ライフサイエンスコーパス: folic acid

1 s (PUFAs) and folate (or the synthetic form, folic acid).

2 duce renal dysfunction and decrease of serum folic acid.

3 ions who were consuming bread fortified with folic acid.

4 , independent of embryo genotype and dietary folic acid.

5 can be achieved with preconceptional use of folic acid.

6 rts of systemic circulation of unmetabolized folic acid.

7 rotective effect currently being achieved by folic acid.

8 most prescriptions contained 1,000 microg of folic acid.

9 ates to 5-MTHF but limited ability to reduce folic acid.

10 te in the hepatic portal vein was unmodified folic acid.

11 re routinely supplemented with high doses of folic acid.

12 or 1 similar to that for its natural ligand, folic acid.

13 with 0.21% (50/24,134) in those unexposed to folic acid.

14 vening reactions could limit the efficacy of folic acid.

15 containing 0.4 to 0.8 mg (400-800 microg) of folic acid.

16 tended negative consequences of supplemental folic acid.

17 p=0.931) for those receiving lamotrigine and folic acid.

18 e showed that high-dose B-vitamin treatment (folic acid 0.8 mg, vitamin B6 20 mg, vitamin B12 0.5 mg)

19 In children whose mothers took folic acid, 0.10% (64/61,042) had autistic disorder, com

20 oth the inability of Juno to bind vitamin B9/folic acid [1], and why mutations within the flexible re

21 s and status compared with nonconsumption of folic acid (18% of the population).

22 icronutrient powder containing iron (60 mg), folic acid (400 mug), and calcium carbonate granules mic

23 Treatment was combined with folic acid 5 mg/week.

24 The main contributor to total folate was folic acid, 5-methyl-tetrahydrofolate was the only minor

25 )) under B-vitamin supplementation (2.5 mg/d folic acid, 50 mg/d vitamin B6, and 1 mg/d vitamin B12),

26 Folic acid 6 days per week (odds ratio, 0.16; 95% CI, 0.

27 Fifteen minutes after a dose of folic acid, 80 +/- 12% of labeled folate in the hepatic

28 of bacteriophage phi29 motor pRNA to escort folic acid, a fluorescent image marker and BRCAA1 siRNA

29 Ds, the biochemical mechanisms through which folic acid acts during neural tube development remain un

30 Folic acid administration 6 or 7 times per week protecte

31 ments containing iron-folic acid versus iron-folic acid alone in 112 953 pregnant women.

32 mparison with placebo, children treated with folic acid alone or in combination with vitamin B-12 had

33 of omega-3 fatty acids, soy, ginkgo biloba, folic acid alone or with other B vitamins, beta-carotene

34 lements containing 15 micronutrients or iron-folic acid alone, taken daily from early pregnancy to 12

35 neural tube defects than can be achieved by folic acid alone.

36 association between food fortification with folic acid and a reduction in the birth prevalence of sp

37 317 participants enrolled in the Bangladesh Folic Acid and Creatine Trial (FACT).

38 the effect of maternal intakes of folate and folic acid and fetal genetic variants in folate metaboli

39 Folic acid and magnesium may also merit supplementation

40 opment, providing a mechanistic link between folic acid and NTDs.

41 of periconceptional multivitamins containing folic acid and of folic acid food fortification on conge

42 The stability of folic acid and the high susceptibility of 5-CH3-H4folate

43 Folic acid and vitamin B-12 from fortified foods and sup

44 Folic acid and vitamin B-12 supplementation significantl

45 d 98 controls) were eligible for analysis of folic acid and vitamin B12 levels.

46 A diet poor in folic acid and vitamin B6 is also associated with a high

47 The objective was to measure the effect of folic acid and/or vitamin B-12 administration on the inc

48 iron and folic acid (IFA; 60 mg Fe + 400 mug folic acid) and 16 clusters received LNS-PLs (20 g/d, 11

49 nds; dietary factors, including vitamin B12, folic acid, and fish oil; obesity; and stress.

50 tituted purine CDK inhibitor conjugates with folic acid as a drug-delivery system targeting folate re

51 l structure of human FRalpha in complex with folic acid at 2.8 A resolution.

52 ollow-up, pregnant women taking supplemental folic acid at or above the recommended dose, combined wi

53 The potential of the folic acid biosynthesis pathway as a target for the deve

54 pairs, several of which putatively mapped to folic acid biosynthesis, a key pathway in colorectal can

55 that captured recent and habitual intakes of folic acid, both as supplements and as fortified foods,

56 ternal periconceptional use of the B vitamin folic acid can prevent many NTDs.

57 , 0.58-11.67) in the Women's Antioxidant and Folic Acid Cardiovascular Study.

58 ) for patients receiving lamotrigine without folic acid compared with 0.12 ([-2.58 to 2.82]; p=0.931)

59 Folic acid conjugated to cytotoxics, a new class of anti

60 A new micelle-forming material, folic acid-conjugated carboxymethyl lauryl chitosan (FA-

61 We suggest that high folic acid consumption reduces MTHFR protein and activit

62 gated the association between the filling of folic acid-containing prescriptions and infant bronchiol

63 Studies administering >400 mug folic acid/d show no dose-response relation and thus wil

64 al tube under conditions of maternal dietary folic acid deficiency.

65 ion of a specific C5aR peptide antagonist to folic acid-deficient pregnant mice resulted in a high pr

66 Vintafolide (EC145) is a folic acid-desacetylvinblastine conjugate that binds to

67 lls were collaterally sensitive to EC0905, a folic acid-desacetylvinblastine monohydrazide conjugate

68 g random-effects models, stratifying by iron-folic acid dose, and exploring individual study effect.

69 irth defect research, the mechanism by which folic acid exerts this benefit remains unknown.

70 with biodegradable copolymer pluronic F-127-folic acid (F-127-FA), RET-BDP molecules can form unifor

71 nts (MMN) or iron + folic acid (IFA), versus folic acid (FA) alone, on risk of spontaneous preterm bi

72 A comparative study is reported where folic acid (FA) and boronic acid (BA) based cytosensors

73 Folic acid (FA) and doxorubicin (DOX) are coupled separa

74 udy compares enzymatic treatments to release folic acid (FA) and endogenous 5-methyltetrahydrofolate

75 ural description of noncovalent complexes of folic acid (FA) and native cyclodextrins (alpha-CD, beta

76 Folic acid (FA) concentrations of nine fortified vitamin

77 New folic acid (FA) coupled three layered micelles (3LM) wer

78 nicotinamide adenine dinucleotide (NADH) and folic acid (FA) for the first time.

79 Folic acid (FA) is a key vitamin in the prevention of ma

80 Folic acid (FA) is a synthetic vitamin commonly used for

81 Supplementation with folic acid (FA) is recommended worldwide before and duri

82 e 1-phosphate, in kidney fibrosis induced by folic acid (FA) or unilateral ischemia-reperfusion injur

83 Maternal folic acid (FA) protects against developmental toxicity

84 Dietary folic acid (FA) supplementation effectively and safely r

85 nt individuals, this process is augmented by folic acid (FA) supplementation, thereby lowering blood

86 ren, although the effects of high dosages of folic acid (FA) supplements are unclear.

87 valently coupled polyethyleneimine (PEI) and folic acid (FA) to the magnetic and fluorescent core/she

88 ed gold (Au) electrode was used to determine folic acid (FA) using square-wave voltammetry (SWV).

89 panish market offers a significant number of folic acid (FA) voluntarily fortified foods.

90 -methyltetrahydrofolate (L-5-MTHF) with free folic acid (FA) when exposed to thermal cooking conditio

91 ed nanogels were surface-functionalized with folic acid (FA) with the help of a PEG spacer without af

92 ful achieved the ultrasensitive detection of folic acid (FA) with the limit of detection (LOD) as 0.8

93 aling unit) bonded in different positions to folic acid (FA), the folate receptor (FR) targeting unit

94 nt, are pregnant, or are lactating consume a folic acid (FA)-containing supplement.We sought to deter

95 ctive tumor-targeting by a novel Cy3-labeled folic acid (FA)-derivatized DNA dendrimer nanocarrier (3

96 tributions of ferroptosis and necroptosis to folic acid (FA)-induced AKI in mice.

97 l multivitamins containing folic acid and of folic acid food fortification on congenital heart defect

98 analysis was used to quantify the effect of folic acid food fortification on nonchromosomal CHD subt

99 Folic acid food fortification was associated with lower

100 face has been covalently functionalized with folic acid for molecular targeting of cancer cells.

101 us folic acid was compared with placebo plus folic acid for up to six menstrual cycles; for women who

102 rived patient safety indicators (PSI) in the Folic Acid for Vascular Outcome Reduction in Transplant

103 traindicated because of reduced GFR from the Folic Acid for Vascular Outcome Reduction in Transplant

104 We conducted a post hoc analysis of the Folic Acid for Vascular Outcome Reduction in Transplanta

105 ubjects were selected randomly from the 4110 Folic Acid for Vascular Outcome Reduction in Transplanta

106 This post hoc analysis of the Folic Acid for Vascular Outcome Reduction in Transplanta

107 Using specimens collected during the Folic Acid for Vascular Outcome Reduction in Transplanta

108 Pre-folic acid fortification (1988-1994), risks of deficienc

109 The United States implemented mandatory folic acid fortification of enriched cereal grains in 19

110 In the context of mandatory and voluntary folic acid fortification, the exposure of children to fo

111 Our data suggest that, after mandatory folic acid fortification, the prevalence of folate-defic

112 red by policy makers who are responsible for folic acid fortification.

113 ve birth rates among a population exposed to folic acid fortification.

114 amins and bone health from a population with folic acid fortification.

115 f nutrient status in a population exposed to folic acid fortification.

116 in Ireland who were exposed to the voluntary folic acid-fortification regimen in place in Ireland.

117 s ethically imperative given the ubiquity of folic acid fortified products in the US.

118 The exposure of primary interest was use of folic acid from 4 weeks before to 8 weeks after the star

119 Mean daily intake of folic acid from fortified foods and supplements was 109

120 tal folate intake (including food folate and folic acid from fortified foods and supplements) or othe

121 ects on food-choice behavior and report that folic acid from the microbiota is sufficient for Drosoph

122 urface plasmon resonance (SPR) sensing using folic acid-functionalized gold nanoparticles (FA-AuNP) i

123 inally, we found that QDs cap-exchanged with folic acid-functionalized ligands could effectively targ

124 imaging of three different endocytic ligands-folic acid, galectin-3 (Gal3) and the Shiga toxin B-subu

125 , and inefficient chemotaxis toward cAMP and folic acid gradient.

126 aths (54.0 per 1000 live births) in the iron-folic acid group and 741 deaths (51.6 per 1000 live birt

127 group and the 22,162 pregnancies in the iron-folic acid group, there were 14,374 and 14,142 live-born

128 d fortification, the exposure of children to folic acid has been a focus of concern, particularly reg

129 Primary prevention with folic acid has been enhanced through introduction of man

130 ablets and were treated with additional iron folic acid if they were anemic (hemoglobin <11 g/dL).

131 The women were provided with one daily iron-folic acid (IFA) capsule, one capsule containing multipl

132 pring from 6 to 24 mo (LNS-LNS), 2) iron and folic acid (IFA) during pregnancy and the first 3 mo pos

133 th multiple micronutrients (MMN) or iron and folic acid (IFA) in Indonesia.

134 for-age z score (LAZ) at 24 mo than iron and folic acid (IFA) provided to women during pregnancy and

135 enatal MM supplementation compared with iron-folic acid (IFA) supplementation was examined for its im

136 with multiple micronutrients (MMN) or iron + folic acid (IFA), versus folic acid (FA) alone, on risk

137 tandard of care comprising CSB+ and iron and folic acid (IFA).

138 ational weeks; 48 clusters received iron and folic acid (IFA; 60 mg Fe + 400 mug folic acid) and 16 c

139 blood cell folate) increased in response to folic acid in a dose-response manner only up to an intak

140 Therefore, chronic liver exposure to folic acid in humans may induce saturation, which would

141 med by the degradation of 5-CH3-H4folate and folic acid in solution, under the same conditions of oxy

142 Therefore, large amounts of unmodified folic acid in the portal vein are probably attributable

143 was reversed completely or in part by excess folic acid, indicating that FRalpha is involved in cellu

144 In mice with folic acid-induced AKI, delayed treatment with Tanshinon

145 PTH secretion after experimental uremia- or folic acid-induced AKI.

146 number of Troy-derived cells increases after folic acid-induced injury.

147 LD4 using specific siRNA protected mice from folic acid-induced kidney fibrosis and inhibited the inc

148 ion of nephrotoxic stress (acute and chronic folic acid-induced nephropathy) in Sirt1(endo-/-) mice r

149 Using RNA sequencing in a mouse model of folic acid-induced nephropathy, we identified ten genes

150 PLD4 inhibition also prevented the folic acid-induced upregulation of this receptor in mous

151 High folic acid inhibited MTHFR activity in vitro, and MTHFR

152 kappaB2 p100 and p52 increased rapidly after folic acid injection, as did DNA binding of RelB and NFk

153 fect the survival rate of either group after folic acid injection.

154 ses in risk were observed for both strata of folic acid intake (<400 microg/day, >/=400 microg/day),

155 Although both folic acid intake and vitamin D levels are hypothesized

156 ta-analysis of the association of folate and folic acid intake during pregnancy and risk of asthma an

157 Impact of folic acid intake during pregnancy on genomic imprinting

158 rodevelopmental problems, such as increasing folic acid intake during pregnancy to decrease the incid

159 Moderately high folic acid intake in pregnant women has led to concerns

160 culated folate biomarker response to a given folic acid intake may be more robust with the use of a m

161 r goal was to investigate the impact of high folic acid intake on liver disease and methyl metabolism

162 50 to 400 mug/d indicated that a doubling of folic acid intake resulted in an increase in serum/plasm

163 ve consumption groups formed on the basis of folic acid intake.

164 recognized folate biomarkers to a change in folic acid intake.

165 rudent class after adjustment of for dietary folic acid intake.

166 R653Q, may modulate the effects of elevated folic acid intake.

167 However, the effects of increased folic acid intakes during pregnancy on maternal and cord

168 iconceptional supplementation have increased folic acid intakes in North American pregnant women.

169 n a subgroup of women with high supplemental folic acid intakes in the second trimester, those with t

170 Folate and folic acid intakes of 368 Canadian pregnant women were a

171 ires that captured recent and habitual daily folic acid intakes of children grouped as follows: 0-5 y

172 Folic acid is an essential component of 1-carbon metabol

173 We tested the assumption that, in humans, folic acid is biotransformed (reduced and methylated) to

174 Although folic acid is essential to numerous bodily functions, re

175 Maternal supplementation with folic acid is known to reduce the incidence of neural tu

176 Increased consumption of folic acid is prevalent, leading to concerns about negat

177 Folic acid is thought to act through folate one-carbon m

178 Subgroup analyses showed that the folic acid level was 1.66 ng/mL (95% CI, 0.10-3.21) lowe

179 eting ligands to nanocarriers (attachment of folic acid ligand recognized by folate receptors of canc

180 all took at least 400 mug/d of supplemental folic acid (median, 500; interquartile range, 400-600 mu

181 -transmembrane receptor fAR1 is required for folic acid-mediated signaling events.

182 samples, we observed that six enzymes of the folic acid metabolic pathway were overexpressed in HGS o

183 gen receptor (TCR) recognises riboflavin and folic acid metabolites bound by MR1 in a conserved docki

184 With a lower dose of folic acid, mice expressing KCP exhibited improved renal

185 ession, but also to be aware that concurrent folic acid might reduce its effectiveness.

186 pression of these genes was also high in the folic acid model and in patients with biopsy-proven kidn

187 ine serum albumin (HS:BSA) mixtures onto the folic acid modified sensor resulted in a highly anti-fou

188 After induction of folic acid nephropathy or unilateral ureteral obstructio

189 rs in animal models with lupus nephritis and folic acid nephropathy.

190 was induced by intraperitoneal injections of folic acid (nephrotoxic acute kidney injury) or by IM in

191 In the folic acid nephrotoxicity model of acute tubular necrosi

192 Neither folic acid nor vitamin B-12 administration reduced the i

193 The effects of folic acid on the liver, the primary organ for folate me

194 l tube defects (NTDs); among nonconsumers of folic acid, only 16% attained optimal RBC folate.

195 vestigating the association between maternal folic acid or folate intake or maternal or neonatal fola

196 widespread fortification of foodstuffs with folic acid or folate supplementation before or during pr

197 eive daily 500 mug vitamin B-12 plus 400 mug folic acid or placebo supplementation for 2 y.

198 n algorithm to lamotrigine or placebo and to folic acid or placebo.

199 Folic acid or vitamin B-12 supplementation did not reduc

200 bjects were randomized to receive daily oral folic acid plus vitamin B12 or placebo.

201 Daily folic acid plus vitamin B12 was associated with improvem

202 Folic acid prevents neural tube closure defects (NTDs),

203 We propose that folic acid promotes normal NTC in some embryos by regula

204 a point-of-care sensor for the detection of folic acid protein (FAP) using graphene-based SPR chips.

205 le micronutrient supplements containing iron-folic acid provided significantly greater reductions in

206 rodent studies, is that physiologic doses of folic acid (pterylmonoglutamic acid), such as dietary vi

207 a valuable target for nuclear imaging using folic acid radioconjugates.

208 pproach, we discovered the long sought after folic acid receptor, fAR1, in D. discoideum.

209 n of FAP is based on the interaction between folic acid receptors integrated through pi-stacking on t

210 as a significant interaction (p=0.028), with folic acid reducing the effectiveness of lamotrigine at

211 est that humans are reliant on the liver for folic acid reduction even though it has a low and highly

212 t gastrointestinal AEs more than once-weekly folic acid, regardless of the total weekly dosage.

213 obesity (35 of 270 patients [13.0%]), but a folic acid regimen was not.

214 ic moiety and the aromatic pteridine ring of folic acid remain outside the cyclodextrin cavity, while

215 es show a similar pattern with high doses of folic acid required to prevent CHD.

216 Therefore, in a mouse model that exhibits folic acid-resistant neural tube defects, we tested the

217 had total intakes above the ULs for iron and folic acid, respectively.The level of intake of some nut

218 eficient mice provide a model to investigate folic acid-responsive NTDs wherein disruption of de novo

219 Conversely, a meta-analysis of folic acid revealed a nonsignificant difference from pla

220 e, magnesium, niacin, phosphorus, potassium, folic acid, riboflavin, and vitamins B-12, C, and E, and

221 Folic acid seems to nullify the effect of lamotrigine.

222 ired nutrients (such as vitamins A, C, or D; folic acid; selenium; or calcium) were scant and heterog

223 and encapsulation techniques led to improved folic acid stability, especially under dry conditions.

224 found in a Higgins test for both omega-3 and folic acid studies; funnel plots also revealed asymmetry

225 Timing, dose, and duration of folic acid supplement use were recorded.

226 r breast-feeding or maternal multivitamin or folic acid supplement use.

227 es compared with male neonates than did iron-folic acid supplementation alone (RR 0.85, 95% CI 0.75-0

228 Folic acid supplementation also did not affect the rate

229 Periconceptional folic acid supplementation and food fortification are re

230 port an association between periconceptional folic acid supplementation and increased risk of asthma

231 Therefore, vitamin B-12 plus folic acid supplementation cannot be recommended at pres

232 n 1984, incidence of neural tube defects for folic acid supplementation compared with trace element s

233 Folic acid supplementation confers modest benefit in sch

234 al multiple micronutrient compared with iron-folic acid supplementation did not reduce all-cause infa

235 reason to alter current recommendations for folic acid supplementation during conception or pregnanc

236 We investigated the association between folic acid supplementation during pregnancy and loss of

237 and animal models led to the hypothesis that folic acid supplementation during pregnancy confers an i

238 To review the evidence on folic acid supplementation for preventing neural tube de

239 ese data show that combined vitamin B-12 and folic acid supplementation had no effect on osteoporotic

240 Daily folic acid supplementation in the periconceptional perio

241 Folic acid supplementation in those with a low vitamin B

242 sed the balance of the benefits and harms of folic acid supplementation in women of childbearing age

243 09, the USPSTF reviewed the effectiveness of folic acid supplementation in women of childbearing age

244 rvices Task Force (USPSTF) recommendation on folic acid supplementation in women of childbearing age.

245 English-language studies of folic acid supplementation in women.

246 Periconceptional folic acid supplementation is a primary care-relevant pr

247 homocysteine with combined vitamin B-12 and folic acid supplementation may reduce fracture risk.

248 molecular mechanism mediating the effect of folic acid supplementation on neonatal and pediatric out

249 We investigated the effects of moderate folic acid supplementation on reproductive outcomes and

250 fortification in the United States in 1998, folic acid supplementation provided protection against n

251 aimed to determine whether vitamin B-12 and folic acid supplementation reduces osteoporotic fracture

252 that the harms to the mother or infant from folic acid supplementation taken at the usual doses are

253 ch can attenuate the measured association of folic acid supplementation with neural tube defects.

254 Newborn Health and Child Health (along with folic acid supplementation, a key reproductive health in

255 d a protective association consistently with folic acid supplementation, with ORs ranging from 0.93 t

256 ed new evidence on the benefits and harms of folic acid supplementation.

257 emain resistant to the beneficial effects of folic acid supplementation.

258 ave possibilities for prevention by maternal folic acid supplementation.

259 stablish causality, they do support prenatal folic acid supplementation.

260 thfd1S(+/+) and Mthfd1S(+/-) mice were fed a folic acid-supplemented diet (FASD) (5-fold higher than

261 ale mice were placed on control diet (CD) or folic acid-supplemented diet (FASD) throughout mating, p

262 Folic acid-supplemented diet (FASD, 10-fold higher than

263 The benefits of the use of folic acid supplements (FASs) during the periconception

264 Use of prenatal folic acid supplements around the time of conception was

265 he increased risk of diarrhea, the safety of folic acid supplements in young children should be furth

266 The addition of choline to folic acid supplements may not further reduce NTD risk.

267 Prenatal folic acid supplements reduce the risk of neural tube de

268 Maternal use of folic acid supplements reduces risk of neural tube defec

269 unders (maternal alcohol consumption, use of folic acid supplements, age, body size, education, and e

270 ications for individuals consuming high-dose folic acid supplements, particularly those who are MTHFR

271 han children born to mothers taking iron and folic acid supplements.

272 iblock conjugated polymer nanoparticles with folic acid surface ligands are highly effective for bioi

273 s suggested that high circulating folate and folic acid (synthetic form of folate) supplement use may

274 All women received routine daily iron folic acid tablets and were treated with additional iron

275 of the women reported not consuming the iron folic acid tablets during pregnancy.

276 , mice expressing KCP survived high doses of folic acid that were lethal for wild-type mice.

277 The consumption of folic acid through fortified foods at low, medium, and h

278 insight into the association behavior of the folic acid toward cyclodextrins evaluated by thermodynam

279 ored concentrations of fasting unmetabolized folic acid (UFA) in the circulation of children living i

280 e breast-milk total folate and unmetabolized folic acid (UMFA) contents and their relation with FA-su

281 d concentrations of folate and unmetabolized folic acid (UMFA) in a cohort of pregnant Canadian women

282 Folic acid use after 12 wk of gestation influences offsp

283 ed with the same maternal characteristics as folic acid use.

284 sted OR for autistic disorder in children of folic acid users was 0.61 (95% CI, 0.41-0.90).

285 ing) were evaluated for the encapsulation of folic acid using both a whey protein concentrate (WPC) m

286 tes, folate analogs that inhibit vitamin B9 (folic acid)-using cellular enzymes, have been used over

287 le micronutrient supplements containing iron-folic acid versus iron-folic acid alone in 112 953 pregn

288 Periconception maternal folic acid (vitamin B9) supplementation can reduce the p

289 w that periconceptional supplementation with folic acid, vitamin B-12, choline, and betaine can induc

290 Mixed results were found for zinc, folic acid, vitamin C, and tryptophan, with nonsignifica

291 Rs for vitamin A, vitamin B-6, vitamin B-12, folic acid, vitamin C, vitamin D, vitamin E, and multivi

292 daily low-dose aspirin (81 mg per day) plus folic acid was compared with placebo plus folic acid for

293 Folic acid was not superior to placebo.

294 Fluorescein labeled folic acid was used for flow cytometric detection of the

295 Leveraging the addiction of ALL to folic acid, we conjugated folate to an alcohol derivativ

296 Recoveries of added folic acid were 112%-114%.

297 red lipid carriers (NLC) functionalized with folic acid were optimized through a Box-Behnken design i

298 ated to interactions between the protein and folic acid which favoured the incorporation of the bioac

299 ors by co-delivering therapeutic agents with folic acid, which in turn leads to significantly increas

300 capsulation efficiency, and stability of the folic acid within the capsules under different storage c