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1 NK cell-derived IFN-gamma may be essential for maintaining a balanced inflammatory environment that
3 ckbone, groups/atoms bridging adjacent rings for maintaining a high planarity, introduction of electr
4 levels at the same time, which is important for maintaining a homeostatic level of this critical met
6 sults suggest that the cerebellum is crucial for maintaining accurate feedforward control of speech,
7 tion of electron transport pathways critical for maintaining active photosynthetic complexes even aft
8 AT activity (especially LPEAT2) is essential for maintaining adequate levels of phosphatidylethanolam
12 ions in the dominant hemisphere are critical for maintaining an adaptive level of baseline parasympat
13 tiple patterns of influx and efflux carriers for maintaining an auxin pattern do not have spatially p
14 Finally, we showed that CHD7 is necessary for maintaining an open, accessible chromatin state at t
15 ops such as maize is of paramount importance for maintaining and increasing yields in a world experie
16 rane potential and the consumption of energy for maintaining and restoring specific intracellular cat
17 prostate cancers develop adaptive mechanisms for maintaining AR signaling to allow for survival and f
20 specific demethylase 1 (LSD1) is responsible for maintaining balanced methylation levels at histone H
21 hromatin of AtrbohD and ICS1 and is required for maintaining basal histone H3 acetylation levels in t
22 othelial beta-catenin signaling is essential for maintaining BBB integrity and central nervous system
24 ughout the world to identify important areas for maintaining biodiversity and functional ecosystems,
25 found skeletal myofiber VEGF to be necessary for maintaining blood flow through hippocampal regions i
27 local sympathetic nervous system is critical for maintaining brown adipocyte phenotypes in classic br
29 irment, suggesting that fission is important for maintaining cardiac and mitochondrial bioenergetic h
30 t that SNRK in cardiomyocytes is responsible for maintaining cardiac metabolic homeostasis, which is
32 that, in somatic cells, MLL4 is dispensable for maintaining cell identity but essential for reprogra
35 SET1B, but not its SET domain, is critical for maintaining cell viability, indicating a novel catal
36 l oxidative phosphorylation and is important for maintaining cellular and organismal glucose homeosta
38 on microscopy reveal that alsin is important for maintaining cellular cytoarchitecture and integrity
41 criptional processes by RNA-binding proteins for maintaining cellular identity among closely related
46 nding factors of the kinetochore responsible for maintaining chromosome-microtubule coupling during c
49 ified that GABAB(1a) receptors are necessary for maintaining contextual memory precision, thereby con
50 y tract is regulated by reflexes responsible for maintaining continence and producing efficient voidi
51 rtant, and perhaps uniquely human, mechanism for maintaining cooperation against free riders is third
52 copper P1B-type ATPases appear to be crucial for maintaining copper homeostasis within plant cells, b
54 that the GTPase activity of OPA1 is critical for maintaining cristae tightness and thus energetic com
56 t the last 63-aa stretch of WUS is necessary for maintaining different levels of WUS protein in the r
59 how the three DNMTs, 1, 3A, and 3B, interact for maintaining DNA methylation abnormalities in cancer.
63 emerged as a molecule putatively responsible for maintaining encoded memories over time because its p
64 ndicate that the NRP2/WDFY1 axis is required for maintaining endocytic activity in cancer cells, whic
65 degradation of fatty acids and is essential for maintaining energy homeostasis in the human body.
67 fibers while suggesting a possible mechanism for maintaining epigenetic programming of large-scale ch
68 Innate lymphoid cells (ILCs) are critical for maintaining epithelial barrier integrity at mucosal
69 n and expansion during pregnancy are crucial for maintaining euglycemia in response to increased meta
72 torage (typically 0-5 degrees C) is critical for maintaining fresh-cut melon quality, but often reach
73 tight transcriptional regulation is critical for maintaining FSH levels within a narrow physiological
75 dependent RNA polymerase (RdRp) is important for maintaining functional genetic information but, at t
78 tifies landscape features that are important for maintaining genetic connectivity between populations
80 epair of DNA double-strand breaks is crucial for maintaining genome integrity and is governed by post
81 functional DNA damage response is essential for maintaining genome integrity in the presence of DNA
82 However, BLM-TopBP1 binding is important for maintaining genome integrity, because in its absence
86 processes underlying DNA replication is key for maintaining genome stability and preventing tumorige
89 cate that liver AMPKalpha1alpha2 is required for maintaining glucose homeostasis during an acute bout
93 hese results argue that TbSmee1 is necessary for maintaining HC morphology, which is important for th
94 beta-catenin signaling, an essential pathway for maintaining HCC stemness, is required for EpCAM(+) H
97 uired for nuclear retention of CA-FOXO3a and for maintaining hematopoietic repopulation of the HSCs.
100 d self-digestion process, which is essential for maintaining homeostasis and viability in response to
101 ier (BBB) is a rigorous permeability barrier for maintaining homeostasis of Central Nervous System (C
102 loss of the cellular compartment responsible for maintaining homeostasis, quiescent or slowly prolife
106 ase I, the resulting crossovers are critical for maintaining homolog interactions and enabling accura
109 per activation of the immune system but also for maintaining immune tolerance, and more recent work h
110 ulatory T cells (Treg) are critical elements for maintaining immune tolerance, for instance to exogen
111 tomatal control of transpiration is critical for maintaining important processes, such as plant water
112 ving inhibition may offer diverse mechanisms for maintaining inhibitory homeostasis.SIGNIFICANCE STAT
114 energy storage in adipose tissue is crucial for maintaining insulin sensitivity and molecules contri
116 solutes into lymphatic vessels is important for maintaining interstitial homeostasis and delivering
117 d intestinal microbial community is critical for maintaining intestinal health and preventing chronic
121 of urban agglomerations and uncover insights for maintaining key ecosystem functions upon which the s
123 cases, HOXA9 has been shown to be necessary for maintaining leukemic transformation; however, the mo
125 pical protein kinase C isoform, is important for maintaining long-term potentiation and storing memor
126 cell (ESC) culture conditions are important for maintaining long-term self-renewal, and they influen
127 tentially offering a more effective strategy for maintaining low concentrations of uranium in groundw
128 a dNTP hydrolase, whose activity is required for maintaining low dNTP concentrations in non-cycling T
130 White adipose tissue (WAT) is essential for maintaining metabolic function, especially during ob
132 issues from high-fat diet fed mice, critical for maintaining metabolic homeostasis, this study demons
133 production from B cells, which is important for maintaining microbial homeostasis in the intestine.
134 degradable miRNAs, providing a useful means for maintaining miRNA/siRNA function as well as developi
135 nventional notion, S-OPA1 is fully competent for maintaining mitochondrial energetics and cristae str
136 tochrome c oxidase assembly gene is critical for maintaining mitochondrial function and preventing po
139 osynthesis revealed cell-specific mechanisms for maintaining mitochondrial NAD(+) concentrations.
140 tigated whether Drosophila USP5 is important for maintaining monoubiquitin in vivo We found that the
142 elial barrier function is therefore required for maintaining mucosal homeostasis and depends, in part
150 lar conduction system (VCS) and is essential for maintaining normal cardiac rhythm and optimal cardia
152 d demonstrate that this pathway is important for maintaining normal cone-driven vision and accelerati
153 ropose a novel regulatory mechanism critical for maintaining normal daily cycle of wakefulness and in
156 R signalling acts as an important checkpoint for maintaining oligodendrocyte homoeostasis, pointing t
157 ter in Escherichia coli that provides energy for maintaining OM lipid asymmetry via the transport of
159 taining silyl amino acids hold great promise for maintaining or reinforcing the biological activity o
162 a strongly suggest that FTT_0924 is required for maintaining peptidoglycan integrity and virulence.
164 ity, indicating that SLOs are a primary site for maintaining peripheral tolerance under homeostatic c
167 diated feed-forward pathway that is required for maintaining photoreceptor homeostasis in the adult a
170 Oct4 is a transcription factor required for maintaining pluripotency and self-renewal in stem ce
172 and embryonic stem cells also require PRMT5 for maintaining pluripotency, suggesting that similar me
173 ane integrity, chlorophyll content, capacity for maintaining potassium homeostasis, CATALASE activity
174 ward, providing a potential neural mechanism for maintaining predictions and updating stored values d
175 tor system and auxin response as a mechanism for maintaining proper auxin maxima during leaf margin m
176 of the postsynaptic endocytic zones required for maintaining proper cell-surface AMPA receptor levels
178 hese results indicate that Nap1 is essential for maintaining proper chromatin composition and modulat
179 n inhibitory interneurons (PVIs) are crucial for maintaining proper excitatory/inhibitory balance and
182 essed in the prostate epithelium, is crucial for maintaining prostate cell fate and suppressing tumor
184 at the extreme C terminus of D4 is essential for maintaining protein integrity, as assessed by its re
185 70) is a major chaperone protein responsible for maintaining proteostasis, yet how its structure tran
186 iRNA-mediated suppression of genes essential for maintaining proteostasis; many are hub genes - invol
187 Findings point to neural signatures of risk for maintaining PTSD symptoms after trauma exposure.
188 eins (RBPs) ZFP36L1 and ZFP36L2 are critical for maintaining quiescence before precursor B cell recep
190 ts in tumours requires coexistent mechanisms for maintaining RAS activation despite ERK-dependent fee
191 lated factor 1 (NRF1) and NRF2 are essential for maintaining redox homeostasis and coordinating cellu
193 his was attributed to more facile mechanisms for maintaining redox homeostasis in normal breast epith
194 ,5-bisphosphate (PIP2), which is fundamental for maintaining regulated exocytosis, as depletion of me
195 nositide 3-kinase (PI3K) pathway is critical for maintaining regulatory T (Treg) cell functions, we i
197 ndent way and that this assembly is required for maintaining repressive chromatin at the hTERT promot
198 ell function under normoxia but are required for maintaining satellite cell self-renewal in hypoxic e
199 uous angiopoietin/TIE2 signaling is required for maintaining SC identity and integrity during adultho
201 degradation and enriches receptors essential for maintaining self-renewal on the cytoplasmic membrane
202 f a variety of immune cells and are critical for maintaining self-tolerance and preventing the develo
203 O-glycans, namely that they are responsible for maintaining separation between ordered domains when
204 hat ER stress and UPR pathways are essential for maintaining skeletal muscle mass and strength and fo
205 ramides are endogenous skin lipids essential for maintaining skin barrier function and loss of cerami
206 dentified an essential role for microtubules for maintaining skin TRM cell shape and cellular integri
210 ine residues, which are most likely critical for maintaining structural integrity of the protein.
213 early organ development, but also important for maintaining survival and function of the highly spec
219 ts indicate that ribosome maintenance is key for maintaining the ability of P. aeruginosa to resuscit
220 l-tRNAs, provides a critical checkpoint both for maintaining the accuracy of translation and for dete
222 jor cellular heme buffer, and is responsible for maintaining the activity of the heme-dependent nucle
223 es, mediated by NMY-1 and NMY-2, are crucial for maintaining the appropriate ring channel diameter an
224 r pUL51, the pUL7-pUL51 complex is important for maintaining the attachment of infected cells to thei
225 ociated transcription factors is responsible for maintaining the balance between transcriptional prog
226 nd the ATR-ATRIP interaction, it is required for maintaining the basal kinase activity of ATR prior t
227 l-terminal domain of Cav2.1 is not essential for maintaining the basic properties of the channel in t
229 at while EC-derived jagged-2 was dispensable for maintaining the capacity of HSPCs to repopulate unde
231 ring the transformation period, but only fMC for maintaining the choice in memory prior to execution.
232 ibitory synaptic structure, and is essential for maintaining the correct balance between excitation a
233 bryos, supporting that SEIPINs are essential for maintaining the correct polarity of LD budding at th
235 gle anionic glutamate residue is responsible for maintaining the disordered bioactive state of the pe
236 es that Top2-Mus101 interaction is important for maintaining the fidelity of chromosome segregation d
237 ers are increasingly appreciated as critical for maintaining the function of ecosystems and their ser
238 val of mitochondria are considered essential for maintaining the functions of the large asymmetric ce
239 WI-interacting RNAs (piRNAs) are responsible for maintaining the genome stability by silencing retrot
240 ediated monomethylation of H4K20 is critical for maintaining the genomic integrity of late replicatin
241 xic tumor microenvironment serves as a niche for maintaining the glioma-initiating cells (GICs) that
242 osis) and reticulon families are responsible for maintaining the high membrane curvature required for
243 asal epithelial cells and its essential role for maintaining the high proliferative potential of thos
244 his cyclic regeneration process is essential for maintaining the homeostasis of living organisms.
245 thylation activity of the Set1/Mll complexes for maintaining the identity and function of adult HSCs.
247 The CUB2 domain is, therefore, not essential for maintaining the inactive conformation of ADAMTS13.
250 1), a DNA methylation "reader," is important for maintaining the integrity of NSCs, which is critical
251 optosis, the signaling of which is essential for maintaining the integrity of the glomerular filtrati
252 he K63-Ub DUB activity, although dispensable for maintaining the integrity of the macromolecular prot
253 meostasis and associated ATP:ADP equilibrium for maintaining the integrity of the photosynthetic appa
254 tously expressed sodium pumps are best known for maintaining the ionic gradients and resting membrane
255 NFS1 activity is particularly important for maintaining the iron-sulfur co-factors present in mu
256 able fragment receptor (FcRn) is responsible for maintaining the long half-life and high levels of th
257 s a lysosomal K(+) channel that is important for maintaining the membrane potential and pH stability
258 , our data demonstrate that Cx43 is required for maintaining the mitochondrial integrity and metaboli
259 ns, labile Zn-sites, where Zn(2+) is crucial for maintaining the native protein structure but the Zn-
260 s self-derived VEGF is functionally relevant for maintaining the neurogenic niche as inducible, NSPC-
262 r, to our knowledge, the dietary requirement for maintaining the nutritional adequacy of vitamin D in
263 al. (2017) show that autophagy is essential for maintaining the replicative quiescence of hematopoie
264 trodes in Li-ion batteries (LIBs) is crucial for maintaining the reversibility, electrolyte decomposi
265 Likewise, the presence of KCNQ3 is essential for maintaining the sAHP when hippocalcin is ablated, a
266 and Fermi energy level position are critical for maintaining the semimetallic functionality of the BN
267 olycomb group (PcG) proteins are responsible for maintaining the silenced transcriptional state of ma
268 patial heterogeneity should be a major focus for maintaining the stability of ecosystem services at l
269 f the Hsp90 molecular chaperone is essential for maintaining the stability of numerous client protein
270 on of NANOG, a transcription factor critical for maintaining the stemness and the self-renewal abilit
271 secretory proteins are known to be critical for maintaining the stemness of stem cells through autoc
272 ts demonstrate that dystroglycan is required for maintaining the structural integrity of the inner li
274 zation that the lipid environment is crucial for maintaining the structure and function of membrane p
275 ein essential in many Gram-positive bacteria for maintaining the thiol-redox balance and protecting a
277 nexpectedly, we found that CHD4 is necessary for maintaining the tumor-forming behavior of AML cells,
281 ood-dependent induction of bursts as well as for maintaining their high rate of pumping through two d
282 ip for women and MD investigators is crucial for maintaining their presence in NIH-funded dermatology
288 The SV-associated synapsins are crucial for maintaining this reserve pool and regulate the mobil
289 ic chromosomes suggest a potential mechanism for maintaining transcriptional programs through the cel
290 ormal kidney tissue function but is required for maintaining transcriptional regulation under conditi
291 critical cofactors and target genes required for maintaining transformation in HOXA9-overexpressing l
292 p21-activated kinase 2 (Pak2), is essential for maintaining Treg stability and suppressive function.
293 surprising, since this pathway is best known for maintaining undifferentiated germline stem cells/pro
294 n tunnel environments are driven by requests for maintaining uninterrupted internet access for users
295 nt findings highlight the necessity of ELMO2 for maintaining vascular integrity, specifically in intr
298 nduction of P. aeruginosa virulence but also for maintaining viability in the hostile environment of
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