ライフサイエンスコーパス: free ligand

1 enefit provided by the use of a nuclear spin-free ligand.

2 e derived by neglecting the concentration of free ligand.

3 the separation of antibody-bound ligand from free ligand.

4 rom the solid state (X-ray) structure of the free ligand.

5 1500 and 1220 cm(-1) that are absent in the free ligand.

6 receptor-fluorescent probe complexes but not free ligand.

7 imulations on this complex as well as on the free ligand.

8 acrylamide was barely different from that of free ligand.

9 FB)+ complex upon administration of the iron-free ligand.

10 rences in the solvation free energies of the free ligands.

11 separation of a protein-ligand complex from free ligands.

12 xazaboronin-6-yl)benzene (4), as well as the free ligand 2-[[(3,5-di-tert-butyl-2-hydroxyphenyl)imino

13 In the electrostatic potential maps of the free ligands, a higher positive charge is present in the

14 orption spectrum, leading to decrease of the free ligand absorption and increase of complex absorptio

15 The decrease of free ligand absorption exposes emission of the transduce

16 wn to occur by a similar process to generate free ligand and a bis-ligand complex formed by reaction

17 erophore, deferoxamine mesylate, in both the free ligand and Fe-bound forms.

18 pable of resolving spectral responses of the free ligand and its acid-base forms along the monomeric

19 e spectroscopy in water and D(2)O, using the free ligand and wild-type and double-mutant enzyme.ligan

20 The distribution coefficient values of the free ligands and corresponding iron(III) complexes betwe

21 tent than their 3-methoxy analogs, while the free ligands and metal(III) ions showed little or no cyt

22 s associated with metal complexes along with free ligands and other related adducts in high-resolutio

23 d provides better contrast between bound and free ligands and requires a protein-ligand ratio ca. 25

24 The pK(a) values of the free ligands and the affinity constants of their iron co

25 d line shape analysis were performed for the free ligands and the complexes.

26 chemical and photophysical properties of the free ligands and their copper complexes were investigate

27 irical values of mobilities of free protein, free ligand, and electroosmotic flow.

28 When nuclear spin-free ligands are employed, vanadium(IV) complexes can sh

29 While the chiroptical spectra of the free ligands are unremarkable, the CD spectra of the com

30 50-kDa complex to a 150-kDa complex and to a free ligand, because the binding of heparin with IGFBPs

31 The bound formate can be distinguished from free ligand by the binding-induced sharpening and downsh

32 extract the binding density as a function of free ligand concentration eluting from the cell.

33 regation phenomenon to directly quantify the free ligand concentration in equilibrated bacteria-ligan

34 egative) often relies on the assumption that free ligand concentration, L, can be approximated by the

35 not its linkage isomers, adopts an organized free-ligand conformation that resembles the STING-bound

36 Our results demonstrate that analyses of free-ligand conformations can be as important as analyse

37 Binding was abolished by competition with free ligands, demonstrating the validity of the affinity

38 VDR on a naked DNA template utilizing a cell-free, ligand-dependent transcription assay.

39 for folding, as NMR and X-ray show that the free ligands do not adopt helical structures.

40 report a vanadium complex in a nuclear-spin free ligand field that displays two key properties for a

41 s complexed with a target are separated from free ligands) for a target in a mixture gives a greatly

42 Crack-free, ligand-free, phase-pure nanostructured solids, usi

43 ple draining device for batch decantation of free ligand from 96 minitubes is used.

44 bility of dry nitrocellulose to separate the free ligand from bound protein-ligand complexes.

45 they facilitated good-quality separation of free ligands from the protein-ligand complexes.

46 t more effective than FeIII(HDFB)+, the iron-free ligand H4DFB+ was significantly more effective than

47 dissociated in the mass spectrometer and the freed ligands identified.

48 stages that can be computed separately: the free ligand in the bulk is first restrained into the con

49 Unexpectedly, dGal-1 bound free ligands in solution with relatively low affinity an

50 ral orders of magnitude in comparison to the free ligands in solution.

51 ability of the possible monomers because all free ligands in the solution were consumed by the side r

52 ably reflects the effect of constraining the free ligand into the conformation required for binding,

53 d ligand at the site of application, whereas free ligand is mobilized by bulk movement of the solvent

54 quantum yield ratio of monozinc complex and free ligand) is qualitatively related to the highest occ

55 arison with MD simulations performed for the free ligand, it has been determined that GS-1-B(4) recog

56 re dependence for the response curves of the free ligand (L), native apo-protein (N), native ligand-b

57 The protonated form of the free ligand (lambda(max) = 336 nm) yields the correspond

58 ds, which lead to bathochromic shifts of the free ligands, lead to similar bathochromic shifts in the

59 r of magnitude affinity enhancement over the free ligand-lectin interactions was observed which can b

60 f H2 to 2 was carried out in the presence of free ligand Mes3SnH (Mes = 2,4,6-Me3C6H2).

61 ceptive potential of these complexes and the free ligands (noncoordinated to ruthenium) was tested in

62 t depend on rapid exchange between bound and free ligand or on stable isotope labeling, relying inste

63 by the presence of sugars, high salt levels, free ligands, or detergents.

64 Whereas the free ligands show a preference for the same enantiomer o

65 longer diffusion times also selectively edit free ligand signal, the measured diffusion coefficients

66 uilibrium concentration distributions of the free ligand species and the corresponding microscopic li

67 variable and the concentration of a bound or free ligand species as dependent variable.

68 igand does not need to be separated from the free ligand thus avoiding vacuum filtration and (ii) the

69 h factor Xa protease, and by the addition of free ligand to the infection.

70 es of 6-60 muM for three unsubstituted metal-free ligands, whereas values for the metal complexes var

71 decrease to the absence of one nuclear spin-free ligand, which served to shield the vanadium centers

72 wer rates, hydride 20 reductively eliminates free ligand, which ultimately generates a bis-ligand com

73 d a bis-ligand complex formed by reaction of free ligand with an active catalyst species.