ライフサイエンスコーパス: formidable

1 This goal is formidable.

2 tangible clinical endpoint are numerous and formidable.

3 ion of reduced virulence in animal models is formidable.

4 to modulate the activity of NaV subtypes is formidable.

5 lymorphism in the AMA1 protein may not be as formidable a problem for vaccine development as anticipa

6 R)-associated (Cas9) technology has proven a formidable addition to our armory of approaches for geno

7 As such, sepsis remains a formidable adversary for surgeons and their patients and

8 ions found in biological matrixes presents a formidable analytical challenge in proteomics experiment

9 isecond) stages of folding still represent a formidable analytical challenge.

10 Pancreatic resection remains among the most formidable and complex of abdominal surgical operations.

11 depressive disorder (MDD) had proven to be a formidable and elusive task, with all individual marker-

12 control of emerging infectious diseases are formidable and range from influencing the factors that d

13 The effect of TEE technology is quite formidable, and numerous investigations have borne this

14 e energy requirements for this expansion are formidable, and T-cell activation is accompanied by dram

15 challenge to deliver therapies to the CNS is formidable, and the solution will require concerted inte

16 ell types, including erythrocytes, creates a formidable antigen sink that may limit the efficacy of C

17 tegies are urgently needed to overcome these formidable apoptotic blockades.

18 ess represents one of the rare chinks in the formidable armor of cancer cells.

19 onment adds another mechanism to the already formidable arsenal of immunoevasion tactics used by soli

20 make an anoxic ocean likely, and would be a formidable barrier to biologic survival.

21 However, its complexity presents a formidable barrier to exploring such possibilities.

22 formation that implicates the nucleolus as a formidable barrier to interaction between DNA sequences

23 ed network of matrix proteins also acts as a formidable barrier to macromolecules and emigrating leuk

24 ity is essential for homeostasis and poses a formidable barrier to pathogen entry.

25 such as Cryptococcus neoformans, provides a formidable barrier to secrete virulence factors that pro

26 , we show in this study that NK cells form a formidable barrier to the long-term engraftment of ES ce

27 lude that anionic oligosaccharides provide a formidable barrier to the uptake of nucleic acids by mam

28 Chromatin is a formidable barrier to transcription.

29 The sheer number of histone PTMs presents a formidable barrier to understanding the molecular mechan

30 Thus, fibrillar collagen can be a formidable barrier to viral distribution and matrix-modi

31 culating oncolytic virus particles remains a formidable barrier.

32 In light of the many formidable barriers against successful NP drug delivery,

33 egeneration after injury in the CNS, several formidable barriers must be overcome, such as scar tissu

34 and scar tissue formed after injury present formidable barriers that must be crossed by axons to res

35 intensities and capital/operating costs are formidable barriers to adoption.

36 limiting our current knowledge and providing formidable barriers to further advancement.

37 tively suppress antitumor immunity, creating formidable barriers to successful cancer immunotherapy.

38 porary phospholipid-based cell membranes are formidable barriers to the uptake of polar and charged m

39 heart muscle (EHM) may overcome all of these formidable barriers.

40 lostridium perfringens are attributable to a formidable battery of toxins.

41 vely, these data suggest that pregnancy is a formidable biologic barrier for women and contributes un

42 These threats and their interactions are formidable, but we review seven strategies that, if impl

43 toma, with therapeutic implications for this formidable cancer.

44 ctivity and long-term stability represents a formidable challenge and has not been extensively addres

45 ing their 110-megadalton structure imposes a formidable challenge and requires in situ structural bio

46 mall iNPs in a controllable manner remains a formidable challenge because of the high temperature gen

47 he development of an HIV-1 vaccine remains a formidable challenge due to multiple circulating strains

48 n a micrometer-thick conductive support is a formidable challenge for achieving high reflection loss

49 ons by means of a catalyst species remains a formidable challenge for chemists to face.

50 esent in glycans and glycoconjugates poses a formidable challenge for comprehensive structural analys

51 riously inconsistent terminology, creating a formidable challenge for data integration.

52 pplicable to HIV infections and represents a formidable challenge for developing effective chemoproph

53 diverse universe of organic pollutants is a formidable challenge for environmental sciences, enginee

54 Sex-role reversal represents a formidable challenge for evolutionary biologists, since

55 underlying disease remains an important, yet formidable challenge for medical genetics.

56 adult neurogenesis in living human brains-a formidable challenge for now-we cannot establish its fun

57 ervation or explicit fossil evidence poses a formidable challenge for paleobiological studies.

58 Autism spectrum disorders (ASDs) represent a formidable challenge for psychiatry and neuroscience bec

59 omparative analysis of such datasets poses a formidable challenge for research groups that do not hav

60 typically longer than 200 aa and represent a formidable challenge for structure prediction.

61 Adaptation to aquatic habitats is a formidable challenge for terrestrial angiosperms that ha

62 as occurs in the atmosphere and ocean, is a formidable challenge for the following reasons: the comp

63 th sustainable alternatives is a crucial but formidable challenge for the modern society.

64 tly localising sensory stimuli in space is a formidable challenge for the newborn brain.

65 Furthermore, a formidable challenge for the treatment of nicotine addic

66 Alzheimer's disease remains a formidable challenge for therapeutic management.

67 ear sites in particular, the goal provides a formidable challenge for, with the exception of iron-sul

68 ree-dimensional structure has proved to be a formidable challenge in biological research, especially

69 ry of biologically active proteins remains a formidable challenge in biomedical research.

70 l molecules, even closely related ones, is a formidable challenge in biomolecular recognition and med

71 ntrolling crystal polymorphism constitutes a formidable challenge in contemporary chemistry.

72 ase of multiple therapeutic agents remains a formidable challenge in drug delivery and synthetic poly

73 delivery via vector-based systems remains a formidable challenge in mammalian synthetic biology and

74 (functionally selective) ligands provides a formidable challenge in medicinal chemistry.

75 A formidable challenge in neural repair in the adult centr

76 C-H bonds in complex molecules represents a formidable challenge in organic chemistry.

77 ld reaction conditions is a longstanding and formidable challenge in organic chemistry.

78 poatrophy, lumpectomy or facial trauma, is a formidable challenge in reconstructive medicine, and yet

79 n acceptors such as fullerene has remained a formidable challenge in the area of organic photovoltaic

80 Perhaps the most formidable challenge is to treat children with CNS relap

81 Human infants face the formidable challenge of learning the structure of their

82 central pattern generators (CPGs) presents a formidable challenge requiring sophisticated tools and w

83 n complex, clinically relevant matrices is a formidable challenge that is complicated by limitations

84 independent of antibody status, presenting a formidable challenge to Ad5 therapeutics.

85 Energy production presents a formidable challenge to axons as their mitochondria are

86 f which (6-4) photoproducts present the most formidable challenge to DNA replication.

87 Hence thermal fluctuations pose a formidable challenge to ectothermic organisms in which b

88 he crowded intracellular environment poses a formidable challenge to experimental and theoretical ana

89 TF) to the wrong locations on DNA presents a formidable challenge to genomes given the relatively low

90 olving landscape of cancer mutations poses a formidable challenge to identify cancer genes among the

91 al growth of genomics data, yet it remains a formidable challenge to interpret such data for identify

92 specific cell populations in vivo remains a formidable challenge to its successful therapeutic appli

93 reased drought frequency and severity pose a formidable challenge to maintaining soybean yield progre

94 organization of the mammalian genome posed a formidable challenge to molecular evolutionists attempti

95 esent in human peripheral blood could pose a formidable challenge to obtaining a sufficient number of

96 rate nature of this reaction has made this a formidable challenge to subdue by asymmetric catalysis.

97 em make this virus and these glycoproteins a formidable challenge to target by vaccination, requiring

98 ability and treating these patients can be a formidable challenge to the clinician.

99 Emerging infectious diseases present a formidable challenge to the conservation of native speci

100 nodeficiency virus type 1 (HIV-1) presents a formidable challenge to the generation of an HIV-1 vacci

101 nfection causing end-organ disease remains a formidable challenge to the hematopoietic cell transplan

102 The mammalian brain poses a formidable challenge to the study and treatment of neuro

103 Thus, a replication impediment constitutes a formidable challenge to these organisms.

104 To address this formidable challenge we developed new chemical approache

105 gineering and environmental fluid flows is a formidable challenge with practical significance because

106 genes within metagenomic sequences remains a formidable challenge, and noncoding RNA genes other than

107 ructural study of the spliceosome presents a formidable challenge, but there has recently been signif

108 hough curing the leukemia is always the most formidable challenge, complications from the disease its

109 rties of ordered organic materials remains a formidable challenge, despite their great potential for

110 unities on host pathophysiology represents a formidable challenge, due to the heterogeneous distribut

111 motion in complex molecular structures is a formidable challenge, for both theory and experiment, bu

112 structure of membrane proteins represents a formidable challenge, particularly when using small-angl

113 While this goal represents a formidable challenge, the modest efficacy of the RV144 t

114 atical models has been widely perceived as a formidable challenge, which has spurred the development

115 lementation of climate mitigation policies a formidable challenge.

116 of causal regulatory mutations represents a formidable challenge.

117 ARTD family members in a cellular context a formidable challenge.

118 nucleic acid cargo intracellularly remains a formidable challenge.

119 s reactivity in a synthetic system remains a formidable challenge.

120 ancer, yet inhibiting its activity remains a formidable challenge.

121 Few biobased polymers have met this formidable challenge.

122 actical and cost-effective manner has been a formidable challenge.

123 cane-N,O-acetal moiety of sieboldine A was a formidable challenge.

124 owever, resistance to these agents remains a formidable challenge.

125 tations of surrounding residues represents a formidable challenge.

126 of free metal ions in deep tissue remains a formidable challenge.

127 owever, resistance to these agents remains a formidable challenge.

128 fication of bona fide enhancers has proved a formidable challenge.

129 hibiting oncogenic beta-catenin has proven a formidable challenge.

130 ication of their functional impact remains a formidable challenge.

131 rol human embryonic development represents a formidable challenge.

132 t antibodies to prevent infection has been a formidable challenge.

133 small molecule agonists and antagonists is a formidable challenge.

134 ell-defined conformations a priori remains a formidable challenge.

135 attributable to these organelles presents a formidable challenge.

136 xon regeneration after chronic SCI remains a formidable challenge.

137 m to salvage the ischemic penumbra remains a formidable challenge.

138 CNS progression remains a formidable challenge.

139 e not known, and their elucidation remains a formidable challenge.

140 a,alpha-disubstituted amino acids presents a formidable challenge.

141 the noncoding regulatory genome has proved a formidable challenge.

142 f type 2 diabetes (T2D) in humans has been a formidable challenge.

143 taract blindness worldwide continues to be a formidable challenge.

144 in melting and freezing processes remains a formidable challenge.

145 , at non-cryogenic temperatures represents a formidable challenge.

146 ins assemble into the NPC scaffold imposes a formidable challenge.

147 samples in ambient mass spectrometry poses a formidable challenge.

148 ion of novel and robust biomarkers remains a formidable challenge.

149 iologically relevant length scales remains a formidable challenge.

150 ill help AVs make these moral decisions is a formidable challenge.

151 ective delivery of therapeutic proteins is a formidable challenge.

152 reat frontier is to cure infected persons, a formidable challenge.

153 ontrol of absolute stereochemistry remains a formidable challenge.

154 encountered at high engine loads, remains a formidable challenge.

155 from large transcriptomic datasets remains a formidable challenge.

156 et the broad range of KRAS mutants remains a formidable challenge.

157 beyond the horizon of Li-ion batteries is a formidable challenge; there are few options.

158 nction of all human genes is a critical, yet formidable, challenge.

159 re specific to paediatric infection, and the formidable challenges ahead to ensure that all children

160 Formidable challenges face health workers who have staye

161 cities fueled largely by fossil energy poses formidable challenges for establishing a sustainable rel

162 time horizon and poor initial cash flow pose formidable challenges for landowners.

163 respective investigational agents, may pose formidable challenges for the development and implementa

164 ore efficiently than classical machines, the formidable challenges in building such devices motivate

165 glycosidic linkages remains one of the most formidable challenges in organic chemistry.

166 logical and pharmaceutical samples represent formidable challenges in sample preparation that hold im

167 with their molecular heterogeneity presents formidable challenges in understanding the specific cont

168 Formidable challenges include glycosidic bond formation

169 However, one of the formidable challenges is to develop ultrafast charging L

170 surface via swarming motility is subject to formidable challenges not encountered during swimming.

171 This has been attributed to the formidable challenges of optimizing drug combinations.

172 ile emphasizing the considerable promise and formidable challenges these advanced composite materials

173 dequate accumulation of therapeutics, remain formidable challenges to drug developers.

174 a cell type that has traditionally presented formidable challenges to efficient retroviral transducti

175 demic, and the rise in MDR tuberculosis pose formidable challenges to the global control of tuberculo

176 srael has achieved in health, in the face of formidable challenges, including rapid population growth

177 ral-membrane proteins in general still faces formidable challenges, the minigluzincin soluble minimal

178 delivery to subcellular compartments remain formidable challenges.

179 Such computations involve formidable challenges.

180 been cultured independently, and this poses formidable challenges.

181 the related drug responses currently remain formidable challenges.

182 Research on biomedical interventions poses formidable challenges.

183 the clinic, antivector immune responses pose formidable challenges.

184 e National Institutes of Health have created formidable challenges.

185 le-based carrier systems still faces certain formidable challenges.

186 netobacter isolates presents clinicians with formidable challenges.

187 e ocean sustainably requires overcoming many formidable challenges: overfishing, climate change, ocea

188 erica, West Nile virus has and will remain a formidable clinical and public health problem for years

189 Cancer stem cells (CSC) present a formidable clinical challenge by escaping therapeutic in

190 ate-stage clear cell renal carcinoma poses a formidable clinical challenge due to the high mortality

191 fective treatment of osteomyelitis remains a formidable clinical challenge.

192 ptive arms of the immune system represents a formidable combinatorial problem but one that needs to b

193 These results not only illustrate the formidable complexity of mechanisms controlling C fluxes

194 t a simple solution to overcome the apparent formidable complexity previously thought to be intrinsic

195 levant native conformation of a protein is a formidable computational challenge given the very large

196 position or size changes) represents such a formidable computational feat that it is widely assumed

197 ve to the number of genetic markers presents formidable computational, statistical and methodological

198 tural and adaptive locomotor movements poses formidable conceptual and technological challenges.

199 and the corneal epithelium combine to make a formidable defense against P aeruginosa infection of the

200 otypic properties of transmitted Envs pose a formidable defense.

201 integrating data from multiple levels remain formidable; developments in this area will significantly

202 Liver failure in newborns can present formidable diagnostic challenges.

203 We also discuss how the nucleoid acts as a formidable diffusion barrier for large bodies in the cel

204 Malignant glioma is a formidable disease that commonly leads to death, mainly

205 become undeniable, at which time in 1993 the formidable drug development resources of large pharmaceu

206 isorders such as anxiety and depression have formidable economic and societal impacts.

207 , small molecules, or cancer cells remains a formidable endeavor.

208 This gain-of-function phenotype provides formidable evidence demonstrating the importance of endo

209 dvanced the field substantially, and promise formidable gains in the years to come as they are applie

210 This is a formidable gap in biomedical knowledge.

211 These genome sequences augment the formidable genetic tools that have made Drosophila melan

212 the coordination of the hand and eye present formidable geometric challenges.

213 ltiple functional groups is a desirable, yet formidable goal.

214 ny neuro-therapeutic molecules, presenting a formidable hurdle to drug development in brain diseases.

215 or drug-like properties of telaprevir were a formidable hurdle, which the manufacturing and formulati

216 e has, in specific instances, proven to be a formidable hurdle.

217 ometric increases in complexity of data make formidable hurdles for exploring, analyzing and presenti

218 Its emerging antibiotic resistance and formidable immune evasion arsenal have emphasized the ne

219 While lending formidable impact to peripheral blood B cells as mediato

220 ation myocardial infarction (STEMI) care are formidable in low- to middle-income countries because of

221 odified thiopeptide antibiotic that displays formidable in vitro activity against a variety of Gram-p

222 he new data types and huge data volume poses formidable informatics challenges for base calling, read

223 or, however, whole parasite vaccines present formidable logistical challenges for production, storage

224 A formidable many-body problem in ecology is to understand

225 eractions using genome-wide approaches poses formidable methodological problems, and elucidating mole

226 The serum complement machinery is a formidable obstacle for bacteria to overcome if they end

227 of plasticity beyond early development is a formidable obstacle for conventional therapies to stimul

228 The persistence of HIV reservoirs remains a formidable obstacle to achieving sustained virologic rem

229 e heterotypic nature of chromatin presents a formidable obstacle to biochemical studies seeking to un

230 DNA-protein cross-links (DPCs) present a formidable obstacle to cellular processes because they a

231 Rapid clearance from the tears presents a formidable obstacle to the delivery of peptide drugs to

232 use proteases to dissolve and traverse this formidable obstacle.

233 offer great promise to safely overcome this formidable obstacle.

234 , the live-attenuated vaccine approach faces formidable obstacles, including development of accurate,

235 Despite these formidable obstacles, thousands of kilometres of high-te

236 In light of these formidable obstacles, viruses have evolved mechanisms of

237 e for patients afflicted with this "... most formidable of catastrophes."

238 nce of scale in the signal makes detection a formidable olfactory task.

239 -type strain reveals the contribution of the formidable outer-membrane permeability barrier that redu

240 rom the medical point of view, H pylori is a formidable pathogen responsible for much morbidity and m

241 us is a commensal species that can also be a formidable pathogen.

242 ent patient-to-patient transmission of these formidable pathogens.

243 ors may present elevated IFP, which can be a formidable physical barrier for delivery of cell nutrien

244 Religious leadership in Israel, with its formidable political influence, can be harnessed to prom

245 cking relativistic quantum particles and its formidable potential in various applications, have ensur

246 Despite the formidable potential of aryl methyl ethers as coupling p

247 anus priscus, the largest lizard known, were formidable predators.

248 Designing effective antisense sequences is a formidable problem.

249 e variants make to a clinical phenotype is a formidable problem.

250 ucture and conformational elements remains a formidable problem.

251 n interdisciplinary researchers in attacking formidable problems.

252 Recent clinical reports support the formidable promise of this approach but also highlight t

253 prevalence of physical inactivity remains a formidable public health issue, participation in exercis

254 a substantial economic and societal burden-a formidable public health issue.

255 havioral flexibility, it presents an equally formidable reinforcement learning problem of discovering

256 s that have increased our knowledge of these formidable respiratory pathogens.

257 or potent immunosuppression coupled with the formidable risk of irreversible antibody-mediated reject

258 is in this setting is limited because of the formidable risk of perioperative bleeding.

259 ogical systems such as actin filaments are a formidable scientific challenge in attaining future life

260 f innovative molecular designs, it remains a formidable scientific challenge to access Earth-abundant

261 mises the health of future generations, is a formidable scientific challenge worthy of investment.

262 ense, solid-state hydrogen storage remains a formidable scientific challenge.

263 This creates a formidable setting from which to isolate the central mec

264 However, the formidable size of the diploid human genome, approximate

265 The income-achievement gap is a formidable societal problem, but little is known about e

266 is a major international concern that brings formidable socioeconomic and healthcare challenges.

267 A formidable source of noncanonical signal transduction co

268 sampled from some number of individuals is a formidable statistical problem.

269 short intermolecular distances and provides formidable strength for some pi-pi stacking interactions

270 The cervix represents a formidable structural barrier for successful induction o

271 ommunity-empowerment approach, we identified formidable structural barriers to implementation and sca

272 Complex AWR represents a formidable surgical challenge.

273 for a leading clinical candidate that posed formidable synthesis challenges.

274 d environmentally friendly fashion remains a formidable synthetic challenge because of the absence of

275 ination, this class of molecules represent a formidable synthetic challenge.

276 decade-long research effort en route to this formidable target compound.

277 atalysed by an immobilised enzyme is a quite formidable task and observed differences in the performa

278 This is a remarkably formidable task considering the limited 0.1-1 A scale of

279 T cells carry out the formidable task of identifying small numbers of foreign

280 structure-function relationship of IDPs is a formidable task that requires detailed characterization

281 l targeting and monitoring to brain remain a formidable task, the discovery of this dissipation-free,

282 rug delivery and on-demand release remains a formidable task.

283 ation within the adult spinal cord remains a formidable task.

284 inst a myriad of unwanted relationships is a formidable task.

285 ineage commitment in the T helper cell was a formidable task.

286 talline phases, like cubic blue phases, is a formidable task.

287 , making de novo riboswitch identification a formidable task.

288 Nevertheless, formidable technical barriers have constrained our under

289 design of hybrid PET/MR scanners presented a formidable technical challenge, and only recently were t

290 technology have been hampered by a number of formidable technical challenges, including the cost and

291 lar mechanisms involved in this process face formidable technical challenges, requiring multiple obse

292 trology, which exploit this scaling, despite formidable technical difficulties.

293 ose quantitative interpretation represents a formidable theoretical challenge.

294 Besides constituting a formidable therapeutic target, MYC also has an essential

295 Asian soybean rust is a formidable threat to soybean (Glycine max) production in

296 en identified in mammals, but they are still formidable to be comprehensively identified and characte

297 omic analysis of native viral gp120 is still formidable to date.

298 as been elegantly solved by the dragonfly, a formidable visual predator on flying insects.

299 Because viral therapy would be formidable, we examined whether a miR-30c mimic can be u

300 formation Miner, an engine which we see as a formidable workflow editor, and the Grid and User Suppor