ライフサイエンスコーパス: food vacuole

1 of the parasite's lysosomal compartment-the food vacuole.

2 t to target green fluorescent protein to the food vacuole.

3 -cell hemoglobin in an acidic organelle, the food vacuole.

4 to have additional distribution outside the food vacuole.

5 dicted accumulation into the acidic parasite food vacuole.

6 n of hemoglobin in the Plasmodium falciparum food vacuole.

7 des occurs in an acidic organelle called the food vacuole.

8 ynthetic path leading to mature PM II in the food vacuole.

9 1 through the parasitophorous vacuole to the food vacuole.

10 grades host cell hemoglobin within an acidic food vacuole.

11 acidic environment of the heme-rich parasite food vacuole.

12 nce of MSP1(19)-containing vesicles with the food vacuole.

13 hibited their own digestion in the protozoan food vacuoles.

14 L272F), causing the development of enlarged food vacuoles.

15 moglobin binding domain in PfHDP resulted in food vacuole abnormalities similar to that seen with a c

16 isinins act by inhibiting PfATP6 outside the food vacuole after activation by iron.

17 PfAPP were evaluated at the acidic pH of the food vacuole and at the near-neutral pH of the cytosol.

18 PfAPP is present in the food vacuole and cytosol of the parasite, a distribution

19 s support a catalytic role for PfA-M1 in the food vacuole and indicate the importance of evaluating t

20 d blood cell, where it is transferred to the food vacuole and persists until the end of the intracell

21 es confirm the location of falcilysin in the food vacuole and reveal association with vesicular struc

22 for PfAPP in peptide catabolism in both the food vacuole and the cytosol and suggest that PfAPP has

23 dase activity, falcilysin, was purified from food vacuoles and characterized.

24 In this study, we purified merozoites, food vacuoles, and parasite membrane fragments released

25 pressed in trophozoites, was concentrated in food vacuoles, and was responsible for at least 93% of t

26 nce of amino acid-generating pathways in the food vacuole as well as the cytosol.

27 falcipain-2 cleaves hemoglobin in the acidic food vacuole at the early trophozoite stage, whereas it

28 -erythrocytic developmental stages in acidic food vacuole compartments.

29 protease activity and swollen, dark staining food vacuoles, consistent with a block in hemoglobin hyd

30 owed that falcipain-2 is a major trophozoite food vacuole cysteine protease.

31 the four aminopeptidases (including the two food vacuole enzymes) for efficient parasite proliferati

32 eptides invokes peptide transport out of the food vacuole followed by hydrolysis to amino acids by cy

33 falciparum degrades hemoglobin in its acidic food vacuole for use as a major nutrient source.

34 The heme polymer hemozoin is produced in the food vacuole (fv) of the parasite after hemoglobin prote

35 lysosomal compartment, the malaria parasite food vacuole (FV), rather than to cytoplasmic endocytic

36 Trafficking to the food vacuole has not been well characterized.

37 RP2-ferric heme complex at pH 5.5 (pH of the food vacuole) has the same heme spin state and coordinat

38 Falcipain-2 and falcipain-3 are food vacuole hemoglobinases that may have additional fun

39 the basic drug is concentrated in the acidic food vacuole in its membrane-impermeable diprotonated fo

40 rasites, and anti-DPAP1 antibody labeled the food vacuole in parasite cryosections.

41 roquine (CQ)-hematin binding in the parasite food vacuole leads to inhibition of hematin polymerizati

42 At the pH of the food vacuole lumen (5.0-5.5), the catalytic efficiency o

43 th stable and active at the acidic pH of the food vacuole lumen.

44 ent protein fluorescence was observed in the food vacuole of live transgenic parasites, and anti-DPAP

45 n (HZ) is an insoluble crystal formed in the food vacuole of malaria parasites.

46 Four paralogous plasmepsins reside in the food vacuole of P. falciparum.

47 The acidic food vacuole of Plasmodium falciparum has been the subje

48 plasmepsins that has been identified in the food vacuole of Plasmodium falciparum.

49 n addition to these functions, the digestive food vacuole of the malaria parasite is a dynamic intern

50 These data imply that the digestive food vacuole of the malaria parasite is functionally aki

51 protease (HAP), have been identified in the food vacuole of the parasite.

52 The swollen food vacuole phenotype of falcipain-2 knockout parasites

53 creased chloroquine sensitivity and enlarged food vacuole phenotype.

54 ous recombination has been employed to study food vacuole plasmepsin function in cultured parasites.

55 spartic protease encode hemoglobin-degrading food vacuole proteases.

56 nance of elevated free Ca2+ in the digestive food vacuole (relative to cytosolic levels) is achieved

57 oupled with biochemical analysis of enriched food vacuoles, revealed the presence of amino acid-gener

58 e pH and reducing conditions of the malarial food vacuole, suggesting that parasite enzymatic activit

59 approximately 200-kDa protein complex in the food vacuole that is required for Hb degradation and Hz

60 ge of native hemoglobin in the P. falciparum food vacuole, that, following initial cleavages, the pro

61 a-Asp repeats and is present in the parasite food vacuole, the site of hemoglobin degradation and hem

62 ia parasites degrade hemoglobin in an acidic food vacuole to acquire free amino acids and maintain pa

63 ance mechanism that acts specifically at the food vacuole to alter the binding of chloroquine to hema

64 alcipain-3 hydrolyze hemoglobin in an acidic food vacuole to provide amino acids for erythrocytic mal

65 ydrolyze erythrocyte hemoglobin in an acidic food vacuole to provide amino acids for parasite protein

66 es, and which gene products are found in the food vacuole where catabolism takes place.

67 d along with its substrate hemoglobin to the food vacuole where it is proteolytically processed to ma

68 al intraerythrocytic parasites; that is, the food vacuole, where the catabolism of host hemoglobin ta

69 CRT-mediated drug resistance, as well as the food vacuole, which is an important target of many antim