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1 ithout inhibitory feedback is functional but fragile.
2 c patient subgroups, such as the elderly and fragile.
3 s cells are dynamic, chemically diverse, and fragile.
4 pristine matter and coherence was considered fragile.
5 remain at risk and hence the gains made are fragile.
7 However, superhydrophobicity is remarkably fragile and can break down due to the wetting of the sur
10 cuticle of LmCYP4G102-knockdown locusts was fragile and easier deformable than in control animals.
12 bers used for in vivo bioanalysis can be too fragile and flexible, which limits suitability for direc
13 population, a situation in which ongoing-but fragile and limited-health cooperation and training arra
18 es in person perception were generally weak, fragile, and fleeting; (2) Social perceptions were often
19 a PET10 deletion strongly aggregate, appear fragile, and fuse in vivo when cells are cultured in ole
20 uption by noise: redundant codes can be very fragile, and synergistic codes can-in some cases-optimiz
21 ce is lost, the vessels can be malformed and fragile, and they can lose arteriovenous differentiation
24 cal CT analysis--those with osteoporosis or "fragile bone strength"--agreed well against classificati
25 ion named seal was produced, associated with fragile bones and susceptibility to fractures (spine and
29 h promotion and basic first-line services in fragile contexts with weak secondary health service infr
30 grid express interactions among modules with fragile couplings that amplify even small shocks, thus p
31 rms well-ordered crystals, whereas rA6 forms fragile crystalline-like structures, and rA5, rA8 and rA
33 ight into why human neoplastic translocation fragile DNA sequences are more prone to enzymes or agent
35 nservation efforts aimed at protecting these fragile ecosystems in the face of anthropogenic warming.
38 Because PT-symmetry has been thought of as fragile, experimental realisations to date have been usu
40 te its remote location, the deep sea and its fragile habitats are already being exposed to human wast
41 s-Danlos syndrome (cEDS) is characterized by fragile, hyperextensible skin and hypermobile joints.
43 ient's blood (e.g., red blood cells are more fragile in patients undergoing chemotherapy) and the car
44 However, existing bioengineered lungs are fragile, in part because of their immature vascular stru
48 that water is a mixture of a high density, "fragile" liquid, and a low density, "strong" liquid, the
50 n excitations are quite similar indicating a fragile low temperature ground state with respect to the
51 ly significant dichotomous results are often fragile, meaning that a difference of only a couple of e
52 usion-promoting proteins, and deliver large, fragile membrane protein complexes into the target bilay
53 s rarely been analyzed, foremost because the fragile membranous structures in the inner ear are hard
55 he experimentally used treatment protocol is fragile (nonrobust) and (ii) discovered an alternative r
57 -encoded nucleosome fragility, we also found fragile nucleosomes at locations where we expected to fi
59 that for nearly all mouse genes, a class of fragile nucleosomes occupies previously designated nucle
67 primary cells steadily accrue macroH2A1.2 at fragile regions, whereas macroH2A1.2 loss in these cells
68 rmation of the apical hook that protects the fragile shoot apical meristem when it breaks through the
69 y reductive amination; (ii) stabilization of fragile sialic acids by carbodiimide coupling; (iii) rel
71 The magnetic structure in GdPd3 is highly fragile since applied magnetic fields of moderate streng
72 In this study, loss of expression of the fragile site-encoded Wwox protein was found to contribut
75 ves late replication intermediates at common fragile sites (CFSs) during early mitosis to trigger DNA
78 addition, important genomic elements such as fragile sites and tRNA genes are found to be clustered s
79 construct a statistical model that separates fragile sites from regions showing signatures of positiv
81 occur either over tumour suppressors or over fragile sites, regions of increased genomic instability.
82 ffected genes overlap with early replicating fragile sites, show elevated levels of gammaH2AX, and su
87 lose their biological activity due to their fragile structural conformation during formulation, stor
90 This presents a difficult situation whereby fragile substrates such as lactone will be hydrolyzed by
92 Members of the Cryptochiridae are small, fragile, symbiotic crabs that live in domiciles in moder
94 ll lines, we show that ALT cells harbor more fragile telomeres representing telomere replication prob
95 ective POT1-TPP1 complex leads to longer and fragile telomeres, which in turn promotes genomic instab
97 -8) Pa, G(T) and D(T) have super-Arrhenius ("fragile") temperature dependences, but both cross over t
98 es of the brain, and provide rigidity to the fragile tissue while eliminating background interference
99 we find that although human life is somewhat fragile to nearby events, the resilience of Ecdysozoa su
104 materials, which originates from relatively fragile/weak bonds between inorganic and organic constit
105 , optimized for filtration, is intrinsically fragile, whereby local transient biochemical imbalances
108 hildren with a disability as a result of the Fragile X (FX) premutation, a genetic abnormality in FMR
109 athophysiology of FXS.SIGNIFICANCE STATEMENT Fragile X (FXS) individuals have a range of sensory rela
110 ngs identify RSK as a therapeutic target for fragile X and suggest the therapeutic potential of drugs
111 enic syndromes highly comorbid with autism - fragile X and tuberous sclerosis types 1 and 2 syndromes
112 related protein 1 (FXR1P) is a member of the fragile X family of RNA-binding proteins, which includes
113 e a long-standing unanswered question in the fragile X field, which is also relevant to autism pathog
114 lb circuits exhibited axonal localization of Fragile X granules (FXGs), structures that comprise ribo
115 l translational machinery is associated with Fragile X granules (FXGs), which are restricted to axons
117 cortex and hippocampus in wild-type (WT) and fragile X knockout (FMR1-KO) mice during the first 5 wee
119 00 CGG repeat expansion in the 5'-UTR of the fragile X mental retardation 1 (FMR1) gene is known as a
123 rative molecular analysis converged on FMR1 (Fragile X Mental Retardation 1), an important negative r
125 e biology: it has a regulatory loop with the fragile X mental retardation homologue FXR1 and regulate
126 Pum2 display RNA-dependent interaction with fragile X mental retardation protein (FMRP) and bind to
127 pathophysiology associated with the loss of fragile X mental retardation protein (FMRP) and haploins
128 nnel open probability was reduced by loss of fragile X mental retardation protein (FMRP) and that FMR
129 es, mRNA, and RNA binding proteins including Fragile X mental retardation protein (FMRP) and the rela
130 mental retardation 1 (FMR1) gene and loss of fragile X mental retardation protein (FMRP) cause fragil
132 es to understand how the loss of function of fragile X mental retardation protein (FMRP) causes fragi
133 brain.SIGNIFICANCE STATEMENT The absence of Fragile X Mental Retardation Protein (FMRP) from birth r
135 ndrome (FXS) is caused by the absence of the Fragile X Mental Retardation Protein (FMRP) in neurons.
138 tic protein synthesis resulting from loss of fragile X mental retardation protein (FMRP) is thought t
141 Here we show that the effect of loss of fragile X mental retardation protein (FMRP) on these pat
142 expected, P = .0062) and for targets of the fragile X mental retardation protein (FMRP) pathway (10
143 opic glutamate receptor signaling though the fragile X mental retardation protein (FMRP) pathway may
148 ires protein translation and is dependent on fragile X mental retardation protein (FMRP), the protein
150 FXS results from the loss of function of fragile X mental retardation protein (FMRP), which repre
158 crucially on protein synthesis controlled by fragile X mental retardation protein and on Arc signalin
160 trated that hYVH1 co-localizes with YB-1 and fragile X mental retardation protein on stress granules
161 anslational regulatory complex that includes fragile X mental retardation protein, DEAD box helicase
162 including Y box-binding protein 1 (YB-1) and fragile X mental retardation protein, proteins that func
163 analyzed 15 synaptic proteins in normal and Fragile X mental retardation syndrome (FXS) model mouse
165 ing networks are altered in the neocortex of fragile X mice such that S6 phosphorylation receives abe
169 itive phenotypes displayed by the Drosophila fragile X model, and thus reveal a metabolic pathway tha
175 ) complexes results in the identification of fragile X protein family (FMRP, Fxr1 and Fxr2) as bindin
176 intact brain that contain one or more of the Fragile X related (FXR) proteins (FMRP, FXR2P, and FXR1P
179 here that in mouse models PFC dysfunction in Fragile X Syndrome (FX) can be attributed to the continu
181 ptors (mGlu1/5) is a core pathophysiology of fragile X syndrome (FX); however, the differentially tra
183 e behavioral and anatomical deficits seen in fragile X syndrome (FXS) are widely believed to result f
184 e X mental retardation protein (FMRP) causes fragile X syndrome (FXS) have largely focused on neurons
195 ssing deficits in FXS.SIGNIFICANCE STATEMENT Fragile X Syndrome (FXS) is the most common inheritable
196 specially in non-neuron glial cells, induces fragile X syndrome (FXS) phenotypes has just begun to be
198 le X mental retardation protein (FMRP) cause fragile X syndrome (FXS), a genetic disorder characteriz
200 ental retardation protein (FMRP) loss causes Fragile X syndrome (FXS), a major disorder characterized
201 autism spectrum disorders (ASDs), including fragile X syndrome (FXS), and frequently leads to tactil
204 ty (ID) and autism spectrum disorders (ASD), Fragile X syndrome (FXS), is caused by loss of the mRNA-
205 trum disorder (ASD), including in those with fragile X syndrome (FXS), one of the most common genetic
207 get for diseases affecting synapses, such as fragile X syndrome (FXS), the most common heritable auti
210 e X mental retardation protein (FMRP) causes fragile X syndrome (FXS), yet the mechanisms underlying
218 man's syndrome (34%), CHARGE syndrome (30%), fragile X syndrome (male individuals only 30%; mixed sex
222 lem in the Fmr1-knockout (KO) mouse model of Fragile X syndrome and describe potentially treatable un
224 hysiology of Autism Spectrum Disorder (ASD), Fragile X Syndrome and Tuberous Sclerosis, the role of o
225 pression) relevant to the pathophysiology of fragile X syndrome as well as neural correlates of cogni
226 tion patterns at specific genomic regions in fragile X syndrome cells, and identified dysregulated ge
228 entiated to dorsal forebrain cell fates, our fragile X syndrome human pluripotent stem cell lines exh
231 This finding is of high relevance because Fragile X syndrome is the most common monogenetic cause
234 tion has been most well characterized in the fragile X syndrome mouse model, the Fmr1 knock-out (KO)
236 ulated gene- and network-level correlates of fragile X syndrome that are associated with developmenta
237 We then describe what we have learned from fragile X syndrome that may be applicable to other psych
240 This form of plasticity is deregulated in Fragile X Syndrome, a monogenic form of autism in humans
241 comprehensive manner, we begin by selecting fragile X syndrome, a neurogenetic disease with cognitiv
242 or fly models of Alzheimer's disease and the Fragile X syndrome, allowing applications such as geneti
243 evelopmental disorders, Rett syndrome (RTT), fragile X syndrome, and CDKL5 syndrome, also affects fem
244 in myotonic dystrophy, and (CGG)n repeats in fragile X syndrome, are also subject to double-strand br
245 otein (FMRP), the protein that is lacking in fragile X syndrome, binds neuroligin-1 and -3 mRNA.
247 expansions, including those associated with fragile X syndrome, Friedreich's ataxia, and Huntington'
248 gh incidence of autistic behaviours, such as fragile X syndrome, has the potential to identify genes
249 expansions in diseases such as hemophilia A, fragile X syndrome, Hunter syndrome, and Friedreich's at
250 ause amyotrophic lateral sclerosis (ALS) and fragile X syndrome, is challenging for short-read whole-
251 of disorders where it is disrupted, such as Fragile X syndrome, Rett syndrome, epilepsy, major depre
255 he impairment in spinogenesis, a hallmark in Fragile X syndrome, thereby linking the regulation of ac
256 onic dystrophy, spinal muscular atrophy, and fragile X syndrome, with broader implications for other
272 othesis of shared pathophysiology of RTT and fragile X, another monogenic cause of autism and intelle
273 omised in a Drosophila melanogaster model of Fragile X, highlighting intriguing new mechanistic conne
281 are associated with FMR1 overexpression and Fragile X-associated tremor/ataxia syndrome (FXTAS), a l
282 e affected by the neurodegenerative disorder fragile X-associated tremor/ataxia syndrome (FXTAS), pri
283 gnitive deficits are common in patients with fragile X-associated tremor/ataxia syndrome (FXTAS), wit
284 sent in a 5' untranslated region that causes fragile X-associated tremor/ataxia syndrome (FXTAS).
285 that translation of expanded CGG repeats in fragile X-associated tremor/ataxia syndrome is initiated
286 AN translation of the CGG repeats that cause fragile X-associated tremor/ataxia syndrome, revealing s
296 BPN14770 may be useful for the treatment of fragile-X syndrome and other disorders with decreased cA
297 rtex of Fmr1 knock-out (KO) mice, a model of Fragile-X Syndrome, to test the E/I imbalance theory.
300 double-strand breaks (DSBs) occurring within fragile zones of less than 200 base pairs account for th
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