ライフサイエンスコーパス: force

1 barrier and is significantly accelerated by force.

2 adapt their growth in response to mechanical force.

3 les into the medium, guided by magnetomotive force.

4 nd older for the US Preventive Services Task Force.

5 the macromolecular structure in response to force.

6 ts to inform the US Preventive Services Task Force.

7 s that leads to an enhanced electric driving force.

8 eton-binding beta-subunits tilted by applied force.

9 rongly sensory neurons respond to mechanical force.

10 chondrial fission is triggered by mechanical forces.

11 ing and function in the presence of physical forces.

12 ture demands based on demographic and market forces.

13 roadly used to measure intercellular tensile forces.

14 l forces; cell-to-cell and cell-to-substrate forces.

15 ensuring effective transfer of OHC isometric forces.

16 d that this behavior depends upon mechanical forces.

17 e of attractive and repulsive intermolecular forces.

18 olution by ultrasound-generated elongational forces.

19 be attributed, in large part, to atmospheric forcing.

20 derstand the contribution of BB to radiative forcing.

21 recasts that utilize daily observed humidity forcing (4.4% and 2.6% respectively).

22 hrough a combination of: (1) prodigious bite forces (8,526-34,522 newtons [N]) and tooth pressures (7

23 shows that the squaraine gem-dimethyl groups force a relatively wide separation between the macrocycl

24 10(17) Previously, atomic interactions have forced a compromise between clock stability, which benef

25 identify the cause as interligand repulsion forcing a wider C-Pd-C angle and tilting of the NHC plan

26 as trigger factor can work as foldases under force, a mechanism which could be of relevance for sever

27 (600 bp) size and is strongly suppressed by forces above 1 pN, consistent with a loop-capture mechan

28 The Task Force achieved a comprehensive position in defining poll

29 ed, shear stress triggers rapid increases in force across PECAM-1 but decreases the force across VE-c

30 es in force across PECAM-1 but decreases the force across VE-cadherin, in close association with down

31 In a more general framework, mechanical forces acting on a molecular system can strongly modify

32 a surface decreased with increasing adhesion-forces acting perpendicular to the surface, (3) nanoscop

33 Due to its significant homology with the force-activated titin kinase, smMLCK is suspected to be

34 The forcing activity demarcates coherent phase space regions

35 rable substances in animal feed entered into force and for the first time was laid down a maximum lim

36 nization, accompanied by reduced contractile force and increased stiffness of cells.

37 which recently have been shown to distribute force and motion in robust ways determined by a nontrivi

38 EFS increased force and phosphorylation of RLC, CPI-17 and MLCK.

39 -muscle models indicate that maximum dynamic force and power output is 1.35 times higher in a chimpan

40 atiotemporal changes of actomyosin-dependent force and stiffness along the antero-posterior and dorso

41 time at FAs was independent of local applied force and substrate stiffness.

42 The absence of the axial scattering force and the enhanced gradient force enable to avoid ov

43 irreversibly remodelled by cellular traction forces and by macroscopic strains.

44 findings provide insights into the selective forces and ecological factors that may have driven the s

45 but he was first to postulate that physical forces and internal growth parameters regulate biologica

46 fts, superradiant decay rates, Van der Waals forces and resonance energy transfer rates, are conventi

47 is imbibed into the shale rock by capillary forces and retained there indefinitely.

48 iff cells that promote strong B cell pulling forces and stringent affinity discrimination.

49 tum measurement backaction exceeding thermal forces and thus strong optomechanical quantum correlatio

50 imulate MU firing rates and isometric muscle forces and, to that model, we added fatigue-related chan

51 to have larger impacts on aerosol radiative forcing and could serve as biomass burning tracers.

52 ntensity forecasts are accurate than with no forcing) and that forecasts generated using daily climat

53 ta1), integrins bind to the prodomain, apply force, and release the TGF-beta growth factor.

54 ion concerning the structure, intermolecular forces, and dynamics of ionic liquids.

55 iven, are intrinsically low-speed and/or low-force; and their camouflage capabilities have not been e

56 We demonstrate that forced apical localization of Par3, which is normally re

57 Depending on the direction of force application, the unbinding forces can more than tr

58 ar, for a left-handed chiral tip, transverse forces are attractive with left-CPL and repulsive with r

59 Mechanical forces are critical but poorly understood inputs for org

60 Measuring and mapping single platelet forces are desired in both research and clinical applica

61 systems, pathways for bottom-up and top-down forces are not necessarily mutually exclusive and togeth

62 These forces are substantially larger than the interaction of

63 eins, are directly examined by measuring the forces arising as an Atomic Force Microscope tip (diamet

64 ups also produce traction hotspots, but with forces around 100 pN that fluctuate rapidly on timescale

65 was much greater than the potential climate forcing associated with higher black carbon emissions.

66 er than structure refinement, is the driving force behind the creation of new prochlorosin structures

67 show that tuning the range of the repulsive force below the particle roughness suppresses the fricti

68 nti-parallel microtubules apart with gradual force buildup while parallel microtubule bundles remain

69 Root mean square electromyography/bite-force calibrations determined subject-specific masseter

70 environment, we hypothesized that exogenous forces can be applied for engineering a variety of signi

71 irection of force application, the unbinding forces can more than triple.

72 to tip a local balance of competing physical forces; cell-to-cell and cell-to-substrate forces.

73 rrences of atrial fibrillation after contact force (CF)-guided pulmonary vein isolation.

74 ts used pointing or left/right 2-alternative forced choice tasks to examine perceptual judgments of s

75 check-all-that-apply questions, treating the forced-choice format as the "gold standard," ranged from

76 In Experiment 1, participants made forced-choice judgments of which of two tactile distance

77 We developed a two-alternative forced-choice task in an automated modified T-maze.

78 own to have highly nonlinear behavior across force conditions that may be exploited at a systems leve

79 odel, we added fatigue-related changes in MU force, contraction time, and firing rate associated with

80 at the steady state, the type of mechanical force controls the outcome: stretch induces cell divisio

81 e coupling of thermal effects and mechanical forces controls the stability of the clusters.

82 The concept of forcing covalent and reversible bonds to mix at molecula

83 and impairment of specific force (isometric force/cross-sectional area) and unloaded shortening velo

84 The second phase of the biphasic force decay upon release of phosphate from caged phospha

85 The maximum force decreased with gel water content in the abdominal

86 dence of the unit's dissociation rate on the force delivered to the rotor.

87 ve cells, we show that B cells primarily use force-dependent extraction and resort to enzymatic liber

88 in an orientation biologically relevant for force-dependent release of TGF-beta from latency.

89 the tissue level the spatial organization of forces determines the morphogenetic output.

90 e model simulations subject to anthropogenic forcing display an increase in the projection of this fi

91 of bacteria adhering to glass and their AFM force-distance curves and include the following observat

92 and include the following observations: (1) force-distance curves showed detachment events indicativ

93 e changes in subseafloor carbon storage that forced distinct episodes of methane release due to natur

94 cal processes.Proteins fold under mechanical force during co-translational folding at the ribosome.

95 These effects are inhibited by forced elevation of NADH, reduced expression of CtBP, or

96 l scattering force and the enhanced gradient force enable to avoid overheating effect while maintaini

97 Preventive Services Task Force endorsed aspirin for primary prevention of cardiov

98 mdx-knockout mice exhibited lower muscle force/endurance as well as increased muscle damage when

99 uMT) that remotely controls the magnitude of force exerted on a single MPN.

100 The nonequilibrium forces exerted by the active bath on the inclusions or b

101 effect of either benralizumab regimen on the forced expiratory volume in 1 second (FEV1), as compared

102 ization, serum total immunoglobulin E (IgE), forced expiratory volume in one-second (FEV1) and forced

103 ene, has been previously associated with the forced expiratory volume/forced vital capacity ratio.

104 Forced expression of Amigo2 in QRsP-11 cells increased l

105 Direct reprogramming can be achieved by forced expression of master transcription factors.

106 s (iCPCs) from mouse adult fibroblasts using forced expression of Mesp1, Tbx5, Gata4, Nkx2.5 and Baf6

107 two types of modules distinguished by unique force-extension signatures.

108 t to enzymatic liberation only if mechanical forces fail to retrieve antigen.

109 Parallel Simulator (LAMMPS) with a reactive force-field (ReaxFF).

110 Whereas the quality of classical MD force fields has improved significantly in recent years,

111 First, all force fields predict that Abeta adopts unfolded structur

112 ul assessment and evaluation of new methods, force fields, and modeling innovations on well-character

113 brations and perturb its motion with optical force fluctuations at a level dictated by the Heisenberg

114 Cadherin complexes transduce force fluctuations at junctions to activate signals that

115 nclude therefore that minimizing the driving force for Cl(-) secretion is the main requirement for se

116 a*CF interactions are the underlying driving force for the origin of the observed helicity in perfluo

117 pyridine) provides the thermodynamic driving force for the reaction.

118 ween strains demonstrated increased adhesion forces for a clinical isolate compared with the lab stra

119 s (ASRS ReST) Committee, an independent task force formed to monitor device-related and drug-related

120 tivity and dispersal constitute an important force fostering evolutionary innovation.

121 Signatures of the forcing frequencies related to the planet's as well as t

122 a combination of increased coat rigidity and force from actin polymerization enables robust vesiculat

123 enerated using daily climatological humidity forcing generally outperform forecasts that utilize dail

124 pical constriction is disrupted, compressing force generated by a tissue-level myosin cable contribut

125 eld apart at the intersection by a repulsive force generated by the Frank elasticity.Disclination lin

126 ationary with a small amount of antagonizing force generated.

127 These synergistic directional forces generated during cell motility are essential for

128 dentify physical parameters that control the forces generated within motor-filament arrays and provid

129 nterpreted as a signature of kinetics of the force-generating step in the cross-bridge cycle.

130 addition, functional studies reveal reduced force generation and a dilated cardiomyopathy (DCM) phen

131 tep in myosin's ATPase cycle associated with force generation and the conversion of chemical energy i

132 acts with dynein and is required for pulling force generation, but the dynamics of this process remai

133 le cytoskeletal networks plays a key role in force generation, while on the tissue level the spatial

134 investigate the dynamics of actomyosin-based force generation.

135 riggering, and that the T cell might use its force-generation machinery to probe the mechanical prope

136 simple-tracking, precision-hold, and maximum force-generation tasks, with each hand.

137 Galphai-LGN-NuMA complex, which targets the force generator dynein-dynactin to the cortex.

138 the pulling of MTs by cytoplasmically bound force generators.

139 d on classical approximations of interatomic forces, giving researchers insight into protein function

140 Overall, we find that humidity forcing improves forecast performance (at 1-4 lead weeks

141 y imaging system in which acoustic radiation force impulse imaging (ARFI) and shear wave elasticity i

142 0 x 10(9) g V/y), humans are the predominant force in the geochemical cycle of V at Earth's surface.

143 sponse of periodontal tissues to orthodontic force in the presence of obesity have potential short- a

144 We hypothesized that mechanical forces in bacterial adhesion could regulate thioester re

145 The importance of mechanical forces in influencing cell behaviour is widely recognize

146 of cellular stresses from measured traction forces in motile tissues and show that such traction-bas

147 Designing the intermolecular forces in the way that cholesterol interacts with sphing

148 eriodic external forcing, like e.g. seasonal forcing in ecology and climate sciences.

149 ential impacts in human health and radiative forcing in the air.

150 mycin, rhamnolipids facilitate proton-motive force-independent tobramycin uptake, and 2-heptyl-4-hydr

151 times under load decrease monotonically with force, indicating slip-bond behavior.

152 such as contact inhibition of locomotion and force-induced cell repolarization.

153 protein to mechanical stress, we studied its force-induced unfolding using single molecule atomic for

154 For this task force initiative of the European Academy of Allergy and

155 ynthetic materials that transduce mechanical force into multifold changes in their intrinsic properti

156 ng as a candidate for transducing mechanical forces into joint cell behaviours.

157 Force is a fundamental regulatory mechanism of biomolecu

158 ivity of a motor's velocity in response to a force is not well-understood.

159 t the relative importance of these selective forces is unknown.

160 gnificant atrophy and impairment of specific force (isometric force/cross-sectional area) and unloade

161 formation as mechanically and Ca(2+)-induced force kinetics (k+Pi(1) approximately k-Pi approximately

162 The other phases of Pi-induced force kinetics that occur in the absence of "give" yield

163 ensure robust vesiculation against opposing forces like membrane tension.

164 many natural systems to a periodic external forcing, like e.g. seasonal forcing in ecology and clima

165 intramolecular electrostatic repulsions and forces local dipoles in each layer of the stacked strand

166 We find that forced maintenance of CRISPR targets induces a fitness c

167 boundaries often regulate function, and such forces may also be exploited in artificial active materi

168 Chemical force measurements in aqueous solution versus methanol a

169 Using single-cell and single-molecule force measurements, we find that SdrC is engaged in low-

170 o accurately assess low frequency trends and forcing mechanisms.

171 a-peptide with the nonpolar tip of an atomic force microscope (AFM).

172 by measuring the forces arising as an Atomic Force Microscope tip (diameter 20 nm) - simulating a nan

173 ause the nanometer-scale radius of an atomic force microscopy (AFM) tip yields a very low signal-to-n

174 ergy dispersive X-ray analysis (EDX), atomic force microscopy (AFM), scanning electron microscopy (SE

175 king were explored in live cells with atomic force microscopy (AFM).

176 arges using a conventional conductive atomic force microscopy (CAFM) without a top electrode is not f

177 Here we present high-speed atomic force microscopy (HS-AFM) observations of membrane-recon

178 duced unfolding using single molecule atomic force microscopy (smAFM) and steered molecular dynamics

179 Traction force microscopy (TFM) revealed that cells produced the

180 t measurements and images obtained by atomic force microscopy also demonstrated the dissociation of t

181 re assembly, we carried out real-time atomic force microscopy and electron microscopy studies.

182 X-ray photoelectron spectroscopy and atomic force microscopy experiments.

183 By combining Kelvin probe force microscopy imaging and phase-field simulations, we

184 Images of the template obtained by atomic force microscopy show that TFAM creates loops in a discr

185 Atomic Force Microscopy showed significant alterations to the s

186 Photoinduced force microscopy shows that doping level can be opticall

187 how a specific interaction between an atomic force microscopy tip decorated with recombinant alphaIIb

188 of molecular dynamics simulation and atomic force microscopy to deliver, in atomic detail, structura

189 Here, we used high-speed atomic force microscopy to directly visualize the membrane-inse

190 trol of RhoA, live-cell imaging and traction force microscopy to investigate the dynamics of actomyos

191 ectric and CuPc films are analyzed by atomic force microscopy, grazing incident X-ray diffraction, X-

192 Atomic force microscopy, high-resolution flow cytometry, real-t

193 Using conducting tip atomic force microscopy, the energies of {Co9(P2W15)3} frontier

194 By using atomic force microscopy, we found that during reverse transcrip

195 With single-molecule atomic force microscopy, we show a specific interaction between

196 Using atomic force microscopy, we studied the elasticity of mouse myo

197 ion, as well as scanning electron and atomic force microscopy.

198 via high-speed non-contact lateral molecular force microscopy.

199 ant increase in surface roughness evident by force microscopy.

200 emonstrate that even though the direction of force might not follow the flow of energy, the positive

201 he transatlantic slave trade was the largest forced migration in world history.

202 ghlights the decisive role of astronomically forced "Milankovitch" climate change in timing and pacin

203 econd timescale when subject to a stretching force of 1-2 nN (depending on isomer).

204 this BM lead to muscle fiber damage from the force of contraction.

205 nderstanding of symbiosis as a major driving force of ecological adaptation.

206 To accurately capture the force of infection (FOI) between districts, we compared

207 we present an alternative model of relative force of infection that better captures the observed bio

208 This driving force of sugar transport is interrupted in fall when can

209 5 was mechanically unfolded and subjected to forces of 50-350 piconewtons, thioester cleavage was no

210 t govern the tug-of-war between evolutionary forces of rigidity and plasticity over transcriptional r

211 is required to offset the positive radiative forcing of increasing CH4 emissions until the end of the

212 Notably, the overall radiative forcing of open-water fluxes (3.5 +/- 0.3 kg CO2 -eq m(-

213 amical and photochemical system to increased forcing of the climate by increasing levels of CO2 and C

214 provides geometry-specific molecular cues or force on specific kinetochore linkages that other attach

215 The optical radiative force on the mechanical structure is also considered in

216 web server enables modeling of electrostatic forces on individual atoms, residues, domains and molecu

217 aortic disease include increased hemodynamic forces on the ascending aorta, typically due to poorly c

218 g-of-war" between retrograde and anterograde forces on the MT, providing an explanation for the frequ

219 dering effect that creates backstresses (the forces opposing deformation) when precipitates are cut b

220 ic cleavage activity, even in the absence of forces or denaturants.

221 itions, is discussed in terms of the driving forces orchestrating this highly efficient multilevel re

222 hat actomyosin meshworks exhibit an inherent force orienting mechanism in response to mechanical cons

223 ects to make reaching movements perturbed by force patterns dependent upon either limb position or ve

224 The compensatory force patterns were largely based on the perturbation ki

225 e quantified the ontogenetic profile of bite-force performance in post-metamorphic Ceratophrys cranwe

226 Mechanical forces play critical roles in collective cell behaviors

227 ctomyosin bundles-are important for cellular force production and adaptation to physical stress and h

228 nonsignificant decrease in diaphragm tetanic force production over the experiment in the ventilated-p

229 Our simulations also predict the adhesion force profile to be distinct for CaCl2 compared with the

230 able nature of the inserted pore, yielding a force profile with barriers for membrane exit due to the

231 iaphragm thickness in response to an applied force provided by an indenter.

232 from sonication-based measurements and from force pulling molecular dynamics simulations, both in wa

233 An international task force recently redefined the concept of sepsis.

234 mental versatility and mostly, automation of force recordings.

235 Hemodynamic forces regulate vascular functions.

236 However, a clear effect was observed on force relaxation: myofibrils with D137L/G126R or D137L T

237 nted the abuses they had suffered, including forced religious conversion, torture, and sex slavery.

238 mitotic kinesin-5 Eg5 generates most of the force required to separate centrosomes during spindle as

239 contractile apparatus Ca(2+) ion responses (force resolution 1microN, 0-10mN for the given sensor; [

240 The kinematics and force response of the cellular metamaterial during foldi

241 on T853A in mice had no effect on muscarinic force responses in isolated tracheal tissues.

242 Roots need to exert higher penetration force, resulting in increased penetration stress when el

243 on the draft document, which the Joint Task Force reviewed before finalizing the guideline.

244 vigorous immune responses in the human host; forcing selection of viral variants that escape cellular

245 of networks with Myo7a motors and coordinate force sensing in stereocilia.

246 This pathway has a force-sensitive activation barrier and is significantly

247 ird International Consensus Definitions Task Force (Sepsis-3) recently recommended changes to the def

248 cal change, one of the most potent selective forces, sexual selection, remains curiously unexplored.

249 ng geochemical regimes is a strong selective force shaping microbial communities throughout the water

250 elayed development stages to infer the major forces shaping range edges and to predict their dynamics

251 en ASA and VSA, and the associated hydraulic force, should be considered when characterizing diastoli

252 diversity associated with a higher radiative forcing signature.

253 f inducing short latency disturbance of grip force, single-pulse TMS should also quickly disrupt ongo

254 er of protein-ssNA crystal structures, while forcing solution investigations to report ensemble avera

255 ever system, a prerequisite for all kinds of force spectroscopy methods, to obtain reliable values in

256 Using force spectroscopy optimized for 1-microsecond resolutio

257 k by Echelman et al. applied single-molecule force spectroscopy to show that an adhesin protein can r

258 Using force spectroscopy, we have measured here the forces tha

259 in, Luciferase, by combining single-molecule force-spectroscopy experiments and coarse-grained simula

260 pecialized interaction mechanisms, including force-strengthened catch bonds.

261 ice and tundra productivity due to a common forcing, such as large-scale atmospheric circulation (No

262 nalysis of tipping phenomena in periodically forced systems and show that, when limit cycles are cons

263 d temporalis muscle activities per 20-N bite-force (T20 N, microV), which defined thresholds.

264 s which actin-cytoskeleton-generated tensile force takes when applied through the integrin beta-subun

265 ion and relaxation in PEL is the key driving force that simultaneously explains both the equilibrium

266 g elastic substrate, the spatially dependent forces that cells or tissues impart on it.

267 ers to productively and efficiently generate forces that could potentially slide microtubules apart.

268 tory elements are currently considered major forces that drive cell differentiation and genome evolut

269 orce spectroscopy, we have measured here the forces that ensembles of purified budding yeast kinesin-

270 1623 1623 References 1624 Understanding the forces that shape the great amount of variation in plant

271 s own requirements and internal logic, which forces the user to become acquainted with each interface

272 In conjunction with the Joint Task Force, the workgroup reviewed the evidence and developed

273 e mechanosensors and the kinds of mechanical forces they can sense and respond to.

274 provide the necessary thermodynamic driving force to make such processes favorable.

275 into actin stress fiber provides a traction force to promote actin retrograde flow and focal adhesio

276 nerates enormous turgor and applies physical force to rupture the rice leaf cuticle using a rigid pen

277 In order to maintain yields, farmers may be forced to change cultivation practices, the timing of cu

278 ndle must be able to apply and sustain large forces to maintain spindle integrity.

279 FORCE trained networks reproduce behaviors comparable in

280 wall of the growing tip acts as a piconewton force transducer that couples the internal stress of a r

281 , multiple lines of evidence have shown that force transduction across the TCR complex is involved du

282 the dynamics of PNC migration under various force-transduction models, including the pushing or pull

283 tive accuracy of US Preventive Services Task Force (USPSTF) and American College of Cardiology/Americ

284 To issue a new US Preventive Services Task Force (USPSTF) recommendation on screening for gynecolog

285 The directions of these force vectors were co-ordinated such that the overall bo

286 Eligible patients, stratified by baseline forced vital capacity (FVC), serum LOXL2 (sLOXL2) concen

287 d expiratory volume in one-second (FEV1) and forced vital capacity (FVC).

288 , and IL4R were associated with reduced FEV1/forced vital capacity ratio (beta = -0.11, -0.08, and -0

289 associated with the forced expiratory volume/forced vital capacity ratio.

290 The task force was unable to reach agreement on a single test tha

291 raction isometric torque and patellar tendon force were significantly lower; (ii) muscle fibres went

292 e assembled through steric and electrostatic forces, where the anions reside in equidistant "clefts"

293 Transposable elements are major evolutionary forces which can cause new genome structure and species

294 ic foundering induces an asthenospheric drag force, which drives continued underthrusting of the Indi

295 unctions determines whether actomyosin-based forces will inhibit or drive the topological transitions

296 formation of a tissue in response to a known force with cellular resolution.

297 we investigate a more random application of forces with a Monte Carlo method and demonstrate pathway

298 ration prevents the buildup of intercellular forces within cell colonies, enabling their expansion.

299 creases the ability of the cell to withstand forces without deformation.

300 activation, where the development of tensile force yields physiological integrin activation.