ライフサイエンスコーパス: free hemoglobin

1 pretreatment (e.g., increases in circulating free hemoglobin).

2 ith severe sepsis and detectable plasma cell-free hemoglobin.

3 as not associated with an increase in plasma-free hemoglobin.

4 ompared with the P(50) of 13.1 Torr for cell-free hemoglobin.

5 hemodynamic reactions or increases in plasma free hemoglobin.

6 -L-arginine (L-NMMA, 10 micromol/L; n=10) or free hemoglobin (1 micromol/L; n=8), preload-induced inc

7 H levels closely correlated with plasma cell-free hemoglobin, accelerated NO consumption by plasma, a

8 Plasma levels of arginine, arginase, cell-free hemoglobin, ADMA, symmetric-dimethylarginine (SDMA)

9 hemolysis was assessed from plasma levels of free hemoglobin and arginase-1.

10 riking nonlinear relationship between plasma free hemoglobin and both TR jet velocity and FMD.

11 ed with chronic hemolysis with elevated cell-free hemoglobin and heme.

12 ays in mice) increases plasma levels of cell-free hemoglobin and heme.

13 ging results with new preparations of stroma-free hemoglobin and hypertonic salt solutions with collo

14 This circulation increased free hemoglobin and LDL- levels compared with non-circul

15 from a caged NO compound, we found that both free hemoglobin and microparticles react with NO about 1

16 Plasma cell-free hemoglobin and nitric oxide (NO) consumption capabi

17 inical studies of solutions of modified cell-free hemoglobin and of perfluorocarbon emulsions have de

18 t be measured due to interferences of stroma-free hemoglobin and PHP.

19 MD were most strongly associated with plasma free hemoglobin and transfusion status (transfusions bei

20 Mortality in Ringer's acetate, stroma-free hemoglobin, and 10% pentastarch treated animals was

21 % for whole blood and 4% PHP, 86% for stroma-free hemoglobin, and 33% for 8% PHP.

22 Serum creatinine, free hemoglobin, and ferritin were measured preoperative

23 elevated concentrations of circulating cell-free hemoglobin are independently associated with an inc

24 Our data do not support free hemoglobin as a significant contributor to toxicity

25 rts these color values to a concentration of free hemoglobin, based on a built-in calibration curve,

26 logy for improved transport containers, cell-free hemoglobin-based oxygen carriers, freeze-dried bloo

27 deleterious vasoconstrictive effects of cell-free, hemoglobin-based blood substitutes have been appre

28 hindering the clinical development of a cell-free, hemoglobin-based oxygen carrier (HBOC) is systemic

29 The ability of cell-free hemoglobin blood substitutes to affect vascular ton

30 multiple organ injury, plasma iron, and cell-free hemoglobin (CFH) levels depending on the age of sto

31 Hemolysis and consequent release of cell-free hemoglobin (CFHb) impair vascular nitric oxide (NO)

32 rvivors had significantly higher plasma cell-free hemoglobin concentrations (median 20mg/dL, interqua

33 measurements were performed and plasma cell-free hemoglobin concentrations were measured.

34 ntial confounders, patients with higher cell-free hemoglobin concentrations were significantly more l

35 Next, while free hemoglobin continued to be infused, the lambs were

36 Plasma-free hemoglobin did not change.

37 cetate, 10% pentastarch, or 4 g/dL of stroma-free hemoglobin, followed by aortic repair and transfusi

38 Haptoglobin (Hp) scavenges free hemoglobin following malaria-induced hemolysis.

39 Free hemoglobin from ongoing hemolysis scavenges nitric

40 This study evaluates the influence of free hemoglobin generation during CPB and the capacity t

41 Free hemoglobin (Hb) and red blood cells augment hypoxic

42 Free hemoglobin (Hb) augments hypoxic pulmonary vasocons

43 Haptoglobin binds and removes free hemoglobin (Hb) from the circulation.

44 ptoglobin-related protein (Hpr), which binds free hemoglobin (Hb) in blood and facilitates the uptake

45 Cell-free hemoglobin (Hb) is being developed as an erythrocyt

46 Systemic exposure to cell-free hemoglobin (Hb) or its breakdown products after hem

47 It has been reported that free hemoglobin (Hb) reacts with NO at an extremely high

48 Although mature HP is known to scavenge free hemoglobin (Hb) to inhibit its oxidative activity,

49 Free hemoglobin (Hb) within the subarachnoid space has b

50 tic lesions, intraplaque hemorrhage releases free hemoglobin (Hb), whose incorporated iron can act as

51 Intraplaque hemorrhage releases free hemoglobin (Hb).

52 Nitric oxide (NO) is inactivated by cell-free hemoglobin in a dioxygenation reaction that also ox

53 Studies on free hemoglobin in circulation have uncovered another tw

54 ng effects of nitrite would be attenuated by free hemoglobin in plasma that would rapidly scavenge NO

55 ikilocytosis, echinocytosis, schistocytosis, free hemoglobin in plasma, hemoglobinuria with hemosider

56 used in part by an increase in NO-scavenging free hemoglobin in the blood, by hypoargininemia, and by

57 Treatment with haptoglobin retained free hemoglobin in the plasma and prevented SRBC-induced

58 Exogenous NO inactivated NO-scavenging free hemoglobin in the plasma and restored nitrite to co

59 y exert a protective effect by reducing cell-free hemoglobin-induced oxidative injury.

60 Plasma free hemoglobin is elevated in SCD patients and acutely

61 centration (r = -0.45, P = .002), and plasma-free hemoglobin level (r = -0.41, P = .01), linking eryt

62 h the infusion of microspheres increase cell-free hemoglobin levels and nitric oxide consumption by p

63 in vitro tests, researchers measured plasma-free hemoglobin levels in a 36-year-old man to assess me

64 Erythrocyte ATP, 2,3-DPG, hemoglobin, and free hemoglobin levels in the supernatant were determine

65 Free hemoglobin levels increased in all patients but did

66 lene conjugate (8% PHP [n = 9], or 8% stroma-free hemoglobin (n = 7).

67 red include platelet activation, toxicity of free hemoglobin, nitric oxide depletion, absence of othe

68 hepatocytes in dogs resuscitated with stroma-free hemoglobin or PHP.

69 lyze in vivo, releases vasoconstrictive cell-free hemoglobin over days, worsens pulmonary hypertensio

70 of products in development are based on cell-free hemoglobin, perfluorocarbon emulsions, or liposome-

71 thologically relevant concentrations of cell-free hemoglobin promoted basal- and agonist-stimulated a

72 , which is associated with microparticle and free hemoglobin release, and age-related loss of enzymat

73 CPB leads to the generation of intravascular free hemoglobin, resulting in increased endothelial and

74 Cell-free hemoglobin's (CFH) high affinity for nitric oxide (

75 observed upon exchange transfusion with cell-free hemoglobin solutions can not be the result of .NO s

76 Many cell-free hemoglobin solutions designed as oxygen-carrying th

77 pport the conclusion that the PHP and stroma-free hemoglobin solutions tested did not produce hepatic

78 eacts at least 1,000 times more rapidly with free hemoglobin solutions than with erythrocytes.

79 Haptoglobin is a plasma protein that binds free hemoglobin, thereby inhibiting hemoglobin-induced o

80 Whole blood viscosity, plasma free hemoglobin, TR jet, and FMD were measured in chroni

81 ith severe sepsis and detectable plasma cell-free hemoglobin, treatment with acetaminophen within 24

82 , 10% pentastarch (one of seven), and stroma-free hemoglobin (two of seven) and was accompanied by an

83 t elevated in those with malaria, and plasma free hemoglobin was elevated only in patients with cereb

84 50-min period; and c) a group in which cell-free hemoglobin was exchanged transfused to reduce hemat

85 of intracellular ATP and 2,3-DPG levels and free hemoglobin was increased in the supernatant.

86 etaminophen in the setting of increased cell-free hemoglobin was independently associated with a prot

87 from blood samples containing PHP and stroma-free hemoglobin were made.

88 me (APTT), heparin concentration, and plasma free hemoglobin were obtained before, during, and after

89 In vitro interferences of PHP and stroma-free hemoglobin with liver function tests were determine

90 , and some have postulated release of plasma-free hemoglobin with subsequent nitric oxide consumption

91 We postulated that plasma free hemoglobin would be negatively associated with both