ライフサイエンスコーパス: forward genetics

1 nesis screen (phenotype-based mutagenesis or forward genetics).

2 germline mutagenesis and positional cloning (forward genetics).

3 and behavior will likely continue to rely on forward genetics.

4 hat have resulted from these applications of forward genetics.

5 using mouse reverse genetics and Drosophila forward genetics.

6 s become the rate limiting step in mammalian forward genetics.

7 tional consequences of mutations obtained by forward genetics.

8 T-DNA insertion collection with traditional forward genetics.

9 ng epidermal barrier formation identified by forward genetics.

10 sis for functional genome annotation through forward genetics.

11 reen for complex I defects, we isolated, via forward genetics, amc1-7 nuclear mutants (for assembly o

12 Independently, forward genetics analysis identified a quantitative trai

13 Here, we integrate forward genetics and biochemistry to gain insights into

14 Using a combination of forward genetics and cytological screening, we uncover a

15 ide a model system in which a combination of forward genetics and live-cell imaging can allow researc

16 Maize, with its excellent forward genetics and male sterility screens, was used to

17 Using forward genetics and quantitative behavioral studies, we

18 one of two distinct lines of investigation: forward genetics and reverse genetics approaches.

19 nas aeruginosa but instead conduct classical forward genetics and select for mutations in a single ge

20 de, including the identification of genes by forward genetics and the study of natural ionomic variat

21 throughput model for developmental biology, forward-genetics, and drug discovery.

22 We used a forward genetics approach and mapped the locus determini

23 ere we develop an alternative to the classic forward genetics approach for dissecting complex disease

24 We conclude with an assessment of a forward genetics approach for identifying genes involved

25 nd milder in C57BL/6 (B6) mice has allowed a forward genetics approach for the identification of gene

26 Using a forward genetics approach in cells coinfected with BTV-1

27 Here, by using a forward genetics approach in mice, we describe the isola

28 The forward genetics approach proceeds from measurable pheno

29 RNA interference (RNAi) presents a powerful forward genetics approach to dissect virus-host cell int

30 In this study, we used a forward genetics approach to identify a mutant mouse str

31 This study illustrates the power of this forward genetics approach to identify atypical virulence

32 Here, we used a forward genetics approach to investigate the mechanism o

33 insertional mutagenesis is a high-throughput forward genetics approach to randomly disrupt (trap) hos

34 Here we employ a forward genetics approach to understand MEP pathway regu

35 Using the forward genetics approach, a suppressor line, termed as

36 Using a forward genetics approach, one nonsense and four missens

37 Using this forward genetics approach, several genes were identified

38 Using a forward genetics approach, we identified the lysosomal e

39 Using a forward genetics approach, we identify a penicillin-bind

40 Using a forward genetics approach, we identify a unique ETI-asso

41 By using a forward genetics approach, we isolated a novel mutant al

42 the primary aims of genetic studies using a forward genetics approach.

43 Our results substantiate the use of a forward-genetics approach for studying sleep behaviours

44 t endomembranes, namely optical tweezers and forward genetics approaches, which are based either on t

45 S, a TM mutation recently identified through forward genetics as a cell culture-adaptive mutation.

46 sis WAVE-DAMPENED 2 (WVD2) was identified by forward genetics as an activation-tagged allele that cau

47 es the power with which RNA interference and forward genetics can be used to expose the dependencies

48 The application of forward genetics can reveal new factors required for the

49 These examples of forward genetics contrast with reverse genetic approache

50 Using a forward genetics ENU mutagenesis screen for recessive mu

51 Classical forward genetics first discovered its immune role in 200

52 ay explores how classical approaches such as forward genetics fit into this emerging framework.

53 e results clearly demonstrate the utility of forward genetics for the discovery of novel genes and pa

54 newal, and illustrates the power of RNAi and forward genetics for the systematic study of self-renewa

55 However, their utility for phenotype-driven forward genetics has been hampered by the difficulty of

56 out an active circulation and amenability to forward genetics has led to the identification of numero

57 Forward genetics identified regulators of lysosomal traf

58 eferred to as Cacng2) has been identified by forward genetics in a spontaneous mouse mutant with atax

59 MutChromSeq enables reference-free forward genetics in barley and wheat, thus opening up th

60 the rate-limiting step, inhibiting unbiased forward genetics in even the most tractable model organi

61 ighlight the potential for GWA to complement forward genetics in identifying the genetic basis of eco

62 g Beauty (SB), the possibility of performing forward genetics in mice has been reinforced.

63 Using forward genetics in mice, we identified an orphan protei

64 To facilitate forward genetics in Neurospora, we have adapted microarr

65 sults showcase the promise of genome-enabled forward genetics in nonmodel species.

66 estigate rosette development, we established forward genetics in S. rosetta.

67 ns that will greatly facilitate the power of forward genetics in vertebrate models.

68 commonly relied on the classical methods of forward genetics, integration of different genomics data

69 ved to be responsible for these disorders, a forward genetics method of gene discovery was used to id

70 the conventional cloning approach and makes forward genetics more feasible and powerful in molecular

71 Empowered by forward genetics, research using Caenorhabditis elegans

72 Using a confocal microscopy forward genetics screen for the identification of Arabid

73 of the auditory sense organs, we performed a forward genetics screen in mice.

74 ed a virus-induced gene-silencing-based fast-forward genetics screen in Nicotiana benthamiana.

75 A forward genetics screen led to the identification of the

76 isolated through a confocal microscopy-based forward genetics screen of the Golgi in Arabidopsis thal

77 nce to biotrophic fungal pathogens, we did a forward-genetics screen using Medicago truncatula Tnt1 r

78 date candidate oncogenic drivers of HCC in a forward genetics screening approach.

79 Transposon-mediated forward genetics screening in mice has emerged as a powe

80 utation cloning will enable broader usage of forward genetics screens and have significant impacts in

81 Forward genetics screens in mice have facilitated the id

82 had been identified previously in extensive forward genetics screens using induced mutants, suggesti

83 for mapping new mutations generated through forward genetics screens.

84 are considered primarily through the lens of forward genetics, starting at the organismal level and p

85 nthesis of alpha-(1,3)-glucan, we employed a forward genetics strategy to isolate physically marked m

86 Numerous forward genetics studies have been performed in Chlamydo

87 abilities such as efficient transposon-based forward-genetics technologies for Anopheles mosquitoes n

88 Absent are powerful forward-genetics technologies, such as enhancer and gene

89 Classical forward genetics, the identification of genes responsibl

90 etter understand the genetic factors we used forward genetics to discover genes that have not previou

91 a powerful vertebrate model system for using forward genetics to elucidate mechanisms of early develo

92 We used forward genetics to identify duplicate T-DNA insertions

93 We used forward genetics to identify the causative gene underlyi

94 Here we use mathematical modelling and forward genetics to reduce an asymmetric cell cycle to i

95 Here we used forward genetics to search for mechanisms underlying nat

96 ene silencing, is a widely used reverse- and forward-genetics tool in plant functional genomics.

97 Forward genetics was used to isolate Chlamydomonas reinh

98 B than type I or type III strains, and using forward genetics we found that this difference is a resu

99 Through forward genetics, we have identified a new mutant with e

100 Using forward genetics, we identified Arabidopsis SP1, which e

101 Using forward genetics, we identify a gene associated with mid

102 Using mouse forward genetics, we report what is, to our knowledge, t

103 advantages of in vivo imaging, the power of forward genetics, well-established high efficiency for t

104 s, together with both classical and chemical forward genetics, were consistent with flux through the

105 approach combines the strength of Drosophila forward genetics with detailed in vivo imaging of ddaC n

106 study in Drosophila, synthesizing classical forward genetics with DNA microarrays, brings us closer

107 Using forward genetics with progeny from a type II x type III