ライフサイエンスコーパス: fruitless

1 ors of sexual differentiation: doublesex and fruitless.

2 ggering-competent H-stem constructs remained fruitless.

3 approaches to solving this conundrum will be fruitless.

4 r neurons that also sex-specifically express fruitless, a tra gene target controlling sexual behavior

5 wever, demonstrating that at a minimum, both fruitless and doublesex are involved in establishing sex

6 cuits expressing the sex-determination genes fruitless and doublesex drive quivering behavior.

7 authors identify the sex determination genes fruitless and doublesex, and a sex-specific P1-DN1 neuro

8 Two genes coding for transcription factors, fruitless and doublesex, have been suggested to play imp

9 itry established by the transcription factor Fruitless and triggered by sex-specific sensory cues.

10 ac,Tramtrack, Broad) domain proteins such as Fruitless are known to play key roles in the neural diff

11 Fruitless AS isoforms have been shown to influence male

12 Inspired by the fictional Baron Munchausen's fruitless attempt to pull himself up, it is demonstrated

13 imorphic transcription factors doublesex and fruitless controls sexual differentiation and sexual beh

14 in certain fru-mutant males, indicating that fruitless controls the formation of these cells or 5-HT

15 ntramolecular Diels-Alder reactions remained fruitless, dialkylaluminum chloride led to the formation

16 tale-we wish to help other researchers avoid fruitless efforts to employ the many, seemingly promisin

17 type II lineages that produce doublesex- and fruitless-expressing neurons and examined whether female

18 This activity involves sexually dimorphic fruitless-expressing neurons in the brain.

19 we demonstrate that knockdown of editing in fruitless-expressing neurons is sufficient to modify the

20 The loss of fruitless expression in these regions likely accounts fo

21 ecified by the male-specific products of the fruitless (fru(M)) gene; males without fru(M) do not cou

22 Fruitless (fru(M))-positive Or47b-expressing OSNs detect

23 orms of the neural sex determination factor, Fruitless (Fru(M)).

24 sex determination genes doublesex (dsx) and fruitless (fru) [1].

25 sex-determination genes doublesex (dsx) and fruitless (fru) [7-9].

26 We show that the sex determination genes fruitless (fru) and doublesex (dsx) both contribute to e

27 behavior in Drosophila are regulated by the Fruitless (Fru) and Doublesex (Dsx) transcription factor

28 coexpression of two sex-determination genes, fruitless (fru) and doublesex (dsx).

29 analysis of complementary DNAs specific for fruitless (fru) and Ods-site homeobox (OdsH) genes extra

30 ns that coexpress the sex-determination gene fruitless (fru) and the proprioceptive neuronal marker p

31 In Drosophila melanogaster, fruitless (fru) encodes male-specific transcription fact

32 ne branch of this hierarchy is headed by the fruitless (fru) gene and functions in the central nervou

33 spliced transcription factors encoded by the fruitless (fru) gene are key determinants of sexual beha

34 Male-specific products of the fruitless (fru) gene control the development and functio

35 In Drosophila melanogaster, the fruitless (fru) gene controls essentially all aspects of

36 and behavioural studies have shown that the fruitless (fru) gene encodes a set of male-specific tran

37 The Drosophila fruitless (fru) gene encodes a transcription factor that

38 The fruitless (fru) gene functions in Drosophila males to es

39 analyses of combinations of mutations of the fruitless (fru) gene have shown that male-specific isofo

40 The fruitless (fru) gene in Drosophila melanogaster is a mul

41 ct regulatory targets of doublesex (dsx) and fruitless (fru) is crucial for an understanding of how t

42 cuitry in which the male-specific product of fruitless (fru) is produced, in a region that has been s

43 ale courtship behavior in the absence of the fruitless (fru) male protein.

44 females do not express transcripts from the fruitless (fru) P1 promoter.

45 tes the splicing of both doublesex (dsx) and fruitless (fru) pre-mRNAs but negatively affects the spl

46 eurons do not express the sexually dimorphic FRUITLESS (FRU) transcription factor, but form male-spec

47 nt of male-specific neurons that coexpressed fruitless (fru), a regulator of male sexual behavior.

48 ship behavior in Drosophila are regulated by fruitless (fru), the first gene in a branch of the sex-d

49 nervous system, likely through regulation of fruitless (fru), to at least partially mediate the sexua

50 pressing the neural sex determination factor fruitless (fru), which have been implicated recently in

51 gaster males, when a subset of male-specific fruitless (fru)- and doublesex (dsx)-expressing neurons

52 avior is regulated in large part by the gene fruitless (fru).

53 -specific behavioral circuit identity marker fruitless (fru).

54 sex determination genes doublesex (dsx) and fruitless (fru).

55 Current models describe male-specific fruitless (fruM) as a genetic 'switch' regulating sexual

56 Male-specific fruitless (fruM) is a major component inducing male beha

57 roductive tract labeled by both ppk-GAL4 and fruitless-GAL4 can sense sex peptide to control the indu

58 n c673a-Gal4-silenced flies, while silencing fruitless-Gal4 neurons alters only metabolism.

59 rform a similar function, the c673a-Gal4 and fruitless-Gal4 neurons.

60 ex peptide is generally believed to modulate fruitless-GAL4-expressing neurons in the central nervous

61 The fruitless gene in Drosophila produces male-specific prot

62 The fruitless gene is a major transcription factor with a wi

63 The fruitless gene is well-known to play a key role in deter

64 The fruitless gene, immediate early genes in discrete seroto

65 ed Hsp22 gene and the male sex-determination fruitless gene.

66 ed by Fru(M), a male-specific isoform of the fruitless gene.

67 ng behavior via sex-specific splicing of the fruitless gene.

68 male courtship is controlled in part by the fruitless gene.

69 gion of chromosome 2 near the candidate gene fruitless, identifying these genes as suitable loci for

70 , the action of the male-specific isoform of fruitless in about 2000 neurons appears to be necessary

71 Here, we examine the structure of fruitless in multiple species of Drosophila, and determi

72 le duration and involve a new doublesex- and fruitless-independent branch of the sex differentiation

73 To understand the molecular etiology of fruitless mutant phenotypes, we compared wild-type and m

74 The fruitless mutants fru3 and fru4 were assessed for sex-sp

75 e reduces male courtship and synergizes with fruitless mutations, suggesting that takeout plays a red

76 Thus, in a subset of fruitless neurons, targets of the TIF and tra pathways a

77 Furthermore, fruitless, one of the major genes functioning downstream

78 By manipulating either the fruitless or transformer genes in the brains of male or

79 ily, ppk23 and ppk29, which are expressed in fruitless-positive neurons on the legs and are essential

80 in the Drosophila melanogaster doublesex and fruitless pre-mRNAs has been well studied and depends on

81 f sex-specific splice sites in doublesex and fruitless pre-mRNAs.

82 ry but this can be a laborious and sometimes fruitless process.

83 ns that expressed male-specific forms of the fruitless protein in the laterodorsal region of the brai

84 ubgroups of neurons expressing male forms of fruitless proteins (Fru(M)).

85 The male-specific Fruitless proteins (FruM) act to establish the potential

86 The male-specific Doublesex and Fruitless proteins together activate Takeout expression,

87 ne function of ms-npf neurons is to modulate fruitless-regulated sexual behavior.

88 egulation differs from that of doublesex and fruitless RNAs.

89 The generalization that fruitless specified the development of the nervous syste

90 Importantly, one of these direct targets is fruitless, the master regulator of courtship.

91 behavior relies on a single splicing of the fruitless transcript, and on a specific olfactory-based

92 Regulating dendritic position, the fruitless transcription factor both connects the male-re

93 emonstrated that male-specific expression of Fruitless transcription factors (Fru(M) proteins) is nec

94 n-neural tissues culminated with claims that fruitless was both necessary and sufficient to establish