ライフサイエンスコーパス: framework region

1 g regions and a fourth loop within the third framework region.

2 o the different placement of the light chain framework region.

3 main by a disulfide bond engineered into the framework region.

4 omplementarity-determining regions (CDRs) or framework regions.

5 H2-terminal V(H) sequences which precede the framework regions.

6 somatic mutations and those occur mainly in framework regions.

7 volved about 1.5- to 2- fold faster than the framework regions.

8 gions and S as opposed to R mutations in the framework regions.

9 -determining regions of the gene than in the framework regions.

10 ht chain variable domains, as well as in the framework regions.

11 ns in complementarity-determining regions or framework regions.

12 verwhelming sequence identity with the human framework regions.

13 with VHa2 structures in the first and third framework regions.

14 Critical amino acids exist in framework region 1 (FR1) of V4-34-encoded Ig, and these

15 ion primers or a panel of VH family-specific framework region 1 (FR1) primers.

16 erformed using a panel of VH family-specific framework region 1 (FR1) primers.

17 aboratory localized the 9G4 reactive area to framework region 1 (FR1).

18 erythrocytes with a specific motif in their framework region 1 (FWR1).

19 VH3 gene products revealed possible sites in framework region 1 and/or framework region 3 that could

20 plementarity determining regions than in the framework regions (2.83 vs 1.41, P < .001), (2) higher t

21 n and counteracts the destabilization by the framework region-2 hallmark amino acids.

22 s remarkable amino acid substitutions in the framework region-2 to generate an antigen-binding domain

23 arity-determining region 1 (CDR1), CDR2, and framework region 3 (FR3) are predicted to be more mutabl

24 gy, whereas hypervariable region 4 (HV4) and framework region 3 (FR3) contributed a minimal amount of

25 plementarity-determining region (CDR) H1 and framework region 3 (FR3) to restore full activity.

26 3.1 utilizes residues from HCDR1, HCDR3, and framework region 3 (FR3).

27 stinct locations within V(H) (three sites in framework region 3 and one in complementarity determinin

28 rised of Vbeta14+ CD4 T cells, reactive to a framework region 3 determinant on the Vbeta8.2 chain, an

29 ory type 1 CD4 T cells, directed against the framework region 3 determinant within the B5 peptide (aa

30 possible sites in framework region 1 and/or framework region 3 that could be involved in SEA-mediate

31 -bp spacer, and nonamer in the 5' portion of framework region 3.

32 segment and map this activity N-terminal of framework region 3.

33 the variable heavy chain on asparagine 85 in Framework Region 3.

34 prisingly, Jkappa2 accounted for >90% of all framework region 4 sequences in the preimmune repertoire

35 ha3-beta8 loop contacting the apical loop of framework region 4, thereby extending the known TCR reco

36 Lastly, comparisons of mutations located in framework region and CDR codons coupled with multinomial

37 evealed that the accumulation of SHM in both framework regions and CDRs contributed to the clonal aff

38 nt junctions, the delineation of IG V domain framework regions and complementarity determining region

39 template structures for the light and heavy framework regions and each of the complementarity determ

40 Characterizing the KIR locus are three framework regions, defining two intervals of variable ge

41 ')2 fragments, especially those bearing VHa2 framework region determinants, specifically interact wit

42 complementarity-determining regions than in framework regions due to the distribution and subsequent

43 antibody fragments, consisting of a constant framework region engineered for optimal cluster binding

44 ds frequently fail to correctly identify the framework regions for which backbones can be copied from

45 Replacing the framework region (FR) of a V(H)4-family single-chain Fv

46 1 variable fragment (Fv) was established and framework region (FR) residues which supported complemen

47 encoded V region is readily delineated into framework regions (FR) and complementarity-determining r

48 geous) and/or decrement of mutability in the framework regions (FR; where mutations are more likely t

49 replacement-to-silent ratios (CDR R/S, 4.60; framework region [FR] R/S, 1.72).

50 g sites combined with diverse human germline framework regions (FRs), which were selected based on st

51 CDR2, and less than two replacements in the framework regions (FRs).

52 complementarity-determining region (CDR) and framework region (FRW) structure/function is not clear.

53 The CDR loops are scaffolded by canonical framework regions (FWRs) that are both resistant to and

54 KIR2DL4 (lineage I) defining the central framework region has been a major target for elimination

55 ctive amino acid substitutions (three in the framework region III and two in the complementarity-dete

56 ce it can be used for accurate prediction of framework regions in homology modeling.

57 by engineering these segments next to human framework regions in the humanized antibody.

58 c mutations in germline encoded positions in framework region IV.

59 ion was 3- to 10-fold higher in CDRs than in framework regions, most were R mutations and transversio

60 od that identifies candidate residues in the framework region of K1 Fv that, when mutated, improved t

61 ed antibody-antigen structure, the conserved framework region of the antibody makes extensive contact

62 ntral cavity of the fragment antigen binding framework region of the chimeric, anti-epidermal growth

63 e neutral residues to acidic residues in the framework region of the Fv portion of an immunotoxin tar

64 ional manner to CDRs and as superantigens to framework regions of anti-SEE IgE in anti-SEE IgE-Fcepsi

65 acid (Asp) instead of asparagine (Asn), with framework regions of epratuzumab, a humanized anti-CD22

66 The framework regions of HuLys were as close or closer in co

67 ntarity-determining regions (CDR) and in the framework regions of nonproductive VHDJH rearrangements.

68 Framework regions of TCRBV genes were extensively conser

69 the complementary-determining region and/or framework regions of the gene).

70 Immunogenic peptides were derived from framework regions of the variable regions of the immunog

71 ides corresponding to hypervariable, but not framework, regions of Ig heavy chain specifically stimul

72 Of the three framework regions, only KIR3DL3 (lineage V), defining th

73 regions (CDRs) of high diversity adjacent to framework regions shared across thousands of IgGs, great

74 Interactions of VH framework region structures with CD5 may affect maintena

75 alpha- and beta-chains and in the beta-chain framework region that is thought to be in proximity to t

76 nctions that utilize double helical stems as framework regions to reliably fold regardless of variati

77 es and as "superantibodies" through CDRs and framework regions to SEEs in SEE-anti-SEE IgE-FcepsilonR

78 man myeloma protein NEW, and the light chain framework regions were consensus sequences similar to th

79 the mouse anti-lysozyme Ab D1.3, heavy chain framework regions were from the human myeloma protein NE

80 entarity-determining region and three in the framework regions) were identified and incorporated into

81 mutations, especially those occurring in the framework regions, were less frequent in productively re

82 uires the replacement of key residues in the framework regions with corresponding residues from the p