ライフサイエンスコーパス: frequenin

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1 tic expression of the Ca(2+) binding protein frequenin.

2 Frequenin, a Ca(2+)-binding protein, has previously been

3 ave examined the effect of overexpression of frequenin, a modulator of phosphatidylinositol 4-kinase

4 Frequenin, also known as neuronal calcium sensor-1 (NCS-

5 The Drosophila protein frequenin and its mammalian homolog neuronal Ca2+ sensor

6 munohistochemical analysis demonstrates that frequenin and Kv4.2 channel proteins are coexpressed in

7 We conclude that frequenin, and by inference, phosphatidylinositol 4-kina

8 in expression, occluded by overexpression of frequenin, and is selective to N-type Ca(2+) channels.

9 determined that the differential effects of frequenin are mediated by means of the Kv4 N terminus.

10 proteins (e.g. recoverin, neurocalcins, and frequenin) are expressed at highest levels in excitable

11 n Pik1 is a hydrophobic alpha-helix and that frequenins bind to one side of this alpha-helix.

12 Frq1 belongs to the recoverin/frequenin branch of the EF-hand superfamily and regulate

13 Overexpression of frequenin did not affect postendocytic trafficking steps

14 ficity for Kv4 currents is suggested because frequenin does not modulate Kv1.4 or Kv3.4 currents.

15 frequenin in motoneurons, and inhibition of frequenin expression or activity prevents the synaptic a

16 Ca(2+) currents is blocked by inhibition of frequenin expression, occluded by overexpression of freq

17 onservation between Saccharomyces cerevisiae frequenin (Frq1) and human NCS-1 is also reflected at th

18 Yeast frequenin (Frq1), a small N-myristoylated EF-hand protei

19 Adenoviral-mediated overexpression of frequenin had no effect on early Golgi transport of memb

20 Frequenin has negligible effects on Kv4.1 current inacti

21 GDNF enhances the expression of frequenin in motoneurons, and inhibition of frequenin ex

22 at of Frq1 in S. cerevisiae and, hence, that frequenins in general may serve as regulators of certain

23 CS-1 (neuronal calcium sensor-1, also termed frequenin) in 3T3L1 adipocytes strongly inhibited insuli

24 Frequenin increases Kv4.2 current amplitudes (partly by

25 Here, we provide direct evidence that frequenin is a potent and specific modulator of Kv4 chan

26 provide strong support for the concept that frequenin may be an important Ca(2+)-sensitive regulator

27 Frequenin/NCS-1 has been shown to enhance exocytotic act

28 kly expressed in human PFs, whereas DPP6 and frequenin (neuronal calcium sensor-1) were enriched.

29 Frq1 (frequenin orthologue) also is essential for viability an

30 Endogenous frequenin was identified in these cells by polymerase ch

31 s severely inhibited in cells overexpressing frequenin, whereas basolateral delivery of the polymeric

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