ライフサイエンスコーパス: formyl peptide receptor

1 onse of these cells to ligands selective for formyl peptide receptor.

2 ned using the open reading frame of murine N-formyl peptide receptor.

3 Fpr-rs7 are 53-74% identical to other mouse formyl peptide receptors.

4 Our results demonstrate that formyl peptide receptor 1 (FPR1) and neutrophilic NADPH

5 Cys549, which then induces TRMP2 binding to formyl peptide receptor 1 (FPR1) and subsequent FPR1 int

6 Binding of formyl peptide receptor 1 (FPR1) by N-formyl peptides ca

7 Formyl peptide receptor 1 (FPR1) is a G protein-coupled

8 ceptor to be described on human neutrophils, formyl peptide receptor 1 (FPR1), is one such receptor t

9 osis by CXC chemokine receptor 2 (CXCR2) and formyl peptide receptor 1 (FPR1), respectively.

10 ted from wild-type mice and mice lacking the formyl peptide receptor 1, we demonstrate that LTB(4) ac

11 In these studies, we performed formyl peptide receptor-1 (FPR) localization and evaluat

12 out experiments to study the capacity of the formyl peptide receptor-1 (FPR1) to desensitize chemokin

13 tein B1 (HMGB1), respectively, as well as to formyl peptide receptor-1 (FPR1), which interacts with A

14 polymorphonuclear neutrophils (PMNs) through formyl peptide receptor-1 and Toll-like receptor (TLR) 9

15 Activation of the G-protein coupled formyl peptide receptor 2 (ALX/FPR2) by the lipid mediat

16 tide receptor-like 1 and its mouse homologue formyl peptide receptor 2 (FPR2) are G protein-coupled r

17 Formyl peptide receptor 2 (FPR2) emerges as a central re

18 Formyl peptide receptor 2 (FPR2) is a chemoattractant re

19 Neutrophils expressing formyl peptide receptor 2 (FPR2) play key roles in host

20 Selective agonists and antagonists of formyl peptide receptor 2 (Fpr2) suggested that Fpr2 med

21 timization of a peptidomimetic antagonist of formyl peptide receptor 2 (FPR2) was explored by an appr

22 Formyl peptide receptor 2 (FPR2), a classical chemoattra

23 Here we report that formyl peptide receptor 2 (Fpr2/3) null mice display a m

24 ding and activation of the human and mouse N-formyl peptide receptor 2 (huFPR2).

25 hat TNF-alpha up-regulated the expression of formyl peptide receptor 2 (mFPR2) in mouse microglial ce

26 ike 1 (FPRL1) and its mouse homologue murine formyl peptide receptor 2 (mFPR2) mediate the chemotacti

27 SAnxA1 bound and activated formyl peptide receptor 2 in a similar way as the parent

28 een phosphatidylserine on the dying cell and formyl peptide receptor 2 on the phagocytosing microglia

29 regulation of ALX/FPR2 (lipoxin A4 receptor/formyl peptide receptor 2) expression.

30 ceptor-2 (FPR2/ALX) and in mFPR2(-/-) (mouse formyl peptide receptor 2) mice lacking the mouse homolo

31 s by airway epithelial cells in an ALX/FPR2 (formyl peptide receptor 2) receptor-dependent manner.

32 roteins, namely protein phosphatase 5 (PP5), formyl peptide receptor 2, and annexin 1.

33 We investigated airway levels of formyl peptide receptor 2-lipoxin receptor (FPR2/ALXR),

34 th human FPRL1 or its mouse ortholog, murine formyl peptide receptor 2.

35 as shown by experiments with DCs lacking the formyl peptide receptor 2.

36 ayed specific binding to the AnxA1 receptor (formyl peptide receptor 2/Lipoxin A4 receptor [FPR2/ALX]

37 Endothelial-bound cathelicidin activates formyl-peptide receptor 2 on classical monocytes, result

38 Here we tested whether the formyl-peptide receptor 2/3 (Fpr2/3)--ortholog to human

39 e, we tested whether the lipoxin A4 receptor formyl-peptide receptor 2/3 (Fpr2/3; ortholog to human F

40 LL-37, via formyl peptide receptor-2 (FPR-2), triggered the release

41 ocortin-4 receptor, the Smoothened receptor, formyl peptide receptor-2 (FPR2), the relaxin receptor (

42 ll interfering RNA-induced knockdown of LXA4 formyl peptide receptor-2 (FPR2/ALX) and in mFPR2(-/-) (

43 293 cells, confirming the use of FPRL1/mouse formyl peptide receptor-2 by CRAMP.

44 cells transfected with either FPRL1 or mouse formyl peptide receptor-2, the mouse homologue of FPRL1,

45 Formyl peptide receptor 3 (Fpr3, also known as Fpr-rs1)

46 c peptide WKYMVm, a selective agonist of the formyl peptide receptor, a 2-fold increase in leukocyte

47 Formyl peptide receptor activation of three mitogen-acti

48 ed gut epithelial cells resulted in specific formyl peptide receptor activation.

49 an intracellular metabolic wave responds to formyl peptide receptor agonists, but not antagonists, b

50 formulate requirements for these specific N-formyl peptide receptor agonists.

51 the role of the inside-out signaling through formyl peptide receptor and CXCR4 in the regulation of a

52 t for two chemoattractant receptor subtypes, formyl peptide receptor and formyl peptide receptor-like

53 t disrupting the ternary complex between the formyl peptide receptor and G alpha(i2).

54 The solubilized N-formyl peptide receptor and Galpha(i3) protein interacte

55 tin polymerization to prevent exocytosis via formyl peptide receptor and Rho kinase signaling pathway

56 -independent pathways of activation by the N-formyl peptide receptor and the chemokine receptors, and

57 we generated a fusion protein between the N-formyl peptide receptor and the G(alpha)(i2) protein.

58 n of MMP-1 secretion was inhibited by both a formyl peptide receptor antagonist and pertussis toxin,

59 We conclude that formyl peptide receptors are coupled to three MAPK casca

60 Formyl peptide receptors are G-protein-coupled, seven-tr

61 of the G(i)-protein-coupled high-affinity N-formyl peptide receptor by f-met-leu-phe and HIV-derived

62 Activation of the low-affinity N-formyl peptide receptor by the HIV-derived F-peptide sup

63 N-formyl peptide receptors comprise a group of Gi-coupled

64 Ternary complexes were assembled using three formyl peptide receptor constructs (wild type, formyl pe

65 We found that formyl peptide receptor could use the endogenous Rac1 as

66 togen-activated protein kinase pathway in an formyl peptide receptor-dependent manner, delineating a

67 rophils, but not nonclassical monocytes in a formyl-peptide receptor-dependent manner.

68 iate these effects, whereas recognition by N-formyl peptide receptor family members was dispensable.

69 e supernatants and a potent agonist at human formyl peptide receptor (FPR) 1.

70 emotaxis, suggesting that this peptide binds formyl peptide receptor (FPR) 2.

71 PSMs exert their function by binding to the formyl peptide receptor (FPR) 2.

72 an endogenous anti-inflammatory circuit via formyl peptide receptor (FPR) 2/lipoxin receptor (ALX) (

73 ta3 in lymphocytes, we coexpressed the human formyl peptide receptor (fPR) and alphaIIb beta3, findin

74 encoding two seven-transmembrane receptors, formyl peptide receptor (FPR) and formyl peptide recepto

75 stributions of two separate receptors, the N-formyl peptide receptor (FPR) and the high-affinity IgE

76 o two different G protein-coupled receptors (formyl peptide receptor (FPR) and the low affinity formy

77 In humans and rabbits, the formyl peptide receptor (FPR) binds N-formyl-Met-Leu-Phe

78 The formyl peptide receptor (FPR) couples to pertussis toxin

79 The formyl peptide receptor (Fpr) family is well known for i

80 G protein-coupled receptor belonging to the formyl peptide receptor (FPR) family, conveys the biolog

81 O receptors comprising 5 of 7 members of the formyl peptide receptor (FPR) family.

82 We asked whether the human neutrophil N-formyl peptide receptor (FPR) forms dimers in Chinese ha

83 rt that following receptor activation, the N-formyl peptide receptor (FPR) forms distinct membrane cl

84 ulation; and 3) potential involvement of the formyl peptide receptor (FPR) in the protective action d

85 timulation of numerous GPCRs including the N-formyl peptide receptor (FPR) initiates rapid cell round

86 The formyl peptide receptor (FPR) is a chemotactic G protein

87 The human N-formyl peptide receptor (FPR) is a member of the family

88 The formyl peptide receptor (FPR) is a prototypical chemoatt

89 The human formyl peptide receptor (FPR) is a prototypical G(i) pro

90 enth transmembrane domain of the chemotactic formyl peptide receptor (FPR) is highly conserved among

91 The human N-formyl peptide receptor (FPR) is representative of a gro

92 One of the major functions of the N-formyl peptide receptor (FPR) is to mediate leukocyte de

93 Leu-Phe binding site in the human neutrophil formyl peptide receptor (FPR) lies in the predicted tran

94 ulture filtrates appeared to act through the formyl peptide receptor (FPR) of PMNs, since it was foun

95 eptide, cFLFLFK-PEG-(64)Cu, that targets the formyl peptide receptor (FPR) on leukocytes is described

96 The formyl peptide receptor (FPR) on neutrophils, which bind

97 ed to express cloned prototype chemotactic N-formyl peptide receptor (FPR) or its variant, FPR-like 1

98 E neutrophils in a dose-dependent manner via formyl peptide receptor (FPR) stimulation.

99 ibit diminished chemotaxis and low levels of formyl peptide receptor (FPR) surface expression.

100 To understand the role of arrestins in N-formyl peptide receptor (FPR) trafficking, we stably exp

101 Following activation by ligand, the N-formyl peptide receptor (FPR) undergoes processing event

102 The specific role of the high affinity formyl peptide receptor (FPR) was then tested using spec

103 The N-formyl peptide receptor (FPR), a G protein-coupled recep

104 s of members of the arrestin family with the formyl peptide receptor (FPR), a member of the GPCR fami

105 alyses of molecular assemblies involving the formyl peptide receptor (FPR), a well described member o

106 mined this mechanism in the context of the N-formyl peptide receptor (FPR), a well-characterized memb

107 The fMLF binding to its receptor, formyl peptide receptor (FPR), resulted in significant a

108 By contrast, formyl peptide receptor (FPR), the primary fMLP receptor

109 In the case of the N-formyl peptide receptor (FPR), these latter two processi

110 f phosphorylation deficient mutants of the N-formyl peptide receptor (FPR), we have explored the role

111 Human formyl peptide receptor (FPR)-like 1 (FPRL1) and its mou

112 Our investigation of formyl peptide receptor (FPR)-mediated chemotaxis reveal

113 did not show NF-kappaB activation, whereas N-formyl peptide receptor (FPR)-transfected HL-60 cells we

114 d phosphorylation-deficient mutants of the N-formyl peptide receptor (FPR).

115 nd-dependent signaling by the G(i)-coupled N-formyl peptide receptor (FPR).

116 eceptor phosphorylation in the case of the N-formyl peptide receptor (FPR).

117 eptor for N-formylated chemotactic peptides, formyl peptide receptor (FPR).

118 recombinant human phagocyte chemoattractant formyl peptide receptor (FPR).

119 d activation of a specific G-protein-coupled formyl peptide receptor (FPR).

120 The expression of the genes encoding formyl peptide receptor (FPR)1 and FPR2, the high- and l

121 R4-initiated signaling events that couple to formyl peptide receptor (FPR)1 mRNA stabilization, macro

122 -37pA induces calcium and chemotaxis through formyl peptide receptor (FPR)2/ALX, whereas its D-stereo

123 luding one compound previously shown to be a formyl peptide receptor (FPR/FPRL1) agonist.

124 the classical chemoattractant C5a (C5aR) or formyl peptide receptors (fPR).

125 he-Leu-Phe-Leu-Phe (Boc-2), an antagonist of formyl peptide receptors (FPR/FPRL1).

126 This suggests that the formyl-peptide receptor (FPR) and its variant FPRL1 (FPR

127 G-protein-coupled receptors, members of the formyl-peptide receptor (FPR) family, appear to mediate

128 peptide Ac2-26 occurred via receptors of the formyl-peptide receptor (FPR) family, most likely FPR-rs

129 s a noncanonical GRK that phosphorylated the formyl peptide receptor FPR1 and facilitated neutrophil

130 N-formyl peptide receptor (FPR1) and N-formyl peptide rece

131 an G protein-coupled receptor related to the formyl peptide receptor (FPR1), was expressed in Sacchar

132 luminal casts depends on the high-affinity N-formyl peptide receptor, Fpr1.

133 The neutrophil formyl peptide receptors, FPR1 and FPR2, play critical r

134 15-epi-LXA4 activated formyl peptide receptor (FPR2) and GPR120 on alternative

135 The N-formyl peptide receptors (FPRs) are a family of G-protei

136 N-formyl peptide receptors (FPRs) are critical regulators

137 N-Formyl peptide receptors (FPRs) are G protein-coupled re

138 Formyl peptide receptors (FPRs) are G-protein-coupled re

139 Wild-type and 35 mutant formyl peptide receptors (FPRs) were stably expressed in

140 cular reference to the potential role of the formyl peptide receptors (FPRs), a family of G-protein-c

141 cquisition of neuronal specificity by immune formyl peptide receptors (Fprs).

142 te ERK pathway activity via interaction with formyl peptide receptors (FPRs).

143 sion of mRNAs for annexin A1 (AnxA1) and the formyl peptide receptors [(Fprs) 1, 2, and 3], a loss of

144 Wild type formyl peptide receptors (FPRwt) and receptors deleted o

145 The N-formyl peptide receptor-G protein interactions were inhi

146 In addition to formyl peptide receptor, Galpha(16) also enhanced NF-kap

147 rmyl peptide receptor constructs (wild type, formyl peptide receptor-Galpha(i2) fusion, and formyl pe

148 S can markedly enhance the expression of the formyl peptide receptor gene (FPR1) in mouse macrophages

149 The formyl peptide receptor gene family contains three membe

150 rmyl peptide receptor-Galpha(i2) fusion, and formyl peptide receptor-green fluorescent protein fusion

151 ligand-receptor interactions with the murine formyl peptide receptor homologs.

152 These include the human formyl peptide receptor, human trace amine-associated re

153 of various mutants of PI 3-kinase with the N-formyl peptide receptor identified a link to class Ia PI

154 This first report of a functional formyl peptide receptor in cells of fibroblast origin op

155 ecently presented evidence for a role of the formyl peptide receptor in vivo.

156 otaxis was not due to a diminished number of formyl peptide receptors in either murine or human PMNs,

157 we identified the expression of functional N-formyl peptide receptors in model SK-CO15 intestinal epi

158 Stimulation of formyl peptide receptors increases the mitochondrial mem

159 drial ATP production and requires an initial formyl peptide receptor-induced Ca(2+) signal that trigg

160 7SH cells, activation of the chemoattractant formyl peptide receptor induces cortical actin polymeriz

161 eins were previously reported to function as formyl peptide receptor inhibitors.

162 ressive periodontitis to study Fc receptors, formyl peptide receptor, Interleukin-6, tumor necrosis f

163 The N-formyl peptide receptor is a G protein-coupled transmemb

164 Human G protein-coupled formyl peptide receptor like 1 (FPRL1) and its mouse hom

165 Human formyl peptide receptor like-1 (FPRL-1) receptor, origin

166 We chose to study formyl peptide receptor like-1 (FPRL1), a chemotactic re

167 The human G-protein-coupled formyl peptide receptor-like 1 (FPRL1) and its mouse hom

168 ed by an agonistic ligand MMK-1 specific for formyl peptide receptor-like 1 (FPRL1) and vice versa, s

169 Formyl peptide receptor-like 1 (FPRL1) is a G protein-co

170 nctions of cathelicidin are mediated through formyl peptide receptor-like 1 (FPRL1), we hypothesize t

171 receptors, formyl peptide receptor (FPR) and formyl peptide receptor-like 1 (FPRL1), which are with h

172 ough the use of a G protein-coupled receptor formyl peptide receptor-like 1 (FPRL1), which has been r

173 Ca(2+) mobilization in, human monocytes and formyl peptide receptor-like 1 (FPRL1)-transfected human

174 N-formyl peptide receptor (FPR1) and N-formyl peptide receptor-like 1 (FPRL1, now known as FPR2

175 Human formyl peptide receptor-like 1 and its mouse homologue f

176 ways involving a G protein-coupled receptor (formyl peptide receptor-like 1 in migration) and the epi

177 ith WRW4, an antagonist of the transmembrane formyl peptide receptor-like 1 protein attenuated LL-37'

178 ion (P < 0.001, r = 0.55) was found with the formyl peptide receptor-like 1 protein that mediates che

179 xis of human phagocytic cells to a number of formyl peptide receptor-like 1-specific ligands but had

180 ceptor subtypes, formyl peptide receptor and formyl peptide receptor-like 1.

181 peptide receptor (FPR) and the low affinity formyl peptide receptor-like-1 (FPRL1)) to initiate a si

182 d by MMK-1, an agonistic ligand specific for formyl peptide receptor-like-1 (FPRL1), and vice versa,

183 lial cells occurs via recently characterized formyl peptide receptors located in the plasma membrane.

184 This system takes advantage of the lack of formyl peptide receptor-mediated response in COS-phox ce

185 high affinity ligand-binding state in the N-formyl peptide receptor (NFPR).

186 migratory events through interactions with n-formyl peptide receptors (nFPRs), we examined the expres

187 the binding of fluorescent peptide to the N-formyl peptide receptor of neutrophils at 37 degrees C h

188 cyl-phenylalanyl-lysine-fluorescein to the N-formyl peptide receptor on human neutrophils were charac

189 leukemia (RBL) cell lines expressing either formyl peptide receptor or FPRL1, Quin-C1 induced enzyme

190 (2+)-mobilizing G protein-coupled receptors (formyl peptide receptor, P2Y2 purinergic receptor, and c

191 ven luciferase reporter, Galpha(16), and the formyl peptide receptor responded to fMLP with a approxi

192 ytometer, we determined that there are two N-formyl peptide receptor states for human neutrophils at

193 ed ERK and p38 MAPK signaling in response to formyl peptide receptor stimulation.

194 ulation and cAMP accumulation in response to formyl peptide receptor stimulation.

195 sing events and cellular responses for the N-formyl peptide receptor system on human neutrophils as a

196 rat basophilic leukemia-2H3 cells expressing formyl peptide receptor, the PKG inhibitors KT5823 and R

197 parison of the coupling of the beta(2)AR and formyl peptide receptor to G(ialpha2) revealed receptor-

198 To study the signaling pathway from the N-formyl peptide receptor to the actin cytoskeleton, we de

199 These results demonstrate that Lsc links formyl-peptide receptors to RhoA signaling pathways that

200 Using formyl peptide receptor-transfected U937 cells, we furth

201 Formyl-peptide receptor type 2 (FPR2), also called ALX (

202 Formyl-peptide receptor type 2 (FPR2; also called ALX be

203 An expression vector coding for the N-formyl peptide receptor was microinjected into porcine a

204 es C by the six different agonists for the N-formyl peptide receptor were measured.

205 centration-dependent reconstitution of the N-formyl peptide receptor with endogenous G proteins.

206 hetic peptide, WKYMVm, a potent activator of formyl peptide receptors with preference for FPRL1 was d

207 icro-opioid, D(1)dopamine, and neutrophil N -formyl peptide receptors with the predictions of our mod