ライフサイエンスコーパス: foregut

1 n, in which the stomodeal ectoderm joins the foregut.

2 Lkr neurons innervate the foregut.

3 specify lung endoderm progenitors within the foregut.

4 lung endoderm progenitors in the developing foregut.

5 ung endoderm progenitors within the anterior foregut.

6 ion of mammalian HCC, a lethal cancer of the foregut.

7 ea midgut but does not form a biofilm in the foregut.

8 ively regulates BMP ligand expression in the foregut.

9 of Y. pestis to produce biofilm in the flea foregut.

10 host embryos are restricted to the proximal foregut.

11 develop from endoderm cells in the embryonic foregut.

12 oliferative response of the anterior ventral foregut.

13 eby influencing patterning and growth of the foregut.

14 Fgf10) in the prospective lung region of the foregut.

15 ventral pancreas emerge, helps close off the foregut.

16 e inner surface of the protocerebrum and the foregut.

17 actors regulating formation of the embryonic foregut.

18 and reduced size in the brain lateral to the foregut.

19 A likely source of this signal is the foregut.

20 for the formation of the mammalian and avian foregut.

21 the definitive ventral endoderm forming the foregut.

22 ancreatic gene regulatory network within the foregut.

23 oused in specialized organs connected to the foregut.

24 ed ability to localize to and block the flea foregut.

25 es the NCC population that migrates into the foregut.

26 netic protein (BMP) signaling in the Xenopus foregut.

27 nts sampled along transects and from gosling foreguts.

28 induction of both lung buds in RA-deficient foreguts.

29 regulation of Tgfbeta targets in Raldh2-null foreguts.

30 field of both Raldh2-null and BMS493-treated foreguts.

31 %) were autologous reconstructions; 88 (44%) foregut, 100 (51%) midgut, and 10 (5%) hindgut.

32 e kiwifruit fibre was highly digested in the foregut (80%), and the insoluble fibre in the hindgut (9

33 that most microspheres were retained in the foregut after dietary exposure due to adherence to the h

34 result, neuroendoderm precursors form in the foregut aided by retention of a SoxB1-dependent pluripot

35 or extent of the embryo and initiates heart, foregut and brain development.

36 A subpopulation of vagal NCCs invades the foregut and colonises the entire gastrointestinal tract

37 which form an epithelial bridge between the foregut and epidermis, but little is known about how dev

38 major morphological events in the developing foregut and eye from Carnegie Stages 12 and 13 human emb

39 ctomyosin contraction drive formation of the foregut and heart tube in the early chick embryo.

40 As early foregut and heart tube morphogenesis are intimately rela

41 nal portal generates tension to elongate the foregut and heart tube.

42 s establish a role for Notch activity in the foregut and highlight the importance of cellular context

43 e expression of genes involved in bilaterian foregut and hindgut patterning during the development of

44 we identified the transcriptomes of Xenopus foregut and hindgut progenitors, which are conserved wit

45 catenin acts as a genome-wide toggle between foregut and hindgut programs.

46 rom neural crest cells (NCCs) that enter the foregut and hindgut to become enteric neural-crest-deriv

47 Firmicutes and Melainabacteria in the murine foregut and hindgut.

48 have disrupted global Notch signaling in the foregut and in the lung during the initial stages of mur

49 ial role in the embryonic development of the foregut and is orthologous to genes encoding the mammali

50 eding behavior, is positioned lateral to the foregut and lacks neural cells at the midline.

51 eveal that lncRNAs play an important role in foregut and lung endoderm development by regulating mult

52 organization of the head as well as neural, foregut and mesoderm tissue formation.

53 es, OnTry-G2, was highly expressed in larval foregut and midgut, whereas another group, OnTry-G3, was

54 ng netrin-1 were expressed in the developing foregut and midgut; netrin-1 immunoreactivity was detect

55 elopment, vagal neural crest cells enter the foregut and migrate in a rostro-to-caudal direction, col

56 The foregut and oral tissues converge at the primary mouth,

57 analysis at later stages revealed a loss of foregut and pancreatic endoderm.

58 se embryonic mesenchyme during the time when foregut and pancreatic progenitors are specified and tes

59 vagal neural crest cells that migrate to the foregut and subsequently colonize and innervate the enti

60 sically altered by their passage through the foregut and were excreted with a smaller overall size an

61 ation in Capitella, which include the brain, foregut, and terminal growth zone.

62 us mammals, which are generally grouped into foregut- and hindgut-fermenters.

63 the differentiation and morphogenesis of the foregut are controlled by several transcriptional regula

64 minal short-chain fatty acids (SCFAs) in the foregut are unknown.

65 rive from migration of ectoderm cells to the foregut, as shown by lineage tracing with the photoactiv

66 ation of the various organs of the posterior foregut, as well as in pancreas and gut endocrine cell d

67 Cells of the posterior foregut assume a pancreatic identity, cells within the e

68 Foregut bariatric surgery can be quite effective in impr

69 report that the ability to produce a normal foregut-blocking infection depends on induction of the Y

70 human pancreatic specification in the distal foregut, bud formation, and early development.

71 expressed dynamically within the developing foregut, but how its expression characteristics are link

72 , and liver arise from the posterior ventral foregut, but the cell-intrinsic pathway by which these o

73 of the proventricular valve in the insect's foregut by a dense aggregate of Yersinia pestis.

74 iciency could be reproduced in RA-sufficient foreguts by hyperactivating Tgfbeta signaling with exoge

75 t it occurs via repulsion of Robo-expressing foregut cells away from the Slit ligand source.

76 In addition, the ventral foregut cells lose adhesion and fail to form a polarized

77 ted decreased proliferation; in addition the foregut cells were enlarged with a randomized orientatio

78 tury, scientists have hypothesized that this foregut chamber houses a microbial community, yet this h

79 nts also exhibit stomach segmentation with a foregut chamber proximal to the stomach.

80 ic day (E) 8.5 because of failure of ventral foregut closure and cardiac bifida, whereas GATA6 is ess

81 e movement of tissue progenitor cells during foregut closure.

82 hs possess a highly conserved, low-diversity foregut community with a highly abundant Neisseria speci

83 dorsal (oesophageal) from ventral (tracheal) foregut components-is a crucial event in gastro-respirat

84 Our observations in mouse foregut cultures are corroborated by data from an in viv

85 A prospectively maintained multidisciplinary foregut database was reviewed for consecutively enrolled

86 Development of more posterior foregut derivatives (stomach and duodenum), as well as l

87 Development of foregut derivatives can be partly restored in mutants by

88 velopmental window, and is not seen in other foregut derivatives such as thyroid and pancreas where F

89 Among distal foregut derivatives, the gastric corpus, antrum, pylorus

90 k is a central process in the development of foregut-derived organs.

91 ption factors in the development of anterior foregut-derived tissues and demonstrating functional coo

92 rs Foxp2 and Foxp1 are expressed in multiple foregut-derived tissues including the lung and intestine

93 l stages of ventral morphogenesis, including foregut development and positioning of head and heart.

94 lear factor 3beta (HNF3beta) is essential in foregut development and the regulation of lung-specific

95 In early Caenorhabditis elegans foregut development, the pioneer factor PHA-4/FoxA binds

96 e cell fate and morphogenesis during Xenopus foregut development.

97 Foregut division-the separation of dorsal (oesophageal)

98 ancreas from a small cluster of cells in the foregut domain of the mouse embryo.

99 In the foregut, ENCC migrated through areas devoid of establish

100 ifferentiate pluripotent cells into anterior foregut endoderm (AFE) derivatives would expand their ut

101 Subsequently, lung-biased anterior foregut endoderm (AFE) is specified by sequential inhibi

102 However, the foregut endoderm also expresses the Wnt-receptor Frizzle

103 ctive signal for posterior neuroectoderm and foregut endoderm and a permissive signal for trunk mesod

104 In addition, we find defects in the foregut endoderm and a reduction in Hex expression, whic

105 on factor Islet1 (Isl1) is expressed in both foregut endoderm and cardiogenic mesoderm and is require

106 blishing the developmental competence of the foregut endoderm and in initiating liver specification.

107 scription factor, FOXA2, is expressed in the foregut endoderm and in subsets of respiratory epithelia

108 d for robust osr1 and osr2 expression in the foregut endoderm and surrounding lateral plate mesoderm

109 r the establishment of competence within the foregut endoderm and the onset of hepatogenesis.

110 Therefore, Hhex expression in the ventral foregut endoderm and/or the endothelium is necessary for

111 N family protein Cerberus within presumptive foregut endoderm as essential for differentiation of car

112 re and heart at E9.0-9.5, and in the ventral foregut endoderm at E8.5-9.0, it has been postulated to

113 Although T1alpha is expressed in the foregut endoderm before the lung buds, T1alpha mRNA and

114 Although the PI3K pathway is activated in foregut endoderm cells, its inhibition does not block he

115 e notochordal plate, prechordal mesoderm and foregut endoderm during gastrulation.

116 The notochord was adjacent to the dorsal foregut endoderm during the fourth week of development b

117 In the absence of cardiac mesoderm, ventral foregut endoderm explants respond to exogenous fibroblas

118 ely, RA receptor function is required in the foregut endoderm for insulin expression, but not in meso

119 h the establishment of competence within the foregut endoderm for responding to organ-specific signal

120 , we propose that the S1P-dependent anterior foregut endoderm functions primarily through Shh to regu

121 s of Nkx2-1(+) progenitors in the developing foregut endoderm give rise to the entire postnatal lung

122 During organogenesis, the foregut endoderm gives rise to the many different cell t

123 ng early respiratory system development, the foregut endoderm gives rise to the tracheal and lung cel

124 marker for developing liver and pancreas in foregut endoderm has recently been shown to interact wit

125 egulating thyroid lineage specification from foregut endoderm in mouse and Xenopus.

126 loss of hdac1 results in an expansion of the foregut endoderm in the domain from which the liver and

127 The onset of pancreas development in the foregut endoderm is marked by activation of the homeobox

128 tion of beta-Catenin (also termed Ctnnb1) in foregut endoderm leads to absence of both the trachea an

129 Loss of Sin3a in mouse early foregut endoderm led to a specific and profound defect i

130 ding indicates that Pdx-1 is required in the foregut endoderm prior to Ptf1a for pancreatic MPC speci

131 However, the molecular pathways specifying foregut endoderm progenitors are poorly understood.

132 ion of the expression domains of several key foregut endoderm regulators.

133 ung development, is expressed in the ventral foregut endoderm shortly after albumin and Pdx1, early m

134 lls are derived from cell progenitors in the foregut endoderm that subsequently differentiate into th

135 he liver and pancreas are specified from the foregut endoderm through an interaction with the adjacen

136 light onto how the multipotent cells of the foregut endoderm, and subsequently those of the hepatopa

137 yngeal pouches, which form by budding of the foregut endoderm, are essential for segmentation of the

138 ased cell death in ventral neuroectoderm and foregut endoderm, but normal cranial neural crest produc

139 alian pulmonary progenitors from the ventral foregut endoderm, but their epistatic relationship and d

140 tissues are both derived from the posterior foregut endoderm, however, the interdependence of these

141 In embryos deficient for both genes in the foregut endoderm, no liver bud is evident and expression

142 s that result in lung specification from the foregut endoderm, prior to lung bud formation, are poorl

143 The stomach, an organ derived from foregut endoderm, secretes acid and enzymes and plays a

144 blished that the fetal liver originates from foregut endoderm, the identity of the mechanisms that ma

145 bryonic stem cells (ESCs) was converted into foregut endoderm, then into replicating Nkx2.1+ lung end

146 re regulated by hedgehog expression from the foregut endoderm, which is required for connection of th

147 Sox2 is expressed in developing foregut endoderm, with highest levels in the future esop

148 In contrast, other foregut endoderm-derived organs, including the thyroid,

149 vates a transcriptional program of embryonic foregut endoderm.

150 helial lineages that arise from the anterior foregut endoderm.

151 rise in close proximity from the multipotent foregut endoderm.

152 id-lineage specification, respectively, from foregut endoderm.

153 swim bladder development from a multipotent foregut endoderm.

154 lishment of respiratory progenitors in mouse foregut endoderm.

155 of both trachea and lung, initiates from the foregut endoderm.

156 ce, Sonic hedgehog (Shh) is downregulated in foregut endoderm.

157 diac mesoderm are involved in patterning the foregut endoderm.

158 mits the right and left sides of the ventral foregut endoderm.

159 s, we identified 363 lncRNAs in the lung and foregut endoderm.

160 ive domain for Wnt signaling activity in the foregut endoderm.

161 maintaining pancreas identity by regulating foregut endodermal fates.

162 xclusively in the cytoplasm of epidermal and foregut epithelia, where it forms belt-like filaments ar

163 human-induced pluripotent stem cell-derived foregut epithelial cells and hypothalamic neurons.

164 Dying cells localise to the fusing foregut epithelial ridges, with disturbance of this apop

165 e that drives recombination in the embryonic foregut epithelium to generate gain- or loss-of-function

166 rp5 is expressed in the surface cells of the foregut epithelium, whereas wnt11 is expressed in the un

167 1 functions postmitotically to establish the foregut epithelium.

168 nversion caused by ectopic activation of the foregut/esophageal differentiation program.

169 provide potential mechanistic insights into foregut exclusion in RYGB and identify SGLT3 as a possib

170 By using a pan-RAR antagonist (BMS493) in foregut explant cultures, we show that bud initiation is

171 rew selectively toward cocultured E14 distal foregut explants (P < 0.01).

172 activity in the posterior endoderm inhibits foregut fate while promoting intestinal development.

173 ch Hdac1 may directly or indirectly restrict foregut fates while promoting hepatic and exocrine pancr

174 related with the plant-feeding adaptation of foregut-fermenting herbivores.

175 or the physical mechanisms of heart tube and foregut formation.

176 questions concerning the traditional view of foregut formation.

177 del in which RA signaling is absent from the foregut from its earliest developmental stages.

178 Our findings suggest that separation of the foregut from the body wall is genetically controlled and

179 ragm malformation is a delayed separation of foregut from the dorsal body wall.

180 bal gene expression analysis of RA-deficient foreguts from a genetic [retinaldehyde dehydrogenase 2 (

181 We show that in the foregut Fzd7 signals via both the Wnt/beta-catenin and W

182 Depletion of Sfrp5 results in reduced foregut gene expression and hypoplastic liver and ventra

183 tain robust pSmad1 levels, causing a loss of foregut gene expression and organ agenesis.

184 rare, should be considered in patients with foregut GISTs; (2) GISTs associated with Carney's syndro

185 The mammalian foregut gives rise to the dorsally located esophagus and

186 type (eg, laparoscopic vs open, intestinal, foregut, hepatopancreaticobiliary vs abdominal wall proc

187 onsequent patterning in the epithelia of the foregut, hindgut, and imaginal discs.

188 rp5 locally inhibits Wnt11 to maintain early foregut identity and to allow an epithelium to form over

189 pressed in the anterior endoderm to maintain foregut identity and to allow liver and pancreas develop

190 ion factor that is required to establish the foregut in embryos and to control growth and longevity a

191 SOX2 is expressed in the developing foregut in mouse and zebrafish embryos and an apparently

192 reas and lung originate from the presumptive foregut in temporal and spatial proximity.

193 Tgfbeta-Fgf10 interactions in the developing foregut, in which endogenous RA controls Tgfbeta activit

194 a arise from vagal NCC that migrate from the foregut into the lung buds; (ii) like ENS precursors, th

195 ion and adherence of the biofilm to the flea foregut is essential for transmission.

196 how that the ventral midline endoderm of the foregut is generated directly from the extreme rostral p

197 e anterior paraxial mesoderm adjacent to the foregut is necessary for the development of insulin-expr

198 y abundant Neisseria species associated with foregut lactate.

199 future segments as well as in the brain and foregut; later, CapI-Notch, CapI-Delta, and CapI-hes2 tr

200 We found normal foregut lengthening despite failure of tracheo-oesophage

201 lls (cDE cells) are specified into posterior foregut-like progenitor cells (cPF cells).

202 ndodermal stem/progenitor cells committed to foregut lineage, possesses potent antioncogenic activity

203 on Six3, both of which are expressed in the foregut lineage.

204 trin from stem/progenitor cells committed to foregut lineage.

205 ndodermal stem/progenitor cells committed to foregut lineage.

206 ing and morphogenetic segregation of ventral foregut lineages.

207 restored proper transgene expression in the foregut, liver, and lung mesenchyme and prevented ectopi

208 The foregut lpm of Osr1/Osr2-depleted embryos fails to expre

209 obox gene hhex, which is one of the earliest foregut markers and is essential for liver and pancreas

210 in human PanIN prompted assessment of other foregut markers by both semiquantitative and real-time r

211 These data show frequent up-regulation of foregut markers in early PanIN lesions and suggest that

212 resulted in up-regulation of the majority of foregut markers seen in early PanIN lesions.

213 this analysis, a cluster of extrapancreatic foregut markers, including pepsinogen C, MUC6, KLF4, and

214 orts the hypothesis that luminal SCFA in the foregut may contribute towards the generation of functio

215 t2 and wnt2b are regulated in the developing foregut mesenchyme is unknown.

216 Ablation of COUP-TFII in the foregut mesenchyme, including the posthepatic mesenchyma

217 We found that woodrats house foregut microbial communities with similar density and v

218 toed sloths have a more variable and diverse foregut microbiota correlated with a variety of SCOAs.

219 The foregut microbiota may provide a number of physiological

220 We hypothesise that adaptation of the foregut microbiota to creosote PSCs in experienced woodr

221 pivot between the notochord and the ventral foregut midline.

222 e transcription factor Sox2 is necessary for foregut morphogenesis and esophagus development.

223 active septation was observed only in normal foregut morphogenesis, indicating a primary role for sep

224 , we examined three outstanding questions of foregut morphogenesis.

225 rphogenesis, particularly implicating Shh in foregut morphogenesis.

226 often resulted in cardia bifida and abnormal foregut morphogenesis.

227 s infects and replicates as a biofilm in the foregut of cat fleas in a manner requiring hmsFR, two de

228 highly expressed in neuronal tissues and the foregut of embryonic day 8.5 (E8.5) embryos and the head

229 gent of plague, replicates as biofilm in the foregut of fleas that feed on plague-infected animals or

230 rial agent of plague, forms a biofilm in the foregut of its flea vector to produce a transmissible in

231 By contrast, the abnormal foregut of Nkx2.1-null embryos expresses elevated Sox2 a

232 ed after it forms a bacterial biofilm in the foregut of the flea vector that interferes with normal b

233 an-fate commitment from within the posterior foregut of the mammalian endoderm is largely unexplored.

234 ntion site of CCYV virons was located in the foregut of virion-fed vectors.

235 ing force exerted by the elongating pharynx (foregut) on the anterior epidermis during C. elegans emb

236 n of virions, were localized in the anterior foregut or cibarium of a whitefly vector biotype but not

237 d virion retention mechanism in the anterior foregut or cibarium of whitefly vectors.

238 verticulated crop is a unique and overlooked foregut organ in the Diptera that affects many physiolog

239 f the anterior endoderm, which gives rise to foregut organs such as the liver, ventral pancreas, thyr

240 ve attempted to rearrange the anatomy of the foregut organs to stop reflux with minimal success.

241 d specifying the anteroposterior location of foregut organs.

242 specification in a molecular pathway linking foregut pattering by FGFs to Wnt-mediated lung specifica

243 Sox2 and Nkx2.1 during early dorsal/ventral foregut patterning.

244 yonic blastomeres in C. elegans develop into foregut (pharynx) cells in response to the selector gene

245 nd development of the Caenorhabditis elegans foregut (pharynx) depends on coordinated gene expression

246 stablished within the Caenorhabditis elegans foregut (pharynx).

247 cardium and myocardium during closure of the foregut pocket and fusion of the bilateral heart primord

248 inal portal which rolls caudally to form the foregut pocket.

249 erm occurs despite the formation of a normal foregut pocket.

250 e prechordal plate during development of the foregut pocket.

251 lier molecular mechanisms that establish the foregut precursors are largely unknown.

252 and duct) that develop from common primitive foregut precursors.

253 of hPSCs into endoderm and subsequently into foregut progenitor (FP) cells, followed by the generatio

254 Fzd7-depleted embryos failed to maintain the foregut progenitor marker hhex and exhibited decreased p

255 w that BMP signaling is required to maintain foregut progenitors and induce expression of the secrete

256 two cell types each originate from Nkx2-1(+) foregut progenitors and the minimal pathways claimed to

257 that beta-catenin activation in hPSC-derived foregut progenitors promoted the development of human fu

258 Wnt signaling that is essential to maintain foregut progenitors.

259 n the anterior to allow the specification of foregut progenitors.

260 Patterning of the primitive foregut promotes appropriate organ specification along i

261 ieve transmission by biofilm blockage of the foregut proventriculus of its flea vector.

262 t growth factor 10 (Fgf10) expression in the foregut region where the lung forms.

263 .5 and E8.5, lack active RA signaling in the foregut region.

264 We found that insect foreguts release prophenoloxidases into the lumen, and t

265 on of the lung primordium from the primitive foregut remain unclear.

266 the anterior visceral head mesoderm and the foregut, respectively; both of these tissues flank the C

267 gut-specific Fzd7-depletion from the Xenopus foregut resulted in liver and pancreas agenesis.

268 as ectopic Notch activation in the embryonic foregut results in reversible defects in villus morphoge

269 ytic activities observed in each gut region (foregut+salivary gland, midgut and hindgut).

270 d transcription factors involved in anterior foregut separation continue to play important roles in t

271 Foregut separation is a rarely considered morphogenetic

272 poptosis in the Apaf1 mutant did not prevent foregut separation, indicating that apoptosis is not req

273 in Adriamycin-treated embryos with defective foregut separation.

274 signaling is identified in tracheoesophageal foregut septation, as animals lacking the cytoplasmic do

275 Explant culture of RALDH2-deficient foreguts show a capacity to undergo lung budding and ear

276 Similar analysis of wild type foregut shows that endogenous RAR alpha activity is requ

277 Foregut-specific Fzd7-depletion from the Xenopus foregut

278 Foregut-specific Szl depletion results in a loss of the

279 ing pathways hPSCs generate ventral-anterior foregut spheroids, which are then expanded into human lu

280 ulated kinase (Erk) in the Bmp4(cko) ventral foregut, suggesting that Bmp signaling promotes Erk phos

281 pression domain of Pdx1 within the posterior foregut suggests that investigating its transcriptional

282 Data on all patients undergoing foregut surgery are collected prospectively.

283 The combination of obesity and foregut surgery puts patients undergoing bariatric surge

284 f sclerotized elements, and a differentiated foregut that is lined with acicular teeth.

285 out the RA-dependent pathways present in the foregut that may be crucial for lung formation.

286 chea and the lungs--arises from the anterior foregut through a sequence of morphogenetic events invol

287 al precursor state, is also expressed in the foregut throughout gastrulation, suggesting that this re

288 diverse contexts and the differentiation of foregut tissue from stem cells.

289 tages that are prior to, or coincident with, foregut tissue patterning (1-3 somites, 4-6 somites, and

290 the pancreas, and a milder decrease in other foregut tissues.

291 r patterning and morphogenesis of the common foregut tube and its derived organs is essential for via

292 Separation of the single anterior foregut tube into the esophagus and trachea involves cel

293 ry outgrowth or progressive septation of the foregut tube.

294 t Tgfbeta signaling was hyperactive in these foreguts when lung agenesis was observed.

295 aling is prominently present in the anterior foregut where the tracheal primordium originates and tar

296 expressed exclusively in the salivary gland/foregut, whereas symbiotic Cell-2, -3, and -4 are highly

297 The lung buds develop as an outgrowth of the foregut, which contains migrating neural crest cells (NC

298 tral epithelial domain of the early anterior foregut, which gives rise to the future trachea and lung

299 ated bacterial biofilm formation in the flea foregut, which greatly increased transmissibility.

300 trachea and lung develop from the embryonic foregut, yet acquire and maintain distinct tissue phenot