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1 th banana flours, especially with the coarse fraction.
2 ctional status in HF with preserved ejection fraction.
3 c inflammation in HF with preserved ejection fraction.
4 was detected relative to the hemoglobin (Hb) fraction.
5 nts with heart failure with reduced ejection fraction.
6 e soluble and/or membrane-associated protein fraction.
7 ot with decline in left ventricular ejection fraction.
8 ilure with reduced left ventricular ejection fraction.
9 e assessed for each surfactant type and mass fraction.
10 cant difference in left ventricular ejection fraction.
11 arison with patients with higher RV ejection fraction.
12 2-tissue-compartment model with blood volume fraction.
13 sverse relaxation rates and the myelin water fraction.
14  ischemic heart disease and reduced ejection fraction.
15 s are reported per SD increase of each lipid fraction.
16 t is insensitive to constant changes in this fraction.
17 s with heart failure have preserved ejection fraction.
18 es are the cellular targets of the L-acetate fraction.
19 10 ng of sample obtained in a collected HPLC fraction.
20 s were not observed in globulin and prolamin fractions.
21 ans (up to R=0.80) in bran and refined flour fractions.
22 ent, and left and right ventricular ejection fractions.
23  globulin, glutein-1, glutein-2 and prolamin fractions.
24 erved in the RP-HPLC profiles of all protein fractions.
25 city was the result of ionic and nonionic Cu fractions.
26 % of the pY-MIP-TiO2-enriched phosphopeptide fractions.
27 ase, were identified in all the three pollen fractions.
28 o delivery to cells, are enriched in certain fractions.
29 arin (C47) and two derivatives in the active fractions.
30  p-coumaric acids were abundant in the bound fractions.
31 ng T2 relaxation times were 24.7 ms, 4.2 ms (fraction 15%) and 30.4 ms (fraction 85%) respectively.
32 ex=0%-92% females, left ventricular ejection fraction=26%-61%).
33 age 62+/-11 years, left ventricular ejection fraction 27+/-7%).
34 mice given CMCs 2 days after MI, LV ejection fraction 28 days later was significantly increased in th
35  bread had higher levels of resistant starch fractions (3.87-10.96%) with low predicted glycemic inde
36 even though Usp14 is present on only a minor fraction (30-40%) of the 26S in WT mouse embryonic fibro
37         We found that the Wogonin containing fraction-4 (F4) was the most potent fraction based on it
38 oing ViR had lower left ventricular ejection fraction (45.6 +/- 17.4% vs. 55.3 +/- 11.1%; p < 0.001).
39  24.7 ms, 4.2 ms (fraction 15%) and 30.4 ms (fraction 85%) respectively.
40  RV mass, end-diastolic volume, and ejection fraction after control for risk factors and copollutants
41 etide in heart failure with reduced ejection fraction and demonstrates that a single infusion of elam
42 maging measures of left ventricular ejection fraction and end-systolic volume, but not with the sever
43 ts degassed or not, an isolated polyphenolic fraction and extract-like model media, allowing the impa
44 artment can be captured within the CD45RA(-) fraction and further defined as positive for CD26 in com
45                 Significantly lower arterial fraction and higher vascular transit time, fractional vo
46 osis with heart failure and reduced ejection fraction and summarizes the current registry and clinica
47  the even-denominator states to both filling fraction and transverse displacement field provides new
48 d isotope ratios to the decreasing substrate fractions and is valid for closed systems.
49 gh resolution mass spectrometry (hydrophilic fraction) and fluorescence spectroscopy.
50 ificantly improved infarct size, LV ejection fraction, and adverse LV remodeling, changes associated
51 treatment improved left ventricular ejection fraction, and clinical status and QOL showed favorable t
52 ed as a function of the microparticle volume fraction, and from this the compressibility of the micro
53 , New York Heart Association class, ejection fraction, and use of background digoxin, a network meta-
54                                 Only a small fraction ( approximately 10%) of genes are predicted to
55 h 85% of identified peptides in the enriched fraction as glycated, high sensitivity for detection of
56  reproducibly higher cytotoxicity than other fractions as well as the unseparated ensemble.
57  to body weight ratios and improved ejection fraction at d5 post-MI.
58      The groups had similar mean LV ejection fraction at diagnosis (29.6 with versus 27.3 without pre
59 o 10(-6) Torr enriched the Al site occupancy fraction at the outermost surface from 0.245(10) to 0.32
60  a model-based method to compare allele read fractions at known single-nucleotide polymorphisms, cons
61 ntaining fraction-4 (F4) was the most potent fraction based on its ability to inhibit ROS production
62         Considering the total and dialyzable fraction, beef is an important source of Cu, Fe, Mg, and
63 the EM algorithm in estimating recombination fractions between dominant loci and recovering true link
64 ulture growth, and their profile in purified fractions (bodies and faeces) and international referenc
65 ity was concentrated in a microsome-enriched fraction but also was present in soluble form.
66  alignment are found to depend on the volume fraction, but not on the size of nanofillers.
67 of varying component bimodal eutectic volume fractions by controlling the cooling rate of the laser s
68  lower RV and left ventricular (LV) ejection fractions compared with controls.
69    In patients with HF with reduced ejection fraction, compared with lower doses, higher doses of ACE
70                                    Thus, TAC fractions contain a specific subset of the processed chl
71  the following metrics: sensitivity, scatter fraction, contrast recovery, uniformity, count rate perf
72 nsferase increase (three [8%]), and ejection fraction decrease (three [8%]).
73 vs. 61 +/- 16%; p < 0.001; n = 95), ejection fraction decreased (58 +/- 11% vs. 55 +/- 10%; p < 0.001
74              At native pH of 8.6, the anoxic fraction, despite its significant Fe(II), approximately
75 le with heart failure and preserved ejection fraction develop increases in left ventricular (LV) end-
76            Novel aleurone-rich wheat milling fraction developed and produced on industry scale is inv
77                                Besides, both fractions did not promote extra formation of acrylamide
78                Scatter sinograms and scatter fractions did not reveal large differences regardless of
79 sonance measurements of extracellular volume fraction (ECV) to discover and quantify diffuse myocardi
80 tic stenosis (LGSAS) with preserved ejection fraction (EF) is incompletely understood.
81     Improvement in left ventricular ejection fraction (EF) to >35% occurs in many patients with reduc
82         Global myocardial function (ejection fraction [EF] and left ventricular end-diastolic pressur
83 ues of atrial dimensions, volumes, and empty fractions (EFs) were provided by short axis (SAX) and ar
84  than 2-fold increase in iron in white flour fractions, exceeding minimum legal fortification levels
85                                   The volume fraction (f) of graphene in ZnO was optimized using simu
86               Derecruited and recruited lung fractions (Fderecruited, Frecruited) were computed based
87 erfusion, specific ventilation (sV), and gas fraction (Fgas) in the 25% of the lung with the lowest s
88      A fractionation on XAD-16 afforded four fractions for each extract.
89                            BR-levels and the fractions free/BR follow characteristic sigmoid plots wh
90             Analysis of the stromal vascular fraction from periprostatic white adipose tissue from ob
91 horylation changes in interphase and mitotic fractions from asynchronously growing human cells.
92 lar and bio-functional properties of protein fractions from Nigella damascena and Nigella arvensis, i
93 oteomics analysis of cytoplasmic and nuclear fractions from normal versus regenerating mouse liver.
94                                       Intake fractions from residential and occupational indoor sourc
95 015 (n=120) of non-transgenic corn and their fractions (germ, pericarp, endosperm, cornmeal and grits
96  HFpEF, defined as left ventricular ejection fraction &gt;/=40%, we derived propensity scores for nitrat
97 ailure (HF) patients with preserved ejection fraction (HFpEF) display irregular breathing, sympatho-v
98        Heart failure with preserved ejection fraction (HFpEF) is common, recalcitrant to treatment, a
99 mon in heart failure with preserved ejection fraction (HFpEF), its functional implications beyond the
100  in heart failure (HF) with reduced ejection fraction (HFrEF; EF <40%) is well established, but its p
101  whether accounting for the bioaccessible Pb fraction improves statistical relationships with childre
102 es, STR-Seq can identify a 0.1% minor genome fraction in a DNA mixture composed of different, unrelat
103  SLAMF7-CAR T cells spares the SLAMF7(-/low) fraction in each cell subset and preserves functional ly
104 nificant change of left ventricular ejection fraction in the cell group.
105 but endogenous C3G is a component of nuclear fractions in a variety of cell types.
106 r associated with soil mineral and aggregate fractions in some of the ecosystems they invade.
107 ds, and thus largely enriched the SDS and RS fractions in starch.
108 rofiling to assess the presence of tumor DNA fractions in the AH cfDNA of the 3 patients.
109 sociated with reduction in oxygen extraction fraction, independent of Hgb level (p = 0.002 vs normal
110 plet radius without affecting the condensate fraction inside it.
111               The cholesterol esterification fraction is a valid biomarker for liver synthesis and al
112 beta-ether bonds, indicating that at least a fraction is incorporated through labile ether bonds.
113  suggests that the smallest molecular weight fraction is more susceptible to processes that lead to r
114  substantial reductions in all 3 major lipid fractions, is caused by mutations that inactivate the ge
115  analyses found no interaction with ejection fraction less than 30%, type of surgery, and preoperativ
116 -one patients with left ventricular ejection fraction &lt;/=35% and New York Heart Association class II
117 artery disease and left ventricular ejection fraction &lt;/=40%.
118        In the derivation cohort, LV ejection fraction &lt;/=47%, infarct size >/=19%LV, and microvascula
119     Patients with PAH with lower RV ejection fraction (&lt;41%) had a significantly reduced heart rate r
120  distinguishing and quantifying smaller size fractions (&lt;1 mm), and this has probably resulted in an
121 ion, CAPB increased the proportion of low MW fractions (&lt;20 kDa) from 4.22% to 39.4%, which are more
122                                  LV ejection fraction (LVEF) less than 50% (P < .001) and anterior in
123 icular volumes and left ventricular ejection fraction (LVEF).
124  hearts with LVSD (left ventricular ejection fraction [LVEF] </=40%) on initial TTE that resolved (LV
125                                      Scatter fraction measured with a (68)Ge line source in the scatt
126 geted MRI method, fast macromolecular proton fraction (MPF) mapping demonstrated a promise as a myeli
127 ees C), Cd amounts in metal sensitive tissue fractions (MSF), in relation to fresh weight, were simil
128 ular risk factors, left ventricular ejection fraction, myocardial scar and ischemia, rate-pressure pr
129 cterized by gas chromatography (semivolatile fraction), negative electron spray ionization high resol
130 bral blood flow (CBF), (2) oxygen extraction fraction (OEF), and (3) cerebral metabolic rate of oxyge
131  MR cine scans with a difference in ejection fraction of -2% +/- 3%.
132 of odds (LOD) of 8 and maximum recombination fraction of 0.35.
133 in patients with a left ventricular ejection fraction of 35% or less who were undergoing cardiac surg
134  6-54%) with mean right ventricular ejection fraction of 48+/-15% (range, 7-78%).
135  detection and discrimination at loci only a fraction of a degree apart within the foveola.
136                 To this aim, the (30)Si mole fraction of a sample of the new material was measured us
137     The variant proportion is defined as the fraction of a specific variant type (e.g. single nucleot
138 loss, which enabled direct estimation of the fraction of accessible DHSs within individual cells.
139 ed to result in an elevation of the cellular fraction of active eEF-2K.
140 surface water source characterized by a high fraction of aquatic humic matter.
141      During this time, the PI success ratio (fraction of basic-science PIs who are R01 grantees) drop
142 mouse embryonic brain in utero increased the fraction of cells expressing Sox2 in the ventricular zon
143 pread is normally restricted to only a small fraction of cells on the corneal surface that connect wi
144       By fluorescently labeling only a small fraction of cellular Pil1p, the main eisosome BAR-domain
145 r, known CD mutations were evident in only a fraction of CH cases.
146 ated rates of "absolute income mobility"-the fraction of children who earn more than their parents-by
147 n in atmospheric particles comprises a large fraction of chromatographically unresolved compounds, of
148 % of SSA particles containing chloride (mole fraction of Cl/Na >/= 0.1, 90% chloride depletion).
149 aining was performed to determine the volume fraction of coherently aligned nanowires in SEM images.
150                                On E15.5, the fraction of competent oscillators increased dramatically
151 e that miR-21-5p is released in the exosomal fraction of cultured DRG following capsaicin activation
152                                      A minor fraction of dendrimers, however, localize to endoplasmic
153 on points can be decreased by increasing the fraction of dependency links or the number of initially-
154                             In a significant fraction of DLBCL patients, tumor cells constitutively p
155 ve lower cut points for IgE levels (268 IU), fraction of exhaled nitric oxide values (14.5 ppb), and
156                         Thus, we show that a fraction of gene-regulatory changes suggest strong mecha
157  of selected candidate genes or a very small fraction of genomic CpG sites in human pancreatic islets
158 nfocal fluorescence microscopy showed that a fraction of HCF222-green fluorescent protein was detecta
159 ly countermanded repression in a significant fraction of heat-repressed genes suggests that repressio
160 ctions, respectively, and measurement of the fraction of histones remaining chromatin-bound in the in
161 wastewaters is limited to hydrocarbons and a fraction of known chemical additives.
162 ific protein mutated in epilepsy, recruits a fraction of mammalian GATOR1 and GATOR2 to form a SZT2-o
163                                Thus, a large fraction of Mars' atmospheric gas has been lost to space
164                                The surviving fraction of MCF7 /: HER2-18 cells treated with (64)Cu-la
165 tween remaining oil saturation (ROS) and the fraction of micro-pores.
166  were longer than a minute for a significant fraction of molecules (characteristic dwell time tau = 1
167 nsional manifolds that capture a significant fraction of neural variability.
168 ake inhibitors, are not ideal because only a fraction of patients achieve remission.
169 ete and durable responses are only seen in a fraction of patients who have cancer.
170 nges in intended management in a substantial fraction of patients with prostate or other types of can
171    Organic aerosol contributes a significant fraction of PM in the United States.
172 ons are due to the newer fleet; an increased fraction of pre-2008 chassis model year vehicles with re
173  parameters were responsible for the highest fraction of predictive uncertainty in modeled biomass, h
174 xing phytoplankton, which contribute a large fraction of primary production in the tropical and subtr
175 nt for patients whose tumours contain a high fraction of replicating cells.
176                                            A fraction of RIP2 localizes to the endoplasmic reticulum
177 ture of amorphous Se relates to the relative fraction of Se atoms residing in infinity1Se chains vers
178 eter SSA number concentrations, and that the fraction of SSA produced by jet drops can be modulated b
179                                            A fraction of Stx3 is localized to late endosomes/lysosome
180                                          The fraction of target compounds in the particulate phase re
181 ixing trees comprise only a slightly smaller fraction of taxa at higher vs. lower latitudes (8% vs. 1
182                  The novel sites form when a fraction of Te(4+) is reduced and emitted from the M1 cr
183 ay technologies that only assay a very small fraction of the CG methylome and entirely miss two forms
184  Balaur can securely outsource a substantial fraction of the computation to the public cloud, while b
185 s a function of size of the probe and volume fraction of the crowder.
186                                   The volume fraction of the fine eutectic decreased with cooling rat
187  expertise (1-9 years) first reviewed only a fraction of the full multiparametric contrast-enhanced M
188 evolutionary expansion of the hypomethylated fraction of the genome, driven both by the birth of new
189 usly proposed models are based on the volume fraction of the hard phase of the composite.
190                 For many years, only a small fraction of the human genome was believed to regulate ce
191                          Still, only a small fraction of the human proteome has chemical ligands.
192 k a unique 3D structure and comprise a large fraction of the human proteome play important roles in n
193 etabolites, allowing the analysis of a large fraction of the metabolome and focused analysis of the d
194 at any height h (a fixed height, not a fixed fraction of the peak maximum) leading to any number of c
195 l inevitably be appropriated by a very small fraction of the population unless effective wealth-equal
196                                A significant fraction of the population was responsive at any given t
197                                A substantial fraction of the proteome is intrinsically disordered, an
198 , we have asked the following question: what fraction of the rotavirus particles that penetrate into
199 mmunities are typically dominated by a small fraction of the species.
200 y reveals that, at pH </= 3.5, a significant fraction of the surface arsenic (30-60%) has an oxidatio
201  formaldehyde hemiacetals are a considerable fraction of the total formaldehyde produced in electroni
202 peded by the inability to access more than a fraction of the total microstate space.
203 eported molecules while needing only to do a fraction of the total possible reactions without any pri
204 .20 (SE=0.02), suggesting that a substantial fraction of the twin-based heritability arises from comm
205 known pigmentation loci explain only a small fraction of the variance.
206 observed heterogeneity only explains a small fraction of the variances in longevity (5.9%), age at fi
207        Under nitrogen-limiting conditions, a fraction of the vegetative cells in each filament termin
208 nce occurs during the day when a substantial fraction of the visual pigment in our photoreceptor cell
209 igher than generic statins, and only a small fraction of their higher cost is likely to be recovered
210 f parental mosaicism indicating that a large fraction of these de novo mutations occurred during earl
211                              Additionally, a fraction of these proteins localized to structures surro
212                                      A large fraction of this gas ( approximately 42%) may reach the
213  reactive B cells may interact with a larger fraction of this repertoire and demonstrate that this wo
214 ffer between individuals, and defining which fraction of this variation can be attributed to the viru
215 bility of set-point viral load, which is the fraction of variation in this phenotype attributable to
216 zation of the input virus, suggesting that a fraction of virus particles are resistant to antibody ne
217 ique, to receive radiotherapy (59.4 Gy in 33 fractions of 1.8 Gy) alone or with adjuvant temozolomide
218 e delivered PMRT at a dose of 36.63 Gy in 11 fractions of 3.33 Gy over 11 days to the chest wall and
219 by an optional mastectomy scar boost of four fractions of 3.33 Gy.
220 aracterized from high-molecular weight (HMW) fractions of an IgG1 monoclonal antibody (mAb).
221 es, flavonoids and procyanidins in different fractions of camelina and sophia extracts.
222                Certified values for the mass fractions of HCB and HCBD were assigned with 120 +/- 8 a
223 e-green algae content produced higher number fractions of individual LSA particles that contained bio
224 d that, at the turgor loss point, only small fractions of leaf vein xylem conduits were embolized, an
225 charge transport is sensitive to even minute fractions of molecular disorder, this work emphasizes th
226  that are well suited to overcoming low mass fractions of nanoparticles, producing stable nanoparticl
227                The results show that, at low fractions of oDMSi-BTA sergeants (<10 mol%), the polymer
228                                          The fractions of particles smaller than 30 nm (F30) varied a
229 nes and aromatics contributed to the largest fractions of photochemical reactivity, suggesting the st
230 dely distributed and often account for large fractions of plant and animal genomes yet the contributi
231  and normal phase chromatography to generate fractions of saturated hydrocarbons, aromatic hydrocarbo
232  Secondly, we predicted significantly higher fractions of SAVs with effect between healthy individual
233                                 The aromatic fractions of snow, lake sediment, and air samples collec
234                                  Analysis of fractions of STP-C1 using UPLC-MS/MS identified sixteen
235 h one of the highest population attributable fractions of the comorbidities (3.4%).
236 e creep rates by augmenting the local volume fractions of TiBw in the network region.
237 es post column processing of chromatographic fractions on chip.
238  in patients with HF with preserved ejection fraction only (hazard ratio, 5.0; P=0.001).
239 derived from HF patients with lower ejection fraction or diagnosed with diabetes.
240  Light fraction organic carbon (LFOC), heavy fraction organic carbon (HFOC), and dissolved organic ca
241                                        Light fraction organic carbon (LFOC), heavy fraction organic c
242 eks or to hypofractionated RT of 60 Gy in 20 fractions over 4 weeks.
243  allocated to conventional RT of 78 Gy in 39 fractions over 8 weeks or to hypofractionated RT of 60 G
244 as associated with left ventricular ejection fraction (P=0.045) and ventricular-vascular coupling rat
245     In heart failure with preserved ejection fraction, patients with diabetes mellitus have more sign
246 ng in ripening states and in different fruit fractions (peel, pulp, and calyx of ripe fruits) were in
247 to be MS-compatible, and the latter requires fraction pooling to create orthogonality.
248 al shifts (change >0.1 in clonal cancer cell fraction, Q < 0.1) in 31% of patients during the first y
249  whole air or synthetic air covered the mole fraction range of (378-420) mumol mol(-1) and were prepa
250  elevated quenching in high molecular weight fractions, rather than increased (3)DOM formation.
251 ent in patients with HF and reduced ejection fraction receiving aggressive vasodilator titration.
252 ated with impaired left ventricular ejection fraction recovery post-transcatheter aortic valve replac
253 art mass, 60-90% reduction in blood ejection fraction relative to control mice, and eventual lethalit
254                   We show that early-eluting fractions represent different G1 subpopulations that pro
255 gut microbiome also includes a non-bacterial fraction represented by eukaryotic cells and viruses.
256                  FBX enhanced the filtration fraction response to hyperglycemia in T1D patients throu
257 as identified in the isolates and their size fractions reveal that SRFA and PLFA have distinct molecu
258                  Global volumes and ejection fraction showed no differences between FD quartiles.
259                                              Fractions showed different amino acid compositions and a
260                            However, specific fractions showed reproducibly higher cytotoxicity than o
261  SHVH-P-FV (</=1kDa) and SHVH-N-FIV (3-1kDa) fractions showed the best ACE-inhibitory activities with
262 hat raspberry metabolites present in the GIB fraction significantly inhibited microglial pro-inflamma
263 tute the roe mass and microencapsulate lipid fraction, so that small oil droplets are entrapped withi
264 nts with heart failure with reduced ejection fraction, such as angiotensin converting enzyme (ACE) in
265  and downregulation of Mfn2 in mitochondrial fractions suggested that loss of fusion capacity targets
266 enic potency correlated well among the three fractions tested, with 1D immunoblots demonstrating a sl
267 eometries with the same extracellular volume fraction the geometry with the most tunnel volume had [F
268  to achieve input compensation: at lower ATP fraction, the individual hexamers make a shorter cycle i
269 in abundance in both cellular and viral size fractions, the viral assemblage was remarkably stable, w
270  the potentially dispersible nanoparticulate fraction, thus providing a benchmark with which to make
271 TH treatment led to an increased bone volume fraction, tissue density and trabecular thickness, with
272 ted in an average increase of the accessible fraction to 49 +/- 2%, whereby primarily the accessibili
273  chemical composition of the coffee volatile fraction to its sensory properties with the end-goal of
274 s with heart failure with preserved ejection fraction to oral KNO3 (n=9) or potassium chloride (n=3).
275                                Fasting lipid fractions (triglycerides [TGs], high-density lipoprotein
276 dal suspensions, at sufficiently high volume fraction (varphi), dynamically assemble into a fully per
277           Exposure to the water-accommodated fraction (WAF) of oil from the spill causes developmenta
278 centration, inspired and expired sevoflurane fraction, wake-up times, duration of sedation, sevoflura
279 yopathy), the mean left ventricular ejection fraction was 32+/-12% (range, 6-54%) with mean right ven
280                                  RV ejection fraction was assessed in 112 patients with PAH.
281                         Although LV ejection fraction was comparable between groups, longitudinal pea
282                The left ventricular ejection fraction was consistently decreased with a median value
283 est in Amb a 6, Amb a 5 and Amb a 3, and TOT fraction was the richest in the Amb a 8 allergens (89% a
284              The antioxidant activity of the fractions was due to oxygenated monoterpenes, specifical
285  biologically detoxified heat stable protein fraction were 35% higher in E. cyaneus.
286 nd alphaII spectrin in the insoluble protein fraction were observed in fibroblasts derived from patie
287 cular size distributions of the fluorescence fractions were broad and chromatographically unresolved,
288 IC method, 350mg of whole egg powder and its fractions were efficiently digested using 50mmolL(-1)NH4
289 cle size, and zeta potential of the micellar fractions were investigated.
290 tal antioxidant capacities in the dialysable fractions were significantly lower than their original.
291                                       Tomato fractions were subjected to pulsed electric fields treat
292 ides with predominant xylotriose into liquid fraction which expressed 1.03+/-0.01 (mumolAAE/g) ABTS r
293 nts with heart failure with reduced ejection fraction who were enrolled in clinical trials, a finding
294 e used to document left ventricular ejection fraction with accuracy comparable with that of MRI.
295 f human heart failure and preserved ejection fraction with sternum intact (n=4).
296 SRSF3 and SRSF7 targets were detected in all fractions, with intron, snoRNA and lncRNA interactions e
297 ge, lower baseline left ventricular ejection fraction, worse post-procedural mitral regurgitation, mo
298                                              Fractions X1C and X2C notably inhibited alpha-glucosidas
299 ) wind-driven outflow with moderate electron fraction (Ye approximately 0.27).
300  transient or oscillatory changes in the ATP fraction, yet is insensitive to constant changes in this

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