ライフサイエンスコーパス: formyl group

1 ituted at the aryl C3 position (ortho to the formyl group).

2 nly beta to the aldehyde carbonyl and in the formyl group.

3 hat the 2-vinyl group has been oxidized to a formyl group.

4 and beta to the aldehyde carbonyl and in the formyl group.

5 o has hydrogen-bonding interactions with the formyl group.

6 of the 5'-hydroxymethyl of riboflavin to the formyl group.

7 e in order to facilitate the transfer of the formyl group.

8 eloped for the synthesis of chlorins bearing formyl groups: (1) reaction of an acetal-substituted 1-a

9 eliver 2,4-cyclohexadienones featuring a key formyl group and a quaternized carbon atom in good yield

10 sm for oxidation of the 2-vinyl group to a 2-formyl group and adds to the surprising array of chemica

11 etic version that features the transfer of a formyl group and hydride from an aldehyde substrate to a

12 eme b by two chemical modifications, the C-8 formyl group and the C-2 hydroxyethylfarnesyl group.

13 A hydrogen bond between the formyl group and the exocyclic amine of the 3'-neighbor

14 sence of hydrogen bonding between the heme a formyl group and the R52 side chain, as suggested from c

15 id and vinyl alcohol vinylogues in which the formyl group and the vinyl group, respectively, were per

16 s to novel polycyclic scaffolds decorated by formyl groups and carboxylates suitable for subsequent m

17 Preactivation of the DDF formyl group appears to be key for catalysis, and struct

18 rved, and the 10 residues coordinating the N-formyl group are almost invariant.

19 h is His in ePL kinase 1, interacts with the formyl group at C-4' of pyridoxal and may also determine

20 e introduction of a TIPS-ethynyl, acetyl, or formyl group at the 7-position was achieved using Pd-cat

21 54) of the intermediate domain transfers the formyl group between the catalytic domains of FDH.

22 Removal of the formyl group by a peptide deformylase renders the dipept

23 n the B ring of a tetrapyrrole molecule to a formyl group by chlorophyllide a oxygenase (CAO).

24 The resultant N-formyl group can be converted to N-H, NCH2OH, or NCH3.

25 The finding that the methyl and formyl groups channel the reaction regiospecificity in o

26 ucts arises from the photosensitizer: The N6-formyl group comes from oxidation of the methyl group an

27 peptide deformylase was shown to retain the formyl group confirming the physiological role of the de

28 in interacts with Arg 303 and Thr 301; its N-formyl group coordinates to Mg2+, and its hydroxyl group

29 We found that the 5-formyl group could increase duplex thermal stability and

30 Each porphyrin bears a formyl group distal to the surface attachment group for

31 e MTF, use N(10)-formyltetrahydrofolate as a formyl group donor.

32 cyanide alpha-carbon to protic solvents as a formyl group during imine formation is indicative of new

33 recombinantly overexpressed AT retains the N-formyl group (fAT), presumably due to incomplete N-formy

34 The requirement of an N-formyl group for channel activity, impermeability to cat

35 reate an oxyanion hole that helps orient the formyl group for nucleophilic attack by the 4-carboxamid

36 l domains: a hydrolase domain that removes a formyl group from 10-formyltetrahydrofolate and a NADP(+

37 ntose sugar and also catalyzes transfer of a formyl group from N-10-formyltetrahydrofolate to the 4'-

38 that catalyzes the removal of the N-terminal formyl group from nascent polypeptides in eubacteria.

39 zes the hydrolytic removal of the N-terminal formyl group from nascent ribosome-synthesized polypepti

40 enzyme that is responsible for removing the formyl group from nascently synthesized polypeptides in

41 a metal-dependent enzyme that removes the N-formyl group from newly synthesized bacterial proteins.

42 PDF) catalyzes the removal of the N-terminal formyl group from newly synthesized polypeptides in euba

43 zes the hydrolytic removal of the N-terminal formyl group from newly synthesized polypeptides in euba

44 lase catalyzes the removal of the N-terminal formyl group from newly synthesized polypeptides in euba

45 e deformylase catalyzes the removal of the N-formyl group from newly synthesized polypeptides in prok

46 atalytically active and able to remove the N-formyl group from several synthetic polypeptides, althou

47 ing of GTP but does not remove the resulting formyl group from the formamide.

48 zes the subsequent removal of the N-terminal formyl group from the majority of bacterial proteins.

49 enzyme in eubacteria for the removal of the formyl group from the N terminus of the nascent polypept

50 peptide deformylase (DEF), which removes the formyl group from the N-terminal formylmethionine in a p

51 oenzyme responsible for the removal of the N-formyl group from the N-terminal methionine of nascent p

52 ase (EC 3.5.1.31) catalyzes the removal of a formyl group from the N-termini of nascent ribosome-synt

53 HsPDF is capable of removing formyl groups from N-terminal methionines of newly synth

54 CH...O hydrogen bonds involving formyl groups have been invoked as a crucial factor cont

55 Prior syntheses of porphyrins bearing meso-formyl groups have generally employed the Vilsmeier form

56 of the chlorophylls and the formation of the formyl group in Chl f.

57 of two steps: (i) hydrolytic cleavage of the formyl group in the N-terminal catalytic domain, followe

58 Removal of the formyl group in these proteins by DEF would explain the

59 The disposition of the N5-formyl group in these structures indicates formation, at

60 In a previous study we proposed that the formyl group is formed by an initial hydroxylation of th

61 The formyl group is held by a novel hydrogen bonding network

62 Our results showed that the 5-formyl group is located in the same plane as the cytosin

63 The formyl group is normally removed from the N-terminal Met

64 ked conformational change near the heme a(3) formyl group is postulated.

65 In this mechanism, it was not clear how the formyl group is transferred between the two catalytic do

66 rs between substrate and cofactor, while the formyl group is transferred from 10-formyltetrahydrofola

67 However, the biochemical provenance of this formyl group is unknown.

68 h formyl-methionine; however, the N-terminal formyl group is usually removed by peptide deformylase,

69 We report that the formyl group must be removed before the methionine resid

70 ance of the hydroxyl group of serine and the formyl group of 5-formyltetrahydrofolate in complexes of

71 because the hydroxymethyl group of 5hmC and formyl group of 5fC adopt restrained conformations throu

72 the methyl group of BChlide c or d into the formyl group of BChlide e or f This probably occurs by a

73 d (2)H) to determine the origin of the C2(1)-formyl group of Chl f and to verify whether Chl f is syn

74 h Q471, appears to be hydrogen-bonded to the formyl group of heme a in the X-ray structures.

75 the multidomain protein, HypX, converts the formyl group of N(10)-CHO-THF into water and CO, thereby

76 en atom derived from molecular oxygen on the formyl group of pyrrole B.

77 ria begins with a formylated methionine, the formyl group of the nascent polypeptide is removed by pe

78 iting reactivity differences between the two formyl groups of A,B-rings 9 to impart excellent regiose

79 me A by a further oxidation of a methyl to a formyl group on C-8.

80 A structure-activity study showed that the formyl group on position 1 and the bromine atom on posit

81 We found that the oxygen atom of the C2(1)-formyl group originates from molecular oxygen and not fr

82 atharanthine N-methyl group or a vindoline N-formyl group precludes Fe(III)-promoted coupling, wherea

83 ch, upon enzymatic removal of the N-terminal formyl group, rapidly release free thiols.

84 ophorbine skeleton and bears a 7-methyl or 7-formyl group, respectively.

85 e a significant fraction of the BST with the formyl group retained.

86 hifted absorption maximum because of a C2(1)-formyl group substitution of Chl f However, the biochemi

87 Formyl group substitutions on the side chains of chlorop

88 construction of pyrroles bearing a 2-keto or formyl group through the intramolecular oxidative aza-an

89 d by (ii) NADP(+)-dependent oxidation of the formyl group to CO(2) in the C-terminal aldehyde dehydro

90 monocytogenes that lacked the ability to add formyl groups to nascent polypeptides.

91 The FAPY formyl group was positioned to form a hydrogen bond with

92 In addition to the normal formyl group, we find that the protein translational mac

93 ttached to lipid A is not derivatized with a formyl group, we postulate the existence of a deformylas