ライフサイエンスコーパス: frequent

1 and surgical intervention are becoming more frequent.

2 pyrimidine-purine mismatches were relatively frequent (10(-5)-10(-6)), whereas C-->G, U-->A, G-->C, a

3 Closed globe injury was most frequent (23 cases), followed by open globe injuries (8

4 < .001), whereas renal involvement was more frequent (77% vs 63%, P < .001) and more severe (renal s

5 GTP misincorporation opposite dT, predicting frequent A-->G errors in RNA with rates of approximately

6 The most frequent aberrancy is the "common deletion" that involve

7 sembly of individual Z-rings, leading to the frequent abortion of septum synthesis, which in turn res

8 ion is a hallmark of cancer characterized by frequent acquisition of new DNA methylation in CpG islan

9 viduals with cystic fibrosis (CF) experience frequent acute pulmonary exacerbations, which lead to de

10 Metronomic dosing of chemotherapy-defined as frequent administration at lower doses-has been shown to

11 The most frequent adverse events were infections (17 [45%] of 38

12 ccur during the first infusion, are the most frequent adverse events.

13 uses on the intended therapeutic effects and frequent adverse reactions.

14 Surgical reinterventions were more frequent after CNF (18% vs 45%; P = 0.002), mainly due t

15 eripheral neuropathy, whereas edema was more frequent after DC.

16 nologies in practice: Technologies generated frequent alarms that placed a burden upon staff, but sta

17 tant to reduce enteric infections, which are frequent also among asymptomatic children.

18 Among the most frequent alterations conferring resistance, we observed

19 risk factors of tobacco and alcohol is more frequent among blacks.

20 izziness, and dental discoloration were more frequent among participants who received minocycline tha

21 Dialysis dependency was more frequent among survivors 80 years old or older (30% vs 1

22 Relapses can be frequent and can result in significant morbidity and cum

23 ersus-host disease (aGVHD) continues to be a frequent and devastating complication of allogeneic hema

24 need to address the potential impact of more frequent and earlier exposure to family member deaths in

25 d 15q11-13 chromosomal triplications cause a frequent and highly penetrant type of autism linked to i

26 istal metastasis of luminal breast cancer is frequent and incurable, yet the metastasis mechanisms ar

27 xtreme precipitation is predicted to be more frequent and intense accompanying global warming and may

28 Expansive vessel wall remodeling was more frequent and intense with the BVS than the metallic DES

29 Droughts are expected to become more frequent and more intense under climate change.

30 ailure of OFOQ to detect HIV-1 infection was frequent and multifactorial in origin.

31 one of four community types that experienced frequent and nonrandom transitions.

32 the process must be large enough to prevent frequent and nonspecific spontaneous fusion events, yet

33 onditioning stimulation in iPMd induced more frequent and powerful inhibitory effects on M1 outputs c

34 imes are ambiguous, across many regions more frequent and severe droughts are expected in the twenty-

35 As floods become more frequent and severe in the future, growing flood-sensiti

36 ic epilepsy syndrome and is characterized by frequent and transient impairment of consciousness.

37 Skipping breakfast is considered a frequent and unhealthy habit associated with an increase

38 h of coupled instability, thus favoring more frequent and weak El Nino events.

39 Children who were susceptible to frequent and/or prolonged Ct infection had a less focuss

40 es such as hypertension and trauma were less frequent, and in no case was an isolated fourth nerve pa

41 [none], 1-2 days [infrequent], or >/=3 days [frequent]) and daily intensity of smoking and vaping (nu

42 Frequent antibiotic treatment of urinary tract infection

43 Frequent antibiotic users were less likely to receive su

44 The most frequent ART regimens were TDF/3TC/EFV (39%) and AZT/3TC

45 If droughts become more frequent, as expected, the time between droughts may bec

46 Ocular complications were more frequent at enrolment than at discharge (142 [18%] vs 61

47 in intensity, of a short duration, and more frequent at high vaccine doses (9 x 10(6) PFU and greate

48 itute T cells in patients with cDGS but with frequent autoimmune complications in survivors.

49 outcome of bullous pemphigoid (BP), the most frequent autoimmune skin-blistering disease, involves ma

50 The results suggest that frequent azithromycin use in populations at high risk of

51 Children across all conditions showed more frequent bilateral, large, brainstem and deep grey matte

52 rences, the consequences of more versus less frequent biopsies seem to be similar across cohorts.

53 nd to evaluate tradeoffs of more versus less frequent biopsies.

54 Chemical control through the frequent 'blanket' administration of anthelmintics (worm

55 family with seven affected members exhibited frequent bone fractures and florid osseous dysplasia (p.

56 dividuals are symptomatic (SYMP) and develop frequent bouts of recurrent disease.

57 moderate-to-vigorous physical activity, more frequent breakfast and family meals, less frequent fast

58 trans-QTL are more frequent but tend to have smaller individual effects tha

59 The frequent, but short-lived, associations of bison with di

60 Early and frequent cannabis use are associated with an increased l

61 ated with atrial fibrillation (AF), the most frequent cardiac arrhythmia.

62 Lung cancer is the most frequent cause of cancer-related deaths worldwide.

63 Ischemic injury represents the most frequent cause of death and disability, and it remains u

64 ns located deep in introns of POLR3A to be a frequent cause of hereditary spastic paraplegia and cere

65 PTCs are a frequent cause of human genetic diseases, and the NMD pa

66 ratory chain complex IV (CIV) assembly are a frequent cause of human mitochondrial disorders.

67 Tuberculous meningitis (TBM) is a frequent cause of meningitis in individuals with human i

68 nosocomialis, and Acinetobacter pittii are a frequent cause of multidrug-resistant, healthcare-associ

69 in most developing countries, where it is a frequent cause of seizures and other neurological diseas

70 Cerebral palsy is the most frequent cause of severe physical disability in childhoo

71 tissues distal to the intestinal tract, is a frequent cause of such infections, is often multidrug re

72 tations in Usherin 2A (USH2A) are not only a frequent cause of Usher syndrome, but also nonsyndromic

73 Cataract, one of the most frequent causes of blindness in developed countries, is

74 utoimmunity is thought to be one of the most frequent causes of CSU.

75 Respiratory tract infections are frequent causes of hospitalization and initiation of emp

76 Infections were the most frequent causes of NC (30%).

77 emature delocalization of Rga1 leads to more frequent Cdc42 repolarization within the division site w

78 One such setting is represented by the frequent CDKN2A deletion in human cancer that, through i

79 Skp2 coupled with underexpression of p27 are frequent characteristics of cancer cells.

80 The most frequent clinical and electrophysiological pattern of ne

81 ism exhibited by other herpesviruses and the frequent coinfection of HIV-positive individuals by KSHV

82 We found frequent complex centromeres in maize and its wild relat

83 AKI is a frequent complication in hospitalized patients.

84 Diarrhea is a frequent complication of solid organ transplantation.

85 Diabetic kidney disease is among the most frequent complications of diabetes, with approximately 5

86 AKI is a frequent condition that involves renal microcirculation

87 Non-syndromic craniosynostosis (NSC) is a frequent congenital malformation in which one or more cr

88 ew study finds that splicing disruption is a frequent consequence of mutations generated by CRISPR/Ca

89 , we demonstrate that mice carrying the most frequent cystic fibrosis transmembrane conductance regul

90 Frequent dairy consumption in childhood has been related

91 This revealed a highly significant and frequent decrease in GRB14 expression in hepatic tumors

92 n, as well as SHM hotspots and intrinsically frequent deletions associated with SHM.

93 None of the 10 most frequent diagnoses was life threatening in the ambulator

94 Overall, cardiac tamponade was the most frequent direct cause of death (40%), and infection was

95 Our results indicate that, despite frequent disturbances in urban parks, urban soil microbe

96 s their applicability to cancer samples with frequent DNA copy-number changes.

97 The most frequent dominant observation varied according to time i

98 Based on the presented results, a less frequent dosing of mavacoxib is proposed compared to cel

99 ntibiotic effects, thereby allowing for less frequent dosing.

100 One major challenge is how to deal with the frequent drop-out events.

101 ncommon, NC after allo-HSCT, may become more frequent due to the improved overall survival in recent

102 Coughs were most frequent during daytime.

103 ble, amphiphilic carbohydrate chain that has frequent dynamic interactions with apolar molecules; bot

104 with higher systolic blood pressure and more frequent ECG abnormalities but not with higher blood glu

105 distinguished those with poor adherence and frequent errors in technique.

106 Point mutation of p53 is a frequent event and a significant factor in cancer develo

107 ermethylation of tumor suppressor genes is a frequent event in ocular tumors, but also unmethylation

108 ants of receptor tyrosine kinases (RTKs) are frequent events during tumorigenesis; however, the cellu

109 me mutations also have been characterized as frequent events in clonal hematopoiesis of indeterminate

110 The frequent evolution of such deceitful imitations provides

111 ient subgroup with more severe disease, more frequent exacerbations, and increased emphysema by QCT.

112 hial/nasal biopsies obtained from 33 SAs (21 frequent exacerbators [FEs]), 31 MAs (3 FEs), and 14 con

113 he cytosolic and mitochondrial dNTP pools in frequent exchange.

114 Simulations show frequent exchanges between terminal aquo groups and adso

115 de for perceptual abstraction or result from frequent exposure to cartoons and illustrations that ant

116 s to test the hypothesis that listeners with frequent exposure to loud music exhibit deficits in supr

117 Reducing these frequent exposures at work might lead to substantial ben

118 ears to be driven by multi-day recovery from frequent facultative anaerobe blooms, which may be drive

119 ical research have led to some prominent and frequent failures in the development of many leading dru

120 re frequent breakfast and family meals, less frequent fast food and meals during television viewing,

121 C22:6n3 and C20:5n3 were the most frequent fatty acids in the esterified forms.

122 ration of the paralabral sulcus was the most frequent finding after arthroscopic hip surgery in both

123 erve and retinal abnormalities were the most frequent findings.

124 nuveitis and posterior uveitis were the most frequent findings.

125 In frequent fire forests of the western United States, a le

126 ge, this is the first study to indicate that frequent fish consumption may help reduce sleep problems

127 Results Overall, MSH6 mutations were most frequent, followed by PMS2, MSH2, MLH1, and EPCAM mutati

128 Delayed initiation was also more frequent for higher OOP cost categories (3% in </= $10 g

129 However, coordination is less frequent for noncoding sequences, suggesting a larger ro

130 They were paradoxically more frequent for patients receiving compliant initial care.

131 e of decline of the Ca(2+) transient and, if frequent, formation of microscopic propagating Ca(2+) re

132 tations and characterized by bone fragility, frequent fractures in absence of trauma and growth defic

133 Trees from seed sources experiencing frequent frosts in autumn or early winter tended to ceas

134 Warmer SSTs generally correlate with more frequent genesis and greater potential intensity, while

135 , TNFRSF14 and MAP2K1 mutations are the most frequent genetic alterations found in PTFL and occur ind

136 human chromosome 21 and represents the most frequent genetic cause of intellectual disability.

137 ts showed that the female subjects with high frequent genotype in GAL3ST4 had a fivefold elevated exp

138 The most frequent grade 3 or worse adverse events in the idelalis

139 e the IL1B promoter activity and is the most frequent haplotype in African Americans.

140 ge disequilibrium is positive (Dij'>0) among frequent haplotypes and negative (Dij'<0) among rare hap

141 ar 5 were independently associated with more frequent HCC development beyond year 5 in multivariable

142 Despite frequent herpes simplex virus (HSV) reactivation, periph

143 INTERPRETATION: Frequent HIV screening combined with a socioeconomic int

144 in supporting HIV interventions that require frequent HIV testing, such as HIV treatment as preventio

145 This mechanism, combined with frequent homologous recombination, is likely responsible

146 Patients with frequent HSK relapses had lower QoL related to "ocular p

147 mice, which carry the orthologue of the most frequent human desmin missense mutation R350P.

148 Preexposure prophylaxis programs involve frequent human immunodeficiency virus (HIV) testing.

149 ctic tundra, it is also likely to cause more frequent icing events.

150 ARM allows frequent identification of arm lymphatics in the axilla,

151 currence of delusions or hallucinations, are frequent in Alzheimer disease (AD), affecting 40 to 60%

152 obacco (Nicotiana tabacum) but 100-fold less frequent in Arabidopsis (Arabidopsis thaliana), preventi

153 th type 2 diabetes compared with type 1, but frequent in both groups.

154 l genetic changes at the Kras/KRAS locus are frequent in cancer and modulate competitive fitness and

155 Recurrent wheeze (RW) is frequent in childhood.

156 ntral Pacific El Nino events may become more frequent in coming decades as atmospheric greenhouse gas

157 Infections and autoimmune disorders are more frequent in Down syndrome, suggesting abnormality of ada

158 oup (p=0.04), with carriers roughly twice as frequent in each A+ group versus the corresponding A- gr

159 K) catalytic subunit alpha gene (PIK3CA) are frequent in endometrial cancer.

160 eizure period, epileptiform spikes were more frequent in epileptic compared with nonepileptic rodents

161 Importantly, NOX4 gene deletions are frequent in HCC patients, correlating with higher tumour

162 osphatidylinositol 3-kinase (PI3Kalpha), are frequent in head and neck squamous cell carcinomas.

163 eover, BAP1-acquired biallelic mutations are frequent in human cancers.

164 Loss of HDV RNA during follow-up was more frequent in IFNalpha-treated patients and strongly linke

165 llowing: (1) decisions to regulate were more frequent in individuals exhibiting higher average levels

166 Esophageal adenocarcinoma is more frequent in non-Hispanic whites, whereas esophageal squa

167 oonotic helminth exposure in Norway was less frequent in offspring than parents; however, Toxocara sp

168 lications and birth defects that become more frequent in older mothers, in both humans and mice, occu

169 linical levels of depression seem to be more frequent in patients at early stages of anti-VEGF treatm

170 Vasomotor dysfunction is frequent in patients with angina and unobstructed corona

171 death (10.0% versus 1.1%; P<0.001) were more frequent in patients with CP.

172 lonus, rigidity and hallucinations were more frequent in patients with sCJD but these features were n

173 Although intraocular involvement is frequent in PCNSL and clinically marked by slowly progre

174 Asthma onset was less frequent in SLIT tablet group than in non-AIT group (odd

175 ounts for 25% (95% CI, 23%-28%), but is less frequent in some South American and Asian countries.

176 Adverse effects more frequent in the augment-aripiprazole group included somn

177 ive to NS, but mild adverse events were more frequent in the HS group.

178 s II human leukocyte antigen region was more frequent in the invasive than the in situ group (P = 4.9

179 Adverse events were more frequent in the KGF group than the placebo group (14 vs

180 nic earthquake recurrence may have been more frequent in the past.

181 Nonreticular pigment changes were less frequent in the periphery than in the posterior pole (46

182 Genotype C HBV infection was more frequent in the vaccine failure group (33.7% vs 13.4%, P

183 Second-line VF was frequent in this setting.

184 ional p53 abnormalities appears to be rather frequent in various AML entities, bearing, presumably, a

185 reported in 934 women (12.2%) and were more frequent in women with previous cesarean deliveries, wit

186 The most frequent indication for TIPS was refractory ascites (50

187 Among individuals aged 18 to 34 years, frequent indoor tanners (>/=10 times in the past year) w

188 Enteroviruses (EVs) are among the most frequent infectious agents in humans worldwide and repre

189 wever, TTP begins as soon as childhood, with frequent inherited forms.

190 Congenital cataract is the most frequent inherited ocular disorder and the most leading

191 Frequent insulin secretion exposes ZnT8 to the cell surf

192 ly, we had studied the methylome in the most frequent intraocular tumors in adults and children (uvea

193 a critical environmental problem, prompting frequent investigations into its consequences for variou

194 pecies are susceptible to drought and demand frequent irrigation thus consuming large amounts of wate

195 black and 50 years or older with chronic and frequent knee pain, a Western Ontario McMaster Universit

196 The most frequent local effects were pain (n=40 [60%]) or tendern

197 Premature ovarian insufficiency (POI) is a frequent long-term complication of classic galactosemia.

198 discrimination between primary SLCs and less frequent, long-latency startle responses (LLCs).

199 f colorectal cancers and cell lines, we find frequent loss of heterozygosity and mutations in BCL9L i

200 breast cancer, although it resulted in more frequent low-grade toxicities.

201 ues of neonatal rats, suggesting that a more frequent, lower-dose supplementation may be necessary to

202 w proliferation but no apoptosis, presenting frequent lymph-node metastasis.

203 A new wave of portable biosensors allows frequent measurement of health-related physiology.

204 ntly, we combined biosensor information with frequent medical measurements and made two important obs

205 ith MYC amplification and/or overexpression, frequent metastasis and a dismal prognosis.

206 phageal cancer is characterized by early and frequent metastasis.

207 rising from centrosome amplification exhibit frequent mitotic errors and possess complex karyotypes,

208 Thereby, it can be used to potentially focus frequent monitoring and more aggressive preventive effor

209 Frequent monitoring for adverse events, outcomes, donor-

210 tions will further enable cost-effective and frequent monitoring of CEA in order to establish its cli

211 ei, we show that it enables more precise and frequent monitoring of chemical reactions.

212 Patients with CTX executed more frequent multistep saccades and directional errors durin

213 The most frequent mutation, JAK2V617F, activates the 3 main myelo

214 nome-wide sequencing studies have identified frequent mutations in genes encoding members of the cohe

215 vealed lower overall mutation rates and more frequent mutations in RHOB and chromatin modifier genes.

216 Here we show that neuroblastoma harbors frequent mutations of genes controlling the Rac/Rho sign

217 nature of their small size, dense growth and frequent need for extracellular metabolism, microbes fac

218 C/neoantigen nanovaccines elicit 8-fold more frequent neoantigen-specific peripheral CD8(+) T cells t

219 160] vs 176 [104, 252]; p < 0.001) and more frequent nonrespiratory organ failure (nonrespiratory Se

220 The most frequent OADs were aminoglycosides (43 patients) and flu

221 The frequent observation of side chains associated with turn

222 eous intracranial hemorrhage (ICH) is also a frequent occurrence in these patients, but there is limi

223 The frequent occurrence of Ser or Thr based helical kinks in

224 ing in a higher open probability due to more frequent opening bursts.

225 Furthermore, we propose that frequent opsin gene loss had a large influence on the ev

226 03 for difference; 8% rare/occasional vs 15% frequent, OR, 2.71, P = .03, vs 23% abundant/continuous,

227 y between relatives) in trait values are two frequent outcomes of the plant-herbivore arms race.

228 gs later (median, 3 vs 2 d; p = 0.001), less frequent palliative care consultation (17.6% vs 32.4%; p

229 y by the immune response or rather is due to frequent pathogen exposure.

230 Influenza virus is a frequent pathogen in older adults with ILI.

231 The most frequent pathogens that cause the corneal ulcers are P.

232 The most frequent patterns were left and right posterior-temporal

233 on the MT, providing an explanation for the frequent pauses of short MTs and the immobility of longe

234 ning pituitary adenomas (NFPAs) are the most frequent pituitary tumors.

235 Our findings of frequent plant-microbe-nutrient interactions are novel a

236 tangle burden in the presence of moderate or frequent plaques would add to the ability to predict cli

237 g; p = 0.17), whereas the ViR group had more frequent post-procedural mitral regurgitation moderate o

238 Sarcopenia or skeletal muscle loss is a frequent, potentially reversible complication in cirrhos

239 cally have high mutation rates, resulting in frequent production of protein variants with compromised

240 All of the 70 most frequent putative pathogenic T cell clones were alphabet

241 awater with more extreme thermal events, and frequent rainfalls in some coastal regions.

242 Arctic atmospheric boundary layer undergoes frequent rapid depletions in ozone and gaseous elemental

243 The most frequent reason for not visiting an HCP was "doing fine

244 Frequent reassessment and updating will be needed.

245 study is to examine the relationship between frequent recreational cannabis (FRC) (marijuana and hash

246 , but current treatments are associated with frequent recurrence.

247 acids-exhibited complex dynamics, including frequent refolding and state occupancies of <10 mus.

248 Although this is a key reason for the frequent regeneration failures in humans, the transcript

249 ombination of a lack of homologous immunity, frequent reinfections, weak competition between types, a

250 seizures throughout the study, those who had frequent relapse and remission, and those who had relent

251 s organizations scramble to keep up with the frequent release of wide-ranging regulations.

252 In ecosystems where fruit represents a frequent, reliable resource (e.g. tropical forests), thi

253 tance among these pathogens have become more frequent, requiring the development of new drugs and a b

254 Apoplastic ROS production is a frequent result of RLK signaling in a multitude of cellu

255 e tomography angiography (OCT-A) detect more-frequent retinopathy in adolescents with SCD.

256 an allelic series of knock-in mice carrying frequent RTT-associated mutations (encoding T158M and R1

257 at high risk for retinoblastoma require more frequent screening, which may preferentially be examinat

258 brain tissue obtained from 20 patients with frequent seizures and a long history of drug-resistant f

259 (16%) of 140 in the placebo group; the most frequent serious adverse events (affecting >/=2% of pati

260 Frequent severe adverse events (>4% difference from plac

261 ong-term disease trajectory and persistently frequent severe exacerbations need to be identified earl

262 h contrast enhancement representing the most frequent sign of inflammation (90% at diagnosis, 100% at

263 The intestine is a frequent site of metastases in melanoma patients.

264 Patients receiving escitalopram had more frequent sleepiness and obstipation than did those in th

265 In contrast, after the disaster, frequent social interactions reverted back to predicting

266 it model illustrated the negative effects of frequent social media use to patient openness (beta=-0.1

267 Although people frequent social platforms for a variety of reasons, we u

268 The most frequent species was Streptococcus agalactiae (34%), and

269 Second, we account for long-range frequent specific genomic interactions.

270 ested in a double oddball paradigm, in which frequent standard stimuli and rare oddball stimuli were

271 The most frequent symptoms were general symptoms (324 [40%] patie

272 l pancreas systems) have been the subject of frequent systematic and narrative reviews, distal techno

273 2 [47%]) at the injection site, and the most frequent systemic reactogenic events were fatigue (29 [4

274 role in 5'-splice site recognition and is a frequent target of alternative splicing factors.

275 data may add to understanding why Gata6 is a frequent target of amplification in cancers.

276 Although ARID1A is the most frequent target of mutations, the mechanism by which its

277 B cells from European blood donors revealed frequent templated inserts originating from transcribed

278 Plasmodium falciparum parasitemia was less frequent than in non-BWF controls, but a higher proporti

279 fantile onset (<3 months), and are thus more frequent than previously reported; (ii) distinct phenoty

280 Serious adverse events were more frequent the in G-CSF and stem-cell infusion group (12 [

281 Papillary thyroid carcinoma (PTC), the most frequent thyroid cancer, is characterized by low prolife

282 1 point) was predictive of the "persistently frequent" trajectory (area under the receiver operating

283 The most frequent treatment-related adverse events of any grade w

284 nti-inflammatory drugs (NSAIDs) are the most frequent triggers of drug hypersensitivity with NSAIDs-i

285 Overly frequent TTEs can impair patient access and reduce value

286 s of the regions at the terminal ends of two frequent types of large structural mosaic events: telome

287 Rapid and systematic reviews with frequent updating and open dissemination are now needed

288 ithine transcarbamylase deficiency, the most frequent urea-cycle disorder.

289 n strategies because of their wide reach and frequent use by children.

290 Frequent use of analgesics has been associated with a hi

291 Despite the frequent use of this model for studying the impact of ge

292 and is correlated with heterozygosity for a frequent variant in the 3' untranslated region (UTR) of

293 e numbers of early cervical lesions revealed frequent viral integration into gene-poor regions of the

294 s also conferred increased seizure risk (37% frequent vs 45% abundant/continuous, OR, 1.64, P = .03 f

295 (95% CI, 1.28-3.98) increase in the odds of frequent (vs no) smoking and a 1.65 (95% CI, 1.09-2.51)

296 (95% CI, 1.09-2.51) increase in the odds of frequent (vs no) vaping at follow-up after adjustment fo

297 Adverse events were more frequent with clindamycin (58 of 265 [21.9%]) than with

298 Adverse events were more frequent with tofacitinib than with placebo.

299 TION: Decline in cognitive function was more frequent with WBRT than with SRS and there was no differ

300 Congenital cytomegalovirus is the most frequent, yet under-recognised, infectious cause of newb