ライフサイエンスコーパス: foveal

1 stromal areas within the macular (6 mm) and foveal (1.5 mm) regions, and choroidal vascularity, whic

2 All 8 patients with CZS had foveal abnormalities in the analyzed eyes (8 eyes), incl

3 properties of the human visual system (high foveal acuity and low peripheral acuity) and observers'

4 acy of peripheral selection, suggesting that foveal analysis and peripheral selection operated indepe

5 Our data show that foveal analysis and peripheral selection proceeded compl

6 In stages 1 to 2, greater foveal and central macular thicknesses (Rho=0.493, 0.544

7 Foveal and parafoveal vascular density were calculated.

8 derwent measurements of superficial and deep foveal and parafoveal vessel density (FVD, PFVD) and cho

9 e differences in the temporal sensitivity of foveal and peripheral midget ganglion cells.

10 While the foveal and peripheral retina share a similar core circui

11 vealed significant thickening of the retinal foveal and the juxtafoveal area, and histological analys

12 diminished foveal contour, persistent fetal foveal architecture, cystoid macular edema (CME), intrar

13 tion of the retinal inner layers in the 1-mm foveal area is associated with VA, and change in DRIL pr

14 Retinal thickness in the foveal area of the right eye was 631 mum.

15 aseline was achieved using a coverage-based, foveal area-weighted IRC parameter (R2 = 0.59; P < .001)

16 opic inner foveal layers crossing the entire foveal area.

17 Yellow-white flecks can be preceded by foveal atrophy and may be visible only on FAF.

18 In 14 out of 50 patients, foveal atrophy occurred before flecks developed.

19 Foveal atrophy was the characteristic most significantly

20 nts, respectively; the other 22 patients had foveal atrophy, atrophic RPE lesions, and/or irregular y

21 flow loss and quantitatively for measures of foveal avascular area, parafoveal flow, and vascular den

22 Analyses of the foveal avascular zone (FAZ) and vasculature surrounding

23 To quantify foveal avascular zone (FAZ) area and macular vascular de

24 Foveal avascular zone (FAZ) area was measured manually;

25 Foveal avascular zone (FAZ) area, vessel densities, and

26 was used to provide quantitative data on the foveal avascular zone (FAZ) features and the total vascu

27 el density (VD), fractal dimension (FD), and foveal avascular zone (FAZ) of superficial and deep capi

28 t colocalized to areas of enlargement of the foveal avascular zone and macular capillary nonperfusion

29 ty in the SRL (0.794 [95% CI, 0.707-0.881]), foveal avascular zone area (0.472 [95% CI, 0.356-0.588])

30 Parameters included: (1) foveal avascular zone area and macular leakage, (2) peri

31 Visual acuity correlated with foveal avascular zone area and parafoveal vascular densi

32 Total avascular area and foveal avascular zone area were greater in eyes with DR

33 al vessel density, total avascular area, and foveal avascular zone as detected with 6 x 6-mm OCT angi

34 For foveal avascular zone grading, agreement was good for th

35 ion was detected between vascular density or foveal avascular zone metrics and hemoglobin A1C or dura

36 luate the area of capillary nonperfusion and foveal avascular zone morphology in patients with RVO.

37 ual acuity was independently associated with foveal avascular zone size and central macular thickness

38 P = .001), there was no association between foveal avascular zone size and peripheral ischemia (r =

39 The size of the foveal avascular zone was also calculated automatically,

40 The nonflow area (foveal avascular zone) was significantly larger in sickl

41 or pole (hyperfluorescent lesion, absence of foveal avascular zone).

42 r pole (hyperfluorescent lesions, absence of foveal avascular zone).

43 SDOCT that co-localized to areas of enlarged foveal avascular zone, areas of no flow between capillar

44 cluded greatest linear dimension and area of foveal avascular zone, perifoveal capillary dropout grad

45 , 3 eyes of 2 patients had irregularities in foveal avascular zones and poor vision.

46 Four fellow eyes with normal foveal avascular zones did not show any retinal changes

47 oidal circulations and irregularities of the foveal avascular zones.

48 al temporal face patch (ML) shows consistent foveal biases but no obvious polar-angle structure.

49 A foveal bulge was not present in 67% of patients.

50 Three patients presented with pseudocystic foveal cavitation similar in appearance to macular telan

51 magnification, loss of spatial resolution of foveal cells, and topographical disarray in the cellular

52 g possibilities have been suggested: loss of foveal cells, reduced cortical magnification, loss of sp

53 I, 1.40-3.08), and intraretinal fluid at the foveal center (aHR, 2.10; 95% CI, 1.34-3.31).

54 ving all inner retinal layers present at the foveal center (odds ratio, 0.04; P = 0.001) and a lower

55 probability of having the EZ present at the foveal center (odds ratio, 0.07; P = 0.024) compared wit

56 but not the foveal center, or present at the foveal center (P = 0.02), respectively.

57 en when the stimulus is already close to the foveal center and precise execution of the movement may

58 nd outer retinal layers were obtained at the foveal center and the nasal and temporal foveal rims.

59 eeks, by a greater than 145 mum reduction in foveal center field thickness and in 6 of 8 eyes by an i

60 mprised best-corrected visual acuity (BCVA), foveal center field thickness assessed by optical cohere

61 Eyes with IRF in the foveal center had worse mean VA than eyes without IRF (5

62 a small, focal hyporeflective lesion at the foveal center in both eyes of the subject with RGS9-asso

63 Outer retinal thickness at the foveal center increased by 3.1 mum/week in untreated eye

64 ppreciation that its enlargement through the foveal center leads to significant vision loss through t

65 retina, and more fluid or material under the foveal center of the retina are more likely to develop s

66 l pigment epithelium fluid; thickness at the foveal center of the retina, subretinal fluid, and subre

67 Eyes with SRF in the foveal center on OCT had better mean VA than eyes with n

68 Cone density at 100 mum from foveal center ranged from 123 132 cones/mm(2) to 140 013

69 Diabetic macular edema involving the foveal center that presented during pregnancy responded

70 The choroidal thickness at the foveal center was measured.

71 Diabetic macular edema involving the foveal center was observed between gestational weeks 9 a

72 compared to the control group, except at the foveal center where abnormal persistence of 1 or more in

73 Migration of the TZs to the foveal center with foveal thinning and structural disorg

74 Cone density was measured at the foveal center, and cone spacing was calculated in sampli

75 the perifoveal macula, initially sparing the foveal center, and over time often expand and coalesce t

76 f the three major carotenoids present at the foveal center, but the mechanism by which it is produced

77 ding the distance of thickest point from the foveal center, choroidal thickness, choroidal volume, ch

78 eater divergence from normal approaching the foveal center, indicating that cone loss predominates ce

79 esent within the central 1 mm(2) but not the foveal center, or present at the foveal center (P = 0.02

80 h more rapid outer retinal thickening at the foveal center, whereas LPC is associated with earlier ex

81 baseline, 77% within 1 disc diameter of the foveal center.

82 coincided with migration of the TZ near the foveal center.

83 the "MacTel area" within 5-6 degrees of the foveal center.

84 ers and delayed development of the EZ at the foveal center.

85 l parameters were evaluated in the 1-mm-wide foveal centered area.

86 cones, thus allowing accurate assignment of foveal centers and assessment of variability in macular

87 Mean foveal, central macular, and choroidal thicknesses were

88 of sub-retinal fluid (SRF) </=200 mum at the foveal centre relative to a T&E protocol that requires c

89 t (resolution of IRF or >200 mum SRF only at foveal centre).

90 Foveal choroidal thickness (FCT), subretinal hyperreflec

91 tive to the controls at all measured points (foveal choroidal thickness, P = 0.042; nasal-500 microns

92 bon synapses and active neurotransmission at foveal cone pedicles are possibly present as early as mi

93 Instead, foveal cone photoreceptors themselves exhibited slower l

94 Peak densities of foveal cones are 168 162 +/- 23 529 cones/mm(2) (mean +/

95 vector delivery mode for safely transducing foveal cones in achromatopsia patients and in other huma

96 No foveal cones were detected in the older brother.

97 In the younger brother, foveal cones were enlarged with low density (peak cone d

98 New instrumentation imaged the smallest foveal cones, thus allowing accurate assignment of fovea

99 HM patients revealed persistent but abnormal foveal cones.

100 smission of mechanical forces to the central foveal cones.

101 The included eyes must present an irregular foveal contour and schitic or cavitated lamellar separat

102 tion, vitreo-laser scar adhesion, diminished foveal contour, persistent fetal foveal architecture, cy

103 he following findings: presence of irregular foveal contour, separation of the layers of the neurosen

104 nced processing speed may lead to overcoming foveal crowding and might be the enabling factor for gen

105 absent in the fovea, earlier studies report foveal crowding upon very brief exposures or following s

106 However, the presence of foveal cystoid change is not significantly associated wi

107 lationship that might exist between MPOD and foveal damage in glaucoma.

108 d for LLVA to be more effective at detecting foveal deficits than BCVA in eyes with increasingly poor

109 4 eyes, 22.1%) ERMs were mild and thin and a foveal depression was present.

110 g of the outer nuclear layer and loss of the foveal depression.

111 Foveal detachment associated with foveoschisis usually t

112 of outer retinal layers after vitrectomy for foveal detachment associated with optic disc pit.

113 eal thickness was 445.1 mum, and the average foveal detachment height was 271.5 mum.

114 was to report the spontaneous resolution of foveal detachment in patients with myopic traction macul

115 t cases of high myopia with foveoschisis and foveal detachment in which the subfoveal fluid had spont

116 Photoreceptor regeneration after foveal detachment surgery has been already described onl

117 The foveal detachment was successfully reattached with compl

118 15-year-old boy with deep optic disc pit and foveal detachment, before and for 10 years after vitrect

119 D), either before or after the resolution of foveal detachment.

120 ucial and unexpected role for ATF6A in human foveal development and cone function and adds to the lis

121 To characterize and quantify early foveal development in preterm infants and to compare thi

122 Similar to foveal development, marmoset neuronal generation was rap

123 veal hypoplasia was indicated by the lack of foveal dip.

124 FT), horizontal and vertical extent of DRIL, foveal DRIL (>500 mum DRIL) hyperreflective foci (HRF),

125 ight motion signals across a narrow range of foveal eccentricities rather than uniformly over the who

126 ain the frequency in which there was minimal foveal edema (<15 mum increase), but non-foveal edema wa

127 mal foveal edema (<15 mum increase), but non-foveal edema was considered severe enough to warrant ret

128 Six patients (67%) had foveal ellipsoid zone disruption, of which 1 had a hypor

129 that cortical magnification is normal in the foveal field of strabismic amblyopes.

130 axis without reference to nodal points, the foveal-fixation axis, is discussed.

131 Foveal function is relatively preserved until the fifth

132 nd in other human retinal diseases affecting foveal function.

133 nal eccentricity compared with those without foveal GCC involvement (P < 0.001, for all).

134 that MPOD is lower in glaucomatous eyes with foveal GCC involvement relative to those without foveal

135 Those with foveal GCC loss also had greater glaucoma severity, and

136 No cases of bilateral foveal hemorrhage were found.

137 duced visual acuity, bull's eye maculopathy, foveal hyperpigmentation, peripapillary atrophy, dyschro

138 on IRR or GDx VCC can occur in patients with foveal hypoplasia and can therefore aid in the diagnosis

139 Patients had evidence of foveal hypoplasia and disruption of the cone photorecept

140 Whenever OCT was performed, foveal hypoplasia was indicated by the lack of foveal di

141 lving the RNFL and GCL, signs reminiscent of foveal hypoplasia were observed in patients with ONH.

142 orm layer in the central retinal area (i.e., foveal hypoplasia) was found in more than 80% of patient

143 raphy, consistent with prior descriptions of foveal hypoplasia.

144 of gaze fixations, during which the current foveal image is analyzed and the next object to inspect

145 f SC organization: an over-representation of foveal information, size-invariant population codes, cas

146 erior ganglion cell complex (GCC) thickness, foveal inner retinal thickness, cup-to-disc area ratio,

147 baseline risk factors included poor VA, RAP, foveal intraretinal fluid, monthly dosing, and treatment

148 , many patients with choroidal melanoma with foveal involvement maintain useful vision.

149 xtafoveal CNVs and 3 extrafoveal CNVs showed foveal involvement.

150 anges of central macular thickness (CMT) and foveal involvement.

151 al GCC involvement relative to those without foveal involvement.

152 Eyes with foveal IRF, abnormally thin retina, greater thickness of

153 ithelium lesion area of 2.6 mm(2), preserved foveal IS/OS in 4.1% of patients, loss of foveal IS/OS i

154 ed foveal IS/OS in 4.1% of patients, loss of foveal IS/OS in 59.2% of patients, and extensive loss of

155 tion is required to compensate for errors in foveal landing positions.

156 ibe the presence of continuous ectopic inner foveal layers associated with epiretinal membranes (ERMs

157 ere associated with continuous ectopic inner foveal layers crossing the entire foveal area.

158 The presence of continuous ectopic inner foveal layers in ERMs is a newly described OCT finding a

159 association with abnormalities of the inner foveal layers on spectral-domain optical coherence tomog

160 The presence of continuous ectopic inner foveal layers was identified in 63 out of 194 eyes (32.5

161 The presence of ectopic inner foveal layers was negatively correlated with the presenc

162 and associated with continuous ectopic inner foveal layers.

163 y, including presence of cataract (P = .05), foveal leakage on fluorescein angiography (P = .04), and

164 played with a green laser developed a yellow foveal lesion and outer retinal streaks in the superior

165 extrafoveal lesions compared with those with foveal lesions (P = 0.001).

166 A 14-year-old boy developed bilateral focal foveal lesions and ellipsoid loss on spectral-domain OCT

167 laser injuries were found to result in focal foveal lesions.

168 ingly, the occipital pole (OP), representing foveal locations, showed higher activation for tactile t

169 ing radial scans, 71% of eyes demonstrated a foveal lucency at 1 month, whose size correlated with vi

170 rative basal hole diameter was predictive of foveal lucency development and size.

171 vity and 70% specificity) were predictive of foveal lucency development.

172 orrected visual acuity (BCVA), postoperative foveal lucency horizontal and vertical size, external li

173 Foveal lucency horizontal and vertical sizes (mum) impro

174 Cataract surgery did not influence foveal lucency resolution and no holes reopened.

175 Horizontal foveal lucency size at 1 month correlated (P < .05) with

176 sal hole diameter correlated with horizontal foveal lucency size at all time points (P < .05).

177 inhibition minimally shaped the responses of foveal midget ganglion cells.

178 Foveal Muller cells may play an integral role in the tra

179 precise and reproducible delineation of the foveal nonflow zone and perifoveal intercapillary area.

180 The size of the foveal nonflow zone and the perifoveal intercapillary ar

181 o model target selection in conjunction with foveal object identification: in parallel and independen

182 Optic nerve and foveal parameters measured using OCT showed high sensiti

183 our treated eyes mfERG revealed an increased foveal peak response over the follow-up.

184 This difference was most apparent for the foveal photoreceptor inner segment (p=0.001).

185 inally developed in mouse retina, to explore foveal physiology in the macaque, which permits the repe

186 The central foveal thickness below the foveal pit was lower in eyes of blacks compared to South

187 The foveal pit was significantly shallower in FRMD7 patients

188 om the fovea, thus forming a bridge over the foveal pit, was observed in 84% of eyes from patients wi

189 Variations in the difficulty of foveal processing did not influence the uptake of periph

190 best-corrected visual acuity improved after foveal reattachment.

191 .001), whereas the opposite was found in the foveal region (27% +/- 5.2% vs 32% +/- 3.2%; P < .001).

192 otal ganglion cell population outside of the foveal region and their proportion increased with eccent

193 dant in the superior quadrant and spared the foveal region.

194 he occipital pole (OP), corresponding to the foveal representation, even though the stimulus was unse

195 with size increasing with distance from the foveal representation.

196 al factors may be operative that protect the foveal retina-retinal pigment epithelial complex.

197 mparing terminals representing peripheral or foveal retina.

198 The central (foveal) retina takes about 30 milliseconds longer to sig

199 ased ellipsoid zone reflectivity in 4 (25%), foveal retinal detachment in 2 (12%), a dome-shaped macu

200 patients revealed either no abnormalities or foveal retinal pigment epithelium (RPE) changes in 10 an

201 o statistical significant difference for the foveal retinal thickness measurements between the two gr

202 On univariate analysis, presentation age, foveal retinoblastoma (at initial examination), use of T

203 The spatial offset of foveal RGCs from their cone inputs makes this method esp

204 the foveal center and the nasal and temporal foveal rims.

205 The main complications were foveal RPE atrophy (n = 73; 47%) and CNV recurrence (n =

206 Foveal RPE atrophy (odds ratio [OR], 7.0), CNV recurrenc

207 Foveal RPE atrophy, CNV recurrence, and PVR carried a wo

208 m (RPE) tear, (3) subretinal hemorrhage, (4) foveal scar tissue of recent onset, or (5) CNV before th

209 Patients with foveal schisis tended to be younger than patients lackin

210 Foveal schisis was observed in 81% of retinoschisis pati

211 s tended to be younger than patients lacking foveal schisis.

212 A higher mean FDP foveal sensitivity in the doxycycline group compared wit

213 tical meridian and share a representation of foveal space with iso-eccentricity lines extending acros

214 area of geographic atrophy (GA) and residual foveal sparing (FS), and to identify the minimum FS and

215 Areas of foveal sparing and GA were measured by 2 independent rea

216 GA, OCTA showed CC flow within the region of foveal sparing in 4 of the eyes.

217 Participants of the FAM study exhibiting foveal sparing of GA.

218 rnating hyper- and hypoautofluorescence, and foveal sparing of photoreceptors and RPE, as seen on SD-

219 tly to GA lesion enlargement due to possible foveal sparing, alternative assessments are being explor

220 an centripetal GA spread in eyes with GA and foveal sparing.

221 Of the 5 eyes exhibiting foveal-sparing GA, OCTA showed CC flow within the region

222 CNV location was foveal-sparing in 12 eyes.

223 rreader agreement for measurements of GA and foveal-sparing size were 0.995 and 0.946, respectively.

224 reviewed to assess the presence of a yellow foveal spot, and SD OCT analysis was performed.

225 This allows for analysis of foveal stimulus processing, and provides a means to corr

226 ography and fluorescein angiography of inner foveal structural abnormalities associated with vision l

227 Even with marked foveal structural abnormalities, vision can be preserved

228 ular retina suggests a vascular cause of the foveal structural changes.

229 om this study suggest that visual acuity and foveal structure in patients with RP are preserved into

230 ng is increased in advanced disease, central foveal structure is maintained until late stages of dise

231 iciency, which partially mimics the all cone foveal structure of human achromatopsia 2 with CNGA3 mut

232 IP can occur with abnormalities of the inner foveal structure seen on spectral-domain optical coheren

233 rventional clinical trials aiming to prolong foveal survival in eyes with GA.

234 ractor conditions, by adjusting an identical foveal target.

235 m) in ranibizumab-treated patients were mild foveal thickening and prominent subfoveal fluid, and tho

236 n sham-treated patients were poor BCVA, mild foveal thickening, and statin usage.

237 area, presence of geographic atrophy, total foveal thickness </=325 mum or >/=425 mum, and elevation

238 vs. 50%; P = 0.03), and greater reduction in foveal thickness (-240 mum vs. -161 mum; P < 0.001).

239 29%; p<0.001) and greater reduction in total foveal thickness (-266microm vs -158u; p<0.001).

240 ize (3.3 vs 2.4 DA; p <0.001), greater total foveal thickness (522microm vs 452microm; p<0.001), more

241 After adjustment for baseline central foveal thickness (CFT) and duration of diabetes, the mea

242 anges in visual acuity (letters) and central foveal thickness (CFT) and frequency of injections after

243 t-corrected visual acuity (BCVA) and central foveal thickness (CFT) at month 6.

244 main endpoint was the change of the central foveal thickness (CFT) obtained by optical coherence tom

245 ified for determining normal average central foveal thickness (CFT) values.

246 ROP and graded for presence of CME, central foveal thickness (CFT), inner nuclear layer thickness, a

247 Changes from baseline in BCVA and central foveal thickness (CFT).

248 ent surgery, was the thinning of the central foveal thickness (CFT, P < .001).

249 ted changes in levels with changes in excess foveal thickness (EFT) to identify potential PPFs contri

250 -corrected visual acuity (P = .098), central foveal thickness (P = .472), or choroidal thickness at a

251 al acuity (P = .7) and postoperative central foveal thickness (P = .5) between the 2 groups.

252 l acuity (R(2) = 0.017; P = .470) or central foveal thickness (R(2) = 0.040; P = .263).

253 bizumab-treated patients with </=10% central foveal thickness [CFT] reduction after 3 injections), im

254 Reduction in excess foveal thickness after dexamethasone implant correlated

255 the drug was discontinued, including loss of foveal thickness and cone structure.

256 ght percentile was associated with increased foveal thickness and ganglion cell damage (RNFL and GCL-

257 ntravitreal treatment led to reduced central foveal thickness and visual improvement in some patients

258 Inner and outer foveal thickness and volume measurements were increased

259 uring the core studies (P = 0.0203), central foveal thickness at baseline (P = 0.0002) and month 36 (

260 The central foveal thickness below the foveal pit was lower in eyes

261 on fluorescein angiography and the change in foveal thickness by optical coherence tomography at 6 mo

262 The OCT foveal thickness decreased by 1.0 mum in the EMB arm and

263 nterior and posterior inflammatory reaction, foveal thickness measured by optical coherence tomograph

264 ected Snellen visual acuity (VA) and central foveal thickness measured on optical coherence tomograph

265 fewer adjunct patients had CMO (42.7%) or a foveal thickness of >300 mum (47.6%) compared with contr

266 or more improvement in DRSS achieved central foveal thickness of 250 mum or less, compared with 65.2%

267 atistically significant reduction in central foveal thickness overall, and subjects with a low CFH ri

268 tly to intravitreal dexamethasone therapy by foveal thickness reduction and visual acuity improvement

269 With persistent VMTS, vision and central foveal thickness remained unchanged.

270 At 1 month, the mean (SE) change in central foveal thickness was +9.6 (7.2) mum in treated eyes and

271 Mean foveal thickness was 240 mum OD (range: 112-606) and 251

272 The average central foveal thickness was 445.1 mum, and the average foveal d

273 Central foveal thickness was measured by time-domain optical coh

274 Macular vascular density, FAZ area, and foveal thickness were measured in all eyes.

275 or better); (2) cystoid macular edema (CMO), foveal thickness, and macular volume; (3) development of

276 fferences include wider fovea, lower central foveal thickness, and thinner inner retina in eyes of bl

277 Regarding the outcome of change in central foveal thickness, improvement was noted in all genotype

278 visual acuity, intraocular pressure, retinal foveal thickness, VCT, or StCT.

279 gnificance of the central macular thickness (foveal thickness-FT) and choroidal thickness (CT) in the

280 n CFH risk and improvement in VA and central foveal thickness.

281 g functional outcome or reduction in central foveal thickness.

282 size, and optical coherence tomography (OCT) foveal thickness.

283 uded other parameters of visual function and foveal thickness.

284 is relationship was not observed for central foveal thickness.

285 th better presenting visual acuities, lesser foveal thicknesses, and no associated PMMs; vision signi

286 gration of the TZs to the foveal center with foveal thinning and structural disorganization heralded

287 ed to determine any potential benefit of the foveal to parafoveal ratio in children with IP.

288 The foveal to parafoveal ratios were greater than 0.57 in 6

289 es, cone densities decline gradually along a foveal to peripheral gradient.

290 ic map, following a consistent path from the foveal to the peripheral representations of space; their

291 Severity of CME, as assessed by foveal-to-parafoveal thickness ratio, within the CME gro

292 ss (CFT), inner nuclear layer thickness, and foveal-to-parafoveal thickness ratio.

293 Mean foveal total thickness was 278 mum, a decrease of 182 mu

294 ion that preserves specialized processing of foveal versus peripheral visual information.

295 In foveal vision collinear facilitation can be observed for

296 ase, which may contribute to preservation of foveal vision in eyes with MAK-related retinal degenerat

297 assesOff's application for iDevices to train foveal vision of young participants.

298 sitivity declines sharply in peripheral (vs. foveal) vision and is typically worse in the upper (vs.

299 ately random, with a modest bias toward more foveal voxels.

300 laucomatous eyes with GCC loss involving the foveal zone on FD-OCT imaging (n = 52) had lower MPOD at