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1 ave developed densities sufficiently high to founder.
2 otype of 1 Mb around LMNA suggested a common founder.
3 % of Sur-TCR-Tg mice derived from 3 separate founders.
4 in three RAG1/RAG2 double-gene mutant (DGM) founders.
5 d multiple lines of single-gene mutant (SGM) founders.
6 ickly and efficiently generate mutant rabbit founders.
7 per-mantle remnant from earlier lithospheric foundering.
8 antitumor efficacy for the anti-HER2 ADCs in Founder 5 was observed with tumor stasis at 0.5-1 mg/kg,
10 predictions using biological invasions since founder alien populations start small, compiling the lar
11 cated that c.254-649T > G CLRN1 represents a founder allele that may significantly contribute to deaf
12 8% (104 of 142) were due to a BRCA1 or BRCA2 founder allele, 4.9% (7 of 142) to another BRCA1 or BRCA
13 ing mutations other than the BRCA1 and BRCA2 founder alleles among patients of Ashkenazi Jewish ances
15 nd progenitor cells are characterized by key founder and driver mutations and are enriched for cytoge
19 ry strains are derived from a limited set of founders and thus contain only a small subset of this va
22 onventional genetic breeding schemes, mosaic founder animals carrying mutant alleles are outcrossed t
23 tablish mutant lines, mosaic gene editing in founder animals, and low homologous recombination rates.
25 other organisms, particularly insect pests, foundered because of difficulties in delivering, sustain
26 dure from target design to identification of founders can take as little as 6 weeks, of which <10 d i
27 of hESC colonies arising from more than one founder cell and the minimal cell number needed for succ
31 lerae biofilm as it develops from one single founder cell to a mature biofilm of 10,000 cells, and to
32 sting that the epigenetic landscape within a founder-cell population may contribute to tumor formatio
33 precedes specification of postembryonic root founder cells, from which roots are initiated through th
40 the Yangtze descended from a small number of founders colonizing the river from the sea during the la
41 ested using Xenopus tropicalis, we show that founders containing transplants transmit mutant alleles
42 l conditions of plant trait abundance (i.e., founder controlled) due to feedbacks of leaf traits on s
49 ables than would be expected from the serial founder effect and show signals of environmental adaptat
52 in studying single-gene disorders, where the founder effect has clearly aided in discovery, and more
55 ance to characterize and confirm the Finnish founder effect in sequencing data and to assess its impl
57 rosatellite genotyping demonstrated a common founder effect shared between 3 Scottish patients with a
62 otracted domestication bottleneck and serial founder effects during post-domestication spread, while
64 ese TMEM126B variants, including evidence of founder effects for both variants, and establish defects
65 ation dynamics, with evidence for persistent founder effects in some ponds, but not in others, and wi
66 er greater loss of language elements through founder effects or drift, or do languages with more spea
67 cifically, reductions in genetic diversity ('founder effects') should be stronger for species with lo
69 thward, experiencing genetic bottlenecks and founder effects, which left high haplotype endemism in s
74 Efforts to model DUX4 myopathy in mice have foundered either in being too severe, or in lacking musc
77 50,000 y ago is characterized by a series of founder events as modern humans expanded into multiple c
78 ersity in China has resulted from successive founder events during range expansion, and that the loss
79 es of more than 1 million, that descend from founder events more extreme than those in Ashkenazi Jews
80 ographic history revealed bottlenecks during founder events, likely promoting ecological divergence a
86 gh-resolution analysis of the genomes of the founder fibroblast cells without being confounded by the
87 the F1 generation by inbreeding two injected founder fish, significantly reducing animal husbandry an
89 the risk of hidden inbreeding due to related founders from the same habitat undetectable by pedigree
92 ly methylated in the liver (87.53%) from the founder generation, whereas its methylation rate was muc
94 lation level by studying the prevalence of 6 founder genetic variants present in the Dutch population
95 dings are consistent with expansion of small founder groups into novel niches by an initial plastic b
96 ya and detect a cluster of major non-African founder haplogroups in a narrow time interval at 47-52 k
98 ed that sequence-level investigation of this founder haplotype could provide significant insights int
99 ABCA4 variant c.5461-10T-->C is located on a founder haplotype lacking other disease-causing rare seq
101 7.5 at reduced penetrance) and lies within a founder haplotype that is also shared by 3 otitis-prone
105 rge numbers of crossover (CO) events between founder haplotypes, and thus present a unique opportunit
106 al challenge by a heterosexually transmitted founder HIV strain, suggesting that VIP may be effective
110 conditions and mechanisms required to induce foundering in deep arc crust are assessed using an examp
111 A haplogroup U is among the initial maternal founders in Southwest Asia and Europe and one that best
112 pulations originating from a small number of founder individuals are therefore considered at increase
115 ng essential genes, efficient mutagenesis of founders is often lethal, preventing the acquisition of
117 ge number of contrasting RSA traits among 25 founder lines of the maize nested association mapping po
118 2 generations of free recombination among 60 founder lines, following modification of the mating syst
121 this study, we generated 18 transgenic (TG) founder mice each carrying a salivary gland specific pro
122 ed into foster mothers efficiently generated founder mice with heritable mutations in targeted genes.
125 and patients suggested that gene-edited RTT founder monkeys would be of value for disease mechanisti
126 inical characteristics and outcome of MYBPC3 founder mutation (FG+) HCM with nonfounder genotype-posi
128 mean [SD] age, 30.1 [9.1] years), a Finnish founder mutation c.652C>T (p.Arg218*) in SPINK5 was iden
133 This report discloses a prevalent SPINK5 founder mutation in Finland and illustrates NS phenotype
134 ted mutations in 1.8%, including a recessive founder mutation in GDF1 accounting for approximately 5%
135 We show that a single shared homozygous founder mutation in SGOL1, a component of the cohesin co
138 we identified a rare variant that arose as a founder mutation in the telomere shelterin gene POT1 (ch
141 followed by whole-exome sequencing (WES) and founder mutation screening revealed two truncating rare
145 cate that LMNA p.(Arg331Gln) is a pathogenic founder mutation with a phenotype reminiscent of other L
146 alogical data defined MYBPC3 c.927-2A>G as a founder mutation, introduced into the Icelandic populati
147 , and a consensus Gaucher disease-associated founder mutation-flanking haplotype was fine mapped.
155 7 probands in the study, 903 probands had no founder mutations in BRCA1 or BRCA2; of these probands,
157 y all affected individuals harbor homozygous founder mutations in WDR73 as well as the closely linked
158 sequencing was performed to detect specific founder mutations known to be prevalent in the AJ popula
162 h respectively mimic the 2 most common BRCA1 founder mutations, BRCA1185delAG and BRCA15382insC.
163 rbid genome of ciliopathies encompasses many founder mutations, the combined carrier frequency of whi
164 breast cancer who do not carry one of these founder mutations, the likelihood of carrying another pa
167 , and the types of strategies present in the founder network, the fluctuating population is found to
168 mosomal deletion and severe apoptosis of the founder neuroepithelial stem cells, accompanied by incre
169 demonstrates highly efficient production of founder NHP with SCID phenotypes, with promises of multi
172 ly forming rosettes, which are abundant with founder NSCs and correspond to the early proliferative d
173 kingly, highly precise positioning of single founder nucleosomes by either chimeric Chd1-Ume6 or endo
175 W complex, questioning a role of CENP-T/W as founder of an independent axis of kinetochore assembly.
176 Stiff Stalk germplasm pool, while PH207 is a founder of Iodent germplasm, both of which have contribu
177 ead of its Division of Structural Studies, a Founder of the European Molecular Biology Organization,
180 onal shear zones is proposed to have induced foundering of excised cumulate material at P > 1.2 GPa.
181 ic transcription regulators, are revealed as founders of a new structural family of dimeric DNA-bindi
182 on this haplotype suggests that unlike most founders of human disease, the common ancestor of HD-aff
187 identified spa t011 as one of the two group founders of the main spa CC identified across the five y
188 ial colonists, help relieve inbreeding among founders, or increase the hazard of the invasion, its de
189 itness but did not prevent adaptation if the founders originated from genetically diverse populations
190 waves of functional innovation that involve founder 'p-loop' and 'winged helix' domain structures.
191 ce was itself short-lived and independent of founders' personality; all communities collapsed within
192 e regulation of HMGCR exon 13 skipping, in a founder population and in two distinct mixed North Ameri
194 (LQT1) in 46 members of a South-African LQT1 founder population carrying the clinically severe KCNQ1
195 opulation, a small and historically isolated founder population comprising about 57,000 inhabitants,
196 1x sequence data across the APOC3 gene in a founder population from the island of Crete in Greece (n
198 Whole genome sequencing in 98 Hutterites, a founder population of European descent, and subsequent i
200 ociations are at lead variants unique to the founder population sequences: chr16:70790626 (high-densi
201 nd ~14,000 years ago descended from a single founder population which forms part of the ancestry of p
202 st Europe represents an early branch of this founder population which was then displaced across a bro
205 l-by-descent (IBD) haplotype sharing in this founder population, we conducted a haplotype association
210 Adaptation requires genetic variation, but founder populations are generally genetically depleted.
215 s at the major site of expansion of infected founder populations in the transition zone and adjoining
216 acan maize cultivation evolving from reduced founder populations of isolated and perhaps self-pollina
217 ctive study includes 184 fetuses from 2 LQT1 founder populations segregating p.Y111C and p.R518X (74
218 opulations, corresponding to several ancient founder populations with little evidence of bottlenecks.
219 on method, particularly useful in studies of founder populations, and reaffirm the benefits of studyi
220 ew thousand from strongly bottlenecked human founder populations, and we provide an analytical approx
222 this study including 184 fetuses from 2 LQT1 founder populations, third trimester fetal heart rate di
223 y be useful for studies of complex traits in founder populations, where hidden relationships may augm
226 , including tier 2 or 3 strains, transmitted founders, quasispecies, and soluble sdAb JM4-resistant s
227 , including tier 2 or 3 strains, transmitted founders, quasispecies, and soluble single domain antibo
228 inimal estimates of the number of rebounding/founder (R/F) variants were determined by single-gene am
229 thereby separating alleles derived from the founder's genome from somatic mutations that must drive
230 the target-specific activity of the sgRNAs; founder screening to identify germline-transmitting muta
231 ity of latent membrane protein 1 (LMP1) gene founder sequences and the level of Epstein-Barr virus (E
233 n may play a role in determining transmitted/founder strain number and infection outcomes following i
235 alysis of the core genome confirmed that the founder strain of this lineage originated from a single
236 ctional Taar1 allele, derived from the other founder strain, C57BL/6J, segregates with low MA drinkin
237 ted inversely with the number of transmitted/founder strains among macaques vaccinated with ALVAC-SIV
238 e human signature was reproduced well in the founder strains of the Collaborative Cross (CC) mice, th
239 Taar1 in the DBA/2J mouse strain, one of the founder strains of the selected lines, and show that thi
241 ntly remained clonal with rapid outgrowth of founder-, sub-, or even fully independent clones, indica
242 Reducing mutagenesis levels may improve founder survival, but results in lower, more variable ra
243 compared the immunogenicity of a transmitted-founder (T/F) B clade Env (B.1059), a global group M con
244 Cs rapidly and efficiently bound transmitted/founder (T/F) CCR5-tropic (R5) viruses, transported them
245 studied molecular clones and two transmitted/founder (T/F) clones for their sensitivities to a panel
247 tically recapitulate features of transmitted/founder (T/F) genomes that are of particular interest in
248 cise molecular identification of transmitted/founder (T/F) HCV genomes that lead to productive clinic
250 nAb titers against breakthrough transmitted/founder (T/F) SIVsmE660-derived envelope glycoprotein (E
252 re correlated with the number of transmitted/founder (T/F) variants that established infection, such
255 t were distinct from both of the transmitted/founder (T/F) viruses and that efficiently engaged the b
258 lization-resistant phenotypes of transmitted/founder (T/F) viruses that establish infection in humans
259 ms race" occurs in which a HIV-1 transmitted/founder (TF) Env induces autologous neutralizing antibod
261 sensitivity of the breakthrough transmitted/founder (TF) viruses from vaccinated and control animals
262 e somatic mosaicism and allele complexity in founders that occurs for targeted genes during CRISPR/Ca
263 rom a single virus particle (the transmitted/founder) that makes it past these defenses and colonizes
264 gests it to be one of the Ashkenazi paternal founders; to have expanded as part of the overall Ashken
267 nfirmed in embryos generated from two of the founder transgenic marmosets that reached sexual maturit
269 ity to distinguish and enumerate transmitted/founder variants by sequence analysis, we generated a vi
270 taining the ability to enumerate transmitted/founder variants by sequence analysis, we modified the S
271 analyses to evaluate the impact of rare and founder variants on stature in 6,307 individuals on the
272 with multiple phylogenetically linked HIV-1 founder variants represent a minority of HIV-1 infection
276 impact of CTL escape and reversion from the founder virus in HIV infection and contribute to the ide
278 In each case, we determined the transmitted founder virus sequence to identify the autologous epitop
279 to a single, C-C chemokine receptor 5-tropic founder virus with shorter, less glycosylated variable r
280 ferred most recent common ancestor (epidemic founder virus) sequence nearly identical to the modern N
281 that causes infection (i.e., the transmitted/founder virus), we sought to generate and characterize i
282 nted role for the replicative fitness of the founder virus, independent of host protective genes and
283 ms of HCV, including full-length transmitted/founder virus, sucrose-purified Japanese fulminant hepat
287 herwise weakly macrophage-tropic transmitted/founder viruses but restrictive for nonmacrophage-tropic
288 of Vpu proteins from the tested transmitted/founder viruses did not differ from the activity of the
290 to SUN1-mediated inhibition, the transmitted founder viruses RHPA and ZM247 are largely resistant.
291 Analysis of a panel of subtype B transmitted/founder viruses showed that splicing patterns are conser
292 the calculated means of the total number of founder viruses transmitted were 4.5 and 14.5 in the exp
293 primary HIV-1 clones, including transmitted founder viruses, in contrast to the laboratory-adapted N
294 IV-1 primary isolates, including transmitted founder viruses, is diminished by IFITM3 to various leve
296 of the chronic Vpu proteins, the transmitted/founder Vpu proteins trended toward having superior acti
299 d, evenly differentiated mosaic of the eight founders, with mapping power and resolution strengthened
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