of structural

60 , qualitatively indicating disruption of the folded structure and development of static conformationa

61 Adenine binding stabilizes the folded structure and significantly decreases the unfoldi

62 ingers are required for processing only as a folded structure and that the location but not the ident

63 helicase activity with substrates containing folded structures and 5' single-stranded tails, suggesti

64 show how primordial functions are linked to folded structures and how their interaction with cofacto

65 e of the protein is a triple funnel with two folded structures and one misfolded structure that are s

66 pro alpha 1 and C-pro alpha 2 have different folded structures and stability.

67 of proteins (for example, three-dimensional folded structure) and other natural materials.

68 IDPs/IDRs) that do not adopt a dominant well-folded structure, and therefore remain "unseen" by tradi

69 e the residues that interact the most in the folded structure, and they are often residues that displ

70 any different protein sequences have similar folded structures, and that there is a relatively high p

71 stacking, and/or binding of Mg2+ within the folded structure are responsible for stabilizing the P4-

72 wo residues, both parallel- and antiparallel-folded structures are able to form.

73 sis reveals that marginally stable partially folded structures are also present in the nominally unfo

74 NMR studies provide strong evidence that the folded structures are conserved in solution.

75 en cyanide chains is observed, even when the folded structures are energetically favored.

76 The partially folded structures are formed predominantly by coiled coi

77 ability of SCHEMA to identify chimeras whose folded structures are likely not to be disrupted by reco

78 Overall, our results imply that the 2 folded structures are preencoded by the alpha-synuclein

79 led an increased order and stability of sRNA folded structure as a result of L7 binding.

80 the F helix is important in stabilizing the folded structure, as shown by the instability of the 1-1

81 thalpy, Deltanion, and DeltanW, the dominant folded structure at high salt is most likely the antipar

82 st to the significant destabilization of the folded structure at high temperatures, Trp-cage cold den

83 DNA containing d(ATTCT)9 forms a folded structure at relatively low temperatures, whereas

84 y of nucleosomal arrays to form higher-order folded structures at all ionic conditions tested.

85 e is greatly influenced by the GC content of folded structures at the mRNA entry site.

86 Stably folded structures based on the design principle describe

87 This folded structure becomes destabilized and loses the U*U

88 When their folded structure breaks down, protein chains do not beco

89 Thermodynamics not only dictates the final folded structure but also is the driving force for the e

90 des, thus enabling not only access to stable folded structures but also the incorporation of exocycli

91 ant amount of alpha-helix, indicating that a folded structure can be maintained despite the loss of i

92 Furthermore, folded structures can be transferred between aqueous sol

93 On the other hand, the fraction of folded structures changes more slowly with time and fits

94 veal that the PEMV-1 pseudoknot is a compact-folded structure composed almost entirely of RNA triple

95 ncy virus type 1 (HIV-1) genome has a highly folded structure, comprising at least two RNA stem-loops

96 be maximized when a well defined pathway of folded structure connects the two sites.

97 This folded structure consists of three short helical segment

98 l, making possible the formation of a stable folded structure containing a single A:T base pair.

99 idence that tertiary interactions within the folded structure contribute to product binding energy.

100 OPUS-Dom generates a large ensemble of folded structure decoys by VECFOLD and labels the domain

101 helices that are prominently exposed in the folded structure decreases the ATPase stimulation by the

102 , the decreased free energy in the partially folded structure (DeltaG(unfold) 10.4 +/- 0.7 kcal/mol)

103 hypothesize the SUMO1 E2 enzyme recognizes a folded structure-dependent motif that includes residues

104 the formation of a compact, intramolecularly folded structure dominated by two stacked guanine quarte

105 zed, indicating that the protein retains its folded structure during the labeling process.

106 ynucleotide tails was studied at pH 5.0, the folded structure entered the nanocavity of alpha-HL from

107 table hairpin with no evidence for any other folded structure even at low pH.

108 ts, favorable conditions for the creation of folded structures exist.

109 data provided evidence that elements of the folded structure form at temperatures well below the Tm,

110 s of 1, 3, 4, 6, and 7 indicate that similar folded structures form in chloroform.

111 The peptide segments in the residual folded structures form the "building block" for aggregat

112 iments reveal NOE contacts typically seen in folded structures formed by guanine quartets, such as th

113 The explanation proposed is that the folded structure found at the telomere helps appose the

114 convergence and identification of correctly folded structures from a large number of simulations.

115 y and physical properties is readily seen in folded structures from intestinal villi and pollen grain

116 clear energetic separation of the correctly folded structures from misfolded structures for the two

117 Origami describes rules for creating folded structures from patterns on a flat sheet, but doe

118 ucleotides that could not form the compactly folded structure had markedly reduced half-lives (t1/2 f

119 , turn, and beta-strand motifs of biopolymer folded structures have been found to prevail also in non

120 r removal produces apo-azurin which adopts a folded structure identical to that of the holo-form.

121 nternal ribosome entry site (CrPV-IRES) is a folded structure in a viral mRNA that allows initiation

122 egments associate noncoaxially in the active folded structure in a way that brings catalytically impo

123 does not prevent the adoption of the natural folded structure in any of the circular proteins.

124 for the intermediate nature of the partially folded structure in comparison to the i-motif.

125 ed that the TDP-43 N terminus encodes a well-folded structure in concentration-dependent equilibrium

126 Here, we show that the stable folded structure in headpiece is localized to a subdomai

127 switch, resulting in destabilization of the folded structure in solution and thereby promoting the i

128 nsfer demonstrated enhanced stability of the folded structure in the context of a four-way helical ju

129 f the aptamer domain, adopts a predominantly folded structure in the presence of Mg(2+) alone.

130 peratures, it appears that the mutants adopt folded structures in solution that are virtually identic

131 R chemical shifts supports the assignment of folded structures in solution.

132 little sequence homology and generally lack folded structures in the absence of their targets, aspec

133 Folded structures in the coding region of an mRNA repres

134 Folded structures in the DNA template, such as hairpins

135 ane-reconstituted GLIC and ELIC both exhibit folded structures in the minimal PC membranes that stabi

136 All mutants have folded structures in their lipid-free state, however the

137 ediate conformation as a collection of fully folded structures in which each of them contains a set o

138 one of the two strands to form a more stable folded structure, in our case the CAGG strand, explains

139 These ions stabilize the folded structures, in part, by accumulating in regions o

140 The stability of the folded structure increases with the charge of the polyam

141 rnative guide regions demonstrated that sRNA folded structure induced by specific guide sequences imp

142 assembled aggregates, this work introduces a folded structure into soft matters formed by amphiphiles

143 A beta 42 folded structure is characterized by a turn in the C-ter

144 This ideal chain-folded structure is corroborated by annealing studies on

145 This implies therefore that its folded structure is important for its biological activit

146 onformational alterations, while the overall folded structure is maintained.

147 anced stability of a pseudorotaxane inside a folded structure is measured to be DeltaG = ca. 0.5 kcal

148 obtained by simulation, we see that the mean folded structure is more similar to the native fold than

149 We find that at room temperature the folded structure is more stable, whereas at higher tempe

150 her that the ability to adopt an intrastrand folded structure is not sufficient for expansion, or tha

151 steric covalent linkages indicates that this folded structure is stable against displacement by the p

152 dicator of the residues not belonging to the folded structure is suggested.

153 This class of chiral folded structures is achieved by controlling the reactiv

154 two positive charges closer together in the folded structures is compensated for by the additional h

155 ximity in either the primary sequence or the folded structure may differ considerably.

156 n in photolyase and cryptochrome, and such a folded structure may have a functional role in initial p

157 roduced in Escherichia coli had little or no folded structure, measured by NMR and CD.

158 arrays can neither condense into extensively folded structures nor cooperatively oligomerize in MgCl(

159 ations impart thermodynamic stability to the folded structure not achievable with unmodified DNA.

160 BM antiserum indicated that acquisition of a folded structure occurred with a similar time course in

161 ically possible to inhibit by disrupting the folded structure of a protein or, in the limit, to bind

162 in emerges from the ribosome can specify the folded structure of a protein.

163 The amyloidogenic folded structure of Abeta is important for the formation

164 r this cotranslational folding can alter the folded structure of an encoded protein in vivo, versus t

165 Previously we found that the whole folded structure of both polypeptides as well as specifi

166 ical for specifying the unique cooperatively folded structure of KIX.

167 The residual folded structure of locally unfolded apoSOD1 corresponds

168 ally employed to assess the stability of the folded structure of mouse mammary tumor virus pseudoknot

169 atures of this algorithm, we incorporate the folded structure of mRNA.

170 ane, an inhaled anesthetic, destabilizes the folded structure of myoglobin.

171 of the PxxP motif within the context of the folded structure of Nef.

172 so that the mechanical stress imposed by the folded structure of one subunit causes the other subunit

173 tin, such that the free energy stored in the folded structure of one subunit is used to drive unfoldi

174 o contribute to the overall stability of the folded structure of peptides and proteins.

175 most anti-PrP antibodies were hidden in the folded structure of PrP(RES), even though these epitopes

176 asis of thermal denaturation, we show that a folded structure of T30177 is much more stable than that

177 Consequently, the N-terminal folded structure of the Arctic mutants closely resembles

178 The folded structure of the bound IDP appears to be defined

179 However, the secondary folded structure of the DNA binding domain of RAR and RX

180 Thus, our study suggests that the folded structure of the H4 basic patch in the nucleosome

181 ses this results in severe distortion of the folded structure of the junction.

182 essibility to proteases, which indicated the folded structure of the loops or their shielding by the

183 Using the folded structure of the monounsaturated fatty acid obser

184 nterior surface of the binding cavity in the folded structure of the oligomer.

185 P4, P6, and P6a, indicating that a partially folded structure of the P4-P6 domain is required.

186 Stabilization of the folded structure of the protein by residue substitution

187 Ribosomal proteins stabilize the folded structure of the ribosomal RNA and enable the rec

188 t the ligand-free state is often a partially folded structure of the RNA, with conformational heterog

189 Human GAPDH was found to destabilize the folded structure of the stem-loop IIIa RNA based upon ob

190 .1a (P13) and P2 and P5c (P14) stabilize the folded structure of the Tetrahymena group I intron.

191 trongly support the importance of the stable folded structure of this family of peptides for binding

192 presented in this work show that the unique folded structure of TolC reflects a unique assembly path

193 gnesium ions are crucial for stabilizing the folded structure of tRNA.

194 h show more hydrogen bonds in representative folded structures of hydrated 1,7-diammoniumheptane vers

195 in packing in specifying and stabilizing the folded structures of proteins.

196 essential for specifying and stabilizing the folded structures of proteins.

197 The computed lowest-energy manifolds for the folded structures of the two beta-hairpins agree closely

198 Predictions of the folded structures of these box C/D snoRNA-like miRNA pre

199 energy and examine the stability of various folded structures of these molecules along a well-define

200 This tandem "flexible-folded" structure of the polypeptide chain derived for t

201 rase that are also nearly identical in their folded structures, only the mitochondrial form (mAAT) is

202 inding: whether the free TAZ1 domain forms a folded structure or behaves as a molten globule will hav

203 der conditions that promote formation of the folded structure or complex, as well as 'control' condit

204 to overcome for the construction of discrete folded structures, particularly for the development of a

205 e unfolded state and flexible linkers in the folded structure play essential roles in protein stabili

206 hat interresidue contacts not present in the folded structure play little or no role in the self-asse

207 It forms a compact folded structure, presenting a loop between Cys8 and Cys

208 Lack of requirement for a folded structure prompted us to investigate antitumor pr

209 The initial folded structure rearranges to form a beta-sheet like st

210 tation, L92V, near the PR active site in the folded structure recently emerged during TL-3 selection.

211 Although the peptide does not adopt a stable folded structure, regions of unstable structure exist ov

212 i-donor-acceptor subunits provides access to folded structures reminiscent of the tertiary structure

213 d equimolar amounts of the N- and C-terminal folded structures, respectively.

214 Heating native p53 to destroy the folded structure restores DNA-independent acetylation si

215 odel three-helix-bundle protein with a known folded structure, reveal that 13C-labeled residues in th

216 The i-motif and the partially folded structure share similar rupture forces of 22-26 p

217 or-acceptor interactions responsible for the folded structure shows a high constant rupture force ove

218 ackbone modifications but nevertheless adopt folded structures similar to those of natural polypeptid

219 d RNA structures, although distinct from the folded structure stabilized by multivalent cations.

220 a replica exchange algorithm that samples a folded structure starting from a completely unfolded sta

221 cid sequences can give rise to more than one folded structure, such as for proteins that undergo larg

222 ype of photoproduct might also form in other folded structures, such as G-quadruplexes and i-motif st

223 riety of sequences prone to the formation of folded structures, such as long hairpins and quadruplexe

224 sed tendency to form alternate, incompletely folded structures, suggesting a more complex picture of

225 events within domains, which might preserve folded structure, target functional residues more freque

226 Despite having a considerably different folded structure than conventional dsRNA, the cytotoxici

227 than the wild-type protein, it adopts a well-folded structure that can be chemically denatured in a c

228 ults suggest that domain III adopts a stably folded structure that can mediate binding of tick-borne

229 h telomeres beyond a threshold length form a folded structure that links the chromosome terminus to t

230 ree-dimensional structure: a single-stranded folded structure that makes multiple contacts with the a

231 this family of pseudoknots adopts a tightly folded structure that maximizes the cooperativity and co

232 RNAs adopt diverse folded structures that are essential for function and th

233 l protein design to investigate the space of folded structures that can be generated by tandem repeat

234 olecules can form complex, three-dimensional folded structures that have surprisingly sophisticated f

235 Both RRM3 and RRM4 adopt folded structures that NMR data show to be similar to th

236 Riboswitches are RNAs that form complex, folded structures that selectively bind small molecules

237 reduced rate of motion backward depended on folded structures that were only present with longer lin

238 protein and its conformation in the overall folded structure, the amino acid sequence corresponding

239 and F488L C-termini mutants retained stable, folded structures, the secondary structures of both muta

240 The folded structure then is derived via a direct molecular

241 results can be rationalized in terms of the folded structure, there are a number of surprises.

242 f deltaX(++), which is the distance from the folded structure to the unfolding transition state.

243 mutations were required to restore a stably folded structure to this RNA.

244 These results suggest that a stable folded structure together with three or more basic amino

245 stable molten globules but lacks a uniquely folded structure-translocase mutants that rescued export

246 In the correctly folded structure, two of the three tyrosines putatively

247 In contrast r(AUUCU)9 forms a folded structure under physiologically reasonable condit

248 that the precursor protein achieves a stable folded structure upon dilution from urea, suggesting tha

249 mbrane transport machineries can translocate folded structures, we overexpressed the 17-kDa subunit o

250 the 2-10 mum range and the retention of some folded structure were associated with an increased respo

251 First, potential VPg folded structures were identified, yielding a suite of p

252 and molecular modeling studies, two types of folded structures were proposed and several conformation

253 show that: (i) 16S rRNA remains in a highly folded structure when it is bound to S15; (ii) in the ab

254 Other motifs form complex folded structures when transcribed as RNA molecules and

255 n extended state, we obtained an ensemble of folded structures, which is on average 1.7A and 1.9A awa

256 cs calculations yielded an unusually stable, folded structure with a double "S"-like bend incorporati

257 oglobin molten globule has a complex, partly folded structure with a folded A[B]GH subdomain; the fac

258 nd adult epithelium develops to form a multi-folded structure with elaborate connective tissue and mu

259 bilization of FAS1-4 and induces a partially folded structure with increased surface exposure of hydr

260 The retained fragments acquired a partially folded structure with intra-chain disulfide bonds and co

261 de oligomers can assemble into cooperatively folded structures with potential application in enzyme d

262 number may result from the formation of more folded structures with similar stability rather than few

263 showed that at pH 5.0, all five circles form folded structures with similar stability, while at pH 7.

264 nian walk in the conformational space to the folded structure, with each step controlled by k(alpha).

265 t are capable of acquiring unique and stably folded structures would be valuable in the examination o

266 -residue description of the evolution of the folded structure, yet contains many fewer adjustable par