ライフサイエンスコーパス: formamidopyrimidine

1 roxy-5-formamidopyrimidine and 4,6-diamino-5-formamidopyrimidine.

2 ss and have a high basal level of endogenous formamidopyrimidines.

3 opyrimidine DNA glycosylase in the repair of formamidopyrimidines.

4 L1 possesses equal specificity for these two formamidopyrimidines.

5 dy examines the role of CSB in the repair of formamidopyrimidines 2,6-diamino-4-hydroxy-5-formamidopy

6 ihydro-8-oxoguanine; 2,6-diamino-4-hydroxy-5-formamidopyrimidine; 4,6-diamino-5-formamidopyrimidine)

7 These were 4, 6-diamino-5-formamidopyrimidine, 5,6-dihydroxyuracil, and 5, 6-dihyd

8 r mutagenic lesions (2,6-diamino-4-hydroxy-5-formamidopyrimidine, 8-hydroxyadenine, 5-hydroxycytosine

9 Fpg protein (formamidopyrimidine/8-oxoguanine DNA N-glycosylase) is a

10 dary lesions, an apurinic site and an AFB(1)-formamidopyrimidine (AFB(1)-FAPY) adduct.

11 B(1) exo-8,9-epoxide hydrolyzes to form the formamidopyrimidine (AFB-FAPY) adduct, which interconver

12 urination or imidazole-ring opening yielding formamidopyrimidine AFB1 (AFB1-Fapy-dG).

13 ine-derived lesions, 2,6-diamino-4-hydroxy-5-formamidopyrimidine and 4,6-diamino-5-formamidopyrimidin

14 rine-derived lesions 2,6-diamino-4-hydroxy-5-formamidopyrimidine and 4,6-diamino-5-formamidopyrimidin

15 substrates, namely, 2,6-diamino-4-hydroxy-5-formamidopyrimidine and 4,6-diamino-5-formamidopyrimidin

16 iety of DNA base damage that is dominated by formamidopyrimidine and 5-hydroxy-6-hydropyrimidine lesi

17 hydroxy-5-formamidopyrimidine; 4,6-diamino-5-formamidopyrimidine) and strong plant growth inhibition

18 Formamidopyrimidines are preferred substrates of D. radi

19 The formamidopyrimidines are produced in significant quantit

20 ]pyridine and the base adduct aflatoxin B(1)-formamidopyrimidine by acylation.

21 the following modified bases: 4,6-diamino-5-formamidopyrimidine, cis- and trans-thymine glycols, 5-h

22 Endonuclease III (Nth), formamidopyrimidine DNA glycosylase (Fpg) and endonuclea

23 Cleavage assays with formamidopyrimidine DNA glycosylase (Fpg) coupled to alk

24 amage was quantitated using Escherichia coli formamidopyrimidine DNA glycosylase (Fpg) in a gene-spec

25 approach was based on digestion of DNA with formamidopyrimidine DNA glycosylase (FPG) to convert 8-o

26 Escherichia coli formamidopyrimidine DNA glycosylase (Fpg), MutY DNA glyc

27 Escherichia coli formamidopyrimidine DNA glycosylase (Fpg), which recogni

28 oxoG), is processed by two DNA glycosylases, formamidopyrimidine DNA glycosylase (Fpg), which removes

29 DNA strand by beta,delta-elimination as does formamidopyrimidine DNA glycosylase (Fpg).

30 e regions of T4-Pdg and the Escherichia coli formamidopyrimidine DNA glycosylase (Fpg).

31 ycosylase (hOgg1) or Escherichia coli enzyme formamidopyrimidine DNA glycosylase (Fpg).

32 spair, and repair of the resulting damage by formamidopyrimidine DNA glycosylase (Fpg).

33 urity is assayed using the DNA repair enzyme formamidopyrimidine DNA glycosylase and by ESI-MS.

34 fferent damage products sensitive to E. coli formamidopyrimidine DNA glycosylase and hot piperidine,

35 at oxidized bases with endonuclease III and formamidopyrimidine DNA glycosylase and then using the l

36 Endo VIII do not serve as back up enzymes to formamidopyrimidine DNA glycosylase in the repair of for

37 t Ug was a better substrate for endo III and formamidopyrimidine DNA glycosylase than Tg; for endonuc

38 ndonucleases Nth (endonuclease III) and Fpg (formamidopyrimidine DNA glycosylase).

39 ndo III), endonuclease VIII (endo VIII), and formamidopyrimidine DNA glycosylase.

40 igestion by the enzymes endonuclease III and formamidopyrimidine DNA glycosylase.

41 with the repair enzymes endonuclease III and formamidopyrimidine DNA glycosylase.

42 dative stress and are efficiently excised by formamidopyrimidine DNA glycosylase.

43 displayed subtle biases in damage chemistry (formamidopyrimidine DNA glycosylase/piperidine ratio).

44 tex were demonstrated using Escherichia coli formamidopyrimidine DNA N-glycosylase (Fpg protein)-sens

45 ve oxygen paralleled a four-fold increase in formamidopyrimidine DNA N-glycosylase (FPG)-sensitive cl

46 reduced the efficiency of 8-oxoG cleavage by formamidopyrimidine DNA N-glycosylase and increased the

47 min of reperfusion based on the presence of formamidopyrimidine DNA N-glycosylase-sensitive sites.

48 es have been identified for Escherichia coli formamidopyrimidine-DNA glycosylase (Fpg) and Drosophila

49 alf-life of Schiff bases formed when E. coli formamidopyrimidine-DNA glycosylase (Fpg) and endonuclea

50 Formamidopyrimidine-DNA glycosylase (Fpg) excises 8-oxog

51 is initiated by DNA glycosylases such as the formamidopyrimidine-DNA glycosylase (Fpg) in Escherichia

52 Formamidopyrimidine-DNA glycosylase (Fpg) is a 30.2 kDa

53 Formamidopyrimidine-DNA glycosylase (Fpg) is a primary p

54 Formamidopyrimidine-DNA glycosylase (Fpg) protein plays

55 ed by treatment with either Escherichia coli formamidopyrimidine-DNA glycosylase (Fpg), Escherichia c

56 counterpart, guanine, by the repair enzyme, formamidopyrimidine-DNA glycosylase (Fpg), likely involv

57 and comet analysis revealed introduction of formamidopyrimidine-DNA glycosylase (Fpg)-sensitive oxid

58 a, whereas in most bacteria it is removed by formamidopyrimidine-DNA glycosylase (Fpg).

59 ndonuclease III, but a sequence homologue of formamidopyrimidine-DNA glycosylase (Fpg).

60 sylases of the base excision repair pathway: formamidopyrimidine-DNA glycosylase and 8-oxoguanine DNA

61 ing oxidative DNA damage (sites sensitive to formamidopyrimidine-DNA glycosylase and single-strand br

62 on (lactoglyglutathione lyase gene), repair (formamidopyrimidine-DNA glycosylase gene), osmotic prote

63 ybrids were used as substrates for bacterial formamidopyrimidine-DNA glycosylase, Nth protein (endonu

64 ares structural and functional homology with formamidopyrimidine-DNA glycosylase.

65 MutY and formamidopyrimidine-DNA-glycosylase (Fpg) are base-excis

66 The formamidopyrimidines Fapy.dA and Fapy.dG are produced in

67 The structure of a formamidopyrimidine (FAPY) adduct arising from imidazole

68 zed ring opening to give a highly persistent formamidopyrimidine (FAPY) adduct which exists as a mixt

69 ic (8-OH) lesions to putatively nonmutagenic formamidopyrimidine (Fapy) lesions of adenine (Ade) and

70 oxypurine (8-OH) and putatively nonmutagenic formamidopyrimidine (Fapy) lesions.

71 uanine, resulting in imidazole ring opening [formamidopyrimidine (Fapy)] and is associated with signi

72 ormamidopyrimidine (FapyG) and 4,6-diamino-5-formamidopyrimidine (FapyA) are formed abundantly in DNA

73 5-formamidopyrimidine (FapyG), 4,6-diamino-5-formamidopyrimidine (FapyA), and 8-oxo-7,8-dihydroadenin

74 rmamidopyrimidine (FapyG) and 4,6-diamino- 5-formamidopyrimidine (FapyA), but not 8-oxo-7,8-dihydrogu

75 ong preference for excision of 4,6-diamino-5-formamidopyrimidine (FapyAde) and 2,6-diamino-4-hydroxy-

76 amidopyrimidine (FapyGua) and 4, 6-diamino-5-formamidopyrimidine (FapyAde) in cultured cells irradiat

77 formamidopyrimidine (FapyGua), 4,6-diamino-5-formamidopyrimidine (FapyAde), and 8-hydroxyguanine (8-O

78 mamidopyrimidine (FapyGua) and 4,6-diamino-5-formamidopyrimidine (FapyAde), which are substrates for

79 amidopyrimidine (FapyGua) and 4, 6-diamino-5-formamidopyrimidine (FapyAde).

80 other common lesion, 2,6-diamino-4-hydroxy-5-formamidopyrimidine (FapydG), shares the same precursor

81 idinohydantoin (Gh), 2,6-diamino-4-hydroxy-5-formamidopyrimidine (FapyG) and 4,6-diamino- 5-formamido

82 induced DNA lesions 2,6-diamino-4-hydroxy-5-formamidopyrimidine (FapyG) and 4,6-diamino-5-formamidop

83 droguanine (8-oxoG), 2,6-diamino-4-hydroxy-5-formamidopyrimidine (FapyG), 4,6-diamino-5-formamidopyri

84 guanine (8-oxoG) and 2,6-diamino-4-hydroxy-5-formamidopyrimidine (FapyG).

85 yguanine (8-OH-Gua), 2,6-diamino-4-hydroxy-5-formamidopyrimidine (FapyGua) and 4, 6-diamino-5-formami

86 cytosine (5-OH-Cyt), 2,6-diamino-4-hydroxy-5-formamidopyrimidine (FapyGua) and 4, 6-diamino-5-formami

87 formamidopyrimidines 2,6-diamino-4-hydroxy-5-formamidopyrimidine (FapyGua) and 4,6-diamino-5-formamid

88 midine (FapyAde) and 2,6-diamino-4-hydroxy-5-formamidopyrimidine (FapyGua) from DNA with no specifici

89 anine (8-OH-Gua) and 2,6-diamino-4-hydroxy-5-formamidopyrimidine (FapyGua) were efficiently excised f

90 on of purine lesions 2,6-diamino-4-hydroxy-5-formamidopyrimidine (FapyGua), 4,6-diamino-5-formamidopy

91 on by S3 protein was 2,6-diamino-4-hydroxy-5-formamidopyrimidine (FapyGua).

92 Escherichia coli formamidopyrimidine (Fpg) DNA glycosylase and MutY DNA g

93 icity by inactivation of the uracil (Ung) or formamidopyrimidine (Fpg) DNA glycosylases but not by in

94 roxy-5-formamidopyrimidine and 4,6-diamino-5-formamidopyrimidine from gamma-irradiated DNA.

95 glycosylases, which specifically remove the formamidopyrimidines from DNA.

96 s and a purine-derived lesion, 4,6-diamino-5-formamidopyrimidine, from DNA containing multiple modifi

97 In bacteria, 8OG is excised by formamidopyrimidine glycosylase (Fpg) as the initial ste

98 Formamidopyrimidine glycosylase (Fpg) is an important ba

99 We apply the assay to the bifunctional formamidopyrimidine glycosylase (Fpg) repair enzyme (E)

100 ion induces a significantly higher amount of formamidopyrimidine glycosylase-sensitive ODD in MCs tha

101 characterize the binding of Escherichia coli formamidopyrimidine-glycosylase (Fpg), a bifunctional re

102 how elevated 8-OHG, 8-OHA, and 5,6-diamino-5-formamidopyrimidine in both nuclear and mtDNA isolated f

103 thropentofuranosyl)-2,6-diamino-4-hydroxy -5-formamidopyrimidine) is a modified purine lesion produce

104 Under conditions of oxidative stress, the formamidopyrimidine lesions (FapyG and FapyA) are formed

105 Oligodeoxynucleotides containing formamidopyrimidine lesions and C-nucleoside analogues a

106 lability of oligodeoxynucleotides containing formamidopyrimidine lesions indicate that Fapy.dA is rea

107 The formamidopyrimidine lesions reduce the T(M) of dodecamer

108 Formamidopyrimidine lesions were introduced as dinucleot

109 i against possible mutations attributable to formamidopyrimidine lesions.

110 d without the addition of the repair enzymes formamidopyrimidine N-glycosylase (Fpg), endonuclease II

111 Endonuclease (Endo) III and formamidopyrimidine-N-glycosylase (Fpg) are two of the p

112 ring-fragmented lesion, N(5)-NM-substituted formamidopyrimidine (NM-Fapy-dG).

113 hat Endo III and/or Endo VIII play a role in formamidopyrimidine nucleoside repair by examining Fapy*

114 sidered whether the genome is protected from formamidopyrimidine nucleosides (Fapy*dA, Fapy*dG) via a

115 Previous reports suggest that the formamidopyrimidine nucleosides are substrates for endon

116 t to their action on duplexes containing the formamidopyrimidines opposite native deoxyribonucleotide

117 8-oxoguanine (8-oxoG), ring-opened purines (formamidopyrimidines or Fapys), and other oxidized DNA b

118 s suggest that CSB plays a role in repair of formamidopyrimidines, possibly by interacting with and s

119 or substrates compared with those containing formamidopyrimidine-pyrimidine base pairs.

120 yladenine and 7-methylguanine whereas methyl-formamidopyrimidine was excised efficiently.

121 roxy-5-formamidopyrimidine and 4,6-diamino-5-formamidopyrimidine were significantly excised.

122 e lesions 8-hydroxyadenine and 4,6-diamino-5-formamidopyrimidine, were not excised from any of the DN

123 duces a variety of DNA lesions including the formamidopyrimidines, which are derived from the purines