ライフサイエンスコーパス: fractalkine

1 arkers, and chemokines, most notably CX3CL1 (fractalkine).

2 x with the chemokine domain of human CX3CL1 (fractalkine).

3 d that TCR-driven TEM is also dependent upon fractalkine.

4 CXCR4 and CX3R1, the receptors for SDF-1 and fractalkine.

5 cells and differentiated osteoblasts express fractalkine.

6 kine receptor and modifies the activities of fractalkine.

7 mutants had a 100-fold decreased affinity to fractalkine.

8 lso showed a 100-fold decreased affinity for fractalkine.

9 GRO-alpha, -beta, and -gamma, and IL-8), and Fractalkine.

10 een these two functionally distinct forms of fractalkine.

11 IL-6 are able to increase the expression of fractalkine.

12 sponsible for the neuroprotective effects of fractalkine.

13 stinal epithelial cells as a novel source of fractalkine.

14 ould be illustrated by CX3CL1, also known as fractalkine.

15 ed that intra-PAG injection of 100 ng CX3CL1/fractalkine 30 min before administration of 400 ng DAMGO

16 ase (eNOS)], pro-inflammatory genes, CX3CL1 (fractalkine), 5-lipoxygenease-activating protein, and ma

17 Fractalkine, a chemokine anchored to neurons or peripher

18 Fractalkine, a chemokine expressed by inflamed endotheli

19 ray on left ventricles (LV) showed increased fractalkine, a chemokine implicated in heart failure.

20 CX3CL1/fractalkine, a chemokine that exclusively binds to CX3CR

21 a at levels sufficient to drive induction of fractalkine, a key marker of inflammation in endothelial

22 a at levels sufficient to drive induction of fractalkine, a key marker of inflammation, in endothelia

23 In addition, we identified CSF fractalkine/Abeta(1-42) that positively correlated with

24 Finally, fractalkine activates the PI3K/Akt survival pathway in h

25 igand 1), and the surface-attached chemokine fractalkine, all implicated in leukocyte trafficking, mi

26 Fractalkine also appears to modulate the effects of intr

27 Fractalkine also binds the human cytomegalovirus recepto

28 The transmembrane chemokines CX3CL1/fractalkine and CXCL16 are widely expressed in different

29 phic effects of fractalkine, suggesting that fractalkine and its receptor are involved in a complex n

30 Fractalkine and its receptor CX3CR1 are expressed in ath

31 tigated the expression of the CX3C chemokine fractalkine and its receptor CX3CR1 in human coronary ar

32 VM) from male C57Bl/6 mice were treated with fractalkine and responses measured under basal condition

33 Comparison of the binding surfaces of fractalkine and the CC chemokine MCP-1 reveals structura

34 pplication of this methodology to the CX3CR1-fractalkine and the CXCR1-IL-8 receptor-ligand systems d

35 to determine the expression and function of fractalkine and the fractalkine receptor CX3CR1 in the h

36 cell damage and loss follow the induction of fractalkine and up-regulation of cell adhesion markers i

37 endothelial damage and apoptosis (release of fractalkine and von Willebrand factor; increased caspase

38 th inflammation, increased levels of CX3CL1 (fractalkine) and its unique receptor, CX3CR1, have been

39 communication between neurons (that produce fractalkine) and microglia (that express its receptor).

40 surface, as well as release of CCL2, soluble fractalkine, and soluble VCAM-1.

41 onclusion, our results indicate that CX3CR1, fractalkine, and the enzymes responsible for its cleavag

42 y reduced by a neutralizing antibody against fractalkine, and they migrate toward a medium conditione

43 the specific receptor for the CX3C chemokine fractalkine--and induction of leukocyte chemotaxis.

44 Both events were inhibited by anti-fractalkine antibody administered directly into the DRG

45 ogether, these results suggest that IL-1 and fractalkine are endogenous regulators of morphine analge

46 US28 recognizes many of the same epitopes of fractalkine as CX3CR1.

47 M10/17) are involved in cleavage of neuronal fractalkine as indicated by studies with pharmacologic i

48 ing interleukin-1beta, interferon-gamma, and fractalkine as well as a decreased expression of synapto

49 Fractalkine attracts and immobilizes leukocytes by bindi

50 tudies support a key regulatory role for the fractalkine axis in advanced and relapsed peritoneal met

51 ted the function of a potentially targetable fractalkine axis in the formation and the development of

52 Step one mediates the high-affinity fractalkine binding involving Tyr14, Asp25, and Glu254.

53 By surface plasmon resonance measurements of fractalkine binding to biosensor chip-immobilized cell m

54 Fractalkine binds CX3CR1 on microglia and circulating mo

55 y protein-1beta), CCL5 (RANTES), and CX3CL1 (fractalkine), but not CXCL12 (stromal-derived factor-1al

56 CR1--the specific receptor for the chemokine fractalkine--by human prostate cancer cells, whereas hum

57 However, fractalkine can also be proteolytically cleaved from its

58 Because fractalkine can be expressed as a cell surface-bound pro

59 A soluble form of fractalkine can be generated by proteolytic cleavage at

60 We show that the cleavage of fractalkine can be markedly enhanced by stimulating cell

61 In addition, fractalkine can be proteolytically released from the cel

62 Both forms of fractalkine can mediate adhesion of cells expressing its

63 .05) cells expressed increased levels of the fractalkine chemokine receptor.

64 nterleukin-8 [IL-8], and I-TAC), and CX(3)C (Fractalkine) chemokines.

65 , we provide data showing that TACE-mediated fractalkine cleavage occurs at a site distinct from the

66 er, dihydrotestosterone was unable to induce fractalkine-cleavage from human bone marrow endothelial

67 mutants had a 2-4-fold decreased affinity to fractalkine compared with wild type CX(3)CR1.

68 vasation of CX3CR1-bearing cancer cells on a fractalkine concentration gradient, while leaving unalte

69 Serum fractalkine concentration peaked at 90 minutes after rep

70 Fractalkine contains a chemokine domain (CDF) attached t

71 talloproteinase ADAM17 and increases soluble fractalkine content in culture medium.

72 Our data suggest that fractalkine contributes to lymphocyte shifts, which may

73 p-regulated in CP patients and together with fractalkine correlated noticeably with severe fibrosis a

74 e receptor that uniquely binds to its ligand fractalkine (CX(3) CL1) and has been shown to be importa

75 Fractalkine (CX(3)CL1) is the first described chemokine

76 In this report, we show that the fractalkine-CX(3)CR1 interaction resulting in recruitmen

77 The soluble form of the chemokine fractalkine/CX(3)CL1 regulates microglia activation in t

78 Fractalkine (CX3 CL1), a chemokine that regulates adhesi

79 More recently fractalkine (CX3C1) and its receptor (CX3CR1) have emerg

80 s a specific receptor for the CX3C chemokine fractalkine (CX3CL1 according to the new chemokine nomen

81 Fractalkine (CX3CL1) and its receptor (CX3CR1) are invol

82 Fractalkine (CX3CL1) and its receptor (CX3CR1) comprise

83 The protective/neurotoxic role of fractalkine (CX3CL1) and its receptor CX3C chemokine rec

84 Interactions between fractalkine (CX3CL1) and its receptor, CX3CR1, mediate l

85 ression, CTLA4 expression and the absence of fractalkine (CX3CL1) in baseline tumour specimens.

86 y be exerting these effects via IL-1 because fractalkine (CX3CL1) induced the release of IL-1 from ac

87 Fractalkine (CX3CL1) is an unusual member of the chemoki

88 Fractalkine (CX3CL1) is an unusual membrane-bound chemok

89 Fractalkine (CX3CL1) is of particular interest in athero

90 Fractalkine (CX3CL1) is synthesized as a type I transmem

91 Fractalkine (CX3CL1), a CX3C chemokine, is expressed in

92 We show that the chemokine fractalkine (CX3CL1), an activating ligand of CX3CR1, re

93 avelled longer distance toward the source of fractalkine (CX3CL1), an endogenous ligand of CX3CR1.

94 yte chemoattractant protein-1 (MCP-1, CCL2), fractalkine (CX3CL1), or their cognate receptors, CCR2 a

95 transendothelial migration (TEM) depends on fractalkine (CX3CL1), PECAM-1 (CD31), and ICAM-1 (CD54)

96 or the 8-kDa chemokine binding domain of rat fractalkine (CX3CL1), the 18-kDa human hormone leptin, a

97 rprising features, especially its mimicry of fractalkine (CX3CL1).

98 Fractalkine (CX3CL1, FKN) is expressed in the inflamed v

99 Fractalkine/CX3CL1 is a membrane-tethered chemokine that

100 rprisingly, some markers of atherosclerosis (fractalkine/CX3CL1, CCL8, M-CSF, HGF), T-cell developmen

101 ults were correlated with mRNA expression of fractalkine, CX3CR1, and with the presence and degree of

102 This study demonstrates that fractalkine-CX3CR1-mediated mechanism may direct lymphoc

103 hese results indicate that the inhibition of fractalkine/CX3CR1 signaling in SGCs may serve as a targ

104 ter postnatal day 5 and is controlled by the fractalkine/CX3CR1 signaling pathway.

105 However, the effect of fractalkine deficiency on atherosclerosis susceptibility

106 Fractalkine-deficient B6.ApoE(-/-) mice were comparable

107 reduced dramatically by approximately 85% in fractalkine-deficient females [42,251 +/- 26,136 microm(

108 < 0.01) and by 50% at the BCA (P < 0.05) in fractalkine-deficient females at 16 weeks of age.

109 ls, aortic-root lesion area was unchanged in fractalkine-deficient male and female B6.ApoE(-/-) mice

110 n, the major reduction of atherosclerosis in fractalkine-deficient mice appears to be at the BCA rath

111 Lesions in fractalkine-deficient mice on the B6.ApoE(-/-) and B6.LD

112 Fractalkine-deficient mice on the C57BL/6 (B6) backgroun

113 we used targeted gene disruption to generate fractalkine-deficient mice.

114 he immune environment at the injury site via fractalkine delivery resulted in a dramatic increase in

115 Fractalkine depresses myocyte contractility by mechanism

116 ion, dependence on ICAM-1, and dependence on fractalkine distinguish TCR-induced TEM from IP-10-induc

117 a positive correlation between the number of fractalkine-expressing cells and the number of CX3CR1-po

118 TNF-alpha provoked a significant increase in fractalkine expression and release of the soluble form,

119 ontrast to previous reports we do not detect fractalkine expression by Langerhans cells or immature d

120 nd Western blot were used to measure overall fractalkine expression in neurons.

121 histochemistry consistently showed increased fractalkine expression in placentas from severe early-on

122 -E8 expression correlated significantly with fractalkine expression, severe fibrosis, and the presenc

123 d CCL11 (eotaxin), CXCL8 (IL-8), and CX3CL1 (fractalkine) expression.

124 of a fragment containing the majority of the fractalkine extracellular domain.

125 The chemokine fractalkine (FK) has two structural features that make i

126 Fractalkine (FK) is a structurally unusual chemokine tha

127 Fractalkine (Fk) is a structurally unusual member of the

128 Fractalkine (FK, CX3CL1) is a novel multidomain protein

129 eukocyte receptor specific for the chemokine fractalkine (FKN or CX3CL1).

130 rophage response to chemoattractants such as fractalkine (FKN) (CX3CL1) and colony-stimulating factor

131 ific receptor for the novel CX(3)C chemokine fractalkine (FKN) (neurotactin).

132 The neuronal chemokine fractalkine (FKN) and its microglial receptor CX3CR1 may

133 We studied the role of fractalkine (FKN) and its receptor, CX(3)CR1, in allogra

134 linked to the 8-kDa chemokine domain of rat fractalkine (FKN) for the purpose of surface exposure up

135 Fractalkine (FKN) is a dual-adhesion molecule-chemokine

136 Fractalkine (FKN) is a membrane-bound chemokine that can

137 very of a cathepsin S (CatS) inhibitor and a fractalkine (FKN) neutralizing antibody, from day 11 to

138 Surface expression of the fractalkine (FKN) receptor CX(3)CR1 was monitored by flu

139 Fractalkine (FKN), a CX(3)C chemokine/mucin hybrid molec

140 sole member of the CX(3)C chemokine family, fractalkine (fkn), induces angiogenesis and that fkn mig

141 We show that the chemokine, fractalkine (FKN), is markedly up-regulated in neurons a

142 ing CX(3)CR1, the receptor for the chemokine fractalkine (FKN).

143 e chemoattractant protein 1 (MCP-1)/CCL2 and fractalkine (FKN)/CX3CL1 in cellular and mouse models of

144 Here, we demonstrate that the fractalkine (FKN)/CX3CR1 system represents a regulatory

145 The membrane-bound chemokine fractalkine (FKN, CX3CL1) on endothelial cells plays a r

146 Fractalkine (FKN/CX3CL1) is a cell surface-expressed che

147 Fractalkine (FKN/CX3CL1) is a unique chemokine combining

148 Fractalkine (FKN/CX3CL1) is a unique member of the chemo

149 nt transendothelial migration in response to fractalkine (FKN; FKN/CX3CL1) and stromal-derived factor

150 vated by the chemokine CX3CL1 (also known as fractalkine [FKN]), which promoted production of reactiv

151 r protease responsible for the conversion of fractalkine from a membrane-bound adhesion molecule to a

152 ived factor 1; SDF-1), regulates cleavage of fractalkine from neurons.

153 erone dramatically increases the cleavage of fractalkine from the plasma membrane of bone cells and i

154 n, SDF-1 also up-regulates expression of the fractalkine gene.

155 eptor CX3CR1 and migrated specifically along fractalkine gradients after activation with IL-2.

156 , treatment with i.gl. fluorocitrate blocked fractalkine (i.gl.)- and carrageenin (paw)-induced hyper

157 Finally we discuss potential roles for fractalkine in constitutive leukocyte trafficking based

158 tudied the influence of the chemokine CX3CL1/fractalkine in de novo breast cancer formation using HER

159 e donors produce soluble factors that induce fractalkine in endothelial cells.

160 f mononuclear cells expresses high levels of fractalkine in human coronary atherosclerotic plaques an

161 cell type expressing transmembrane forms of fractalkine in human skin, the tonsil, and the large int

162 mechanisms regulating the levels of soluble fractalkine in the bone marrow, we focused on androgens,

163 However, the role of fractalkine in the healthy intestine and during inflamma

164 as used to measure protein levels of soluble fractalkine in the medium of rat neuronal cultures expos

165 s [interleukin-1beta (IL-1)] and chemokines (fractalkine) in acute analgesia and in the development o

166 educing contractility after Iso stimulation, fractalkine increased the Ca(2+) transient amplitude but

167 Fractalkine induced hyperalgesia in rats without CP, whi

168 incubation of isolated and cultured SGC with fractalkine induced the production/release of TNF-alpha,

169 Fractalkine-induced hyperalgesia was blocked by minocycl

170 ly, the activation of the CX3CR1 receptor by fractalkine induces the release of interleukin-1beta fro

171 helial cultures were monitored for levels of fractalkine induction as a marker for initiating the hos

172 endothelial monolayers is required for this fractalkine induction, where the endothelial cells appea

173 ron and tumor necrosis factor alpha, driving fractalkine induction.

174 The administration of fractalkine into the DRG (L5) produced mechanical hypern

175 DAMs) 10 and 17, which convert transmembrane fractalkine into the soluble form, was significantly inc

176 Fractalkine is a CX3C-family chemokine, highly and const

177 Fractalkine is a unique chemokine that combines properti

178 Fractalkine is a unique CX(3)C chemokine/mucin hybrid mo

179 Fractalkine is also highly expressed in neurons, and its

180 Thus, fractalkine is an important player in the early inductio

181 The chemokine CX3CL1/fractalkine is expressed by neurons as a transmembrane-a

182 Indeed, at this developmental stage fractalkine is overexpressed within the barrels and CX3C

183 For example, fractalkine is present in human atherosclerotic lesions

184 We therefore hypothesized that fractalkine is regulated by PGE2 and contributes to depr

185 uggest that, during peripheral inflammation, fractalkine is released in the DRG and contributes to th

186 We demonstrate that under normal conditions fractalkine is synthesized as an intracellular precursor

187 We examined whether placental fractalkine is up-regulated in severe early-onset PE and

188 vascular cell adhesion molecule-1, IL-6, and fractalkine) is particularly high in malignant RCCs.

189 ty-prone mouse strain, the chemokine CX3CL1 (fractalkine) is rapidly induced in the neurons of the hy

190 cell response can result in the induction of fractalkine, leading to chronic inflammation and endothe

191 Stimulation of hPSCs with fractalkine led to a significant increase in MFG-E8 expr

192 peptide 1-42 (Abeta(1-42)), Flt3 ligand, and fractalkine levels in CSF in a large cohort of PD patien

193 ase activity and markedly diminishes soluble fractalkine levels, leading to cell death.

194 Fractalkine localized with caveolin-1 in detergent-insol

195 otactic protein-1, interleukin [IL]-8, IL-6, Fractalkine, macrophage inflammatory protein (MIP)-1beta

196 hemokine (SLC), EBI1-ligand chemokine (ELC), fractalkine, macrophage inflammatory protein-1gamma (MIP

197 Fractalkine may be exerting these effects via IL-1 becau

198 potential role of this signaling cascade in fractalkine-mediated chemotaxis is discussed.

199 Our results suggest a fractalkine-mediated interaction between macrophages and

200 Similarly, the responses of fractalkine(-/-) mice to a variety of inflammatory stimu

201 of minocycline (inhibitor of microglia) and fractalkine (microglia-activating factor) on visceral hy

202 neuron-to-microglia signaling via chemokine fractalkine, microglia to astrocyte signaling via the cy

203 pression on endothelial cells, suggests that fractalkine might mediate adhesion of leukocytes to the

204 mino- or carboxyl-terminal ends of the human fractalkine molecule have revealed that epithelial cells

205 The basal expression of fractalkine mRNA and protein in the intestinal epithelia

206 Fractalkine mRNA expression has been observed in the int

207 Furthermore, fractalkine mRNA expression was significantly up-regulat

208 he reagent used in previous studies, an anti-fractalkine N-terminal peptide antisera, cross-reacts wi

209 of CC chemokines and a structure similar to fractalkine (neurotactin) in having a transmembrane regi

210 s such as fibroblast growth factor-4, CX3CL1/fractalkine, neurotrophin 4 oncostatin-M, pulmonary and

211 The effect of fractalkine on contractility and intracellular calcium w

212 ts we do not detect high-level expression of fractalkine on endothelial cells in normal or inflamed c

213 Fractalkine, or neurotactin, is a chemokine that is pres

214 on and platelet activation serum biomarkers (fractalkine, platelet P-selectin, platelet factor 4 [PF4

215 We have previously shown that the chemokine fractalkine promotes the adhesion of human prostate canc

216 of activation-associated chemokines such as fractalkine, RANTES (regulated on activation, normal T c

217 sults suggest that in human atherosclerosis, fractalkine, rather than mediating inflammatory cell rec

218 Using these specific anti-fractalkine reagents we do not detect high-level express

219 nced in mice lacking the microglial-specific fractalkine receptor (CX3CR1) and is dependent upon func

220 r mouse model studies support a role for the fractalkine receptor (CX3CR1) in the initiation of perit

221 shown that the deficiency of the microglial fractalkine receptor (CX3CR1) led to the acceleration of

222 Although fractalkine receptor (CX3CR1) on microglia was found to

223 t of spirulina to increase expression of the fractalkine receptor (CX3CR1) on microglia.

224 ntrathecal neutralizing antibody against the fractalkine receptor (CX3CR1) potentiated acute morphine

225 CNS, are the only CNS cells that express the fractalkine receptor (CX3CR1).

226 to a mouse line that lacks expression of the fractalkine receptor (CX3CR1).

227 the interaction between the chemokine CX3CL1/fractalkine receptor and mu, delta or kappa opioid recep

228 this study, we investigated the role of the fractalkine receptor chemokine CX3C motif receptor 1 (CX

229 ll subsets correlated with expression of the fractalkine receptor CX3CR1 (r2 = 0.99, P = 0.006).

230 al intraepithelial lymphocytes expressed the fractalkine receptor CX3CR1 and migrated specifically al

231 al fibrillary acidic protein (GFAP), and the fractalkine receptor CX3CR1 in DRGs.

232 pression and function of fractalkine and the fractalkine receptor CX3CR1 in the human small intestina

233 vious studies have shown that the microglial fractalkine receptor CX3CR1 is involved in synaptic deve

234 lysosome content, but signaling through the fractalkine receptor CX3CR1 is not an essential componen

235 flammatory cells with high expression of the fractalkine receptor CX3CR1 that has been implicated in

236 hat a single chemokine receptor subtype, the fractalkine receptor CX3CR1, is able to reduce both infl

237 uscle cells within the neointima express the fractalkine receptor CX3CR1.

238 T cell subsets based upon expression of the fractalkine receptor CX3CR1.

239 In this study, we show that fractalkine receptor expression marks emigrating subpopu

240 We also discover that the fractalkine receptor increases on peripheral CD8(+) T ce

241 [chemokine receptor-2 knockout (CCR2(KO)) or fractalkine receptor knockout (CX3CR1(KO))] failed to re

242 nce, however, for an association between the fractalkine receptor polymorphism (CX3CR1-I249) and coro

243 vascular endothelium-homing receptor CX3CR1 (fractalkine receptor) are enriched in HIV-infected ART r

244 Impaired signaling via CX3CR1, the fractalkine receptor, promotes recovery after traumatic

245 The inhibition of hypothalamic fractalkine reduces diet-induced hypothalamic inflammati

246 Thus, it has been proposed that fractalkine regulates cellular communication between neu

247 he protease responsible for this PMA-induced fractalkine release.

248 teraction, an extensive mutagenesis study of fractalkine's chemokine domain was undertaken.

249 Fractalkine's effect appears to be dependent on the acti

250 Fractalkine's hypernociceptive effect appears to be indi

251 EP4 KO mice but surprisingly, PGE2 regulated fractalkine secretion only in fibroblasts.

252 rols (WT) by ELISA and the effect of PGE2 on fractalkine secretion was measured in cultured neonatal

253 ipts, including CXCL1/KC, LCN2, iNOS, CX3CL1/fractalkine, SERPINA3G, and IkappaBalpha ("marker genes"

254 The observation that fractalkine serves as a survival factor for primary micr

255 The data show that the rate of fractalkine shedding in healthy cultures positively corr

256 neural hearing loss by examining the role of fractalkine signaling after aminoglycoside ototoxicity o

257 and T280M, have been associated with reduced fractalkine signaling characterized by decreased adhesiv

258 To investigate the role of fractalkine signaling in macrophage recruitment, we cros

259 The present study examined the role of fractalkine signaling in regulating the injury-evoked be

260 Our data suggest that fractalkine signaling in the cochlea is neuroprotective,

261 s demonstrate that loss of neuron-microglial fractalkine signaling leads to reduced beta-amyloid depo

262 eukocytes into the spiral ganglion, and that fractalkine signaling plays a role in macrophage recruit

263 Disruption of fractalkine signaling reduced macrophage recruitment int

264 Here we show that fractalkine signaling regulates macrophage recruitment i

265 Fractalkine signaling, a pathway mediating the communica

266 By ruling out an essential role for fractalkine signaling, our study narrows the search for

267 hPSCs overexpress MFG-E8 upon fractalkine stimulation in vitro, which underlines the s

268 show that the source of calcium mobilized by fractalkine stimulation is the extracellular pool.

269 d evaluated for MFG-E8 mRNA expression after fractalkine stimulation.

270 n the neuroprotective role of both SDF-1 and fractalkine, suggest that this novel interaction between

271 eceptors mediate the neurotrophic effects of fractalkine, suggesting that fractalkine and its recepto

272 biosensor chips showed a higher affinity for fractalkine than non-sulfated peptides.

273 rostatic interactions with basic residues on fractalkine that are necessary for receptor function but

274 he CX3CR1 receptor and undergo chemotaxis to fractalkine that can be inhibited by G protein inactivat

275 e phagocytic capability of microglia through fractalkine (the ligand of CX3CR1) signaling and by prom

276 CX3CL1 (fractalkine), the only member of the delta subclass of c

277 Fractalkine, the first member of the CX(3)C chemokine fa

278 This membrane-bound localization allows fractalkine to function as an adhesion molecule for cell

279 Fractalkine treatment of AVM decreased both the speed of

280 capture by and firm adhesion to immobilized fractalkine under physiologic flow conditions.

281 By electron microscopy, fractalkine was 29 nm in length with a long stalk (mucin

282 leukin-6, interleukin-8, interleukin-10, and fractalkine was identified to be the most important.

283 LV fractalkine was increased in EP4 KO mice but surprisingl

284 Fractalkine was measured in LV of 28-32 week old male EP

285 Cellular distribution of fractalkine was regulated during polarization of T-84 ce

286 NF-alpha-mediated up-regulation of placental fractalkine was reversed in the presence of the aspirin-

287 leukin-6, interleukin-8, interleukin-10, and fractalkine, was significantly higher in patients who de

288 To determine the biologic role of fractalkine, we used targeted gene disruption to generat

289 The effects of fractalkine were assessed on the visceromotor response i

290 row aspirates express the cell-bound form of fractalkine, whereas the soluble form of the chemokine i

291 tivated by the neuronal chemokine CX3CL1 (or fractalkine) which controls key functions of microglial

292 y epithelial cells are a source of CX(3)CL1 (fractalkine), which mediates cell adhesion and acts as a

293 We tested the hypothesis that fractalkine, which is constitutively expressed by primar

294 factors may be the proinflammatory chemokine fractalkine, which is expressed in the syncytiotrophobla

295 elopment, and the neuroprotective chemokine, fractalkine, which is upregulated during postnatal devel

296 en MFG-E8 and the pro-inflammatory chemokine fractalkine, which may determine the severity of pain, f

297 late the expression and release of placental fractalkine, which, in turn, may contribute to an exagge

298 ymphotactin, and the murine CX(3)C chemokine fractalkine with high affinity (K(d) = 1.6 to 18.7 nM).

299 mutant receptors E13A, D16A, and D266A bound fractalkine with high affinity but were unable to induce

300 Thus, the interaction of fractalkine with its receptor CX3CR1 could play a crucia