ライフサイエンスコーパス: force production

1 scle histology and restored muscle function (force production).

2 d prevent both kinesins from contributing to force production.

3 tion at higher frequency for optimal tetanic force production.

4 modulate stiffness along the axis of muscle force production.

5 responsible for the variability in traction force production.

6 p abruptly transitions from motion to static force production.

7 affinity and affect dynein processivity and force production.

8 s important for efficient actin assembly and force production.

9 malian cochlea include the size and speed of force production.

10 a2+] and/or agents that inhibit cross-bridge force production.

11 against a simple-lever arm model for dynein force production.

12 ared outcome of prenatal defects in myofiber force production.

13 ein's enzymatic properties to its mechanical force production.

14 the pathway of coupling of ATP hydrolysis to force production.

15 leton and adhesions, that decreases traction force production.

16 and the substratum, which increases traction force production.

17 (96-148)) and (b) the calcium sensitivity of force production.

18 bility or to store energy in the polymer for force production.

19 Cs) presumably by their somatic motility and force production.

20 tabilizing microtubules and counterbalancing force production.

21 ergo an ordered-to-ordered transition during force production.

22 te chemical and mechanical signals to direct force production.

23 to decreased muscle mechanical stability and force production.

24 ed thin filament sliding speed and isometric force production.

25 ord unified control of posture, movement and force production.

26 e compact, and only those substrates support force production.

27 Ca2+, thus altering the Ca2+ sensitivity of force production.

28 unction, and particularly movement time, and force production.

29 r repolarization of the action potential and force production.

30 ulted in elevation of [Ca2+]i and maintained force production.

31 ring walking, reaching, flying, or isometric force production.

32 ibit ATP turnover as part of the coupling to force production.

33 osin, inhibit adaptation by abolishing motor force production.

34 p with a remarkable enhancement in sustained force production.

35 le degeneration is dependent on exercise and force production.

36 agm muscle fiber size and diaphragm-specific force production.

37 weakness by decreasing Ca(2+)-induced muscle force production.

38 ng proper filament polarity and facilitating force production.

39 sin interactions and overall lowers myofibre force production.

40 in kinase (MLCK), a primary regulator of VSM force production.

41 s the thermodynamic driving force underlying force production.

42 rk, entanglement, mechanical interaction and force production.

43 ckground of inhibition, the greater the peak force production.

44 dergo large structural changes important for force production.

45 , mediating free energy changes that lead to force production.

46 f network cohesion and the lack of effective force production.

47 prepositioning the cross-bridge for optimal force production.

48 the tissues showed an additional increase in force production (1.34+/-0.19 mN/mm(2)), with no change

49 microtubule-binding activities required for force production [1].

50 llows for fast, processive movement and high force production (7 piconewtons).

51 exhibit an increase in muscle mass and total force production, a reduction in specific force, an accu

52 We further introduce two models of active force production: a cytoskeletal swelling force and a po

53 The task involved trading handgrip force production against monetary benefits.

54 rs exhibited a high correlation between mean force production and active workspace (R = 0.90).

55 ctomyosin bundles-are important for cellular force production and adaptation to physical stress and h

56 MV) results in reduced diaphragmatic maximal force production and diaphragmatic atrophy.

57 ithic processing technologies affect chewing force production and efficacy in humans consuming meat a

58 would, however, have facilitated aerodynamic force production and enhanced muscle power output for an

59 The mutant muscle displays decreased force production and increased mitochondrial lipid perox

60 eries, together with measurement of arterial force production and intracellular [Ca(2+)].

61 , our results suggest that cardiac myofibril force production and kinetics of activation and relaxati

62 that genetic factors that coordinately alter force production and mechanical resistance are common du

63 (1) Force production and mechanical resistance can be couple

64 ents within living cells accounting for both force production and mechanical stiffness.

65 ial to determining an atomic-level model for force production and motion by the motors.

66 However, its mechanism of force production and movement is not understood.

67 tical in vivo for the coordination of dynein force production and movement when the motor is heavily

68 into account the state dependence of muscle-force production and multijoint mechanics, I show that c

69 , like motor domain lesions, would influence force production and propagation.

70 coupled to tissue architecture, which change force production and pumping function in the diseased he

71 Heart rate, blood pressure, force production and ratings of perceived exertion were

72 ly little is known about their mechanisms of force production and regulation.

73 , normalized whole body force, and increased force production and resistance to repeated contractions

74 ndividual striations can be monitored during force production and shortening.

75 Whereas all NTPs studied support force production and stiffness that vary by a factor 2 o

76 Dependence of force production and stress resistance on cross-sectiona

77 F-actin organization and by measuring tissue force production and structural stiffness of the blastop

78 mutants decreased the calcium sensitivity of force production and that the two missense mutations (Il

79 inal and transverse directions during active force production and that transverse strains are on aver

80 Force production and the propagation of stress and strai

81 old age and has implications for contractile force production and the rapid execution of motor tasks.

82 surface can work collectively for increased force production and travel distance.

83 ression of NMJ-related genes, in situ muscle force production, and clearance of glycogen in conjuncti

84 or activities such as cell-shape regulation, force production, and cytokinesis.

85 amics involved in the formation, activation, force production, and disappearance of the cleavage furr

86 The size, force production, and pathology of isolated gastrocnemiu

87 recombinant heavy chain alone is capable of force production, and should lead to rapid progress in d

88 regarding the possibility of maximal muscle force production, and suggest that only 97% of the true

89 -terminal portion of troponin I in enhancing force production, and the severe impairment associated w

90 Both innervation and in vivo force production are enhanced when implantation of bioco

91 Muscle size and force production are thought to influence growth of the

92 developed a novel gel-based sensor to report force production as a tissue changes shape; we find that

93 s instead of the hindlimbs are recruited for force production as the wings are much more powerful tha

94 all the flat-plate wings in terms of usable force production as well as the ratio of lift to power b

95 in skinned muscle fibers, thereby increasing force production at longer sarcomere lengths.

96 inity, which results in an increased rate of force production at submaximal [Ca2+].

97 nvolvement of different muscle groups during force production at the distal (DT) and proximal (PR) ph

98 Two fatiguing exercises were used, involving force production at the distal phalanxes and at the prox

99 During force production at the other site, MVC dropped by 23 %.

100 the fatiguing exercise, but increased during force production at the other site.

101 the rates of mass and heat exchange and the force production between an organism and its environment

102 es with the rate, level, and coordination of force production but has little effect on preparatory pr

103 nificant decrement in diaphragmatic specific force production, but to a lesser degree than 12CMV and

104 MgATP, but all the data are consistent with force production by a lever arm mechanism for both subst

105 ere, we used computer simulations to analyze force production by an ensemble of myosin motors against

106 e of outer doublet microtubules, the site of force production by ciliary dynein.

107 Force production by Cin8p was directed toward the plus e

108 ling and common upper limit of mass-specific force production by cyclical motion motors has not been

109 been made on understanding the mechanism of force production by kinesins and myosins.

110 Force production by kinesins has been linked to structur

111 However, isolated reports of yeast-like force production by mammalian dynein have called intersp

112 investigated the energetics associated with force production by measuring the force generated by ski

113 Results for ATP and CTP, which do support force production by muscle fibers, are compared to those

114 response is distinct from a loss in specific force production by muscle, and that sarcolemma-localize

115 veral current hypotheses of the mechanism of force production by muscle, the primary mechanical featu

116 Force production by one finger was accompanied by involu

117 ers of a hand was accompanied by involuntary force production by other fingers (enslaving).

118 by one finger was accompanied by involuntary force production by other fingers (enslaving).

119 Force production by some fingers of a hand was accompani

120 Peritonitis decreased maximal force production by the diaphragm (23.6+/-0.6 versus 21.

121 During heart failure, force production by the heart decreases.

122 in several fields, such as the following: i) force production by the myofibroblast and mechanisms of

123 grel dogs (n= 6) K(+) infusion did not alter force production by the skeletal muscle.

124 ng transport, there was little evidence that force production by the two opposing motors was competit

125 Force production by type IV pilus retraction is critical

126 The biophysics of force production by various kinesins is known in detail.

127 Membrane electromechanical force production can occur at speeds exceeding those of

128 to be the result of a basic deficit in their force production capacity or to be a compensatory mechan

129 s with widely divergent demands in regard to force production, capacity to move processively, and spe

130 e at day 2 to 3 showed a marked reduction in force production compared to that of control littermates

131 ce have an increase in muscle blood flow and force production, compared with the mdx mice.

132 lationship between cardiac morphogenesis and force production (contractility).

133 TnC in aqueous solutions, and its effects on force production could be reversed by extraction of CDZ-

134 mechanism by which muscle function shifts as force production declines, from motor to spring.

135 The PNB attenuated force production despite encouragement to attain the sam

136 , and suggests that the mechanism for dynein force production differs substantially from that of othe

137 e conclude that biaxial strain during active force production distinguishes aponeuroses from free ten

138 reased SR Ca(2+) leak at rest, and depressed force production due to impaired SR Ca(2+) release upon

139 nts that contribute to reduced smooth muscle force production during altered metabolism.

140 s the ability of skeletal muscle to maintain force production during and after exercise.

141 properties of muscle limit maximal voluntary force production during anisometric tasks, i.e., when mu

142 t illustrate the basic processes involved in force production during ATP binding.

143 ymerizing actin to membranes and so mediates force production during compensatory endocytosis.

144 cortex in structural units called nodes for force production during cytokinesis.

145 ertebrate morphogenesis, is not required for force production during late gastrulation and early neur

146 To test whether depolymerization can explain force production during nematode sperm crawling, we cons

147 ting differences in contraction velocity and force production exhibited by the various skeletal muscl

148 there are two possible mechanisms underlying force production for cell motility: the focal adhesion m

149 tubule binding by Ska, rather than acting in force production for chromosome movement, may instead se

150 via alpha(5)beta(1) integrin, depresses the force production from papillary muscle bundles, partly a

151 To distinguish contributions to force production from the mechanotransducer (MET) channe

152 ity greatly reduced the impact that impaired force production had on absolute peak power.

153 esults in a decreased calcium sensitivity of force production (half-maximum at 2.5 vs. 1.3 microM cal

154 This 'reverse transduction' force production has never been demonstrated experimenta

155 because the cross-bridge states involved in force production have yet to be elucidated, the effects

156 ults suggest a novel mechanism for enhancing force production in a muscle, and may be relevant to und

157 the efficient coupling of ATP hydrolysis to force production in a processive reaction whereby force

158 nt from the thin filament and thereby modify force production in activated cardiac muscle.

159 heral nerve reinnervates muscle and restores force production in adult cats, the muscle does not resp

160 However, the role of OHC force production in cochlear amplification and frequency

161 conditions would have augmented aerodynamic force production in early forms of flying insects.

162 hysiological functions is the enhancement of force production in fast twitch skeletal muscle fibres.

163 production in a processive reaction whereby force production in forming a tight microtubule complex

164 and to what extent 4AP could enhance muscle force production in HCSMA.

165 lting in a small but significant increase in force production in isolated single fibres and indicatin

166 te (BDP) and prednisolone acetate (PDNA), on force production in isolated, intact, mouse skeletal mus

167 In addition, muscle force production in isometric contraction was increased

168 ion area, levels of contractile proteins and force production in isometric contractions.

169 , leads to pronounced muscle hypertrophy and force production in mice and monkeys.

170 sponding nucleotide triphosphates to support force production in muscle fibers.

171 , which demonstrated a dramatic reduction in force production in nebulin-deficient skeletal muscle.

172 echanism, regulating structural assembly and force production in relation to cell migration and mecha

173 ials caused a 25-40 % reduction in diaphragm force production in response to bilateral phrenic nerve

174 l sites for interaction with myosin, enhance force production in response to pressure.

175 Direct measurements of isometric force production in single cardiac myocytes demonstrated

176 expression increased the Ca2+ sensitivity of force production in single cardiac myocytes in a transge

177 nemius aponeurosis during active and passive force production in situ.

178 t amino acid residues 110-121 that inhibited force production in skinned carotid artery.

179 ADP dose-dependently increased force production in the absence of Ca(2+) in membrane-pe

180 mol/L, the N-terminal C0C2 peptide activated force production in the absence of calcium (pCa 9).

181 ast, there is no decrease in maximal tetanic force production in the mutant diaphragm or soleus muscl

182 for geometrical and mechanical patterning of force production in tissues.

183 ortening velocity at the time of peak muscle force production increased with walking speed, impairing

184 ative capacity and a significant decrease in force production indicative of lack of efficient myoblas

185 With no effect on muscle force production, inhibiting alphaARs (phentolamine; 10(

186 With no effect on muscle force production, inhibiting alphaARs improved ROV in ol

187 ate of relaxation (lusitropy), and increased force production (inotropy) in response to epinephrine.

188 There is significant interest in quantifying force production inside cells, but since conditions in v

189 smooth muscle that a significant portion of force production is associated with ADP release.

190 In support of this model, mechanical force production is compromised and cell proliferation i

191 This correlation between step size and force production is consistent with a molecular gear mec

192 behaviour of the aponeurosis during passive force production is consistent with uniaxial loading, as

193 voltage-gated Ca2+ release, maximal tetanic force production is decreased and the force frequency cu

194 (3) Force production is distributed between neural and mesod

195 ss; muscle core pO2 approximately 400 mmHg), force production is enhanced but control of contractilit

196 d (approximately 11 microm/h), yet the total force production is five times higher on FN than RGD (ap

197 ations of purified LDs, where duration of LD force production is more than doubled.

198 the two heads of myosin II during motion and force production is poorly understood.

199 How myosin II force production is shaped by isoform-specific motor pro

200 uncertain, and the mechanism of MT-dependent force production is unknown.

201 n Ca(2+) dependence of myofilament isometric force production, isometric ATPase rate, and thin filame

202 in order to spatially and temporally control force production-issues that touch on fundamental aspect

203 MLC levels, which is critical for mechanical force production, likely through the direct induction of

204 ormed during single- and multifinger maximal force production (maximal voluntary contraction, MVC) fo

205 In analogy to the actomyosin-based force production mechanism in striated muscle, it was or

206 lyte slime ejected from these nozzles as the force production mechanism, and our experiment found a l

207 ssue and modify AChR mRNA expression, muscle force production, motor endplate area, and innervation s

208 investigations and models of skeletal muscle force production must incorporate Tmods.

209 conformational cocking of S1 for subsequent force production occurs just before or during ATP hydrol

210 imately 20 nm/mV for 50-microm-long cell and force production of 0.1 nN/mV by the cell.

211 The force production of a bidirectional kinesin-5 has not ye

212 eins and insulin-like growth factor 1 on the force production of engineered skeletal muscle was chara

213 To investigate the force production of mouse motor units, we simultaneously

214 In this study we examined the force production of sperm reactivated with 0.1 mM ATP wi

215 its activation of myosin ATPase activity and force production of striated muscles at low free Ca(2+)

216 th heads contributing equally to the maximal force production of the dimer.

217 Absolute force production of the extensor digitorum longus muscle

218 contribution from an increase in the maximum force production of the myofibrils.

219 stroglycan and integrin alpha7 contribute to force-production of muscles, but that only disruption of

220 Conversely, forced production of ALDH2 sharply diminished the N(2)-e

221 anism dictates the pattern of transcription--forcing production of monocistronic mRNAs--and the patte

222 ere arise physical limits to the accuracy of force production on contact.

223 nonsignificant decrease in diaphragm tetanic force production over the experiment in the ventilated-p

224 g the stimulation frequency causes increased force production per unit calcium concentration and decr

225 te directly to kinetochore-MT attachment and force production, perhaps by forming a sliding ring enci

226 associated with mitochondrial proton-motive force production preferentially in the cell periphery an

227 hese observations, we present a theory where force production, rather than displacement, was selected

228 How birds coordinate aerodynamic force production relative to changes in body orientation

229 er maximum forces observed or time course of force production; relaxation was faster in 7 of 11 arter

230 apoptosis proteins were down-regulated, but force production remained normal.

231 However, force production required in the polymerization model is

232 lecular-mechanical model of MT structure and force production shows that a single depolymerizing MT c

233 gen that contain the RGD motif, also reduced force production significantly.

234 ing myocardium is characterized by decreased force production, slowed relaxation, and depressed respo

235 ditions to be met for models of cytoskeletal force production, such as the dynamic network contractio

236 f transduction following inhibition of motor force production suggest that the gating and extent spri

237 s elements (sub-synergies) of a multi-finger force production synergy, while only inhibitory projecti

238 , high-fidelity enzymatic reaction cycle for force production that does not require elongating filame

239 ave shown that mavacamten inhibits sarcomere force production, thereby reducing cardiac contractility

240 Motors that use force production to accomplish steady translational moti

241 ations to alter the direction of aerodynamic force production to change their flight trajectory.

242 uture: first, characterizing the coupling of force production to chemical and mechanical changes in m

243 l microfilaments at the edge are involved in force production to drive the cell margin forward while

244 del system for analyzing mechanisms coupling force production to microtubule plus-end polymerization/

245 used fascicle shortening at the time of peak force production to shift to much slower velocities.

246 Whole-muscle force drops from peak force production to zero with just a few micrometers of

247 ically adaptive; dorsal tissues can increase force production up to threefold to overcome a stiffer m

248 d ATPase and in vitro motility but increased force production using an optical trap.

249 nity cross-links, but they can transition to force production via the positive-feedback mechanism des

250 Force production was largely independent of the directio

251 vidence for agonist-induced Ca2+-independent force production was observed.

252 At the cellular level, single muscle fibre force production was reduced in OA patients in myosin he

253 After 24 hrs, diaphragm force production was significantly lower in mechanically

254 (TnC) can influence the rate of cross-bridge force production, we studied the effects of calmidazoliu

255 For measuring axial stiffness and force production, we used an experimental configuration

256 When symmetrical sites of force production were used in the two hands, BD was lowe

257 NudE abrogates dynein force production, whereas LIS1 alone or with NudE induce

258 Anticipatory force production with both familiar and novel objects wa

259 actin (NEM-HMM/HMM = 0.43), suggesting lower force production with yeast actin.

260 d the same steep Ca(2+) dependence as active force production, with a Hill coefficient (n(H)) close t

261 This enables subsequent force production, with cross-bridge targeting further en

262 ongly-bound cross-bridges and rate of myosin force production, with the larger parameter reductions i