ライフサイエンスコーパス: fragment

1 t) with a total yield of 24% (36% for the EF fragment).

2 arent gold hydride to a bent d(10) copper(I) fragment.

3 al oligoguanine motifs of an individual tRNA fragment.

4 PARgamma) at Asp64, thus generating a 41 kDa fragment.

5 eract both with itself and with a C-terminal fragment.

6 ce, were recloned as IgE and antigen-binding fragments.

7 x-ray scattering on full-length ColN and its fragments.

8 d by 454 pyrosequencing of the 16S rRNA gene fragments.

9 mosomes combining up to eight unrelated gene fragments.

10 used for removal, and follow-up of retained fragments.

11 urrent model available from studies with IgG fragments.

12 ear import of PSA-lacking and -carrying NCAM fragments.

13 t any degradation or alteration in the major fragments.

14 <0.2 mm) compared with coarse-sized (5.0 mm) fragments.

15 a few confounding effects such as in-source fragments.

16 homo-trimeric DNA binding of Myrf N-terminal fragments.

17 , producing comparably large oligosaccharide fragments.

18 aspase or calpain into at least two receptor fragments.

19 nctions to proteolytically generated F(ab')2 fragments.

20 nse of sAPPalpha and other non-amyloidogenic fragments.

21 ted solid-phase assembly of the oligorhamnan fragments.

22 icated in discrete segments known as Okazaki fragments.

23 72 years, on average, relative to individual fragments.

24 the descriptors: Property-Labelled Materials Fragments.

25 SAR investigation of fragment 1, aided by X-ray structure-based design, enabl

26 used for immobilization of anti-cytokeratin fragment-21-1 (anti-Cyfra-21-1) for the electrochemical

27 ction by a monoclonal antibody targeting the fragment-5 region disrupted normal wound closure in both

28 ers (+40+/-5%, P<0.0001) and vWF degradation fragments (+53+/-6%, P<0.0001).

29 Recombinant fragments (60-79 aa), which together span the entire len

30 ixture of Abeta1-28WT and a short N-terminal fragment, Abeta1-6A2V, which supports a role of Abeta's

31 romosomes and a systematic dispersal of gene fragments across the multipartite genome.

32 Early generation of bioactive matrix fragments activates proinflammatory signaling.

33 se of native mass spectrometry for screening fragments against a protein-DNA interaction.

34 random priming, creating multiple sequencing fragments along each transcript.

35 tting DNA binding sequences into overlapping fragments along with a simplified integrative energy fun

36 This SAA1(46-112) fragment and its human equivalent SAA1(47-104) were chem

37 ats and allows the user to infer the sets of fragment and neutral loss features that co-occur togethe

38 The binding occured within the PLA2R NC3 fragment and was increased in acidic pH.

39 Genes often appear fragmented and are split into more genes during annotati

40 the past decade, but these genomes are often fragmented and missing complex repeat regions.

41 aptation complex, which excises spacer-sized fragments and channels them for insertion into CRISPR ar

42 ted specificity for protease-cleaved F(ab')2 fragments and did not bind the intact IgG counterpart.

43 Obtaining the full MS/MS map for fragments and precursors of complex mixtures without hyp

44 -MS pesticide library (containing exact mass fragments and retention times).

45 roduce; however, the introduction of new rAb fragments and single-domain Abs have reinvigorated the c

46 Chromatin Immunoprecipitation (ChIP), which fragments and solubilizes total chromatin, CUT&RUN is pe

47 The tropics house around 50 million forest fragments and the length of the world's tropical forest

48 Removal was successful for 63 (81%) of 78 fragments and varied by location.

49 yzed the effects of a set of distinct formin fragments and VASP on site-specific, lamellipodial versu

50 the biological functions of Myrf N-terminal fragment, and that the region adjacent to the DNA-bindin

51 sus nurture, coherent theories versus theory fragments, and symbolic versus sub-symbolic representati

52 10 (which contains the 7B7 Fab, where Fab is fragment antigen-binding region of an antibody), yet it

53 sosomal accumulation of APP carboxylterminal fragments (APP-CTFs) and oligomeric amyloid beta (oAbeta

54 g continuity and genome completeness as long fragments are able to extend paths into problematic or r

55 ucts possessing structurally different amide fragments are detected either by (1)H or (13)C NMR.

56 In complementation assays, the reporter fragments are directly fused to the interacting proteins

57 These fragments are generated from much longer S1-nuclease sen

58 Because extravascular fragments are not readily accessible for removal, many p

59 ow that, in normal conditions, these UQCRFS1 fragments are rapidly removed, but when TTC19 is absent

60 Plasma levels of cytokeratin-18 fragments are reliable noninvasive markers of AH.

61 l role of sAPPalpha or other non-amyloid APP fragments as acute modulators of mitochondrial metabolis

62 es graph-based assembly outputs in graphical fragment assembly (GFA) format for analysis or integrati

63 In primary emissions, OA mass spectral fragments associated with oxygenated species (primary bi

64 is in complex with a 12 base palindromic DNA fragment at a resolution of 3.2 A.

65 y phosphine sulfide, possessing a cyclohexyl fragment at the phosphorus.

66 1 km in width among the largest and closest fragments at 11 locations.

67 To address this challenge we developed a fragment based high-resolution peptide-protein docking p

68 We performed fragment-based and high-throughput screens against an am

69 By utilization of fragment-based drug discovery (FBDD), a new class of inh

70 Fragment-based drug discovery and continuous improvement

71 At the same time fragment-based drug discovery has matured into a powerfu

72 Fragment-based drug discovery is an increasingly popular

73 We have applied this fragment-based hyphenated MS technology to oligosacchari

74 Fragment-based lead discovery is becoming an increasingl

75 n structure-guided target identification and fragment-based lead discovery with efforts to develop ne

76 interacting with KHK were discovered through fragment-based screening and subsequent optimization usi

77 Fragment-based screening has emerged as a powerful appro

78 Fragment-based screening in human cells thus provides an

79 A fragment-based screening, reporter gene assay, and pharm

80 Here, we have adopted a fragment-based strategy that allowed us to obtain high-q

81 A crystal structure of a Complexin-I fragment bearing a so-called 'superclamp' mutation bound

82 how that a blocking antibody antigen-binding fragment binds to the extracellular surface of PAR2, pre

83 Notably, all recombinant subtype H fragments branched basal to the H clade.

84 have been implemented to ligate two protein fragments, but multiple ligations, which are necessary t

85 n at rs604723 increased the activity of this fragment by promoting serum response transcription facto

86 surface labeled and biotin captured peptide fragments by LC/MS/MS.

87 t menin and its calpain-dependent C-terminal fragment (C-menin) regulate the subunit-specific transcr

88 Furthermore, biologically active fragments C3a and C5a, produced during complement activa

89 of the complement response is the activation fragment C5a, which, through its receptor C5aR1, is a po

90 Conclusion Intravascular filter fragments can be removed safely with success rates that

91 These fragments can then be analyzed by MALDI mass spectrometr

92 The bioactive LN-511-E8 fragment carrying only C-terminal domains showed similar

93 e split RNAP tags improve upon other protein fragment complementation (PFC) approaches by offering bo

94 ions of osteoprotegerin (OPG)-immunoglobulin fragment complex (OPG-Fc) completely restore the functio

95 Thus, predicted interfaces range from short fragments composed of few residues to domains of protein

96 We show that an N-terminal fragment comprising the catalytic domain can interact bo

97 ads to the appearance of a carboxyl-terminal fragment consistent with intramembrane proteolysis.

98 cifically near the mismatch site on a 27-mer fragment, consistent with mismatch targeting.

99 n extended time, and therefore, reconnecting fragments could prevent species losses and allow locally

100 reductive elimination to enable alkyl-alkyl fragment coupling.

101 achieve a series of discrete yet fundamental fragment-coupling steps.

102 nor ligand to the catalytically active metal fragment [Cp*RuCl] but switches to adopt a two-electron

103 with a subsequent decrease in APP C-terminal fragment (CTF) content in secreted exosomes, but had min

104 This study assesses whether C-terminal fragments (CTF) of the amyloid precursor protein (APP) a

105 f amyloid precursor protein (APP) C-terminal fragments (CTFs) by gamma-secretase underlies the pathog

106 When forest is fragmented, cut, thinned, cleared or otherwise altered i

107 the anomeric signature is also observable in fragments derived from larger glycans.

108 Finally, the protein fragments derived from P. vivax containing well-known an

109 ional analysis was successfully applied to a fragment-derived lead resulting in AT-IAP, a potent, ora

110 94 pair, resulting in a truncated N-terminal fragment disrupted for inducing cell pyroptosis.

111 white spruce genome sequence remains highly fragmented, dozens of scaffolds encompassing more than o

112 Here, we show that a fragmented draft assembly is sufficient to perform mappi

113 ave shown that the aggregation of N-terminal fragments (encoded by HTT exon 1) underlies the disease

114 es containing different quantities of a KRAS fragment encoding G12D, an important genetic marker for

115 All extravascular fragments except one were retained.

116 Moreover, C-terminal fragments exhibited significantly altered mobility in de

117 tterns between intra-protein binding peptide fragments exist, they can be extracted using a deep lear

118 (monoclonal antibody and the antigen binding fragments F(ab')2 and Fab) targeting epidermal growth fa

119 work, we adopt a methodology using antibody fragments (Fab) conjugated to gold nanoparticles (immuno

120 When reformatted as soluble antigen-binding fragments (Fab), these clones expressed well, were predo

121 y phage display library to engineer antibody fragments (Fabs) that can modulate the activity of the e

122 Unlike intact SAA1alpha, these SAA fragments failed to directly chemoattract neutrophils an

123 Engineered crystallizable fragment (Fc) regions of antibody domains, which assume

124 tory infected coral systematically exhibited fragmented fluorescent pigments adjacent to the disease

125 d tool, that automates the generation of DNA fragments for integration.

126 functionalized with anti MC-LR antibody Fab' fragments for the selective capture of MC-LR from aqueou

127 derstand orangutan movement in disturbed and fragmented forests of Malaysian Borneo.

128 E complex zippering have opposing effects on fragment formation and verify that this affects the morp

129 o better understand this process, we studied fragment formation during homotypic vacuolar lysosome me

130 taneously, rendering 34 (54%) of 63 patients fragment free.

131 for removal, many patients are not rendered fragment free.

132 A 300 bp specific fragment from the cDNA fragment was chosen to insert int

133 alyzed through the amplification of a 148 bp fragment from the cyt b gene with a universal primer pai

134 es auto-processing to release its N-terminal fragment from the ER, which enters the nucleus to work a

135 of three nuclear genes and three plastid DNA fragments from 109 accessions of Avena L.

136 e pPSU1 and pPSU2 plasmids provide reference fragments from 50 to 10000 bp at a fraction of the cost

137 We focus on fragments from fish epithelial keratocytes, which are es

138 Thus, the 20 kDa fragment functions to provide stability to the C-termina

139 gammel, a package that simulates ancient DNA fragments given a set of known reference genomes.

140 groups obtained by implanting primary-cancer fragments harvested from patients into mice.

141 Antibody Fab fragments have been exploited with significant success t

142 The 100 bp ladder fragments have been optimized to migrate appropriately o

143 twist a bound molecular guest, and molecular fragments have been selectively transported in either di

144 The synthesized TA fragments have been used to unravel their role in immuno

145 stable in human serum, and most serum-stable fragments have full activity.

146 ee energy profiles are uphill for HTT exon 1 fragments having 20 or 30 glutamines, the aggregation la

147 rce, ageing and turnover of village doctors, fragmented health information technology systems, a pauc

148 ay crystal structure of caspase-7 bound to a fragment hit and a thorough kinetic characterization of

149 mization of crystallographically intractable fragment hits into more potent binders.

150 lution X-ray crystal structure of a sigma(N) fragment in complex with its cognate promoter DNA, revea

151 r data indicate that deletion of this 197-aa fragment in the spike protein can attenuate a highly vir

152 omes, and precisely processed tRNA and Y RNA fragments in EVs and exRNPs.

153 y differential migration behavior of protein fragments in gel electrophoresis.

154 of Trex2 results in the accumulation of DNA fragments in the cytoplasm of cornifying lingual keratin

155 time of the anti-IL-17A and anti-IL-13 Fab' fragments in the lungs but PEGylation was able to prolon

156 ential for dentinogenesis and processed into fragments in the odontoblast-like cells and the tooth co

157 highly efficiently cleaved DSP into distinct fragments in vitro, and the deletion of Mmp9 caused impr

158 y 53 (27%) of these were shared by all three fragments, including known genes involved in early phase

159 types A1, F, G, H, J, and K and unclassified fragments, including one subtype CRF25 isolate, which br

160 Thus, protein fragments increased remarkably in samples with higher pr

161 istance of 0.603 for pair-wise comparison of fragments indicating significant heterogeneity between t

162 ding insights into events related to Okazaki fragment initiation and the overall functioning of DNA r

163 We have modeled repeated cycles of Okazaki fragment initiation using a collision with a completed O

164 resence of integrated surface structure from fragmented input.

165 his new state of matter, the magnetic moment fragments into an ordered part and a persistently fluctu

166 e to capture and integrate short foreign DNA fragments into the CRISPR locus, enabling adaptation to

167 We performed fragment ion quantification using DIA data using this li

168 es a similarity score based on matching both fragment ions and neutral losses.

169 mining the structures for both precursor and fragment ions as well as the fragmentation mechanisms.

170 by coeluting peaks containing precursor and fragment ions differing by -116.0473 Da, attributed to t

171 gae data set, we show that quantification of fragment ions extracted with a customized MS/MS library

172 The extensive generation of fragment ions in AI-ETD+ substantially increases peptide

173 However, there are no distinctive fragment ions in positive mode that provide fatty acyl i

174 ows direct correlation between precursor and fragment ions without isolation prior to fragmentation.

175 specific J1 [M - 173](+) and J2 [M - 291](+) fragment ions, as well as additional characteristic mark

176 ndidate geometries for the distinct anomeric fragment ions, in turn shedding light on gas-phase disso

177 over, we also demonstrate that activation of fragmented IP3R1 can result in a distinct functional out

178 the nuclear import of the PSA-carrying NCAM fragment is mediated by positive cofactor 4 and cofilin,

179 In this location, the alphaC fragment is unable to form the conserved catalytic inter

180 o the first determined extinction across all fragments is 7 years.

181 Rapidly regenerating forest among fragments is important, because mean time to the first d

182 Here, the synthesis of a set of oligorhamnan fragments is reported using the cyanopivaloyl (PivCN) es

183 This eliminates low-intensity fragments, isotopes, and adducts and may exclude relevan

184 t forest loss is most detrimental in already fragmented landscapes.

185 ese declines is challenging in heterogeneous fragmented landscapes.

186 0 mm were analyzed for voltage and abnormal (fragmented/late potential) electrogram characteristics.

187 ion of both terminal additions in HTT exon 1 fragment leads to a complex aggregation mechanism with a

188 ng origin dependence and determining Okazaki fragment length by restricting Pol delta progression.

189 Furthermore, analysis of 176 amplified fragment length polymorphisms revealed significant genom

190 ign and NMR screening of focused and diverse fragment libraries.

191 binding chemotype from screening a nonbiased fragment library is reported.

192 methods that consider the complete (i.e. per-fragment) likelihood, while retaining the computational

193 scNOMe-seq therefore controlled for fragment loss, which enabled direct estimation of the fr

194 al methods result in the generation of short fragments (<150 base pairs) or highly branched long DNA

195 Computational fragment mapping methods aim to predict hotspots on prot

196 tutions do not affect the peptide parent and fragment masses.

197 ggested that loss of fusion capacity targets fragmented mitochondria to the pre-autophagic pool and u

198 highly connected versus those with a highly fragmented mitochondrial structure, suggesting the feasi

199 ) and caspase-cleaved (M30) serum keratin-18 fragments (n = 204) with histological parameters (n = 10

200 algorithms used to construct and search the Fragment Network and provides examples of how it may be

201 The Fragment Network is a graph database that allows a user

202 based on a fragment of a fertile leaf preserved in Burmese amber th

203 hypothesis proposes that a small amphipathic fragment of APP, the amyloid beta-protein (Abeta), self-

204 (SCC) EVs were enriched with the C-terminal fragment of desmoglein 2 (Dsg2), a desmosomal cadherin o

205 table mutant of hGal1 (hGal-1), a C-terminal fragment of hGal-3 (hGal-3C) and hGal-7), with known HMO

206 R6/2 mice contain an N-terminal fragment of human huntingtin with an expanded polyQ and

207 ATCC 27405, with both SAM and an N-terminal fragment of its peptidyl-substrate at 2.04 A resolution.

208 interaction study of the C-dots and the DNA fragment of lambda bacteriophage was performed, and the

209 stal structures of an anaerobically prepared fragment of mouse viperin (residues 45-362) complexed wi

210 he nuclear translocation of an intracellular fragment of ODZ1 through proteolytic cleavage by signal

211 The N-terminal Gly-rich fragment of rSp0032 and the C-terminal His-rich fragment

212 esent the crystal structure of an N-terminal fragment of Saccharomyces cerevisiae Hsp104 with the N d

213 Here, we present the structure of the Fab fragment of such an antibody.

214 be on the gold sensing chip and the unpaired fragment of target DNA works as a trigger to initiate th

215 By sequencing a subgenomic fragment of the HIV-1 envelope from study participants i

216 Cambodia and after successful DNA extraction fragment of the nuclear rhodopsin gene (RH1) and 9 micro

217 We report on a fragment of the quasicrystal-bearing CV3 carbonaceous ch

218 polymerase chain reaction amplification of a fragment of tpi and bg genes.

219 -bound A1 single domain and A1A2A3 tridomain fragment of VWF under shear stress in an ex vivo shear f

220 with an ATP analogue, RNA, and a C-terminal fragment of Yra1 (Yra1-C) at 2.6 A resolution.

221 of the chemical syntheses of oligosaccharide fragments of cellulose, hemicellulose, pectin, and arabi

222 Fragments of Ef-Tu retain binding capabilities to host p

223 Furthermore, fusion of short fragments of EWSR1 to FLI1 is sufficient to recapitulate

224 course of CRISPR interference Cas3 generates fragments of foreign DNA that are recognized by the Cas1

225 rated from much longer S1-nuclease sensitive fragments of foreign DNA that require Cas3 for their pro

226 Because only fragments of its habitat are accessible to humans, this

227 Thick fragments of laminar crustacean cuticle are scattered wi

228 1-3], and they have been restricted to short fragments of mitochondrial DNA.

229 Rare surviving fragments of mycelium, usually around branches, appear t

230 Vasoinhibins are N-terminal fragments of prolactin that prevent BRB breakdown during

231 Our convergent approach couples two achiral fragments of similar complexity and employs an enantiose

232 nd partitioning of large single-stranded DNA fragments of the homologous chromosome pairs allows for

233 roteins by searching minimal common sequence fragments of the interacting protein pairs.

234 elopment and reintroduced variably truncated fragments of the pxr region to test for their ability to

235 Previous studies indicate that larger fragments of Tiam1, such as the region encompassing the

236 inst recombinantly expressed N-terminal LRP2 fragments on Western blots and immunoprecipitated the re

237 free energy perturbation method (MD/FEP) in fragment optimization for the A2A adenosine receptor, a

238 n using a collision with a completed Okazaki fragment or primer-primase complexes as the recycling me

239 ied upon the aforementioned diagnostic EIEIO fragment peaks to determine the relative contribution of

240 IsoEM2 estimates fragments per kilobase million (FPKM) and transcript per

241 However, the SAA fragments potently synergized with CCL3 to induce monocy

242 a Poisson distribution for the number of DNA fragments present in each chamber, the DNA concentration

243 ssociated with increased expression of C3/C3 fragments primarily in the intestinal epithelial cells,

244 By considering the appropriate conditional fragment probabilities, and adopting improved, data-driv

245 alternatively the increased level of cFGF23 fragments, probably is an important mediator of the asso

246 case activity has been implicated in Okazaki fragment processing during DNA replication but is though

247 highly reproducible jigsaw map of dysferlin fragments protected from digestion.

248 tion was mediated by neonatal crystallizable fragment receptor (FcRn)-dependent transfer of maternal

249 success rate and complications of filter and fragment removal, symptoms relating to the filter or fra

250 ted: posterior capsule rupture, dropped lens fragments, retinal detachment, and suspected endophthalm

251 ly composed of beta-conglycinin and glycinin fragments rich in glutamine.

252 ry are especially strong in catchments where fragmented rocks are more exposed to weathering, and the

253 p) were grafted onto a single-chain variable fragment (scFv) acceptor framework.

254 gment of rSp0032 and the C-terminal His-rich fragment show unique transformations by either intensify

255 rm the amide bond between respective protein fragments significantly extends the current capabilities

256 This affinity approached that of fragment sized primary benzenesulfonamides, the classica

257 rococcus furiosus, actively incorporates DNA fragments (spacers) from both plasmid (foreign) and host

258 iated with construction of 154 barriers that fragment stream habitats, increased depth to groundwater

259 Injection of 3(rd) nymphs with dsRNA fragments successfully knocked down the target gene expr

260 All peptides were collagen fragments, suggesting that these may be causally related

261 removal, symptoms relating to the filter or fragment, techniques used for removal, and follow-up of

262 of infectious diseases, as its cationic-rich fragment TGRAKRRMQYNRR (UBI) has been functionalized wit

263 transmembrane domain and releases a protein fragment that activates transcription in the synaptic pa

264 emble modeling yielded models of the PHn-PHc fragment that indicate it is in equilibrium between "ope

265 after Asp270 to generate a necrotic DFNA5-N fragment that targets the plasma membrane to induce seco

266 Existing knowledge-based methods only use fragments that are the same length as the target, even t

267 identification of several structurally novel fragments that bind to diverse Cyp isoforms in distinct

268 as low as 10(-8) and average 500-kb-long DNA fragments that can be assembled into haplotype contigs w

269 urn-on RNA aptamer, Broccoli, into two split fragments that could tandemly bind to target mRNA.

270 eaved during stress response to produce tRNA fragments that function to repress translation in vivo.

271 Platelets are anucleate cytoplasmic fragments that lack genomic DNA, but continue to synthes

272 nsertions by releasing cleaved antibody gene fragments that subsequently reintegrate into DNA breaks

273 10-20mum long could be imaged as 2-5mum long fragments that survived rehydration on natural and artif

274 NS-MGCA derived from cell fragments that were discarded by spermatids during sperm

275 nucleosomes were defined by nucleosomal DNA fragments that were recovered preferentially in early MN

276 and Trex2 causes massive accumulation of DNA fragments throughout the cornified layers of the tongue

277 phenyleneiodonium, DNase or blocking F(ab')2 fragments to CD16, CD18, CD32 and CD64.

278 Employing selenocysteine-containing protein fragments to form the amide bond between respective prot

279 ful tool in structure-driven optimization of fragments to lead candidates.

280 nd fitting of the crystal structures of MotB fragments to the small angle X-ray scattering (SAXS) dat

281 hat is, isoforms of miRNAs, and tRNA-derived fragments (tRF).

282 cis-decalin skeleton, and a late-stage large fragment union exploiting a Micalizio alkoxide-directed

283 Fragment union using a modified Julia reaction then enab

284 dentified and the relative abundance of each fragment was accurately quantified by integrating the io

285 tiple bond between a Ce(IV) ion and a ligand fragment was also isolated by encapsulation of a Cs(+) c

286 A 300 bp specific fragment from the cDNA fragment was chosen to insert into vector pFGC1008 at fo

287 A major peptide fragment was detected at m/z 1088 by a MALDI-TOF mass sp

288 iled-coil bundle and an Fc-binding Protein A fragment, we generated the Hex nanocarrier that is effic

289 n mass spectrometry, 104 unique muropeptides fragments were identified and the relative abundance of

290 Two major occludin fragments were identified in the blood during cerebral i

291 After 7, 15, 30, and 50 days, maxillary fragments were processed for paraffin embedding or for t

292 In all, 63 (54%) of 116 fragments were removed percutaneously, rendering 34 (54%

293 The tubules rapidly fragment when GTP hydrolysis of Sey1p is inhibited, indi

294 show PDAC cells are able to take up collagen fragments, which can promote PDAC cell survival under nu

295 ict hotspots on protein surfaces where small fragments will bind.

296 Sal-1, one such fragment with the highest copy number in the infected ce

297 30 glutamines, the aggregation landscape for fragments with 40 repeats has become downhill.

298 ong, linear bundles, or "fibers," to shorter fragments with a mesh-like organization.

299 lysis results in the generation of bioactive fragments with novel functions (VCAN-derived matrikines)

300 ivery of the anti-IL-17A and anti-IL-13 Fab' fragments within the lungs had a major impact on their r