ライフサイエンスコーパス: frail

1 alyses are scarce and often methodologically frail.

2 h treated HIV infection may be identified as frail.

3 Overall, 30% of participants were frail.

4 exploring how people over time manage being frail.

5 in capacity and quality of life whilst being frail.

6 +/- 4.5%, and 33.9% of patients were deemed frail.

7 eneous health status--ranging from robust to frail.

8 ally frail and those who were not physically frail.

9 e offered to patients who are older and more frail.

10 rval [CI], 1.21-4.07) were more likely to be frail.

11 identification of particular individuals as frail.

12 -nine of 120 patients (33%) were assessed as frail.

13 e elderly population (those >/=65 years) are frail.

14 ence, and disability compared with those not frail.

15 with scores of 3 or higher characterized as frail.

16 ty Scale (range, 1 [very fit] to 7 [severely frail]).

17 ts had IADL impairment (52%) compared to non-frail (11%) persons, agreement was poor (weighted kappa

18 ess for standard therapy (ie, fit, unfit, or frail); (2) leukemia resistance (high vs low probability

19 Elderly people may be categorized as fit or frail according to clinical, functional, cognitive, and

20 an males, with life expectancy for the least frail adult females reaching up to 4.23 years, while for

21 aching up to 4.23 years, while for the least frail adult males it was of 2.68 years.

22 lead to evidence-based care for older and/or frail adults with cancer.

23 therapeutic clinical trials for older and/or frail adults.

24 Between 2010 and 2013, 98 patients (frail = age >/= 50 years and Karnofsky performance statu

25 ance status [KPS] of 50% to 70%; elderly and frail = age >/= 65 years and KPS of 50% to 70%; elderly

26 vulnerable or frail and fit or vulnerable v frail), agreement among the four classifications ranged

27 Whereas robust and frail alike must allocate investments between current an

28 Within 1 year, 13.6% (n = 855) of frail and 4.8% (n = 9433) of nonfrail patients died.

29 ding reduced starting doses of chemotherapy, frail and elderly patients can participate in a randomis

30 rail) or two categories (fit v vulnerable or frail and fit or vulnerable v frail), agreement among th

31 75 years of age or older who were physically frail and living at home to undergo a six-month, home-ba

32 many people in late old age find themselves frail and living at home, often alone.

33 endence were common, with a majority of both frail and nonfrail participants experiencing at least on

34 In a nested case-control study of frail and nonfrail subjects, we measured serum IL-6, tum

35 bserved for participants who were physically frail and those who were not physically frail.

36 x medical care, and end-of-life care of this frail and vulnerable population.

37 le used, 20-46% of patients were found to be frail, and 5-76% were found to have at least 1 disabilit

38 the majority of patients are neither fit nor frail, and current evidence is insufficient to either qu

39 term statin users tend to be healthier, less frail, and more adherent to therapy than nonusers, howev

40 l: 1.1, 2.4; p < 0.05) more likely to become frail, and those who never left their homes experienced

41 who had spent the prior 7 years prefrail or frail as compared with 4.7 mL (95% confidence interval:

42 ng women aged 65 years or older who were not frail at baseline.

43 Over time, -/- mice became frail because of abnormalities in their kidneys, an orga

44 iologically younger than their age) to being frail (biologically older than their age).

45 home, being aged 85 or older and regarded as frail by a clinical multi-disciplinary intermediate care

46 and 262 completed SPPB assessments; 28% were frail by FFP (95% confidence interval [CI], 24-33%) and

47 iver Disease (MELD) MELD of 12.10 (25%) were frail by Fried Frailty Index >/=3.

48 Frail CCS were more likely than nonfrail survivors to ha

49 -visual analogue scale scores were lower for frail compared with not frail patients at 6 months (52.2

50 nd death, and other demographic differences, frail decedents were more than 8 times more likely than

51 1.49-2.70] vs 3.66 [2.94-4.38], P<.001); and frail decedents were relatively more disabled in the fin

52 idence base for person-centred approaches to frail elder care.

53 levels were elevated in skeletal muscle from frail elderly (81+/-1 year) as compared to healthy young

54 amples were collected from healthy young and frail elderly adults, and IgA titers to respiratory sync

55 easure virus-specific IgA, is problematic in frail elderly adults.

56 tance exercise affects TNF-alpha expression, frail elderly men and women were randomly assigned to a

57 This industry does not target the frail elderly or inner-city ethnic minorities, groups fo

58 In community-dwelling frail elderly patients with hip fracture, 6 months of ex

59 therapies that can be tolerated by the more frail elderly patients with this disease are urgently ne

60 ut riskier treatments (eg, thrombolysis) for frail elderly patients.

61 t is the optimal treatment approach for more frail elderly patients?

62 ould be the basis for a shift in the care of frail elderly people towards more appropriate goal-direc

63 Frail elderly people with hMPV infection frequently soug

64 this risk is heavily influenced by deaths in frail elderly people.

65 nly 4% of the Medicare population, high-cost frail elderly persons accounted for 43.9% of total poten

66 Frail elderly persons accounted for most spending relate

67 asurement of stature is not possible in many frail elderly persons because of problems affecting thei

68 tions, should be used to estimate stature of frail elderly persons for whom standing height cannot be

69 Aspiration pneumonia is common among frail elderly persons with dysphagia.

70 ations, with the majority concentrated among frail elderly persons.

71 ut avoidable cause of acute renal failure in frail elderly persons.

72 RSV infection was prospectively evaluated in frail elderly persons.

73 the use of large catheters in a very old and frail elderly population), whereas the pathophysiology o

74 eumonia was much lower than expected in this frail elderly population.

75 ucosal response to candidate RSV vaccines in frail elderly populations.

76 Compared with young subjects, frail elderly subjects also exhibited a blunted and some

77 addition, NS results were reproducible when frail elderly subjects were sampled several weeks apart

78 fficacy and toxicity of new drugs in fit and frail elderly subpopulations.

79 In physically frail elderly women, 9 months of HRT significantly incre

80 about the osteoprotective effects of HRT in frail elderly women.

81 claims-based algorithm: nonelderly disabled, frail elderly, major complex chronic, minor complex chro

82 mortality have been reported in the affected frail elderly.

83 f physical and cognitive functioning as more frail, elderly individuals survive with health problems,

84 atic hypotension occurs in more than half of frail, elderly nursing home residents, but is highly var

85 Functional decline in physically frail, elderly persons is associated with substantial mo

86 ssion of functional decline among physically frail, elderly persons who live at home.

87 ) inactivated influenza vaccine (IIV) in 205 frail, elderly residents of LTCFs during the 2011-2012 a

88 Among frail, elderly residents of LTCFs, HD influenza vaccine

89 nterventions designed to improve outcomes in frail elders with CVD such as multidisciplinary cardiac

90 e benefits for patients who are very old and frail, especially those taking numerous medications, are

91 ) The current state of the art: preoperative frail evaluation.

92 gical treatment, or for patients who are too frail for drug treatments.

93 l group compared with only 54 +/- 9% for the frail group (P < 0.005).

94 rd rate = 1.55 95% CI: 1.30-1.86; P < 0.001; frail hazard rate = 0.97, 95% CI: 0.79-1.19, P = 0.80; P

95 Frail HCT survivors are at increased risk of subsequent

96 risk for low bone mineral density (BMD) and frail health, outcomes potentially modifiable by alterin

97 ced for medical conditions and indicators of frail health.

98 e-fitness (HR, 1.23; P = .217), and 34.0% in frail (HR, 1.74; P < .001) patients.

99 e-fitness (HR, 1.41; P = .052), and 31.2% in frail (HR, 2.21; P < .001) patients.

100 zard ratio [HR], 1.61; P = .042), and 57% in frail (HR, 3.57; P < .001) patients.

101 1.85-5.88), and being both HIV-infected and frail (HR, 7.06; 95%CI 3.49-14.3).

102 Compared with non-frail participants, pre-frail (HR: 1.51 95%CI [1.12-2.02]) and frail participant

103 nonresponse bias due to a high proportion of frail, ill, and cognitively impaired persons, strategies

104 er time of home-dwelling older people deemed frail, in order to enhance the evidence base for person-

105 ity within 1 month after hospitalization for frail individuals was 34.9% (95% CI, 34.5%-35.3%) vs 4.9

106 ATIV is preferentially recommended for more frail individuals, subjects vaccinated with ATIV were ol

107 nce in the timing of death by a few days for frail individuals.

108 ght be a useful tool for identifying fit and frail individuals.

109 sons, particularly those who were physically frail, intervening illnesses and injuries greatly increa

110 Investigation of the experience of being frail is a complementary and necessary addition to inter

111 Frail KT recipients are more likely to experience a long

112 Identifying frail KT recipients for targeted outpatient monitoring a

113 Frail KT recipients were much more likely to experience

114 n subjected to environmental stressors abort frail male fetuses implies that climate change may affec

115 Of 202 811 patients, 6289 (3.1%) were frail (mean [SD] age, 77 [7] years).

116 HIV-infected frail men (n = 155) were matched to nonfrail, HIV-infect

117 A cohort of 190 frail nursing home residents aged 80-102 years and a coh

118 e threatens the overall care of increasingly frail nursing home residents who have medically complex

119 iscontinuing inappropriate medication use in frail nursing home residents without a decline in their

120 vaccine (hereafter, "varicella vaccine") in frail nursing homes residents nor about immune phenotype

121 One hundred seven frail, obese older adults were randomly assigned to a co

122 g population, preoperative assessment of the frail older adult requires evaluation beyond simply acco

123 nition is a recognized characteristic of the frail older adult.

124 practice, common problems and symptoms that frail older adults experience, and approaches to these i

125 ss comprehensively the nutritional status of frail older adults living in an urban area and to identi

126 d in personalizing therapy for vulnerable or frail older adults.

127 ate palliative care and hospice referral for frail older adults.

128 ciated with serious respiratory illnesses in frail older adults.

129 vel to pay for the time required to care for frail older patients and to teach and do research about

130 Conversely, frail older patients are more likely to suffer adverse o

131 n may be used to predict hydration status in frail older people (as a first-stage screening) or to es

132 ive integrative model of supportive care for frail older people is developed from the findings.

133 Data on the experience of 15 frail older people were collected by visiting them up to

134 These data suggest that, among frail older people, even modest levels of physical activ

135 For frail older people, the presence of others to engage wit

136 y, but nonetheless remarkable, experience of frail older people.

137 dated spectacles could increase fall rate in frail older people.

138 iabetes clinical trial data were lacking for frail, older patients.

139 riori because real-life patients can be more frail or present with 1 or more comorbidities.

140 assification into three (fit, vulnerable, or frail) or two categories (fit v vulnerable or frail and

141 ns who were cognitively impaired, physically frail, or severely disabled (ie, in 3-4 ADLs) at onset w

142 Prevention of falls among frail, osteoporotic persons would likely reduce the freq

143 Fat area was significantly higher in frail participants (22.0%, SE = 0.9) than in participant

144 ) and muscle area (71.2%, SE = 0.4) than did frail participants (69.8 mg/cm(3), SE = 0.4; and 68.7%,

145 , pre-frail (HR: 1.51 95%CI [1.12-2.02]) and frail participants (HR: 1.73 95%CI [1.22-2.43]) had a hi

146 8 and 0.19; 0.40 and 0.20, respectively, for frail participants and 0.61 and 0.16, respectively, for

147 Although a greater proportion of frail participants had IADL impairment (52%) compared to

148 ipment and protocols not easily tolerated by frail participants or those with reduced mental capacity

149 Compared with non-frail participants, pre-frail (HR: 1.51 95%CI [1.12-2.02

150 ence between a 70-year-old fit patient and a frail patient above the age of 80.

151 (2) How do we identify the frail patient prior to the operating room?

152 (5) Intraoperative management of the frail patient: does anesthesia play a role?

153 (6) Postoperative care of the frail patient: is rescue the issue?

154 Improvement was greatest among frail patients (12.2% [24 of 197 patients] to 3.8% [16 o

155 ed an increased relative hazard for death in frail patients (hazard ratio, 35.58; 95% CI, 29.78-40.19

156 Analysis Index (RAI), and the records of all frail patients (RAI score, >/=21) were flagged for admin

157 We conducted a randomized trial involving frail patients 65 years of age or older who were hospita

158 reatment, thus avoiding the overtreatment of frail patients and the undertreatment of fit patients.

159 Surgically unresectable VHL-HBs or those in frail patients are challenging problems.

160 Frail patients are known to have poor perioperative outc

161 cores were lower for frail compared with not frail patients at 6 months (52.2 +/- 22.5 vs 64.6 +/- 19

162 Frail patients described lower health-related quality of

163 ariations in the increased risk for death in frail patients existed between different surgery types a

164 nd their role in the first-line treatment of frail patients or those who relapse after previous treat

165 Among frail patients or those with multiple comorbidities, ove

166 Frail patients reported greater problems with mobility (

167 Especially elderly frail patients seem to benefit because of reduced cardio

168 Although surgeons agreed that very frail patients should not have surgery, they held confli

169 Frail patients were older, had more comorbidities, and h

170 and aneurysm-related mortality in physically frail patients with abdominal aortic aneurysm (AAA) rand

171 d to seek objective predictors of outcome in frail patients with advanced colorectal cancer.

172 Elderly and frail patients with cancer, although often treated with

173 Frail patients with cirrhosis had poorer performance in

174 imal radiotherapy regimen for elderly and/or frail patients with newly diagnosed glioblastoma remains

175 ded as a treatment option for elderly and/or frail patients with newly diagnosed glioblastoma.

176 rd treatment after medical intervention; and frail patients with non-reversible impairment who should

177 Identification of frail patients with the slowest gait speeds facilitates

178 rable patients, and best supportive care for frail patients).

179 deintensified in 18.3% of patients (21.2% of frail patients, 19.4% of those with multiple comorbiditi

180 oposed to preoperatively identify and assess frail patients, though they differ in their clinical uti

181 cluded in trials to better assess fit versus frail patients.

182 d claim-based algorithm was used to identify frail patients.

183 2.8 [1.5-5.3]; p = 0.001) compared with not frail patients.

184 s; and (4) hypertension may be beneficial in frail people older than 85 years.

185 g the benefits of hypertension treatment for frail polymedicated octogenarians, for whom treatment sh

186 In this frail population, alternative strategies to manage psych

187 is necessary to optimize management of this frail population.

188 as 35 +/- 11 points, indicating a physically frail population.

189 d because of the healthy-user effect and, in frail populations, because of confounding by functional

190 adults with multiple morbidities and who are frail pose specific challenges for the management of hea

191 By 2 years after transplantation, 54% of frail recipients and 45% of nonfrail recipients experien

192 Frail recipients were 1.29 times (95% confidence interva

193 , intermediate fitness (score = 1, 31%), and frail (score >/=2, 30%).

194 sociation functional class III/IV in 82.5%), frail (slow 5-m walk test in 81.6%), and have poor self-

195 increased the proportion of time spent in a frail state.

196 Frail subjects tended to have higher plasma IL-6 and tum

197 ltimore group had 28 subjects with falls, 32 frail subjects, and 5 deaths.

198 Frail subjects, identified by an easy and inexpensive fr

199 he evaluation of the CV risk in very elderly frail subjects.

200 key points regarding care for the geriatric frail surgical patient.

201 Frail survivors of critical illness experienced greater

202 on, better cognitive function, and were less frail than the standard discharge group (>48 hours).

203 T survivors were 8.4 times more likely to be frail than their siblings (95% CI, 2.0-34.5; P = .003).

204 e specific (0.97), classifying only 3.7% as "frail." The RAI-C and RAI-A represent effective tools fo

205 ompared with participants who did not become frail, those with 1 modified Fried criterion (p = 0.03)

206 hospitalization in older adults who were not frail, though VE diminished as frailty increased.

207 ck of follow-up measurements on subjects too frail to return.

208 al therapy was low (14%), but in prefrail or frail (v robust) women the odds of noninitiation were 1.

209 ted 35-item scale and grouped as prefrail or frail versus robust.

210 Persons who were physically frail were oversampled.

211 of at least 21 classified 18.3% patients as "frail" with a sensitivity of 0.50 and specificity of 0.8

212 djusted point estimates of HRs (95% CIs) for frail women scoring in the second, third, and fourth qua

213 lights the importance of nutrition in older, frail women.