ライフサイエンスコーパス: fragility

1 plex environments outside factories is their fragility.

2 results in leading strand-specific telomere fragility.

3 e HIV-1 capsid protein (CA) exhibits extreme fragility.

4 :osteoclast (OB:OC) ratio and increased bone fragility.

5 ication, and prevents repeat instability and fragility.

6 enging because of its small size and extreme fragility.

7 characterized this in terms of their kinetic fragility.

8 liquid, demonstrating a structural basis for fragility.

9 and clinical features of trauma-induced skin fragility.

10 mportant component of bone strength and bone fragility.

11 echanism involving reduced myofiber membrane fragility.

12 driving force for crystallization and liquid fragility.

13 embryos present with growth delay and tissue fragility.

14 posure impairs bone metabolism and increases fragility.

15 d by membrane protein oxidation and membrane fragility.

16 ree energy landscape--is a good predictor of fragility.

17 banding decreases OS rigidity, reducing its fragility.

18 to OS radius, so that thinner OS have lower fragility.

19 ioned observations connecting elasticity and fragility.

20 ystem with simple modular parts can increase fragility.

21 ad increased rose bengal staining and cornea fragility.

22 protects mammalian telomeres from fusion and fragility.

23 f telomeric signals associated with telomere fragility.

24 cted that might lead to telomere/subtelomere fragility.

25 1(-/-) cells but failed to suppress telomere fragility.

26 ound tumor resistance due to Treg functional fragility.

27 characterized by increased bone density and fragility.

28 ds for the assessment and prevention of bone fragility.

29 ) intake has been suggested to increase bone fragility.

30 intracellular calcium, and elevated osmotic fragility.

31 cta is a heritable disorder that causes bone fragility.

32 nal null (Klf4CN) corneas display epithelial fragility.

33 at ATM contributes to FdU-induced chromosome fragility.

34 ontractions, and repeat-mediated chromosomal fragility.

35 systems, where elasticity directly reflects fragility.

36 e in skeletal muscle independent of membrane fragility.

37 eat contractions downstream of Fcy1, but not fragility.

38 tion of yeast RNaseH genes and caused repeat fragility.

39 ynthesis as a potential therapeutic point of fragility.

40 c variation based on replication-derived DNA fragility.

41 derlie genetic diseases typified by cellular fragility.

42 ta1-integrin underlies Kindler syndrome skin fragility.

43 ce, identifying immune-independent beta cell fragility.

44 transplantation as a countermeasure to bone fragility.

45 acterized by progressive muscle weakness and fragility.

46 logical characteristics, e.g. their density, fragility, adhesive properties, etc.

47 ll linked to age-associated conditions: bone fragility after estrogen loss (osteocalcin) and arterial

48 identified here as significant predictors of fragility allow us to draw valuable inferences on the mo

49 FANC pathway are characterized by chromosome fragility, altered mutability, and abnormal regulation o

50 fect in two unrelated girls with severe bone fragility and a clinical diagnosis of osteogenesis imper

51 y nail dystrophy and late onset of mild skin fragility and acral blistering.

52 sion by elevating miR-155 increased telomere fragility and altered the structure of metaphase chromos

53 (basal keratinocyte layer), leading to cell fragility and blistering.

54 otential connection between progressing bone fragility and bone marrow failure after Pneumocystis lun

55 gnificantly decreased the rate of CAG repeat fragility and contractions in the rnh1Deltarnh201Delta b

56 gaments and tendons correlates with the bone fragility and contracture phenotype in humans.

57 similar skeletal abnormalities causing bone fragility and deformity.

58 aim of this study is to investigate vascular fragility and endothelial glycocalyx (ECG) in images of

59 nexpected role for Slac2-b in inherited skin fragility and expand the clinical spectrum of human diso

60 ntrations than brain or blood, increase bone fragility and fracture risk.

61 d by low bone mass leading to increased bone fragility and fracture susceptibility.

62 sis imperfecta (OI) is characterized by bone fragility and fractures that may be accompanied by bone

63 EL1 mutations displayed telomere shortening, fragility and fusion, and growth defects in culture.

64 The difference in fragility and growth between the different conformers ex

65 systemic skeletal disorder resulting in bone fragility and increased fracture risk.

66 pathological conditions, leading to skeletal fragility and increased marrow adiposity during aging, e

67 nective tissue disease characterized by bone fragility and increased risk of fractures.

68 subcomplex and Slx5/8 suppresses CAG repeat fragility and instability.

69 cription initiation are found to be prone to fragility and large-scale expansions.

70 , which is essential for preventing telomere fragility and loss.

71 brittle bone disorder characterized by bone fragility and low bone mass.

72 r of connective tissue characterized by bone fragility and low bone mass.

73 el, we show that histones induce erythrocyte fragility and lysis in a concentration-dependent manner.

74 med of the molecular basis of patient's skin fragility and mottled pigmentation phenotype.

75 diminished cell adhesion facilitates tissue fragility and neoplastic growth.

76 it is not characterized by generalized bone fragility and presented with cataracts in the original f

77 ese mutant mice displayed marked sarcolemmal fragility and reduced muscle exercise tolerance.

78 With their fragility and sensitivity to hydrologic shifts and land-

79 unctional type VII collagen, leading to skin fragility and subsequent trauma-induced separation of th

80 ization of NSPC RDCs reveals a basis of gene fragility and suggests potential impacts of DNA breaks o

81 so far semi-empirical relationships between fragility and the activation energy is shown.

82 , a linear relationship is found between the fragility and the energy scales of both the screened Cou

83 chanism for leading strand-specific telomere fragility and the first known role for FEN1 in leading s

84 s no correlation between promoter nucleosome fragility and the levels of histone modifications or his

85 Extreme corneal fragility and thinning, which have a high risk of catast

86 We present an analytic scheme to connect the fragility and viscoelasticity of metallic glasses to the

87 d approaches suffer from small domain sizes, fragility and weak long-range internal order.

88 e area at constant volume, increased osmotic fragility, and decreased deformability.

89 ic cemento-osseous lesions of jawbones, bone fragility, and diaphyseal sclerosis of tubular bones.

90 ausing replication fork stalling, chromosome fragility, and impaired repair.

91 with a special necessity by the complexity, fragility, and inaccessibility of intact nervous systems

92 enetrance of brachydactyly, syndactyly, bone fragility, and learning disabilities.

93 repair, provoking fork stalling, chromosome fragility, and recombination.

94 ' UTR of the FMR1 gene, and alleles prone to fragility are associated with Fragile X (FX) syndrome, o

95 echanisms underlying this increased skeletal fragility are unknown.

96 We propose that HU-induced chromosome fragility arises at higher frequency near HU-induced gen

97 Tumor suppressor network fragility as a paradigm within this and other regulatory

98 calizing activity and increased muscle fiber fragility as a result of loss of costamere-associated dy

99 lear deformation load, nuclear stiffness and fragility as compared to controls.

100 Skeletal fragility, as reflected in brittle and weak femora, is a

101 CCACCTCT motif plays a critical role in its fragility, as shown by sequential mutagenesis.

102 , this versatility comes with a trade-off of fragility, as there exist numerous paths to altered sign

103 s of chromosome 14, whereas the mechanism of fragility at BCL2 mcr remains unclear.

104 ming CGG/CCG repeats and prevents chromosome fragility at the repeat, whereas it does not affect repl

105 an inherited disorder characterized by skin fragility, blistering, and multiple skin wounds with no

106 EXPH5 in three siblings with inherited skin fragility born to consanguineous Iraqi parents.

107 mice are overhydrated and exhibit increased fragility both in vitro and in vivo.

108 complex, involving not only muscle membrane fragility, but also dysregulated calcium homeostasis.

109 ome is instrumental to understanding genomic fragility, but current methods are limited in versatilit

110 L1 and PCNA is important to prevent telomere fragility, but how RTEL1 engages with the telomere to pr

111 crease short-term variance creates ecosystem fragility by changing the boundaries of safe operating s

112 s during the past 20 years has targeted bone fragility by decreased resorption.

113 nd QP elements at CFS regions contributes to fragility by perturbing replication through multiple mec

114 FEN1 limits leading strand-specific telomere fragility by processing RNA:DNA hybrid/flap intermediate

115 te alloys with tailored thermoelasticity and fragility by rationally tuning the chemical composition

116 forming ability of FRA16B contributes to its fragility by stalling DNA replication, and this mechanis

117 s involvement in impaired erythroid membrane fragility by zinc restriction.

118 n, (iii) five textural parameters: hardness, fragility, cohesiveness, springiness and adhesiveness an

119 r stirring conditions exhibited an increased fragility compared with fibrils formed quiescently after

120 The concept of 'fragility' constitutes a central point of the glass tran

121 , replication forks stall within the AT-rich fragility core of CFS, leading to dormant origin activat

122 r mechanical transducers, which increase the fragility, cost, and complexity of the device.

123 Nrp1 dependency and the key drivers of Treg fragility could help to improve immunotherapy for human

124 h3) endonuclease caused R-loop-dependent CAG fragility, defining an alternative function for this com

125 468G>A, in the JUP gene that results in skin fragility, diffuse palmoplantar keratoderma, and woolly

126 idermolysis bullosa (RDEB) is a genetic skin fragility disorder characterized by injury-driven bliste

127 dermis, and its mutations cause a human skin fragility disorder coined recessive dystrophic epidermol

128 The best-studied skin fragility disorder is epidermolysis bullosa simplex (EBS

129 Cole-Carpenter syndrome is a severe bone fragility disorder that is characterized by frequent fra

130 We now report an inherited skin fragility disorder with a homozygous nonsense mutation i

131 e in a patient with suspected inherited skin fragility disorder.

132 Skin fragility disorders caused by keratin mutations are incu

133 molysis bullosa is a group of heritable skin fragility disorders with considerable morbidity and mort

134 phenotypic spectrum of human inherited skin fragility disorders, and we propose the addition of EBS

135 etibial hyperpigmentation, skin and vascular fragility, easy bruising, and variable musculoskeletal s

136 l through CDK9, providing potential nodes of fragility for therapeutic intervention, potentially dist

137 less than -2.0 taking exemestane, one had a fragility fracture and four had other fractures, whereas

138 postmenopausal women with osteoporosis and a fragility fracture and randomly assigned them in a 1:1 r

139 We used Cox regression models to assess fragility fracture risk factors including the VACS Index

140 Risk of fragility fracture should be assessed primarily using th

141 ONCLUSION In postmenopausal women at risk of fragility fracture who were receiving adjuvant anastrozo

142 menopausal women, patients with a history of fragility fracture, patients receiving chronic glucocort

143 frailty, as assessed by the VACS Index, and fragility fracture.

144 e assigned to one of three strata by risk of fragility fracture.

145 Fragility fractures (FFxs) and osteoporosis occur freque

146 the VACS Index, is an important predictor of fragility fractures among HIV-infected male Veterans.

147 ractures, those taking anastrozole had three fragility fractures and five other fractures.

148 s, whereas those taking anastrozole had five fragility fractures and one other fracture.

149 re of -2.0 or more taking exemestane had two fragility fractures and two other fractures, those takin

150 h issue, and effective treatments to prevent fragility fractures are available.

151 Bone atrophy and its related fragility fractures are frequent, late side effects of r

152 reatment-related osteoporosis and associated fragility fractures are potential complications of andro

153 Patients with GIO experience fragility fractures at better dual-energy x-ray absorpti

154 Fragility fractures caused by osteoporosis affect millio

155 a marker of bone strength, in subjects with fragility fractures compared with control subjects.

156 train rates correlate with the occurrence of fragility fractures in osteoporosis, while improvements

157 Use of these agents to reduce fragility fractures in patients with low bone mineral de

158 Non-vertebral fragility fractures occurred in 25 (4.0%) patients in th

159 They experienced 588 first fragility fractures over 6.0 +/- 3.9 years.

160 e currently available to treat osteoporosis, fragility fractures remain a significant problem worldwi

161 sal women with (n = 22) and without (n = 22) fragility fractures were matched for age and body mass i

162 sensitized to the fact that the presence of fragility fractures will alter patient care, and these f

163 Low bone mass and strength lead to fragility fractures, for example, in elderly individuals

164 justed life year (QALY) gained and number of fragility fractures.

165 hemophilia and may result in high-morbidity fragility fractures.

166 potential to prevent a substantial number of fragility fractures.

167 ts may reduce the burden of osteoporosis and fragility fractures.

168 c strategies to mitigate the risk of GIO and fragility fractures.

169 , and previously identified risk factors for fragility fractures.

170 s susceptibility for osteoporotic low-energy fragility fractures.

171 collagen mutations and characterized by bone fragility, frequent fractures in absence of trauma and g

172 oxide value (PV)], textural (i.e., hardness, fragility, gumminess, chewiness, springiness, cohesivene

173 Whether vitamin A promotes skeletal fragility, has no effect on fracture rate, or protects a

174 XA also displays a second form of chromosome fragility in absence of FdU, which our data suggest is n

175 y molecular mechanism that underlies corneal fragility in BCS and controls normal corneal development

176 mpound pyridostatin (PDS) increases telomere fragility in BRCA2-deficient cells, suggesting that G4 f

177 oss-of-function mutations in WNT1 cause bone fragility in children and adults.

178 define the incidence and prevalence of bone fragility in children with inflammatory conditions demon

179 tion, as well as a clearer awareness of bone fragility in children.

180 The structural underpinnings for skeletal fragility in coinfected women have not been characterize

181 The mechanisms underlying skeletal fragility in diabetes are not completely understood, but

182 insight into the cause of the profound bone fragility in DS and identify PTH as a potential anabolic

183 islets, demonstrating the role of beta cell fragility in genetic predisposition to diabetes.

184 ations in SPARC can give rise to severe bone fragility in humans.

185 dence that WNT1 mutations contribute to bone fragility in OI patients and demonstrates that the Wnt1(

186 epidemiology and pathophysiology of skeletal fragility in patients with diabetes and the emerging dat

187 r loss of BLM dramatically enhanced telomere fragility in RTEL1-deficient cells but had no impact on

188 counteract inflammation and RBC rigidity and fragility in SCD.

189 wn to contribute to erythrocyte rigidity and fragility in SCD.

190 ssions for the shear modulus, viscosity, and fragility in terms of the ion-ion interaction.

191 eats also cause length-dependent chromosomal fragility in yeast.

192 f the ear and the tail epidermis, corneocyte fragility, increased transepidermal water loss, and loca

193 phthalmology RCTs through application of the Fragility Index (FI), a novel metric of the robustness o

194 We advocate the reporting of fragility index for future trials in critical care to ai

195 This study aimed to calculate the fragility index of clinical trials in critical care medi

196 1-3.5), and greater than 40% of trials had a fragility index of less than or equal to 1.

197 The median fragility index was 2 (interquartile range, 1-3.5), and

198 The fragility index, which is a measure of how many events t

199 rted p value was negatively correlated, with fragility index.

200 eported loss to follow-up greater than their fragility index.

201 ary of basing decisions on trials with a low fragility index.

202 s and increased aphidicolin-induced telomere fragility, indicating a role for RECQL1 in telomere main

203 two distinct phases of water and to extract fragility indices m = 14 for the low-density and m = 20-

204 A promising approach to reducing robot fragility involves having robots learn appropriate behav

205 Cortical-bone fragility is a common feature in osteoporosis that is li

206 To determine whether fragility is a general property of HIV-1 proteins, we cr

207 ns, our results suggest that R-loop-mediated fragility is a mechanism that could cause DNA damage and

208 Skeletal fragility is a poorly understood chronic complication of

209 Nucleosome fragility is broadly implicated in multiple chromatin pr

210 This report shows that fragility is determined by the ratio between two fundame

211 est that in C. elegans promoters, nucleosome fragility is in large part DNA-encoded and that it poise

212 spontaneously during replication, but their fragility is increased by hydroxyurea, ATR inhibition, o

213 we show that FEN1 depletion-induced telomere fragility is increased by RNA polymerase II inhibition a

214 Although membrane fragility is known to potentiate injury in DMD, whether

215 in glass formation-the microscopic origin of fragility is poorly understood.

216 n ATM inhibitor, the incidence of chromosome fragility is reduced, suggesting that ATM contributes to

217 We also show that IFNgamma-induced Treg fragility is required for response to anti-PD1, suggesti

218 Finding the fundamental meaning of fragility is the 'condicio sine qua' for reaching the lo

219 While fragility is widely recognized as an important concept-b

220 e report a new type of complexity-nucleosome fragility, manifested as high sensitivity to micrococcal

221 These results reveal that skeletal fragility may be an undesirable consequence of chronic F

222 gesting that cancer therapies promoting Treg fragility may be efficacious.

223 croarchitectural deterioration and increased fragility, may accompany declining kidney function, but

224 er, our analysis also allowed us to identify fragilities of the model leading to the accumulation of

225 Our models are predictive of the fragility of aCFSs mapped at a higher resolution.

226 As a consequence of the high fragility of AIST, experimental diffusivities display a

227 The environmental fragility of cities under advanced urbanization has moti

228 Krt12Cre/Cre, which can be explained by the fragility of corneal epithelial cells that did not produ

229 ration of decorin GAG may contribute to skin fragility of elderly people.

230 of the glass transition temperature and the fragility of glass formation.

231 ical heterogeneity inherently relates to the fragility of glass-forming materials.

232 tic identification schemes, and rareness and fragility of initiation intermediates.

233 in the epidermal barrier, although increased fragility of isolated corneocytes was demonstrated.

234 graphy of colonialism and its effects on the fragility of nations.

235 d tomography and biomechanics confirmed bone fragility of OVX-Diet rats, and quantitative RT-PCR reve

236 romic microcytic anemia with reduced osmotic fragility of RBCs.

237 obullous genodermatoses characterized by the fragility of skin and mucous membranes.

238 obullous genodermatoses characterized by the fragility of skin and mucous membranes.

239 Common experience suggests that this fragility of sleep is highly variable between people, bu

240 skeleton produce phenotypes characterized by fragility of specific subsets of epithelial tissues.

241 nterferon-gamma (IFNgamma), which drives the fragility of surrounding wild-type Tregs, boosts anti-tu

242 ful effects on genome integrity owing to the fragility of the displaced DNA coding strand.

243 hod has been relatively neglected due to the fragility of the initial films.

244 o limits protein evolvability because of the fragility of the interactions networks that maintain pro

245 ir real-time applications are limited by the fragility of the lipid membrane into which the protein p

246 n of temperature correlates with the kinetic fragility of the liquid, demonstrating a structural basi

247 ions, and appears to correlate well with the fragility of the metallic glass.

248 nert surface to overcome the problems of the fragility of the microwire and the possible interference

249 The fragility of the old (99)Mo supply chain is being addres

250 tration in crystals yields insights into the fragility of the ordered state.

251 s of protein therapeutics are limited by the fragility of the protein, resulting in minimal quantitie

252 requently criticized because of the inherent fragility of the resulting catalysts, when exposed to ex

253 t is a simple closed-form expression for the fragility of the supercooled liquid metal in terms of fe

254 lso attribute this different behavior to the fragility of the system, in combination with the very fa

255 as too unstable to isolate, underscoring the fragility of these linkages.

256 A major obstacle is the extreme fragility of these qubits due to interactions with their

257 The fragility of this interplay makes the kidney susceptible

258 e association energy is weak compared to the fragility of those where association is strong suggests

259 with HNF1A(-/-) plasma increased the osmotic fragility of WT erythrocytes in vitro.

260 Angell introduced a dimensionless 'fragility parameter', m, to characterize the fall of ato

261 ological and ultrastructural epithelial cell fragility phenotypes.

262 ome, a genetic disease characterized by skin fragility, photosensitivity, and increased risk of squam

263 High levels of fragility plus constraints operating on approximately 15

264 vironmental changes suggests that nucleosome fragility poises genes for swift up-regulation in respon

265 ailure syndrome characterized by chromosomal fragility, progressive marrow failure, and cancer predis

266 ume, cellular dehydration, increased osmotic fragility, reduced deformability, and heterogeneity in o

267 esent new experimental evidence showing that fragility reflects the strength of the repulsive part of

268 spects of the microscopic structure controls fragility remains a challenge.

269 that the reported increase in IRBCs' osmotic fragility results from a reduction in surface area and i

270 Substantial evidence shows that skeletal fragility should be considered among the complications a

271 lease activity independently causes telomere fragility, suggesting a requirement of the SLX4 complex

272 infected IFrag(-/-) mice also exhibited bone fragility, suggesting loss of bone mass.

273 epeats, which are associated with chromosome fragility, suggests sequence capture during repair of do

274 n is a more effective treatment for skeletal fragility than previously recognized that confers dual a

275 sition leads to a super-strong liquid of low fragility that dynamically controls collapse, before a s

276 percooled liquids are characterized by their fragility: The slowing down of the dynamics under coolin

277 s and metalloids and the viscoelasticity and fragility thereof.

278 bundant but, because of their small size and fragility, they fossilize poorly.

279 yed 2 different mouse models of genetic skin fragility to assess the role of the basement membrane pr

280 mere loops (T loops) and suppresses telomere fragility to maintain the integrity of chromosome ends.

281 tes t-loop unwinding and suppresses telomere fragility to maintain the integrity of vertebrate telome

282 ing osmolarity, it results in a trade-off of fragility to non-natural oscillatory inputs that match t

283 pe is characterized by mild generalized skin fragility, trauma-induced skin blistering since infancy,

284 roenvironment has offered potential nodes of fragility under therapeutic development.

285 We propose that nucleosome fragility underscores distinct functional statuses of th

286 Repeat-mediated fragility was also affected by the Tof1 and Rad5 protein

287 Although skin fragility was mild, it provided clues to the diagnosis.

288 Chromosome fragility was normal in all 4 FAN1-deficient patients, a

289 Nucleosome fragility was strongly and positively correlated with th

290 In addition to DNA-encoded nucleosome fragility, we also found fragile nucleosomes at location

291 To address this fragility, we demonstrate how to engineer autoinhibition

292 ndence of Sigma(T) correlates with the glass fragility, we show that the validity of the Adam-Gibbs r

293 Also, aCFSs have high fragility when colocated with evolutionarily conserved c

294 uggests that many are in regions of inherent fragility, whereas a small subset overlies recessive can

295 f liquids is frequently characterized by the fragility, which can be defined from the temperature dep

296 is characterized by the unifying concept of fragility, which has spurred the search for a 'universal

297 makes manufacturing errors more likely, and fragility, which makes postrelease damage more likely.

298 ecessive clinical picture that includes bone fragility with a moderately severe and progressive prese

299 stimulation can identify and help to repair fragilities within a signaling network, while using line

300 addition to a mutation associated with skin fragility/woolly hair syndrome, impair gap junction loca