ライフサイエンスコーパス: folding of

1 uggest that many rRNA-folding steps, such as folding of 5.8S rRNA, occur at a very specific stage of

2 ing of various design rules, and demonstrate folding of a 6-kb template by as few as 10 unique strand

3 The bacterial chaperonin GroEL/GroES assists folding of a broad spectrum of denatured and misfolded p

4 Our model system is the binding and folding of a chaperone substrate, immunity protein 7 (Im

5 Here, we asked whether folding of a complex RNA can be understood from its stru

6 Folding of a disordered loop in the allosteric effector

7 It does so by regulating the folding of a diverse portfolio of metastable client prot

8 cosity dependence of helix formation and the folding of a helix-containing protein, is the insensitiv

9 Correct folding of a mAb is critical for drug efficacy, while mi

10 ail collapse and DNA unwrapping), and mixed (folding of a miniprotein) conformational changes, with n

11 resence of multiple intermediates during the folding of a model polypeptide, polyproline.

12 Recently, we reported that amine-induced folding of a more fluorescent, more linear structure int

13 ons are generated and transmitted during the folding of a neuroepithelial layer.

14 Spontaneous folding of a polypeptide chain into a knotted structure

15 es to control the simulated, cotranslational folding of a protein in a user-prescribed manner.

16 The structure and folding of a protein in solution depends on noncovalent

17 een CCT and a cochaperone to orchestrate the folding of a protein substrate.

18 ogs, we also established a mechanism for the folding of a random coil oligo into the iM.

19 an intramolecular chaperone that facilitates folding of a second catalytic module.

20 olecular dynamics in describing the unbiased folding of a simple RNA secondary structure motif.

21 vitro translation system to investigate the folding of a small five-helix protein domain-the N-termi

22 is also observed during the fast spontaneous folding of a structural homolog of DapA from a bacterium

23 p57 is a disulfide isomerase involved in the folding of a subset of glycoproteins in the ER as part o

24 together with its cofactor Hsp10, catalyzes folding of a subset of mtHsp70 client proteins.

25 perimental evidence for cooperativity in the folding of a triple-stranded parallel beta-sheet, and we

26 Glycholine allows for the folding of a two-dimensional DNA origami at 20 degrees C

27 nterface is sufficiently stable to drive the folding of adjacent E and G5 domains along a parallel fo

28 s A-E (TBCA-E), and GTP are required for the folding of alpha- and beta-tubulin subunits and assembly

29 mitochondrial chaperones and assists in the folding of alpha-ketoglutarate dehydrogenase (OGDH), a r

30 Here the use of AFM to directly monitor the folding of an alpha/beta protein, NuG2, by using low-dri

31 or this finding was obtained by showing that folding of an enhanced green fluorescent protein variant

32 Self-folding of an information-carrying polymer into a define

33 gions of gp15 drives correct positioning and folding of an inner gp16 loop to interact with equivalen

34 nd master equation analysis to elucidate the folding of an RNA pseudoknot structure.

35 mutations are likely to disrupt the correct folding of an RNA secondary structure required for viral

36 e how the drug mitoxantrone can bind, induce folding of and stabilise i-motif forming DNA sequences,

37 r pifithrin-mu (an HSP70 inhibitor) restored folding of, and hence dopamine transport by, dDAT-G108Q

38 regions affecting: lobe size and attachment, folding of antihelix, helix rolling, ear protrusion and

39 lding stress rather than achieving efficient folding of any single component of the proteome, (ii) ho

40 TRiC facilitates folding of approximately 10% of the eukaryotic proteome,

41 fugation techniques, we observed spontaneous folding of AT-IN nucleosome arrays into highly compact s

42 emerged as a powerful tool for studying the folding of biological macromolecules.

43 Although the folding of both proteins exhibited similar kinetics, the

44 To explain this phenomenon, we show that the folding of c-Myb is templated by the structure of KIX.

45 Maintaining the correct folding of cellular proteins is essential for preserving

46 agnesium ion concentration that disrupts the folding of certain genetic variants of this ribozyme and

47 y of CFTR at the cell surface, and disrupted folding of CFTR at the endoplasmic reticulum.

48 proteostatic mechanism that couples protein folding of channels to forward trafficking in the secret

49 of folding mechanisms centres on reversible folding of chemically denatured membrane proteins.

50 e early events leading to frustration in the folding of CheY.

51 hese findings indicate that the higher order folding of chromatin topology may act as a molecular-pat

52 1 is critical for regulating translation and folding of collagen polypeptides.

53 DE6 and that it enables low yield functional folding of cone PDE6C in cultured cells.

54 Here we characterize the oxidative folding of Cox19, a twin CX9C Mia40 substrate.

55 transitions associated with the buckling and folding of curved multilayered surfaces-which are common

56 tructures and shape transformable materials, folding of curved shells is still not fundamentally unde

57 Folding of CyaA into a monomeric form was found to be cr

58 interaction governed by the binding-coupled folding of disordered regions in both interacting partne

59 st a conserved strategy for the assembly and folding of diverse protein complexes.

60 We compared estimates of D for the folding of DNA hairpins found from measurements of rates

61 n of DPP6 plays an important role in protein folding of DPP6 that is required for transport of DPP6/K

62 participate in a quality control pathway for folding of EGF repeats in proteins such as Notch.

63 Correct folding of ER proteins requires covalent attachment of N

64 How chaperonins orchestrate the successful folding of even the most elaborate of proteins is a ques

65 PBI dimer pairs and accordingly template the folding of even-membered PBI macrocycles into ropelike f

66 +) and/or S-adenosylmethionine (SAM)-induced folding of full-length transcripts of the ligand binding

67 ell-permeable orthosteric ligands can assist folding of G protein-coupled receptors in the endoplasmi

68 Folding of G-protein coupled receptors (GPCRs) according

69 ty of co-replicational or co-transcriptional folding of G-quadruplex inside the polymerase machinery

70 reveals previously unknown principles of the folding of G-rich oligonucleotides that could be applied

71 PC4 did not enhance the rate of folding of G4DNA, and formation of the PC4-G4DNA complex

72 The folding of genomic DNA from the beads-on-a-string-like s

73 been performed for G-quadruplexes formed by folding of GGG(TTAGGG)3 single strands in buffered solut

74 We investigate the folding of GlpG, an intramembrane protease, using perfec

75 ng on proteins and inhibit three-dimensional folding of glycoproteins.

76 idase family of enzymes and subsequently the folding of glycosylated proteins, both viral and host.

77 are believed to be indispensable for proper folding of gp120 and for viral infectivity.

78 ular dynamics simulations to investigate the folding of gpW, a protein with two-state-like, fast fold

79 t with experiment, suggesting that oxidative folding of guanylin in vitro occurs under kinetic contro

80 In addition, we have simulated oxidative folding of guanylin within the 94-aminoacid prohormone p

81 he environment, that is, uranyl enhances the folding of HA via electrostatic interactions, whereas CN

82 Here we describe principles to guide the folding of highly knotted single-chain DNA nanostructure

83 roups within the initial 140 microseconds of folding of horse cytochrome c.

84 Thereby, Aha1 promotes effective folding of Hsp90-dependent clients such as steroid recep

85 molecular dynamics simulations to study the folding of Htt-exon-1 across five different polyQ-length

86 s support elevated tensions that promote the folding of interfaces along paths that can be predicted

87 sister chromatid cohesion, and higher order folding of interphase chromatin are mediated by condensi

88 (Minimal Chromatin Model) that explains the folding of interphase chromosomes and generates chromoso

89 t La's RNA chaperone activity can change the folding of its binding site.

90 for Tsc1 as a facilitator of Hsp90-mediated folding of kinase and non-kinase clients-including Tsc2-

91 Folding of knots is encoded by the arrangement of module

92 ndings provide mechanistic insights into the folding of knotted proteins both in vitro and in vivo, t

93 The folding of knotted proteins is on the timescale of minut

94 glycosylation of N582, suggesting that rapid folding of local conformation prevents glycosylation of

95 open up potential new avenues to control the folding of macromolecules.

96 The molecular mechanisms underlying folding of mammalian chromosomes remain poorly understoo

97 Folding of mammalian genomes into spatial domains is cri

98 Folding of many cellular substrates of TRiC cannot be as

99 al functions, and are crucial for productive folding of many glycoproteins.

100 The proper folding of many proteins can only be achieved by interac

101 aperonins are ATP-ases indispensable for the folding of many proteins that play a crucial role in Arc

102 residues are essential to the structure and folding of many proteins.

103 ted protein degradation (ERAD), monitors the folding of membrane and secretory proteins whose biogene

104 reticulum (ER) is the site of synthesis and folding of membrane and secretory proteins.

105 ctions, single-molecule FRET measurements of folding of model RNAs revealed constant DeltaDeltaGtert

106 Our study reveals folding of N-glycosylated membrane proteins in the ER as

107 he endoplasmic reticulum (ER) to promote the folding of N-glycosylated membrane proteins.

108 Co-translational secondary folding of nascent chains inside the ribosome has profou

109 hanisms that prevent aggregation and promote folding of nascent G protein-coupled receptors (GPCRs) r

110 Protein chaperones promote native folding of nascent polypeptides and refolding of misfold

111 at interacts with the ribosome to assist the folding of nascent polypeptides.

112 disulfide rearrangements required for proper folding of nascent proteins synthesized in the endoplasm

113 ngly disparate cellular functions, including folding of nascent proteins, breakup of misfolded protei

114 We hypothesize that strong folding of nascent RNA weakens R-loops and hence decreas

115 The folding of natural proteins typically relies on hydropho

116 labeling modification might affect rates of folding of near-neighbor structural elements, and thus l

117 s played a transformative role in growth and folding of neocortex as well as archicortex.

118 protein, a disordered structure found before folding of newly synthesized protein or after protein de

119 Hsp70 chaperones assist de novo folding of newly synthesized proteins in all cells.

120 The molecular chaperone Hsc70 assists in the folding of non-native proteins together with its J domai

121 understood and yet clearly essential to the folding of nucleic acids and proteins into correct, nati

122 of ligand-receptor systems and the unfolding/folding of nucleic acids or proteins reveal information

123 causing cystic fibrosis, DeltaF508, impairs folding of nucleotide binding domain (NBD) 1 and stabili

124 -shock protein (Hsp90) assists in the proper folding of numerous mutated or overexpressed signal tran

125 -regulated in cancer and is required for the folding of numerous signaling proteins.

126 Hg-T complex thus causing the "hairpin-like" folding of oligonucleotide, leading to an improved elect

127 into a leading core that enabled the correct folding of other functionalities fused to the RNA comple

128 This strategy could be used to design folding of other knotted programmable polymers such as R

129 ction fidelity, as it correlates with better folding of overexpressed membrane proteins.

130 kinetics and thermodynamics, we followed the folding of P4-P6, a domain of the Tetrahymena group I ri

131 5-fold, we demonstrate that slow spontaneous folding of PepQ is not caused by aggregation.

132 d anaerobic electron acceptors for oxidative folding of periplasmic proteins.

133 athways, akin to Levinthal's paradox for the folding of polypeptide chains.

134 The folding of polypeptide side chains into alpha-helices dr

135 iological boundaries of MP insertion and the folding of polytopic MPs in vivo.

136 fibril formation and prevent the beta sheet folding of portions of the Abeta1-40 peptide.

137 pproach demonstrate that the main barrier to folding of pp32 is quite broad and lies near the unfolde

138 ail how assembly factors regulate the timely folding of pre-18S rRNA.

139 he role of modest free energy changes in the folding of pre-integration forms of a hyperstable outer

140 Oxidative folding of (pro)insulin is crucial for its assembly and

141 The unfolding and folding of protein barnase has been extensively investig

142 the rates of translation and cotranslational folding of protein domains monitored in real time by For

143 en widely used to probe the fast dynamics of folding of proteins and nucleic acids.

144 Folding of proteins entering the secretory pathway in ma

145 3/Oxa1 family functions in the insertion and folding of proteins in the bacterial cytoplasmic membran

146 The proper folding of proteins is continuously challenged by intrin

147 Proper folding of proteins is critical to producing the biologi

148 cooperativity and downhill, or barrier-free, folding of proteins under highly stabilizing conditions

149 Folding of proteins usually involves intermediates, of w

150 ilar cooperative closure (reminiscent of the folding of proteins) is also displayed with multipeptide

151 ying amino-groups, glycation interferes with folding of proteins, increasing their aggregation potent

152 to soluble state, analogous to pH-dependent folding of proteins, while at neutral and high pH self-a

153 or mitochondrial biogenesis, like import and folding of proteins.

154 s a structural element enabling the adequate folding of proteins.

155 leus to maintain cell homeostasis via proper folding of proteins.

156 The folding of representative members of the SAM-I family of

157 Insertion is initiated by the folding of residues 3-11 into an alpha-helix, and mediat

158 oting protein transport, NLSs may facilitate folding of ribosomal RNA.

159 to investigate the principles governing the folding of RNA in vivo and in vitro.

160 play crucial roles in directing the overall folding of RNA molecules as well as in a variety of biol

161 tain knowledge about approximate topological folding of RNA.

162 o the well-known "simultaneous alignment and folding" of RNAs.

163 omplex multistep process, results in correct folding of rRNAs, incorporation of >50 ribosomal protein

164 The initial folding of secreted proteins occurs in the ER lumen, whi

165 quality control coupling because it supports folding of select client proteins yet also robustly asso

166 in the conformational search associated with folding of SERT.

167 -helix (Thr(603)-Thr(613)) was important for folding of SERT.

168 ay was recruited to the C terminus to assist folding of SERT.

169 By investigating the folding of several bacterial OMPs using membranes with n

170 le to determine the internal friction in the folding of several peptides and miniproteins.

171 cleation core that initiates Ag(+) -mediated folding of SilE.

172 roughput screening method to investigate the folding of silk protein molecules as they abandon their

173 hat allows, for the first time, the study of folding of single proteins during week-long experiments.

174 n oxidizing machinery that drives import and folding of small cysteine-containing proteins without ta

175 Folding of small proteins often occurs in a two-state ma

176 ructural reorganization essential to overall folding of small subunit rRNA.

177 e more effective than the BAM complex in the folding of some substrate proteins.

178 ecular chaperone UNC-45B is required for the folding of striated muscle myosin II.

179 n, we monitored the kinetics of K(+)-induced folding of Tel22 by circular dichroism (CD), intrinsic 2

180 Sp) reduce the thermostability and alter the folding of telomeric quadruplexes in a location-dependen

181 n the assembly process and contribute to the folding of the 3' domain of 16S rRNA.

182 atured, transition, and native states in the folding of the activation domain of human procarboxypept

183 The correct folding of the active site and ribozyme tertiary structu

184 rge density of the assembly, a result of the folding of the alpha-helical polypeptide, provides enhan

185 independently refold, thereby templating the folding of the alpha-subunits, which then chaperone the

186 Here, we show that the biosynthesis and folding of the AML1-ETO protein is facilitated by intera

187 end of the aptamer followed by a directional folding of the aptamer around its target from 5'-end to

188 By monitoring the folding of the aptamer, kissing loop, and riboswitch exp

189 machinery (SAM complex) mediates subsequent folding of the beta-barrel and its integration into the

190 or the BAM complex not only in insertion and folding of the beta-barrel but also for passenger transl

191 these alpha-subunit roles was necessary for folding of the beta-subunit.

192 teins (PrP(Sc)) replicate by redirecting the folding of the cellular prion glycoprotein (PrP(C)).

193 n to the pre-rRNA is mutually exclusive with folding of the central pseudoknot (CPK), a universally c

194 The data reveal that folding of the central pseudoknot (T1), the most crucial

195 However, U3 must be removed to allow folding of the central pseudoknot, a key feature of the

196 sociated both regionally and temporally with folding of the cerebral cortex.

197 BG have been implicated in the expansion and folding of the cerebrum and cerebellum, respectively.

198 sal progenitors in the evolution of cortical folding of the cerebrum and cerebellum.

199 lements that determine the three-dimensional folding of the chromatin fiber and organize the chromoso

200 ,3,3,3-hexafluoro-2-propanol (v/v) confirmed folding of the complete 2F5 epitope within continuous ki

201 necessarily recapitulated by Mg(2+)-induced folding of the corresponding full-length RNA in vitro.

202 Folding of the cortex and the persistence of radial glia

203 The folding of the cortex in mammalian brains across species

204 Brain gyrification, or folding of the cortex, is as highly evolved and variable

205 ion and AP-1 binding are dependent on proper folding of the cytoplasmic domains, the signal provides

206 Folding of the disordered protein before binding does no

207 n synonymous codon substitutions that impair folding of the encoded protein.

208 n identity-could coordinate co-translational folding of the encoded protein.

209 Here, we slowed the folding of the Escherichia coli beta-barrel protein, Lpt

210 e optical properties are attributable to the folding of the even-membered macrocycles into exciton-vi

211 (Hsp) Hsp10-Hsp60 chaperone complex mediates folding of the fatty acid oxidation enzyme medium-chain

212 the beta 2-adrenergic receptor (beta 2-AR), folding of the FiP35 WW domain, and dimerization of the

213 energy transfer, we studied cotranslational folding of the first nucleotide-binding domain from the

214 Beyond intradomain misfolding, folding of the full-length protein is further slowed by

215 The flanking sequences impact the folding of the functional elements both at the level of

216 to neutralizing antibodies by perturbing the folding of the fusion machinery.

217 a disulfide bridge essential for the proper folding of the G protein-coupled receptor proteolytic si

218 changes, and lead to aggregation or abnormal folding of the gluten proteins.

219 geometric constraints favoring an optimized folding of the glycoligand minimizing steric repulsions.

220 Folding of the green-type RbcL subunits in cyanobacteria

221 rotein trimer, others are necessary to allow folding of the H-oligomer in a standard conformation con

222 olecular weight molecule), which changes the folding of the hairpin structure and consequently the ac

223 The Hsc70/Hsp70 chaperones assist the folding of the hERG cytosolic domains.

224 the BOLD signal induced by the morphological folding of the human cortex.

225 at most CDC73 missense mutations disrupt the folding of the hydrophobic core of hCDC73-NTD, while oth

226 tions with a protein partner lead to partial folding of the IDR.

227 Using NMR spectroscopy, we show that folding of the inhibitory helix requires a buried charge

228 pendent on salt-bridge formation and correct folding of the intact protein receptor.

229 younger than 20 years and had CFCs with fine folding of the internal limiting membrane and mild pigme

230 Here we present a study of the folding of the intrinsically disordered transactivation

231 ere, we describe in detail the structure and folding of the isolated pseudoknot, which forms a compac

232 uctuations and is responsible for a peculiar folding of the local spectrum.

233 tend to play a crucial role in governing the folding of the longer oligoviologens.

234 Folding of the LTR promoter into dynamic G-quadruplex co

235 In contrast, in aromatic solvents folding of the macrocycles with a distinct odd-even effe

236 s at the beta-signal motif to the unassisted folding of the model beta-barrel protein PagP.

237 tponed cleavage of gp160 enhances functional folding of the molecule.

238 mechanism by which it contributes to proper folding of the myosin head remains unclear.

239 contribute to efficient translocation and/or folding of the N-terminal virulence region (the 'passeng

240 Folding of the nascent chain already occurs during synth

241 ap optical tweezers and observe simultaneous folding of the nascent polypeptide chain in real time.

242 in response to translation, processing, and folding of the nascent RNA.

243 cleoli to the nuclear lamina facilitates the folding of the neutrophil genome into a confined geometr

244 rocyclization proceeds efficiently, inducing folding of the o-phenylenes.

245 Further, we followed the folding of the P4-P6 RNA and showed that differences in

246 %) partially folded intermediate in tertiary folding of the P5abc subdomain of the 'Tetrahymena' grou

247 ntrolled, non-equilibrium process coupled to folding of the passenger and propose a model connecting

248 moves in the hydrophobic groove formed after folding of the peptide in the presence of zinc ions.

249 This is the first evidence that folding of the polypeptide chain precedes disulfide form

250 Early folding of the predominantly beta-sheet ATIII domain in

251 sidues is disrupted lead to major changes in folding of the protein and the size and shape of the sub

252 Our observations show that cotranslational folding of the protein, which folds autonomously and rap

253 significant effects on the structure and the folding of the protein.

254 disulfide bond, which assists the functional folding of the protein.

255 HP, and there were no indications of altered folding of the proteins that remain in solution.

256 e BDES-Pvs25-PvCSP vaccine displayed correct folding of the Pvs25-PvCSP fusion protein on the viral e

257 folding nucleus correctly, which then drives folding of the rest of the domain.

258 hat promote high-fidelity co-transcriptional folding of the riboswitch but are only indirectly linked

259 g(2+) concentration is required for complete folding of the ribozyme and stabilization of the active

260 from chain connectivity prevent the complete folding of the ribozyme.

261 contribution of the C terminus in supporting folding of the serotonin transporter (SERT; SLC6A4).

262 and DFT quantum mechanics indicate that the folding of the shorter oligoviologens is dominated by in

263 gp160 chain termination and is dependent on folding of the soluble subunit gp120 to a near-native co

264 hile it evidently plays a role in the proper folding of the SPOR domain of FtsN, this domain is non-e

265 We found that folding of the TCR alpha chain constant domain Calpha is

266 analysis mainly detects selection for proper folding of the TCR receptor protein.

267 a-sheet catalytic core but likely assist the folding of the TIKI domain.

268 s in a stepwise, hierarchic fashion from the folding of the triple helix to the assembly of fibrils i

269 The folding of the triple-labeled mutant is monitored by the

270 constraints imposed upon them by the native folding of the viral spike.

271 We show that folding of the Wnt signaling coreceptor LRP6 is promoted

272 nslation system to study translocon-mediated folding of the WT pro-SP-C poly-Val and a designed poly-

273 The results show that the co-translational folding of the WT pro-SP-C TM segment is inefficient, th

274 e time required for beta 2-AR activation and folding of the WW domain are greatly diminished using ev

275 ase Rtt109, and the N-terminal tail of H4 in folding of the yeast genome.

276 lity to resolve fine differences in rates of folding of these elements.

277 igoviologens induce intra- or intermolecular folding of these homologues.

278 The folding of these oligomers is only weakly solvent-depend

279 mechanisms and the energetics that drive the folding of these proteins are poorly understood.

280 asible, a major anticipated challenge is the folding of these proteins into their active conformation

281 Proper folding of these proteins is monitored by the unfolded p

282 barrel fold, but how the chaperonin promotes folding of these proteins is not known.

283 lipids are generally involved in the proper folding of these proteins.

284 ded justification for the co-transcriptional folding of these species.

285 rum by focused-ion-beam based patterning and folding of thin film nanostructures.

286 s to be important for ligand recognition and folding of this domain to potentiate DNA binding but doe

287 dazole deprotonation is not a barrier to the folding of this protein.

288 Mutations designed to disrupt folding of this region into amphipathic helices (AHs) si

289 ht to identify the proteins that control the folding of this region of proviral genome by inducing/st

290 n-canonical ER quality control mechanism for folding of thrombospondin type 1 repeats by protein O-fu

291 Folding of transmembrane and secretory proteins occurs i

292 t remains unknown, however, whether tertiary folding of transmembrane domains begins after the nascen

293 s sufficient for successful co-translational folding of two bacterial alpha-helical membrane proteins

294 y desirable to be able to study the rates of folding of two or more neighboring subdomain structures

295 Here we show that FKBP22 catalyzes the folding of type III collagen and interacts with type III

296 ciated with it, significantly slows down the folding of UCH-L1.

297 , prevent the aggregation and premature (mis)folding of unfolded proteins.

298 volves VCP/p97, an AAA ATPase regulating the folding of various cellular substrates including ubiquit

299 lp explain how chaperones can facilitate the folding of various unrelated proteins.

300 The folding of wild type Pin1 WW domain, which has two posit