ライフサイエンスコーパス: free base

1 ed osmotic pump (initial dose 2.0 mg/kg/day, free base).

2 in the periplasm and enters the cell as the free base.

3 of the adenine can be rescued by adding the free base.

4 tabolism that bind only small nucleosides or free bases.

5 talyzed coupling steps to assemble the final free base 1 in high yield and regioselectivity.

6 lubility and bioavailability compared to the free base, 1.

7 nt acid treatment provided the corresponding free-base 10(3)-(2-hydroxyethyl)benzochlorin, which upon

8 d to nicotine (4.5 mg/kg per day of nicotine free base, 15 to 22 days via osmotic minipump).

9 Photolysis of metalated (Cu and Ni) and free base 2-diazo-3-oxochlorins within a frozen matrix (

10 To overcome these limitations, a synthetic free base 3,13-dibromobacteriochlorin (BC-Br(3)Br(13)) h

11 Iodination or bromination of a free base 5,10-diaryloxochlorin gave a mixture of produc

12 d two, three or four doses of 2.5 mg/kg MPTP free base administered subcutaneously at 2-h intervals.

13 Compared to the free-base analogue, these complexes showed a remarkable

14 tral features that closely resemble those of free base analogues of chlorophyll b.

15 metalated derivatives than the corresponding free-base analogues to produce the corresponding excited

16 mers with fixed orientation, compared to the free-base analogues, the related mono- and di-Zn(II) com

17 The excited-state dynamics of the purine free base and 9-methylpurine are investigated using expe

18 synthesis of a pyrimidine nucleoside from a free base and a nonactivated sugar in a plausible prebio

19 Altogether four free base and four zinc chlorins have been prepared.

20 A new class of redox-active free base and metalloporphyrins fused with the 1,3-dithi

21 Crystal structures of free base and monoprotonated form are discussed.

22 Free base and N-oxides were observed by this method.

23 , is consistent with the pK(a) values of the free base and not the sulfate salt form of the drug.

24 Free base and Pd porphyrin derivatives of horseradish pe

25 l shifts (Deltadelta > 90 ppm) between their free base and protonated forms.

26 osides and 2'-deoxypurine nucleosides to the free base and ribose (or 2'-deoxyribose) 1-phosphate.

27 s been employed to prepare several arrays of free base and zinc porphyrins.

28 extensive fluorescence quenching in both the free base and Zn dyads is associated with an extremely r

29 sis of 2'-deoxypurine ribonucleosides to the free bases and 2-deoxyribose 1-phosphate.

30 each of which is distinguished by different free bases and protonation states.

31 raaryl- and beta-octaethylchlorins, as their free bases and zinc complexes, now fully delineate the t

32 Free bases and Zn complexes fluoresce with quantum yield

33 according to the Periodic Table, describing free-base and main-group element corrole derivatives, th

34 Shifts in the resonance Raman lines of free-base and metalated porphyrins bound to the wild-typ

35 ro-diporphyrins and triporphyrins, including free-base and metalloporphyrin hetero dimers.

36 The synthesis and chiral resolution of free-base and Ni(II) complexes of a number of derivative

37 he relative stereostructures of a variety of free-base and Ni(II) complexes of these morpholinochlori

38 morpholino-substituents, which differ in the free-base and Ni(II) complexes, and in the monoalkoxy, b

39 a facile approach for the preparation of the free-base and the related Zn(II) benzochlorins containin

40 Free-base and zinc(II) porphyrins bearing either one, tw

41 The free-base and Zn-containing dyads were subjected to exte

42 f 12 explicit H-bonding waters around the Sp free bases; and (4) reevaluation of calculated specific

43 a monoprotonated form and the corresponding free bases appeared to be relatively unstable.

44 We recommend that the community adopt PCR-free-based approaches to reduce PCR bias that affects ca

45 selectivity of unprotected azadiene in metal-free base-assisted hetero-Diels-Alder reaction is exploi

46 provided two atropisomers 5a and 5b for the free base at equilibrium (1:2.3 at room temperature in C

47 s allowed the first structural analysis of a free base azuliporphyrin to be conducted.

48 ubstituted bacteriochlorin (HBC-type), and a free base B,D-tetradehydrocorrin (TDC-type).

49 ture of two free base bacteriochlorins and a free base B,D-tetradehydrocorrin.

50 afforded a readily separable mixture of two free base bacteriochlorins and a free base B,D-tetradehy

51 Altogether 22 free base bacteriochlorins have been prepared.

52 tion spectra typical of bacteriopheophytins (free base bacteriochlorophylls), with a strong near-infr

53 base or their protonated analogues, with the free base being more strongly associated with the chiral

54 n, which upon a sequence of reactions gave a free-base benzochlorin bearing a carboxylic acid functio

55 coupled-cluster calculations proved that the free base BHPs, although highly symmetric, exhibited the

56 The free-base bromoporphyrins also were coupled with tri-n-b

57 ylase removes 5-methylcytosine from DNA as a free base, but its involvement in this process is unknow

58 deamination of cytosine to uracil, using the free base C, its nucleosides, and nucleotides as substra

59 The free base carbaporphyrin and carbachlorin, and the nicke

60 The free base carbasapphyrins were unstable but the monoprot

61 In the free-base case, this regioselectivity can be explained u

62 onfirmed the aromatic characteristics of the free-base, cationic, and anionic structures.

63 easily demetalated to give the corresponding free base chlorin.

64 The reduction of a free-base chlorin generally forms a bacteriochlorin (BC)

65 Two free base chlorins have been prepared wherein each chlor

66 n the absorption maximum (637-655 nm for the free base chlorins, 606-628 nm for the zinc chlorins) an

67 all found to be severely ruffled whereas the free-base chromophores are more planar.

68 We report that free-base cocaine administered in volatile form to the f

69 ay structures of the Cu complex with C60 and free-base complexes with C70 and a pyrrolidine-derivatiz

70 of H2TTFP(2+) (1200 GM) was obtained for the free base compound, a value that is much higher than tho

71 ve a limited binding capacity with a maximum free base content of 0.7 eq/L, which corresponds to a so

72 cal molecules using a model system involving free-base coproporphyrin (COP) complexed with horse hear

73 nd geometric properties of surface-supported free-base corrole molecules.

74 The first example of covalently linked free-base corrole-fullerene dyads is reported.

75 with concentrated sulfuric acid yielded the free-base cyanobenzochlorins in major quantity along wit

76 nalogous dependence is also observed for the free-base derivative, with the exocyclic ring-containing

77 n various ways (e.g., both labeled and label-free based detection).

78 moiety, and liberation of the corresponding free-base dipyrrin.

79 fullerene triplets are formed only with the free base dyad in toluene, where triplet formation from

80 Quenching is also observed in the free base dyad, where 1P(H2)-Sp(o) and P(H2)-1Sp(o) exch

81 In toluene, the lifetimes of the free base dyads are 600-790 ps compared to 10.1 ns for t

82 phyrin (ZnP) dyads were made by treating the free base dyads with zinc acetate.

83 er ear of live mice to achieve specific, DNA-free base editing in vivo.

84 lexes into mammalian cells, establishing DNA-free base editing.

85 (UNG), an enzyme normally involved in error-free base excision repair.

86 e zinc oxochlorins (Phi(f) = 0.030-0.047) or free base (Fb) oxochlorins (Phi(f) = 0.13-0.16) are comp

87 mprised of five zinc (Zn) porphyrins and one free base (Fb) porphyrin (cyclo-Zn(5)FbU) while the othe

88 pectively; and the output unit consists of a free base (Fb) porphyrin.

89 s have been synthesized in which the zinc or free base (Fb) porphyrins are joined by a 4,4'-diphenyle

90 The arrays contain alternating Zn and free base (Fb) porphyrins or all Zn porphyrins.

91 ate energy transfer from a zinc chlorin to a free-base (Fb) chlorin occurs with a rate constant of (1

92 tation of a pellet containing 25 mg morphine free base for 4 days or by injecting morphine (20 mg/kg,

93 llography, with the alpha,beta-isomer as the free base form and the alpha,alpha-isomer as the zinc co

94 pH-dependence studies confirm that the free base form of imidazole is the rescue agent.

95 he observed pK(a) values associated with the free base form of paromomycin are lower in magnitude tha

96 ant, the minor one has the alpha-amino group free base form of SAM reacting with the protonated imine

97 ther to the partitioning of the circulating, free base form of the drug into subcutaneous fat.

98 ealed a signal corresponding to the soluble, free base form of the drug.

99 oncentrated CDCl(3) solutions of the neutral free base form of this prodiginine derivative.

100 potentials can be tuned by metalation of the free base form, H2TTFP.

101 Addition of base gave the unstable free base form, while pyrrolidine formed an unstable add

102 bind to the enzyme with its imidazole in the free base form.

103 dlB in its zwitterionic state and not in the free-base form as had been previously suggested.

104 This porphyrinoid was nonaromatic in the free-base form but showed significant diatropicity upon

105 to Lys47; hence, this residue exists in the free-base form for catalysis.

106 irst 57 patients to be enrolled received the free-base form of rociletinib (150 mg once daily to 900

107 ng from 780 to 880 m(2)/g was synthesized in free-base form via the reaction of meso-tetrakis(pentafl

108 These results establish that the free base forms of these imidazoles facilitate HRP turno

109 The free base forms of thia- and selenaazuliporphyrins both

110 minant contribution to reaction by the amine-free base forms, the only species found to bind to the e

111 in dyads in distinct metalation states (zinc/free base, free base/zinc) were prepared by Sonogashira

112 protein efficiently liberates 8-oxoGua as a free base from the damaged DNA substrate.

113 -cyclo-2'-deoxyguanosine (cyclo-dG), and the free base guanine (Gua).

114 -Oxo-7,8-dihydroguanine (8-oxoG, or OG) as a free base has been widely considered as a biomarker for

115 nd compared: two for the pyridine-containing free base hosts and two for encapsulated F(-) complexes

116 on the leading reaction of formaldehyde with free bases: hydroxymethylation of cytosine amino groups.

117 emission of fluorescence equal to that of a free base in all three positions.

118 ty at ambient temperature and degradation to free base in vivo.

119 mic exposure in rats to nicotine (0.17 mg/kg free base) increases the ratio of DA neuronal currents m

120 h 5,7-dihydroxytryptamine (5,7-DHT; 3 microg free base) into both the dorsal and median raphe, which

121 ) that received daily MPTP injections (15 mg free base/kg body weight, s.c.) for 6 consecutive days e

122 administering nicotine (approximately 1.5 mg free base/kg/day), we found a significant increase of ni

123 Zn(II) or Cr(III) metalation of the free-base ligand shifted the equilibrium to the single d

124 d by the antenna chromophores is 80% for the free base molecule and 96% for the zinc analogue.

125 Model-free-based NMR dynamics studies have been undertaken for

126 human alkyltransferase is inactivated by the free base O6-benzylguanine, raising the possibility that

127 d not differ from P140A in reaction with the free base O6-benzylguanine.

128 ion, some of the DNA cleavages seen with the free base of 19a (compound 18c) in the presence of top1

129 trocytosine (NitroC), 2-pyrimidinone (P; the free base of zebularine) and 6-methylfuranopyrimidinone

130 e model has refined to give R-work 19.2 %, R-free (based on 5 % of the data) 23.0 %.

131 biosensor for HbA1c detection which is label-free based on the impedance measurement, and it features

132 d whether schools self-designated as "peanut-free" based on policies.

133 idazole (14)N nucleus in enzyme-bound versus free base-on cob(II)alamin shows an enhanced delocalizat

134 contrast, the addition of porphyrin (either free base or metalated) to E287Q is substoichiometric, a

135 Analytes can be complexed as either the free base or their protonated analogues, with the free b

136 of mono- and dioxabacteriochlorins, as their free bases or Zn(II) complexes, were determined by singl

137 the UV-vis absorption spectrum, addition of free-base or metalated porphyrins to wild-type ferrochel

138 ophile, the imidates can react either as the free-base or the hydrochloride salt in a telescoped proc

139 erent diameter ((n,m) = (6,5) and (7,6)) and free-base or zinc porphyrin bearing peripheral positive

140 The free base oxacarbaporphyrin and the palladium derivative

141 The free base oxacarbaporphyrin reacted with Pd(OAc)(2) in D

142 The free base oxodibenziphlorins were rather unstable in sol

143 n covalently linked to a zinc (PZn) and to a free-base (P(H2)) porphyrin.

144 rconnected pathways involving methylation of free bases, phospho-bases, or phosphatidyl-bases.

145 ree base porphyrin) transmission unit, and a free base phthalocyanine output unit for studies in arti

146 nthesis, and avoidance of the poorly soluble free base porphine.

147 ive coupling mechanism between unsubstituted free-base porphine units yielding dimers, trimers, and l

148 The crystal structure of a free base porpholactone N-oxide carrying the N-oxide on

149 d current densities have been calculated for free-base porphynoids using the gauge including magnetic

150 inequivalent sites [zinc porphyrin (Zn) and free base porphyrin (Fb)] give an upper limit of approxi

151 ipheral Zinc porphyrins (ZnPs) and a central free base porphyrin (H2P)-all rigidly linked to each oth

152 The molecular triad consists of a free base porphyrin (P) linked to both a C(60) electron

153 y arranging the zinc-porphyrin (ZOR) and the free base porphyrin (POR) donors in an energetically fav

154 ds were constructed using zinc porphyrin and free base porphyrin (Zn(i + 2)-Zn(i + 6)), and highly ef

155 methane, DDQ oxidation) afforded the desired free base porphyrin in yield comparable to that obtained

156 electrochemically oxidized and the attached free base porphyrin is photoexcited.

157 in current were observed with a monolayer of free base porphyrin or palmitic acid.

158 ent of the resulting meso-acetal-substituted free base porphyrin to gentle acidic hydrolysis yields t

159 ay via a mixed cyclization involving the bis(free base porphyrin) and 4-tert-butylphthalonitrile, and

160 s consisting of a perylene input unit, a bis(free base porphyrin) transmission unit, and a free base

161 porphyrin is readily demetalated to give the free base porphyrin.

162 demetalation, affording Zn-pbp-Fb where Fb = free base porphyrin.

163 The encapsulation of a free-base porphyrin [5,10,15,20-tetrakis(1-methyl-4- pyr

164 Unexpectedly, the free-base porphyrin binds C60 more strongly than the met

165 rs indicate quenching of the S1 state of the free-base porphyrin in all benzoquinone-containing dendr

166 timized wave function of the monosubstituted free-base porphyrin intermediate carrying a bromine atom

167 r facile in situ encapsulation of a cationic free-base porphyrin, and the alpha-cage of our (In-imida

168 a molecular light absorber, in the form of a free-base porphyrin, coupled to a Co3O4 nanoparticle cat

169 first example of a stable cis tautomer of a free-base porphyrin, the long-postulated intermediate of

170 unit is not similarly isolated in the corner free-base porphyrin-2,3,7,8-tetraone [C-(P-tetraone)2H].

171 R spectra of the radical anions derived from free-base porphyrin-2,3-dione [(P-dione)2H] and porphyri

172 A series of rigid polyphenylene, free-base porphyrin-containing dendrimers terminated wit

173 b3g) and 3(au, b3g) electronic states of the free-base porphyrin.

174 Altogether seven new aldehydes, eight free base porphyrins and eight zinc porphyrins have been

175 inc porphyrins at the termini and 1, 2, or 3 free base porphyrins at the core.

176 A new approach for the synthesis of free base porphyrins bearing one or two (cis or trans) m

177 d the zincated porphyrins (the corresponding free base porphyrins did not undergo dimerization).

178 On the other hand, catalytic properties of free base porphyrins have been less explored.

179 The free base porphyrins in the tetrad and pentad are joined

180 yrins in each array are attached to the core free base porphyrins via 1,4-diphenylethyne linkers.

181 The free-base porphyrins 5-bromo-10,20-diphenylporphyrin and

182 The corresponding halogenated free-base porphyrins also underwent the cross-coupling r

183 The free-base porphyrins are stable under conditions of wate

184 -histidine-tagged peptides and proteins, and free-base porphyrins coated on AFM probes, can be chelat

185 Tessellation of nine free-base porphyrins into a 3 x 3 array is accomplished

186 rporating respectively Zn(II) porphyrins and free-base porphyrins, is reported.

187 lding microporous MOFs containing accessible free-base porphyrins, it is noteworthy that the LbL grow

188 xes give similar SHG signals to those of the free-base porphyrins, while exhibiting no detectable two

189 owed Soret and Q-band absorptions typical of free-base porphyrins.

190 s greatly upshifted relative to those of the free-base protoporphyrin in solution.

191 RR data on the binding of free-base protoporphyrin IX and its metalated complexes

192 Similarly for free-base protoporphyrin, the natural substrate of ferro

193 T must recognize the guanine in tRNA and the free base queuine or preQ(1) to catalyze this exchange.

194 e-Q(0)) intermediate, but mammals import the free base, queuine, obtained from the diet or the intest

195 es [8, 25, and 75 microg/kg/injection (inj), free base], rats responded approximately equally for any

196 tautomer of a variety of substituted amidine free bases reacts with nitric oxide (NO) to produce comp

197 irect injection of approximately 4 microgram free base, resulted in dopamine overflow with a maximum

198 s and nucleosides than for the corresponding free bases, revealing an unprecedented effect of ribosyl

199 analysis that included patients who received free-base rociletinib at a dose of 900 mg twice daily or

200 observed when bis(3-pyridyl)-functionalized free-base salen-type ligand was employed in the reaction

201 t(OTf)(2) with bis(4-pyridyl)-functionalized free-base salen-type ligands.

202 lation of the corresponding hitherto elusive free base secochlorin bisaldehyde.

203 ere readily demetalated and separated as the free base species.

204 rate of reaction with O(6)-benzylguanine, a free base substrate, as on the repair of methylated DNA.

205 The reaction sequence is applicable to the free base systems as well as their Zn(II), Ni(II), Pd(II

206 The crystal structure of a free base tetraarylporphyrin N-oxide demonstrates the de

207 hose of zinc tetraphenylporphyrin (ZnTPP) or free base tetraphenylporphyrin (FbTPP), respectively.

208 Indeed, we have found that free base tetraphenylporphyrin (H2TPP) is an efficient p

209 t lengths, while a zinc tetraphenylporphyrin free base tetraphenylporphyrin dyad constitutes the mini

210 nthesis involved oxidative heterocoupling of free base tris-aryl-p-aminophenyl porphyrins with a p-am

211 ave a monocation in chloroform, although the free base was generated in 5% Et(3)N-chloroform.

212 Free bases were of limited stability.

213 ontinuous administration of nicotine (4.5 mg free base x kg(-1) x day(-1)) for 1 and 7 days led to in

214 distinct metalation states (zinc/free base, free base/zinc) were prepared by Sonogashira coupling re

215 cofacial motif previously demonstrated with free-base, Zn(II), and Ni(II) porphyrins.