ライフサイエンスコーパス: formylate

1 indicated that the amino group of Val226 is formylated.

2 eaction was the use of iron pentacarbonyl to formylate an aryllithium when DMF and methyl formate pro

3 n (S5 and S27 also appeared to be internally formylated and acetylated, respectively).

4 a-toxin accumulated in the culture medium in formylated and deformylated forms.

5 alpha,beta-Unsaturated imides, formylated at the nitrogen atom, comprise a new and valu

6 receptors that respond to proinflammatory N-formylated bacterial peptides (e.g., formyl-Met-Leu-Phe,

7 id expansion of CD8+ T cells by presenting N-formylated bacterial peptides.

8 bsequent superoxide release triggered by the formylated bacterial tripeptide formyl-Met-Leu-Phe, and

9 onjugated BODIPYs in high yields by treating formylated BODIPYs with alkyl/aryl ylides under simple r

10 vector, the levels of PDF were increased and formylated BST was undetectable.

11 hmtRNA(Met) that can be aminoacylated is not formylated by the mitochondrial Met-tRNA transformylase

12 , G-protein-coupled phagocyte receptor for N-formylated chemotactic peptides, formyl peptide receptor

13 In contrast, only formylated delta-toxin accumulated after the early poste

14 ncides with the transition to producing only formylated delta-toxin and results in an increased infla

15 nd neutrophil chemotactic activity only with formylated delta-toxin.

16 ptide deformylase has been developed using a formylated dipeptide, formyl-Met-Leu-p-nitroanilide, as

17 isplays Michaelis-Menten kinetics toward the formylated dipeptide, with K(M) = 20.3 +/- 1.3 microM, k

18 Strikingly, the amino group of GAR that is formylated during the reaction lies at 2.8 A from one of

19 gh M3-restricted CTLs preferably recognize N-formylated epitopes, i.e., those of mitochondrial or pro

20 that 5-formylTHF is a storage form of excess formylated folates in mammalian cells.

21 Existence of formylated folates in RBCs only from individuals with th

22 A portion of Met-tRNA(Met) is formylated for initiation, whereas the remainder is used

23 omolar concentrations of an amino-terminal N-formylated hexapeptide, fMIGWII, targeted cells for lysi

24 ially available pyrazoles were alkylated and formylated in a regiocontrolled manner to give pyrazole-

25 e initiator tRNA is aminoacylated but is not formylated in H. volcanii.

26 This compound was then formylated in the 6-position.

27 dithienyl-borondipyrromethene (BODIPY) dyes formylated in the beta'-position (2b, 2c) have been trea

28 In contrast, the initiator Met-tRNA is formylated in the respective "wild-type" parental strain

29 acteria, can at least to some extent utilize formylated initiator Met-tRNA to initiate protein synthe

30 chloroplasts is widely believed to require a formylated initiator methionyl tRNA (fMet-tRNA(fMet)) fo

31 itochondria and chloroplasts normally uses a formylated initiator methionyl-tRNA (fMet-tRNA(f)(Met)).

32 chloroplasts is widely believed to require a formylated initiator methionyl-tRNA (fMet-tRNAfMet) in a

33 erevisiae were synthesized in the absence of formylated initiator tRNA.

34 Formylated Met-Leu-Phe (fMLF) is shown to stimulate a ra

35 hils stimulated with the chemotactic peptide formylated Met-Leu-Phe (fMLP) demonstrated transient PS

36 ynthetic respiratory defect in cells lacking formylated Met-tRNA(f)(Met) due to loss of the MIS1 gene

37 s accessory factor might be unnecessary when formylated Met-tRNA(f)(Met) is present but becomes essen

38 the pattern did not change in cells lacking formylated Met-tRNAfMet.

39 protein synthesis in bacteria begins with a formylated methionine, the formyl group of the nascent p

40 , where new peptides are initiated with an N-formylated methionine.

41 ted peptides and higher affinities than some formylated mitochondrial peptides.

42 90; MLIIWG; MLIIWGV; and MLIIWGI, as well as formylated MLIIW.

43 ophages effectively, suggesting that these N-formylated Mtb peptides are presented as the naturally p

44 ungs, spleen, and lymph nodes responded to N-formylated Mtb peptides in an M3-restricted manner.

45 Four of the N-formylated Mtb peptides were able to elicit cytotoxic T

46 id polypeptide secreted predominantly with a formylated N-terminal methionine, which led us to invest

47 the origin of the enzyme's specificity for N-formylated over N-acetylated substrates.

48 J774 cells did not migrate toward the formylated peptide (fMet-Leu-Phe; fMLF), and chemotaxis

49 is that an interaction with the receptor for formylated peptide (FPR), so far reported only in vitro,

50 Pseudopod growth was stimulated using N-formylated peptide (N-formyl-methionyl-leucyl-phenylalan

51 The lack of endogenous N-formylated peptide allows discovery of novel pathogen-de

52 ed T-cell response is T cells that recognize formylated peptide antigens presented by M3 molecules.

53 We now present evidence that the formylated peptide f-Met-Leu-Phe (fMLP), a bacterial che

54 tion enhances the neutrophil response to the formylated peptide FMLF, leading to increased reactive o

55 d whether hPepT1 could transport the model n-formylated peptide fMLP and, if so, whether such cellula

56 tors; the systemic administration of Boc2, a formylated peptide receptor (fpr) antagonist, abrogated

57 contribution from P2'and P3' positions of a formylated peptide substrate to turnover.

58 rified deformylase is highly active toward N-formylated peptide substrates.

59 n response to tumor necrosis factor (TNF) or formylated peptide.

60 Formylated peptides (e.g. n-formyl-Met-Leu-Phe (fMLP)) a

61 by prior exposure to the chemoattractants N-formylated peptides (fMLP) or a complement cleavage prod

62 mponent of the bacterial outer membrane, and formylated peptides (fMLP), a bacterial-derived peptide,

63 the fifth component of complement (C5a) or n-formylated peptides (formylmethionylleucylphenylalanine,

64 lls with cDNAs encoding receptors for either formylated peptides (FR), a product of the fifth compone

65 ptors for platelet-activating factor (PAFR), formylated peptides (FR), or interleukin-8 (CXCR1) were

66 nociceptor neurons, in part via bacterial N-formylated peptides and the pore-forming toxin alpha-hae

67 Bacterial formylated peptides are important chemotactic molecules

68 de deformylase using a series of synthetic N-formylated peptides as substrates.

69 Endogenous formylated peptides can come from the N-terminus of each

70 Although three N-formylated peptides derived from L. monocytogenes are kn

71 omplex (MHC) class Ib molecule H2-M3 binds N-formylated peptides from mitochondria and bacteria.

72 cell surface by addition of high-affinity N-formylated peptides from mitochondria and listeria.

73 Our data show that formylated peptides function as important virulence fact

74 Given the presence of formylated peptides in bacteria and mitochondria, possib

75 The role of formylated peptides in S. aureus infections has been unk

76 involved in a signaling pathway triggered by formylated peptides leading to the selective activation

77 whereas tapasin is critical for loading of N-formylated peptides onto the intracellular pool of M3.

78 Formylated peptides produced as a byproduct of bacterial

79 s Ib molecule that preferentially presents N-formylated peptides to CD8(+) T cells.

80 MHC class Ib molecule H2-M3 presents N-formylated peptides to CD8+ CTLs.

81 ty complex class Ib molecule that presents N-formylated peptides to cytotoxic T cells.

82 However, the signaling pathway triggered by formylated peptides to integrin activation and leukocyte

83 Addition of N-formylated peptides to TAP(o) cells stabilizes M3 in the

84 s that appeared to be involved in binding of formylated peptides were located at sites analogous to t

85 T cells, which recognize short hydrophobic N-formylated peptides, appear to comprise a substantial po

86 Upon addition of exogenous N-formylated peptides, M3 trafficks rapidly to the cell su

87 to the classic bacterial chemoattractants, n-formylated peptides, or other soluble bacterial factors.

88 chemokines, such as interleukin-8, bacterial formylated peptides, platelet-activating factor, leukotr

89 n is catalytically active in deformylating N-formylated peptides, shares many of the properties of ba

90 Recent reports have indicated that non-formylated peptides, such as MMWLL can also activate thi

91 of the mouse with a unique preference for N-formylated peptides, which may come from the N-termini o

92 in (Deltafmt) lacking the ability to produce formylated peptides.

93 release pro-inflammatory molecules including formylated peptides.

94 e in degrading bacterial and mitochondrial N-formylated peptides.

95 in-deficient mice, even in the presence of N-formylated peptides.

96 Ib molecule with a high propensity to bind N-formylated peptides.

97 xin A4 receptor, a low affinity receptor for formylated peptides; and 4) either highly conserved or d

98 covalent thiohemiacetal was formed between a formylated phosphotyrosine analog and the thiol side cha

99 The 3-formylated product was reduced to the 3-methyl derivativ

100 cell folate and was inversely related to the formylated proportion of red blood cell folates (P < 0.0

101 previously unreported) accumulation of an N-formylated protein species.

102 The formylated resorcinarene reacts easily with primary alip

103 binding peptides representing the N-terminal formylated sequences from five Cpn Ags sensitized target

104 N-terminally formylated signal peptide fragments with variable sequen

105 in the mitochondria, along with its putative formylated substrates; however, the cellular function of

106 The structure of the formylated sugar nucleotide generated in vitro by ArnA w

107 We further demonstrate that only the formylated sugar nucleotide is converted in vitro to an

108 n was found as manifested by the presence of formylated tetrahydrofolate polyglutamates in addition t

109 rary that contains all possible N-terminally formylated tetrapeptides was constructed on TentaGel res

110 in amine of ornithine, which is subsequently formylated to generate the iron-chelating hydroxamates o

111 neutrophil chemoattractants, particularly N-formylated tripeptides and possibly leukotriene B(4) and

112 ding neutrophil chemotactic agents such as N-formylated tripeptides, have all been refuted by recent

113 , as well as the low relative affinity for N-formylated tripeptides, suggest that neither the copurif

114 Neither ligand is displaced by added N-formylated tripeptides.

115 In addition, the [alpha-(32)P]UDP-l-Ara4N is formylated when N-10-formyltetrahydrofolate is included.