ライフサイエンスコーパス: fructose-6-phosphate

1 ibrium constants of the binding of substrate fructose 6-phosphate.

2 apparent cooperativity in the interaction of fructose 6-phosphate.

3 itive inhibitor for the allosteric activator fructose 6-phosphate.

4 conversion of fructose 1,6-bisphosphate into fructose 6-phosphate.

5 e interconversion of mannose 6-phosphate and fructose 6-phosphate.

6 isomerization of D-glucose 6-phosphate to D-fructose 6-phosphate.

7 ne might be a precursor to 3-amino-3-deoxy-D-fructose 6-phosphate.

8 donor substrates, namely l-erythrulose and d-fructose-6-phosphate.

9 isomerization of D-glucose-6-phosphate to D-fructose-6-phosphate.

10 terconversion of D-glucose-6-phosphate and D-fructose-6-phosphate.

11 ncentration and by addition of its substrate fructose-6-phosphate.

12 ical conditions proceeds to the formation of fructose-6-phosphate.

13 e interconversion of glucose-6-phosphate and fructose-6-phosphate.

14 lycerate, as well as glucose-6-phosphate and fructose-6-phosphate.

15 mes alcohol dehydrogenase and pyrophosphate, fructose 6-phosphate 1-phosphotransferase, and approxima

16 en developed using the enzyme pyrophosphate--fructose-6-phosphate 1-phosphotransferase (EC 2.7.1.90)

17 Pyrophosphate-dependent fructose-6-phosphate 1-phosphotransferase (PFP) catalyze

18 Constitutive expression of FBPase and fructose-6-phosphate-1-kinase coupled with the absence o

19 A bifunctional enzyme, fructose-6-phosphate 2-kinase-fructose 2, 6-bisphosphata

20 g of the Walker motif residues of rat testis fructose 6-phosphate, 2-kinase:fructose-2,6-bisphosphata

21 A bifunctional enzyme, fructose-6-phosphate, 2-kinase:fructose-2, 6-bisphosphat

22 ptophan residues, of the bifunctional enzyme fructose 6-phosphate,2-kinase-fructose 2,6-bisphosphatas

23 Fructose-6-phosphate,2-kinase and fructose-2,6-bisphosph

24 A bifunctional enzyme, fructose-6-phosphate,2-kinase/fructose 2, 6-bisphosphata

25 Fructose-6-phosphate,2-kinase/fructose-2,6-bisphosphatas

26 -3 proteins, raising the question of whether fructose-6-phosphate,2-kinase/fructose-2,6-bisphosphatas

27 mmercially available TK substrates, namely d-fructose-6-phosphate a physiological donor and glycolald

28 the conversion of glucosamine-6-phosphate to fructose-6-phosphate, a reaction that under physiologica

29 The method utilizes the recently discovered fructose-6-phosphate aldolase (FSA), which is functional

30 om dihydroxyacetone and aminoethanol using D-fructose-6-phosphate aldolase and L-rhamnulose-1-phospha

31 The activity of glutamine:fructose-6-phosphate amido-transferase (GFAT), the first

32 Specific inhibitors of glutamine: fructose 6-phosphate amidotransferase (GFAT), an enzyme

33 nzyme for hexosamine biosynthesis, glutamine:fructose-6-phosphate amidotransferase (GFA) in human ske

34 Glutamine:fructose-6-phosphate amidotransferase (GFA) is the rate-

35 Glutamine:fructose-6-phosphate amidotransferase (GFA) is the rate-

36 g enzyme for hexosamine synthesis, glutamine:fructose-6-phosphate amidotransferase (GFA), specificall

37 Glutamine:fructose-6-phosphate amidotransferase (GFA), the first a

38 e rate-limiting enzyme of the HBP, glutamine:fructose-6-phosphate amidotransferase (GFA), was overexp

39 hosphate by the rate-liming enzyme glutamine:fructose-6-phosphate amidotransferase (GFA).

40 Glutamine:fructose-6-phosphate amidotransferase (GFAT) catalyzes t

41 Glutamine-fructose-6-phosphate amidotransferase (GFAT) catalyzes t

42 Glutamine:fructose-6-phosphate amidotransferase (GFAT) is the enzy

43 Glutamine:fructose-6-phosphate amidotransferase (GFAT) is the rate

44 to glucosamine through the enzyme glutamine:fructose-6-phosphate amidotransferase (GFAT) was blocked

45 with approximately 75% homology to glutamine-fructose-6-phosphate amidotransferase (GFAT) was termed

46 novirus-mediated overexpression of glutamine:fructose-6-phosphate amidotransferase (GFAT), the first

47 ted by azaserine, an inhibitor of glutamine: fructose-6-phosphate amidotransferase (GFAT), which is t

48 tance, we measured the activity of glutamine:fructose-6-phosphate amidotransferase (GFAT; rate-limiti

49 P) via regulation of expression of glutamine:fructose-6-phosphate amidotransferase 1 (GFAT1), the rat

50 e hexosamine biosynthesis pathway (glutamine:fructose-6-phosphate amidotransferase [GFA]) makes the c

51 enzyme in hexosamine biosynthesis (glutamine:fructose-6-phosphate amidotransferase [GFA]) was overexp

52 Azaserine, a glutamine:fructose-6-phosphate amidotransferase inhibitor, reverse

53 Glutamine:fructose-6-phosphate amidotransferase(GFAT) is the rate-

54 of the rate-limiting enzyme GFAT (glutamine:fructose-6-phosphate amidotransferase) did not protect a

55 enzyme in the hexosamine pathway (glutamine:fructose-6-phosphate amidotransferase).

56 eversed by antisense inhibition of glutamine:fructose-6-phosphate amidotransferase, the rate-limiting

57 Glutamine-fructose-6-phosphate aminotransferase (Gfa1) is an essen

58 first enzyme in chitin synthesis (glutamine fructose-6-phosphate aminotransferase) is reported.

59 glutamine, were determined to be 0.8 mm for fructose 6-phosphate and 1.2 mm for glutamine, which are

60 Glucosamine 6-phosphate is converted to fructose 6-phosphate and ammonia by the action of the en

61 e, one could observe substrate inhibition by fructose 6-phosphate and apparent cooperativity in the i

62 e was a mixed inhibitor with respect to both fructose 6-phosphate and ATP.

63 monophosphorylated sugars, including beta-D-fructose 6-phosphate and beta-D-mannose 6-phosphate, a p

64 C8 backbone of MTL moiety is derived from D-fructose 6-phosphate and D-ribose 5-phosphate via a tran

65 sphosphatases (PFKFB1-4), which interconvert fructose 6-phosphate and Fru-2,6-BP.

66 ncrease in glucose 6-phosphate, no change in fructose 6-phosphate and fructose 1,6-diphosphate, an in

67 Both fructose 6-phosphate and glutamine protect the enzyme fr

68 m values for the two substrates of reaction, fructose 6-phosphate and glutamine, were determined to b

69 hosphomannose isomerase, which interconverts fructose 6-phosphate and mannose 6-phosphate (Man-6-P),

70 maximal in the presence of divalent cations, fructose 6-phosphate and orthophosphate, which together

71 Diabetes elevated glucose 6-phosphate, fructose 6-phosphate and oxidised (NAD+ and NADP+) and r

72 allowing independent bindings of substrates, fructose-6-phosphate and ATP, with higher affinities tha

73 ed to estimate the dissociation constants of fructose-6-phosphate and fructose-2,6-bisphosphate, whic

74 wo other maize AGPase allosteric activators (fructose-6-phosphate and glucose-6-phosphate) did not al

75 by ATP and (i) manno(fructo)kinase, to form fructose 6-phosphate, and (ii) phosphofructokinase, to f

76 mutase interconverting glucose 6-phosphate, fructose 6-phosphate, and glucose 1-phosphate.

77 mannose 6-phosphate, galactose 6-phosphate, fructose 6-phosphate, and inorganic phosphate.

78 synthesis and purification of the substrate, fructose 6-phosphate, and methods for a radiometric assa

79 ose 1-phosphate but not glucose 6-phosphate, fructose 6-phosphate, and sedoheptulose 7-phosphate as p

80 The dissociation constants of the substrate, fructose 6-phosphate, and the allosteric ligands, as wel

81 s of hexose phosphates (glucose-6-phosphate, fructose-6-phosphate, and fructose-1,6-bisphosphate) wer

82 trates including glyceraldehyde-3-phosphate, fructose-6-phosphate, and glucose-6-phosphate; (ii) has

83 xyacetone phosphate, glucose-6-phosphate and fructose-6-phosphate as additional CggR ligands that can

84 se 6-phosphate at 1.16 A resolution and with fructose 6-phosphate at 1.5 A resolution.

85 apparent Michaelis-Menten constant (K(m)) of fructose 6-phosphate at different temperatures and (ii)

86 ps of the glycolysis: the phosphorylation of fructose 6-phosphate at position 1.

87 xed with the cyclic form of its substrate, D-fructose 6-phosphate, at 2.1 A resolution.

88 products of the reaction (orthophosphate and fructose 6-phosphate) bind to the active site in a manne

89 In the case of fructose-6-phosphate binding, the increased anisotropy w

90 e conversion of fructose 1,6-bisphosphate to fructose 6-phosphate by a fructose bisphosphatase (FBPas

91 us taken into the cells is phosphorylated to fructose 6-phosphate by ATP and a cytosolic fructo(manno

92 phosphate) and MPI (mannose 6-phosphate <--> fructose 6-phosphate) deficiencies reduce the metabolic

93 Protection studies with fructose 6-phosphate demonstrate that the value of the d

94 ition to its function as the proton donor to fructose-6-phosphate during formation of the transient p

95 oxal resulted in complete desensitization to fructose 6-phosphate (F6P) activation, and partial desen

96 lex with three zinc cations and the products fructose 6-phosphate (F6P) and phosphate (Pi) reveals lo

97 version of D-glucose 6-phosphate (G6P) and D-fructose 6-phosphate (F6P) and plays important roles in

98 bacterium tumefaciens enzyme is activated by fructose 6-phosphate (F6P) and pyruvate.

99 interconverts glucose 6-phosphate (G6P) and fructose 6-phosphate (F6P) but, outside the cell, is a m

100 not the Zn(2+) complexes), the 1-OH group of fructose 6-phosphate (F6P) coordinates to the metal at s

101 inase (PFK) catalyzes the phosphorylation of fructose 6-phosphate (F6P) to give fructose 1,6-bisphosp

102 ordered mechanism with MgATP binding before fructose 6-phosphate (F6P).

103 y covalent binding of the enzyme substrate d-fructose 6-phosphate (F6P).

104 rconversion of glucose 6-phosphate (G6P) and fructose 6-phosphate (F6P).

105 constants were determined for the activator fructose-6-phosphate (F6P) and substrate adenosine 5'-tr

106 ), intermediates (glucose-6-phosphate (G6P), fructose-6-phosphate (F6P), fructose-1,6-bisphosphate (F

107 pair, which enhances methanol conversion to fructose-6-phosphate (F6P).

108 0) fructose-1,6-bisphosphate (FBP; 1 mm) and fructose-6-phosphate (F6P; 1 mm) caused a transient incr

109 ree-step biochemical conversion of GlcNAc to fructose 6-phosphate first described in Escherichia coli

110 phoenzyme intermediate and release of beta-D-fructose 6-phosphate, followed by hydrolysis of the phos

111 place Mg2+ from site 3 and the 1-OH group of fructose 6-phosphate from in-line geometry with respect

112 e active pocket, slowing down the release of fructose-6-phosphate from the phosphoenzyme intermediate

113 th respect to the total free energy of MgADP/fructose 6-phosphate (Fru-6-P) activation in the control

114 hospho(enol)pyruvate (PEP) on the binding of fructose 6-phosphate (Fru-6-P) and MgATP to phosphofruct

115 ings between these ligands and the substrate fructose 6-phosphate (Fru-6-P) have also been determined

116 cat) = 250 s(-)1) that binds the cosubstrate fructose 6-phosphate (Fru-6-P) with relatively low affin

117 fied to block binding of both the substrate, fructose 6-phosphate (Fru-6-P), and the allosteric inhib

118 (EcPFK) that interact with bound substrate, fructose 6-phosphate (Fru-6-P), are examined for their p

119 The substrate, fructose 6-phosphate (Fru-6-P), binds along the other di

120 hosphoenolpyruvate (PEP), and the substrate, fructose 6-phosphate (Fru-6-P), in phosphofructokinase f

121 analysis of the three-ligand interaction of fructose 6-phosphate (Fru-6-P), phosphoenolpyruvate (PEP

122 cherichia coli phosphofructokinase (PFK) for fructose 6-phosphate (Fru-6-P).

123 ability of the enzyme to bind the substrate fructose 6-phosphate (Fru-6-P).

124 nversion of glucose 6-phosphate (Glc-6-P) to fructose 6-phosphate (Fru-6-P).

125 ely low affinity for the acceptor substrate, fructose 6-phosphate (Fru-6-P, K(m) 0.2-1 mm).

126 me, catalyzing the interconversion of beta-D-fructose- 6-phosphate (Fru-6-P) and fructose-2,6-bisphos

127 four active sites, which bind the substrates fructose-6-phosphate (Fru-6-P) and MgATP.

128 strong direct interaction between AMPPCP and fructose-6-phosphate (Fru-6-P) is found.

129 The affinity for the substrate fructose-6-phosphate (Fru-6-P) of a single wild-type act

130 s a 3-fold smaller K(0.5) for the substrate, fructose-6-phosphate (Fru-6-P), as compared to the wild-

131 r that could phosphorylate either glucose or fructose 6-phosphate (fructose-6-P) as a substrate to a

132 from l-glutamine to the acceptor substrate, fructose 6-phosphate, generating the products glucosamin

133 3-Amino-3-deoxy-D-fructose 6-phosphate has previously been demonstrated to

134 e interconversion of glucose 6-phosphate and fructose 6-phosphate, has been suggested to operate via

135 ression enhanced glucose 1-phosphate but not fructose 6-phosphate hydrolysis in intact microsomes, pr

136 se 6-phosphates d-allulose 6-phosphate and d-fructose 6-phosphate in a catabolic pathway for d-allose

137 as well as fructose-1,6-bisphosphate but not fructose 6-phosphate in vitro.

138 se, the feedback inhibition of hexokinase by fructose-6-phosphate, in a first refinement of the model

139 insulin resistance by increasing the flux of fructose-6-phosphate into the hexosamine pathway.

140 t the value of the dissociation constant for fructose 6-phosphate is 3.3 (+/-0.5) x 10(-7) m, approxi

141 In fact, compared to 3-PGA, fructose-6-phosphate is a more efficient activator in tw

142 osamine biosynthesis pathway (HBP), in which fructose-6-phosphate is converted to glucosamine 6-phosp

143 accumulation of the glycolytic intermediate fructose 6-phosphate, leading to engagement of the hexos

144 2-fold elevation in glucose 6-phosphate and fructose 6-phosphate levels, whereas fructose 1,6-bispho

145 und mannose and fucose residues stemmed from fructose 6-phosphate, not glucose 1-phosphate; therefore

146 ransaldol reaction catalyzed by LmbR using D-fructose 6-phosphate or D-sedoheptulose 7-phosphate as t

147 fector preference from 3-phosphoglycerate to fructose-6 phosphate or fructose-1,6-bis-phosphate, effe

148 amino group from the L-glutamine amide to D-fructose 6-phosphate, producing glutamic acid and glucos

149 ddition of glycolytic compounds like G6P and fructose-6-phosphate rescues the alphaMG growth defect o

150 The binding of fructose-6-phosphate resulted in a significant increase

151 se 1-phosphate <--> glucose 6-phosphate <--> fructose 6-phosphate, showed a large decrease in 3H:14C

152 tructure shows an EDTA molecule bound to the fructose-6-phosphate site of the 6-phosphofructo-2-kinas

153 The A. tumefaciens ADPGlc PPase/fructose 6-phosphate structural model along with sequenc

154 In the presence of fructose-6-phosphate, the protein inhibits glucokinase i

155 In contrast, the binding of fructose-6-phosphate, the reaction product, to the resti

156 y activated by both fructose-1-phosphate and fructose-6-phosphate; the strength of the activation res

157 lease and transfer ammonia from glutamine to fructose 6-phosphate through a channel.

158 te pathway to glyceraldehyde 3-phosphate and fructose 6-phosphate, thus bypassing fructose-1,6-bispho

159 Systematic addition of fructose 6-phosphate to phosphofructokinase in the absen

160 tivator, MgADP, also altered the affinity of fructose 6-phosphate to the enzyme by forming a ternary

161 Binding of fructose 6-phosphate to the enzyme displayed a two-step

162 catalyzes the ATP-independent conversion of fructose-6-phosphate to fructose-1,6-bisphosphate in gly

163 hat catalyzes the irreversible conversion of fructose-6-phosphate to fructose-1,6-bisphosphate.

164 step of the glycolytic pathway by converting fructose-6-phosphate to fructose-1,6-bisphosphate.

165 The kinetics for the isomerization of fructose-6-phosphate to glucose-6-phosphate (F6P --> G6P

166 The enzyme phosphorylates fructose-6-phosphate to produce fructose-1,6-bisphosphat

167 with the 2-Pase domain to secure binding of fructose-6-phosphate to the active pocket, slowing down

168 thway, which splits xylulose-5-phosphate (or fructose-6-phosphate) to acetate precursor acetyl phosph

169 f the corresponding human gene for glutamine-fructose-6-phosphate transaminase (GFPT), located at 2p1

170 Glutamine-fructose-6-phosphate transaminase 1 (GFAT) is the rate-l

171 Mutations in the gene encoding glutamine-fructose-6-phosphate transaminase 1 (GFPT1) cause the ne

172 Glutamine-fructose-6-phosphate transaminase 1 (GFPT1) is a key rat

173 GFA1 encodes glutamine-fructose-6-phosphate transaminase.

174 he formation of glucosamine 6-phosphate from fructose 6-phosphate using glutamine as the ammonia sour

175 erization of d-tagatose 6-phosphate C-4 to d-fructose 6-phosphate via a member of Pfam family PF08013

176 Fructose 6-phosphate was found to be a potent activator

177 ate was uncompetitive, whereas inhibition by fructose 6-phosphate was mixed.

178 domains binds the allosteric regulator, and fructose 6-phosphate was modeled into this region.

179 The apparent K(m) of GFAT1Alt for fructose-6-phosphate was approximately twofold higher th

180 from exchange of the lower three carbons of fructose-6-phosphate with unlabeled three-carbon precurs