ライフサイエンスコーパス: fragile X mental retardation protein

1 ic RNA granules with Pur alpha and FMRP (the fragile x mental retardation protein).

2 s shown to affect synaptic morphology (e.g., Fragile X mental retardation protein).

3 hannel signaling and binding partners of the fragile X mental retardation protein).

4 FMR1 and loss of the encoded protein, FMRP (fragile X mental retardation protein).

5 inked FMR1 gene, leads to the absence of the fragile X mental retardation protein.

6 ion 1 (FMR1) gene and consequent loss of the fragile X mental retardation protein.

7 caused by the loss of the Fmr1 gene product, fragile X mental retardation protein.

8 ilencing of the FMR1 gene, which encodes the fragile X mental retardation protein.

9 repeats in the 5' untranslated region of the fragile X mental retardation protein 1 (FMR1) gene expan

10 The resulting absence of fragile X mental retardation protein 1 (FMRP) leads to b

11 ted mental retardation caused by loss of the fragile X mental retardation protein 1 (FMRP).

12 aused by loss of the FMR1 gene product FMRP (fragile X mental retardation protein), a repressor of mR

13 necessary for LTH, these data indicate that fragile X mental retardation protein and Atx2 act via at

14 ated with higher, more typical levels of the fragile X mental retardation protein and inversely corre

15 crucially on protein synthesis controlled by fragile X mental retardation protein and on Arc signalin

16 argonaute-3 and argonaute-4, Dicer, and the fragile X mental retardation protein, are found in devel

17 that are enriched in G-quadruplex motifs and fragile X mental retardation protein-associated RNAs and

18 skeleton-associated protein interactors, the fragile X mental retardation protein complex, voltage-ga

19 n contrast, interactions of BC1 RNA with the fragile X mental retardation protein could not be docume

20 dies have linked three RNA-binding proteins, fragile X mental retardation protein, cytoplasmic polyad

21 anslational regulatory complex that includes fragile X mental retardation protein, DEAD box helicase

22 ct and corrects behavioural abnormalities in fragile X mental retardation protein-deficient mice.

23 Fragile X mental retardation protein deletion in mice en

24 Here we identify Drosophila fragile X mental retardation protein (dFMRP) as a robust

25 Here, we demonstrate that Drosophila fragile X mental retardation protein (dFMRP) is required

26 Drosophila Fragile X mental retardation protein (dFMRP; FMR1), a tr

27 The fragile X mental retardation protein FMRP is an RNA bind

28 lectual disability, is caused by loss of the fragile X mental retardation protein FMRP.

29 Fragile X mental retardation protein (FMRP) and Ataxin-2

30 Pum2 display RNA-dependent interaction with fragile X mental retardation protein (FMRP) and bind to

31 late translation of the RNA-binding protein, Fragile X mental retardation protein (FMRP) and FMRP tar

32 pathophysiology associated with the loss of fragile X mental retardation protein (FMRP) and haploins

33 rome critical region1 (DSCR1) interacts with Fragile X mental retardation protein (FMRP) and regulate

34 nnel open probability was reduced by loss of fragile X mental retardation protein (FMRP) and that FMR

35 es, mRNA, and RNA binding proteins including Fragile X mental retardation protein (FMRP) and the rela

36 mental retardation 1 (FMR1) gene and loss of fragile X mental retardation protein (FMRP) cause fragil

37 cognition memory indicating that the loss of fragile X mental retardation protein (FMRP) causes defec

38 The loss of Fragile X mental retardation protein (FMRP) causes Fragi

39 Absence of the fragile X mental retardation protein (FMRP) causes fragi

40 Loss of fragile X mental retardation protein (FMRP) causes fragi

41 es to understand how the loss of function of fragile X mental retardation protein (FMRP) causes fragi

42 brain.SIGNIFICANCE STATEMENT The absence of Fragile X Mental Retardation Protein (FMRP) from birth r

43 Loss of fragile X mental retardation protein (FMRP) function cau

44 In humans, failure to express the fragile X mental retardation protein (FMRP) gives rise t

45 Genetic deletion of fragile X mental retardation protein (FMRP) has been sho

46 Fragile X mental retardation protein (FMRP) has been sho

47 To investigate how the loss of fragile X mental retardation protein (FMRP) impacts the

48 To examine the role of the Fragile X mental retardation protein (FMRP) in altering

49 How the loss of fragile X mental retardation protein (FMRP) in different

50 ndrome (FXS) is caused by the absence of the Fragile X Mental Retardation Protein (FMRP) in neurons.

51 We report a function for the fragile X mental retardation protein (FMRP) in the rapid

52 We identified mRNA for the fragile X mental retardation protein (FMRP) in these pro

53 Fragile X mental retardation protein (FMRP) is a multifu

54 Fragile X Mental Retardation Protein (FMRP) is a regulat

55 The fragile X mental retardation protein (FMRP) is a ribosom

56 The fragile X mental retardation protein (FMRP) is a selecti

57 The fragile X mental retardation protein (FMRP) is a selecti

58 The fragile X mental retardation protein (FMRP) is an mRNA b

59 The fragile X mental retardation protein (FMRP) is an RNA bi

60 Fragile X mental retardation protein (FMRP) is an RNA bi

61 Fragile X mental retardation protein (FMRP) is an RNA-bi

62 Fragile X mental retardation protein (FMRP) is an RNA-bi

63 The expression of the RNA-binding factor Fragile X mental retardation protein (FMRP) is disrupted

64 Although the encoded fragile X mental retardation protein (FMRP) is known to

65 Fragile X mental retardation protein (FMRP) is thought t

66 tic protein synthesis resulting from loss of fragile X mental retardation protein (FMRP) is thought t

67 In fragile X syndrome, the absence of fragile X mental retardation protein (FMRP) leads to def

68 Loss of Fragile X mental retardation protein (FMRP) leads to Fra

69 y, and its local translational regulation by fragile X mental retardation protein (FMRP) linked to fr

70 Fragile X mental retardation protein (FMRP) loss causes

71 Here we show that the effect of loss of fragile X mental retardation protein (FMRP) on these pat

72 expected, P = .0062) and for targets of the fragile X mental retardation protein (FMRP) pathway (10

73 opic glutamate receptor signaling though the fragile X mental retardation protein (FMRP) pathway may

74 The fragile X mental retardation protein (FMRP) plays an imp

75 The tandem Agenet domain (TAD) of fragile X mental retardation protein (FMRP) protein is c

76 Thus, the Fragile X Mental Retardation protein (FMRP) regulates ex

77 The Fragile X mental retardation protein (FMRP) regulates ne

78 Loss of the RNA-binding protein fragile X mental retardation protein (FMRP) represents t

79 Loss of function of the fragile X mental retardation protein (FMRP) results in d

80 Deficiency in fragile X mental retardation protein (FMRP) results in f

81 Fragile X mental retardation protein (FMRP) sculpts syna

82 FXS patients have a deficit for the fragile X mental retardation protein (FMRP) that results

83 m lack of expression of a functional form of Fragile X mental retardation protein (FMRP), a cytoplasm

84 deficit caused by the functional absence of fragile X mental retardation protein (FMRP), a dendritic

85 Fmr1 encodes fragile X mental retardation protein (FMRP), a dendritic

86 der, is the result of loss or dysfunction of fragile X mental retardation protein (FMRP), a highly se

87 plasticity were studied in mice lacking the fragile X mental retardation protein (FMRP), a model for

88 Fragile X mental retardation protein (FMRP), a neuronal

89 It is associated with the lack of fragile X mental retardation protein (FMRP), a regulator

90 mental retardation and is caused by loss of fragile X mental retardation protein (FMRP), a selective

91 at RNA localizes to granules that label with fragile X mental retardation protein (FMRP), a transport

92 mental retardation, is caused by the loss of fragile X mental retardation protein (FMRP), an mRNA bin

93 ional silencing, resulting in the absence of fragile X mental retardation protein (FMRP), an mRNA bin

94 drome is caused by the absence of functional fragile X mental retardation protein (FMRP), an RNA bind

95 syndrome (FXS) is caused by the loss of the fragile X mental retardation protein (FMRP), an RNA bind

96 e show that this transition is controlled by fragile X mental retardation protein (FMRP), an RNA-bind

97 Here, we show that fragile X mental retardation protein (FMRP), an RNA-bind

98 It is caused by loss of expression of the fragile X mental retardation protein (FMRP), an RNA-bind

99 In humans, the absence of Fragile X mental retardation protein (FMRP), an RNA-bind

100 , is caused by the functional absence of the fragile X mental retardation protein (FMRP), an RNA-bind

101 e is caused by loss-of-function mutations in Fragile X mental retardation protein (FMRP), an RNA-bind

102 A current hypothesis proposes that fragile X mental retardation protein (FMRP), an RNA-bind

103 This gene encodes for the fragile X mental retardation protein (FMRP), an RNA-bind

104 The disease is caused by loss of fragile X mental retardation protein (FMRP), an RNA-bind

105 We describe here an essential role for fragile X mental retardation protein (FMRP), an RNA-bind

106 More recently, fragile X mental retardation protein (FMRP), an RNA-bind

107 elimination in mouse neurons, which requires fragile X mental retardation protein (FMRP), an RNA-bind

108 l line revealed reduced levels of endogenous fragile X mental retardation protein (FMRP), and a repor

109 ) gene leads to absence of the gene product, fragile X mental retardation protein (FMRP), and consequ

110 Mutations in FMR1, which encodes the fragile X mental retardation protein (FMRP), are the cau

111 s caused by the absence of a single protein, fragile X mental retardation protein (FMRP), because the

112 silencing of the FMR1 gene that encodes the fragile X mental retardation protein (FMRP), but the pat

113 volving dual leucine zipper kinase (DLK) and fragile X mental retardation protein (FMRP), control Dsc

114 ding proteins, the Drosophila homolog of the fragile X mental retardation protein (FMRP), dFXR, and V

115 caused by absence of the RNA-binding protein fragile X mental retardation protein (FMRP), encoded by

116 l retardation caused by inadequate levels of fragile X mental retardation protein (FMRP), is characte

117 y the loss of FMR1 gene function and loss of fragile X mental retardation protein (FMRP), is the most

118 lar interest because of its interaction with Fragile X mental retardation protein (FMRP), its upregul

119 new insight into the mechanistic function of Fragile X Mental Retardation Protein (FMRP), paving the

120 enes encoding mRNAs that can be regulated by fragile X mental retardation protein (FMRP), some of whi

121 Loss of fragile X mental retardation protein (FMRP), the defect

122 The fragile X mental retardation protein (FMRP), the functio

123 The fragile X mental retardation protein (FMRP), the gene pr

124 Fragile X mental retardation protein (FMRP), the lack of

125 Fragile X mental retardation protein (FMRP), the protein

126 ires protein translation and is dependent on fragile X mental retardation protein (FMRP), the protein

127 ted cytoskeletal-associated protein (ARC) or fragile X mental retardation protein (FMRP), translation

128 The miRNA machinery interacts with fragile X mental retardation protein (FMRP), which funct

129 cription but impair rapid translation of the Fragile X mental retardation protein (FMRP), which is ab

130 herited neurologic disease caused by loss of fragile X mental retardation protein (FMRP), which is hy

131 d by the absence of the mRNA-binding protein Fragile X mental retardation protein (FMRP), which may p

132 iciently and specifically capture endogenous Fragile X Mental Retardation Protein (FMRP), which recog

133 FXS is caused by loss of expression of fragile X mental retardation protein (FMRP), which regul

134 FXS results from the loss of function of fragile X mental retardation protein (FMRP), which repre

135 Fragile X syndrome is caused by the loss of fragile X mental retardation protein (FMRP), which repre

136 f neurons in fragile X syndrome patients and fragile X mental retardation protein (FMRP)-knockout mic

137 mutation that disrupts the transcription of Fragile X Mental Retardation Protein (FMRP).

138 rum disorder (ASD), results from the loss of Fragile X mental retardation protein (FMRP).

139 dent on mGluR1 activation and independent of fragile X mental retardation protein (FMRP).

140 X syndrome (FXS) results from deficiency of fragile X mental retardation protein (FMRP).

141 lting in the loss of the RNA-binding protein fragile X mental retardation protein (FMRP).

142 unction mutations in an RNA-binding protein, Fragile X Mental Retardation Protein (FMRP).

143 of the mRNA-binding translational suppressor Fragile X Mental Retardation Protein (FMRP).

144 lyposis coli (APC) tumour suppressor and the fragile X mental retardation protein (FMRP).

145 mental retardation, is caused by the loss of fragile X mental retardation protein (FMRP).

146 FMR1 gene and, consequently, the loss of the fragile X mental retardation protein (FMRP).

147 terized of these RNA-binding proteins is the fragile X mental retardation protein (FMRP).

148 hat results from the loss of function of the fragile X mental retardation protein (FMRP).

149 ardation caused by the absence of functional fragile X mental retardation protein (FMRP).

150 and is caused by the loss of function of the Fragile X mental retardation protein (FMRP).

151 ome is caused by a loss of expression of the fragile X mental retardation protein (FMRP).

152 etardation resulting from the absence of the fragile X mental retardation protein (FMRP).

153 retardation, is caused by the absence of the fragile X mental retardation protein (FMRP).

154 mutations of the Fmr1 gene that encodes the fragile X mental retardation protein (FMRP).

155 UTR and leads to the loss of protein product fragile X mental retardation protein (FMRP).

156 n in the FMR1 gene leading to absence of the fragile X mental retardation protein (FMRP).

157 etardation due to the absence of the encoded fragile X mental retardation protein (FMRP).

158 ndrome arises from blocked expression of the fragile X mental retardation protein (FMRP).

159 sulting from the partial or complete loss of fragile X mental retardation protein (FMRP).

160 The process is antagonized by fragile X mental retardation protein (FMRP).

161 on is controlled by repressors including the fragile X mental retardation protein (FMRP).

162 leading to the absence of its gene product, fragile X mental retardation protein (FMRP).

163 and it is caused by loss of function of the fragile X mental retardation protein (FMRP).

164 pe Ca(V) channels (Ca(V)2.2) is regulated by fragile X mental retardation protein (FMRP).

165 nd those whose messenger RNAs are targets of fragile X mental retardation protein (FMRP).

166 mental retardation, is caused by loss of the fragile X mental retardation protein (FMRP).

167 l disorder caused by the loss-of-function of fragile X mental retardation protein (FMRP).

168 of the Fmr1 gene resulting in the absence of fragile X mental retardation protein (FMRP).

169 1, which encodes the translational repressor fragile X mental retardation protein (FMRP).

170 disability and results from the loss of the fragile X mental retardation protein (FMRP).

171 th learning deficits, results from a loss of fragile X mental retardation protein (FMRP).

172 al disease caused by loss of function of the fragile X mental retardation protein (FMRP).

173 gulated by repressors, including BC1 RNA and fragile X mental retardation protein (FMRP).

174 FMR1, resulting in reduced expression of the fragile X mental retardation protein (FMRP).

175 Loss of the RNA-binding fragile X protein [fragile X mental retardation protein (FMRP)] results in

176 Similar to reports in autism, targets of the fragile X mental retardation protein (FMRP, product of F

177 etic variants that affect genes regulated by Fragile-X mental retardation protein (FMRP), thought to

178 the survival motor neuron protein (SMN), and fragile-X mental retardation protein (FMRP).

179 in response to ethanol treatment, requiring fragile-X mental retardation protein (FMRP).

180 mr1, that codes for an mRNA-binding protein (fragile X mental retardation protein, FMRP) present in n

181 Fragile X mental retardation protein, FMRP, is absent in

182 e is caused by the loss of expression of the fragile X mental retardation protein, FMRP.

183 retardation caused by functional loss of the fragile X mental retardation protein, FMRP.

184 ss of function of a single gene encoding the Fragile-X mental retardation protein, FMRP, an RNA-bindi

185 -out and rescue mice, we further reveal that fragile X mental retardation protein function in amygdal

186 Exon 15 of the fragile X mental retardation protein gene (FMR1) is alte

187 d behavioral consequences of the loss of the fragile X mental retardation protein in the PFC of Fmr1

188 nstrate a direct interaction between PAK and fragile X mental retardation protein in vitro.

189 tion of Drosophila PIWI, DICER-1, and dFMRP (Fragile X Mental Retardation Protein) in germline determ

190 a molecule involved in synaptic pruning, the fragile-X mental retardation protein, increases sleep in

191 ) gene results in the absence of the encoded fragile X mental retardation protein, known to play an i

192 Loss of the Fragile X mental retardation protein leads to excessive

193 Loss of the RNA-binding protein FMRP (fragile X mental retardation protein) leads to fragile X

194 A and occur despite consistent expression of fragile X mental retardation protein levels at approxima

195 oid 2-arachidonoyl-sn-glycerol, is absent in fragile X mental retardation protein-null mice.

196 trated that hYVH1 co-localizes with YB-1 and fragile X mental retardation protein on stress granules

197 ts (SNVs; P=5.4 x 10(-4)) and targets of the Fragile X mental retardation protein (P=0.0018).

198 sciatic nerve contains Argonaute2 nuclease, fragile X mental retardation protein, p100 nuclease, and

199 including Y box-binding protein 1 (YB-1) and fragile X mental retardation protein, proteins that func

200 rly demonstrating that in mice levels of the fragile X mental retardation protein regulate sensorimot

201 studies reveal novel mechanisms by which the Fragile X Mental Retardation protein regulates selective

202 has been shown to interact with Rac and the fragile-X mental retardation protein, suggesting intrigu

203 or translational control of target mRNAs of fragile X mental retardation protein, the gene product o

204 netic cause of autism, is due to loss of the fragile X mental retardation protein, which regulates si