ライフサイエンスコーパス: founder effect

1 ies, shaped patterns of collection bias via 'founder effects'.

2 e in 1800 in north-west Puerto Rico due to a founder effect.

3 eles arose independently, thus eliminating a founder effect.

4 ence of the disorder occurs as a result of a founder effect.

5 viremia, thereby fixing a novel genotype by founder effect.

6 diately distal to the MET gene, suggesting a founder effect.

7 high frequency in Ashkenazi Jews suggests a founder effect.

8 the BS mutation in the Ashkenazim is due to founder effect.

9 rin gene of only one haplotype, indicating a founder effect.

10 rom the same ethnic population, suggesting a founder effect.

11 ited retinal dystrophies and is owing to the founder effect.

12 ions of separate compartments to exploit the founder effect.

13 study population is likely due to a British founder effect.

14 ad a homozygous Q289X CARD9 allele, due to a founder effect.

15 ion), which originated as a consequence of a founder effect.

16 r endogamous practices following the initial founder effect.

17 n arise via a selective sweep or through the founder effect.

18 s such as gene flow, self-fertilization, and founder effect.

19 e mutation in all individuals, unravelling a founder effect.

20 eir haplotypes (AGXT*LTM), consistent with a founder effect.

21 1600, and that there is a 14484/haplogroup J founder effect.

22 Haplotype analysis indicated a founder effect.

23 ype at the mal de Meleda locus, suggesting a founder effect.

24 hboring populations and shows no evidence of founder effects.

25 ance, of historic population bottlenecks and founder effects.

26 Arg417*, and p.Gln336Arg) indicated possible founder effects.

27 also ultimately produce new species through founder effects.

28 ported locus homogeneity, and did not detect founder effects.

29 y have not experienced recent bottlenecks or founder effects.

30 in mapping disease genes and in establishing founder effects.

31 single dispersal, accompanied by a series of founder effects.

32 s in additional environmental factors and/or founder effects.

33 ing cave age challenges traditional views on founder effects.

34 t colonization occurred locally and involved founder effects.

35 rent viral lineage and resulting from strong founder effects.

36 lance established in this population through founder effects.

37 ptible to a high false discovery rate due to founder effects.

38 se on other secondary hosts, possibly due to founder effects.

39 as a consequence of separate bottlenecks and founder effects.

40 ently old to have recovered from any initial founder effects.

41 lection for regional diets or of independent founder effects.

42 localization of genetic defects, even when a founder effect accounts for only a fraction of the disor

43 of hyperuricemia and gout, which suggests a founder effect across the Pacific region.

44 storic perturbation of populations including founder effects, admixture, or incomplete selective swee

45 for an ancestral haplotype consistent with a founder effect and an identical-by-descent mutation.

46 nfirms that the disease is probably due to a founder effect and extends the phenotypic spectrum assoc

47 On the basis of this study, we conclude that founder effect and independent mutational events are res

48 ables than would be expected from the serial founder effect and show signals of environmental adaptat

49 in neighboring populations, suggesting that founder effects and genetic drift may have had a conside

50 We tested for evidence of founder effects and genetic isolation in early season po

51 ed experiment in nature, we showed that both founder effects and natural selection jointly determine

52 The relative contribution of founder effects and natural selection to the observed di

53 To determine the respective contributions of founder effects and natural selection, we conducted an e

54 els of haplotype homozygosity, indicative of founder effects and recent population expansion.

55 The combination of founder effects and subpopulation turnover can result in

56 ies complex are rarely accompanied by severe founder effects, and multiple founder events and/or long

57 onization of distal tissues, suggesting that founder effects are limited and there is not a strict li

58 ber of effective founders and indicates that founder effects are weak because island populations are

59 in the spleen and demonstrated the action of founder effects as well as significant variation in the

60 many different mutational events, without a founder effect, as is expected for a disorder with a pre

61 nhanced genetic drift', complementary to the founder effect associated with spatial bottlenecks.

62 oups is probably the result of isolation and founder effects associated with the history of migration

63 an ancient mutation, thus excluding a major founder effect at the OPA1 locus.

64 Haplotype analysis excluded a founder effect at this locus.

65 amily led us to consider the hypothesis of a founder effect being present.

66 e wild can result from bottlenecks (that is, founder effects), biparental inbreeding or self-fertiliz

67 er varying demographic conditions, including founder effects, bottlenecks, and migration, and at vary

68 oexistence and antagonistic effects promoted founder effects (but favored the less exploitative type

69 ombined action of recombination hotspots and founder effects, but cannot be explained by random recom

70 A founder effect can account for the presence of an allele

71 A pronounced founder effect can be observed among mutations arising i

72 Thus, we conclude that genetic drift and founder effect contribute to diversification of individu

73 he mutational data, as well as the role that founder effect, demographic history, and penetrance play

74 cation that largely follows a clinal "serial founder effect" distribution model.

75 does not follow the predictions of a serial founder effect during human expansion out of Africa.

76 decreased phytotoxin production rather than founder effects during introduction and spread.

77 otracted domestication bottleneck and serial founder effects during post-domestication spread, while

78 tional load in populations undergoing serial founder effects during range expansions.

79 the high-geotaxis line was probably due to a founder-effect event.

80 s on chromosome 6p2l.23, suggesting a strong founder effect exerted by a common Celtic ancestor.

81 n disease-associated haplotype, suggesting a founder effect for CFEOM2.

82 nce the loss of genetic diversity due to the founder effect for mutations under frequency-dependent s

83 This presumably reflected a founder effect for the HPS mutation in Puerto Rico.

84 ance from Africa, as expected under a serial founder effect for the out-of-Africa spread of human pop

85 ns, while the mutation distribution suggests founder effects for a few mutations, such as c.866A>G in

86 ese TMEM126B variants, including evidence of founder effects for both variants, and establish defects

87 f similar genetic backgrounds, suggesting a "founder effect" for these mutations.

88 habitats, are likely causes of the observed "founder effects" for the two organisms in the Northeast.

89 in studying single-gene disorders, where the founder effect has clearly aided in discovery, and more

90 ciation studies of complex traits, where the founder effect has had less obvious impacts.

91 on, population migration, genetic drift, and founder effects have shaped the world in which we practi

92 , the latter of which likely resulted from a founder effect, have for 60 y restricted the ability of

93 e, a statistical test of both aspects of the founder-effect hypothesis is developed.

94 zation events could be localized and involve founder effects, impacting genetic diversity, population

95 ses, this is probably the result of a strong founder effect in a geographically circumscribed populat

96 Assuming a founder effect in a large Old Order Amish pedigree, we c

97 cosan body disease mutation explains another founder effect in all Ashkenazi-Jewish cases.

98 mAsh was independently established through a founder effect in Ashkenazic Jews and in immigrants to f

99 disease haplotype associated with a presumed founder effect in families of Mexican-American descent p

100 carried the 964del13 mutation, suggesting a founder effect in our population.

101 sides on a common haplotype, indicative of a founder effect in patients of northern European descent.

102 ance to characterize and confirm the Finnish founder effect in sequencing data and to assess its impl

103 sequilibrium with the mutation, suggesting a founder effect in the Northern European population.

104 ommon as (GCG)(9), evidence against a strong founder effect in the UK population.

105 American families analyzed, substantiating a founder effect in this population.

106 segregating disease chromosome, suggesting a founder effect in this population.

107 families, and haplotype analysis suggested a founder effect in two of them.

108 ttleneck during colonization, resulting in a founder effect in which the most successful mutant varie

109 c clustering, reflecting the central role of founder effects in establishing distinct clades.

110 tic nature of long-distance dispersal causes founder effects in pathogen populations, such that the g

111 ation dynamics, with evidence for persistent founder effects in some ponds, but not in others, and wi

112 The high degree of inbreeding and/or founder effects in some small population isolates result

113 ignal of which has been somewhat blurred via founder effects in the non-African samples.

114 sity, a result of what is called the "serial founder effect." In addition to genomic data, the serial

115 shift duplication, the result of an apparent founder effect, is nearly ubiquitous among Puerto Rican

116 d genetic variation due to genetic drift and founder effects limits the ability of a population to ad

117 sm among Hawaiian Drosophila, perhaps due to founder effects, low population sizes, and hitchhiking e

118 Evidence of a founder effect made if feasible to use a homozygosity ma

119 esponsible for RCDP (PBD CG11) and suggest a founder effect may explain the high frequency of L292ter

120 g isolates in a subpopulation suggested that founder effects might play a role in shaping the genetic

121 ct." In addition to genomic data, the serial founder effect model is now supported by the genetics of

122 patterns and fit to an Out-of-Africa serial founder effect model, which is known to structure neutra

123 ocess of island colonization in the original founder effect model.

124 Our findings suggest a founder-effect mutation in the MESP2 gene as a major cau

125 be designed around populations with frequent founder-effect mutations, despite the obvious limitation

126 lotypes, indicating that these were probably founder effects, not public mutations.

127 Consistent with a founder effect occurring as colonizers moved into these

128 ing support for random genetic drift (chance founder effects, one approximately 11 centuries ago that

129 languages, perhaps arising from a linguistic founder effect or a desire to establish a distinct socia

130 ng the Upper Palaeolithic, (iii) there was a founder effect or bottleneck associated with the Last Gl

131 er greater loss of language elements through founder effects or drift, or do languages with more spea

132 ation of new habitats may result from drift (founder effect) or altered selection pressures in the ne

133 s will exhibit linkage disequilibrium due to founder effect over longer distances than a population i

134 imate may have been inflated by inclusion of founder effects peculiar to Finland.

135 Founder effects provide a more convincing explanation fo

136 Our findings are a classic example of founder effect, provide evidence for sensitivity of this

137 available genetic data are consistent with a founder effect resulting from a severe bottleneck in pop

138 otype analysis identified a common ancestral founder effect RSPH4A mutation present in UK-Pakistani p

139 rosatellite genotyping demonstrated a common founder effect shared between 3 Scottish patients with a

140 cifically, reductions in genetic diversity ('founder effects') should be stronger for species with lo

141 etween these populations as envisioned under founder-effect speciation models.

142 a set is consistent with a model of a serial founder effect starting at a single origin.

143 f divergent SIVsm strains in PCs resulted in founder effects, superinfections, and recombinations.

144 f genetic diversity across China reveal weak founder effects that are driven largely by low-diversity

145 e time of origin of BRCA1 mutations having a founder effect, the interpretation of the significance o

146 e data revealed the substantial influence of founder effects upon viral evolution and HLA association

147 We measure the extent of founder effects using allozymes and microsatellites, and

148 d age effects; (iii) somatic mosaicism; (iv) founder effects; (v) mutation rates; (vi) the factor IX

149 A founder effect was excluded by linkage analysis.

150 frequency of the L292ter allele is due to a founder effect, we identified five polymorphic markers (

151 Recessive inheritance of Naxos disease and a founder effect were demonstrated.

152 the initial expansion and subsequent serial founder effect were determined by demographic and socioc

153 thward, experiencing genetic bottlenecks and founder effects, which left high haplotype endemism in s

154 are larger than in Europe, reflecting strong founder effects whose signatures have been maintained fo

155 However, genetic drift, particularly due to founder effects, will also commonly result in differenti

156 s consistent with the hypothesis of a serial founder effect with a single origin in sub-Saharan Afric

157 6.5 cM in the candidate region, suggesting a founder effect with an ancestral mutation that occurred

158 d had shown that the ethnic bias is due to a founder effect, with >99.5% of disease alleles sharing a