ライフサイエンスコーパス: fucose

1 iphosphate glucose, isocitrate, lactate, and fucose).

2 distinction of GlcNAc from GlcNAc with core fucose.

3 the fuc locus and is unable to swim towards fucose.

4 6-deoxygulose and likely regeneration of TDP-fucose.

5 red with antibodies with a high amount of Fc fucose.

6 mannose-terminated glycans with and without fucose.

7 ructure that mimicked the pyranoside ring of fucose.

8 resistant to CCL2, which binds core alpha1,3-fucose.

9 he genes in the locus is highly inducible by fucose.

10 specifically binds to terminal alpha-linked fucose.

11 n site, enabling Glu-88 to engage Ca(2+) and fucose.

12 te GDP-Arap, while synthesizing abundant GDP-fucose.

13 examined biofilm formation and chemotaxis to fucose.

14 and the fucP mutant are chemotactic towards fucose.

15 roteins were able to salvage l-fucose to GDP-fucose.

16 tions and prevented by specific removal of L-fucose.

17 e (N)-linked paucimannosylation (mannose(1-3)fucose(0-1)N-acetylglucosamine(2)Asn).

18 contains the DC-SIGN-targeting carbohydrates fucose (1.35 nmol/mg), mannose (2.68 nmol/mg), N-acetylg

19 bidopsis thaliana revealed that 2-fluoro 2-l-fucose (2F-Fuc) reduces root growth at micromolar concen

20 subsequent repeats of this unit composed of fucose, 3OMe6dTal, and MeGlcA would be assembled by a cy

21 the affinities of the protruding domain for fucose (460 muM) and H type 2 trisaccharide (390 muM), a

22 in cancer cells using peracetylated 5-thio-L-fucose (5T-Fuc).

23 plex N-glycans (i.e. contained xylose and/or fucose) (88 %), whereas complex N-glycans comprised a mu

24 Our findings suggest that EHEC uses fucose, a host-derived signal made available by the micr

25 L-fucose, a monosaccharide widely distributed in eukaryote

26 WreT would each act once to attach mannose, fucose, a second fucose, and 3-O-methyl-6-deoxytalose (3

27 ovo synthesis of guanosine diphosphate (GDP)-fucose, a substrate for fucosylglycans, requires sequent

28 ovo synthesis of guanosine diphosphate (GDP)-fucose, a substrate for fucosylglycans, requires sequent

29 ed fraction indicate that AAL binds O-linked fucose added to Ser/Thr residues present in or adjacent

30 Fucose affects the expression of microbial metabolic pat

31 biosynthesis; however, the secretion rate of fucose-alkyne-labeled pectin is greatly decreased in fra

32 triflation at O2, O3, and O4 of l-rhamnose/l-fucose allowed selective inversions at respective positi

33 The disaccharide motif fucose-alpha(1-2)-galactose (Fucalpha(1-2)Gal) is involv

34 Although fucose-alpha(1-2)-galactose (Fucalpha(1-2)Gal)-containin

35 11168 forms less biofilms in the presence of fucose, although its fucose permease mutant (fucP) shows

36 this approach, we found that an alkynylated fucose analog (FucAl) is metabolically incorporated into

37 To address this, we screened a panel of fucose analogues and identified 2-fluorofucose and 5-alk

38 accharide modifications (i.e., core alpha1,3-fucose and beta1,2-xylose) showed significantly enhanced

39 FusK senses fucose and controls expression of virulence and metaboli

40 The comparison of growth on L-fucose and D-glucose allows first insights into the geno

41 In vitro unfolding assays demonstrate that fucose and glucose stabilize folded TSRs in an additive

42 Fringe enzymes add N-acetylglucosamine to O-fucose and modify Notch signaling by altering the sensit

43 al C-H...O hydrogen bond between H-C(5) of L-fucose and O(5) of D-galactose was identified.

44 domains 11-13) of human Notch1 (hN1) with O-fucose and O-glucose glycans and shown by flow cytometry

45 Taken together, this work suggests that O-fucose and O-glucose glycans cooperatively stabilize ind

46 A new study shows that O-fucose and O-glucose stabilize the repeats but that exte

47 residues on Notch1 are functionalized with O-fucose and O-glucose, which act as surrogate amino acids

48 on sources, the pathway for the breakdown of fucose and rhamnose is encapsulated within a bacterial m

49 The breakdown of fucose and rhamnose released from plant cell walls by th

50 of the d-absolute configuration, except for fucose and rhamnose which are l.

51 S. typhimurium accesses fucose and sialic acid within the lumen of the gut in a

52 on data revealed PLL to be specific toward l-fucose and the disaccharide glycan 3,6-O-Me2-Glcbeta1-4(

53 single oligosaccharide residues, i.e., core fucose and xylose, and terminal galactose.

54 ies required for salvage and conversion of l-fucose and/or d-Arap into the nucleotide-sugar substrate

55 minic acid (Neu5Ac), galactose, mannose, and fucose) and significantly (p < 0.05) alter infection.

56 act once to attach mannose, fucose, a second fucose, and 3-O-methyl-6-deoxytalose (3OMe6dTal), respec

57 olved in the utilization of glucose, xylose, fucose, and arabinose, which are also substrates for the

58 nt of beta-glucan reveal binding to mannose, fucose, and glucose residues by Ca(2+) coordination of v

59 containing two GlcNAcs, three mannoses, one fucose, and one xylose (N2M3FX) as a substrate.

60 quenching, decreased apparent affinity for L-fucose, and significant inhibition of active L-fucose tr

61 glycogene regulatory networks: high mannose, fucose, and terminal beta-GalNAc, identifying miRNA regu

62 group adjacent to the linking position of L-fucose, and the hydrophobic interaction of L-fucose with

63 lower action where sialic acid neighbors the fucose, and the neuraminidase showed statistically lower

64 ennary structures, only alpha1,6-linked core fucoses, and more LacNAc repeat structures; the MDA-MB-2

65 ike particles (VLPs) and identified alpha1,2-fucose as a key attachment factor.

66 ped by attachment of di- or tri-O-methylated fucose as catalyzed by glycosyltransferase WreB.

67 f apoFgFCO1 and an open complex with product fucose at atomic resolution.

68 lar, collectin-11 has been shown to engage L-fucose at sites of ischemic stress, activating the lecti

69 Fringe-catalyzed addition of GlcNAc to the O-fucose at T466 in EGF12 substantially increases binding

70 Ac and blocking the addition of galactose or fucose at the carbon 4-position of 4-F-GlcNAc.

71 lactose at the Le(a) nonreducing end nor the fucose at the Le(x) reducing end; the pentasaccharides o

72 ) transfer N-acetylglucosamine (GlcNAc) to O-fucose attached to EGF-like repeats of NOTCH receptors.

73 fucose from host glycans, resulting in high fucose availability in the gut lumen.

74 fuc + strains, are involved in coordinating fucose availability with biofilm development.

75 Here we show that the fucose-binding Aleuria aurantia lectin (AAL) binds to nu

76 A novel fucose-binding lectin (SL2-1) from the bacterium Strepto

77 the family 51 carbohydrate-binding module, a fucose-binding lectin from Ralstonia solanacearum, and h

78 the native source, and characterized as an l-fucose-binding lectin, named P. luminescens lectin (PLL)

79 ifaria genome identified BambL as a putative fucose-binding lectin.

80 teins, but are related to certain eukaryotic fucose-binding lectins.

81 s that have no similarity to known bacterial fucose-binding proteins, but are related to certain euka

82 beta-propeller fold creating seven putative fucose-binding sites per monomer.

83 aled that it associates as a trimer with two fucose-binding sites per monomer.

84 Although the labelling by the fucose-binding Ulex europaeus agglutinin I (UEA-I) was c

85 lex confirmed that at least three sites were fucose-binding.

86 New work suggests that fucose can have a protective role in both gut-centered a

87 od source for beneficial gut symbionts, host fucose can suppress the virulence of pathogens and patho

88 plex forms (e.g. beta1,2 xylose and alpha1,3 fucose) can render the product immunogenic.

89 Within Fut2(-) mice, the B. thetaiotaomicron fucose catabolic pathway was markedly down-regulated, wh

90 Fucose chemotaxis also correlated with possession of the

91 This study suggests that components for fucose chemotaxis are encoded within the fuc locus, but

92 Selective fucose cleavage from the H2-antigen saccharide enables e

93 e crystal structure of the recombinant PLL.l-fucose complex confirmed that at least three sites were

94 Mice were placed on standard chow or fucose-containing diet (equivalent to a control fucosylg

95 L-Fucose-containing glycoconjugates are essential for a my

96 immunohistochemistry confirmed that alpha1,2-fucose-containing H and A antigens of the HBGA family we

97 ive binding to this glycan compared to other fucose-containing oligosaccharides results from addition

98 n (AAL), lectins which bind sialic acid- and fucose-containing structures, respectively.

99 he polyanionic polysaccharides alginates and fucose-containing sulfated polysaccharides.

100 ever, Fsar's polydispersity index (1.12) and fucose content (34.50%) were lower than those of Fysk, a

101 Furthermore, these lines display reduced L-fucose content in N-glycan structures accompanied by sev

102 p at the C-6 position of the nonreducing end fucose could elicit a strong IgG immune response.

103 ange of substrates, including L-arabinose, D-fucose, D-galactose, D-glucose, and D-xylose.

104 roduce the same biochemical phenotype of GDP-fucose deficiency.

105 he inhibitors were used in vitro to generate fucose-deficient antibodies with enhanced antibody-depen

106 In the fucose-deficient murus1 mutant, AGPs lack these fucose m

107 bon sources and revealed a new pathway for L-fucose degradation in S. solfataricus.

108 Within the newly discovered pathway for L-fucose degradation the following key reactions were iden

109 he structures of the fuconolactonase and the fucose dehydrogenase were determined by X-ray diffractio

110 The enzymatic product of an adjacent L-fucose dehydrogenase, BmulJ_04919, was shown to be L-fuc

111 ly synthesized from 4-deoxy-L-fucose using L-fucose dehydrogenase.

112 The observation of the m/z 587.3 core fucose diagnostic peak corresponding to [GlcNAc + Fucose

113 er the O-fucose monosaccharide or the GlcNAc-fucose disaccharide at T466 of EGF12 and observed no cha

114 Antibodies with a low amount of fucose displayed higher binding affinity to FcgammaRIIIa

115 Transitions specific to outer arm fucose document a disease-associated increase in outer a

116 at and that addition of both O-glucose and O-fucose enhances stability in an additive manner.

117 arrying complex N-glycosylation lacking core fucose exhibited superior potency (ED(50) = 3 mug).

118 hese results establish a requirement for GDP-fucose for L. major viability and predict the existence

119 Moreover, the fucose-free antibodies generated in N. benthamiana are c

120 ties, we have now produced glycan-optimized, fucose-free versions of PG9 and RSH in Nicotiana bentham

121 transferase (FucT) catalyzes the transfer of fucose from GDP-fucose to asparagine-linked GlcNAc of th

122 yltransferase FUT1 catalyzes the transfer of fucose from GDP-fucose to terminal galactosyl residues o

123 on produces multiple fucosidases that cleave fucose from host glycans, resulting in high fucose avail

124 on contributes to EHEC virulence by cleaving fucose from mucin, thereby activating the FusKR signalli

125 arium graminearum (FgFCO1) actively releases fucose from the xyloglucan fragment.

126 Here, we show that removing fucose from trastuzumab (Herceptin) increased its bindin

127 Using a unique system, the fucose (fuc) regulon, in which IS5 insertion and excisio

128 re, we show that the mice immunized with a l-fucose (Fuc)-enriched Reishi polysaccharide fraction (de

129 I, which may compensate for the loss of core fucose functions.

130 paration of nine determined monosaccharides (fucose, galactose, arabinose, glucose, rhamnose, xylose,

131 Fucose, galactose, arabinose, glucose, sucrose, rhamnose

132 Previous analyses showed the presence of GDP-fucose (GDP-Fuc), the precursor for all fucosylation rea

133 Starting from L-fucose, GDP-fucose is constructed by one bifunctional en

134 espond to one of four new inducer molecules: fucose, gentiobiose, lactitol and sucralose.

135 m Notch target activation, indicating that O-fucose glycans are critical for efficient Notch-ligand b

136 Therefore, the presence of Gal on O-fucose glycans differentially affects DLL1-induced NOTCH

137 e combined data support a key role for the O-fucose glycans generated by Pofut1 in Notch regulation o

138 ions in hematopoiesis of Notch modified by O-fucose glycans, we examined mice with inducible inactiva

139 r Lec8 or Lec20 CHO mutants lacking Gal on O-fucose glycans.

140 that the lectin AAL had higher binding where fucose groups are displayed on separate branches.

141 FucP of Escherichia coli catalyzes L-fucose/H(+) symport, and a crystal structure in an outwa

142 erminal galactose, bisecting GlcNAc and core fucose has been realized.

143 product characterization, and lot release as fucose has been shown to adversely affect the ability of

144 Host cells modify secreted proteins with O-fucose; here we describe the O-fucosylation pathway in t

145 nt subclasses (IgG1-4) with and without core fucose (i.e., 20% fucose remaining).

146 GFT1-silenced plants are almost devoid of L-fucose in cell wall-derived xyloglucan and rhamnogalactu

147 The key role played by fucose in glycoprotein and cellular function has prompte

148 DP-N-acetylglucosamine, GDP-mannose, and GDP-fucose in Plasmodium falciparum intraerythrocytic life s

149 Although the function of fucose in the parasite is not known, the presence of GDP

150 of three metabolites (copper, trehalose, and fucose) in the environment of a cell population over tim

151 The interface between collectin-11 and L-fucose, in both the recipient and the allograft, is an a

152 e degree of galactosylation of core alpha1,6-fucose increased, and a novel Galalpha1,2Fucalpha1,3 moi

153 e used by fucosyltransferases to incorporate fucose into protein and cellular glycans.

154 eotide sugar transporter for import of GDP-L-fucose into the Golgi and is required for proper plant g

155 de sugar transporter that translocates GDP-L-fucose into the Golgi lumen.

156 to FcgammaRIIIa is markedly affected by core fucose, irrespective of its plant-specific alpha1,3 or m

157 Fucose is a common monosaccharide component of cell surf

158 Fucose is a sugar present in glycoconjugates often assoc

159 O-fucose is added to cysteine-rich domains called thrombos

160 Fucose is an L-configuration sugar found abundantly in t

161 Starting from L-fucose, GDP-fucose is constructed by one bifunctional enzyme L-fucos

162 re active in vitro, indicating that most GDP-fucose is formed by a de novo pathway that involves the

163 Fucose is highly abundant in the intestine.

164 sylated proteins are shed into the lumen and fucose is liberated and metabolized by the gut microbiot

165 e N-glycan structure confirmed that alpha1,3-fucose is missing from the N-glycans of allelic fuct-1 a

166 metabolic labeling experiments showing that fucose is not significantly incorporated by the parasite

167 duce epithelial fucosylation, and epithelial fucose is used as a dietary carbohydrate by many of thes

168 The incorporation of alpha-fucoses is demonstrated for H-type I and II; alpha(1,3)-

169 To test whether GDP-fucose itself was essential for Leishmania viability, we

170 and WbdP) and they transfer glucose (Glc), L-fucose (L-Fuc) and N-acetylperosamine (PerNAc) onto GalN

171 nd not by sequential domains like the fungal fucose lectin from Aleuria aurantia.

172 ages, with additional alpha1,2- and alpha1,3 fucose linkages found in MCF-7 cells.

173 ith terminal alpha2,3-sialidic acid and core fucose linkages, with additional alpha1,2- and alpha1,3

174 During growth on L-fucose major changes in the central carbon metabolic net

175 overall yield from commercially available l-fucose, making it the most efficient route reported to d

176 chains consist of typical M. xanthus lipids, fucose, mannose, N-acetylglucosamine and N-acetylgalacto

177 locus revealed that Cj0485 is necessary for fucose metabolism and chemotaxis.

178 g genes for import of fucosylated molecules, fucose metabolism and two alpha-fucosidases.

179 reveals concomitant shifts in cyclic AMP and fucose metabolism consistent with phototaxis and extrace

180 n the parasite genome, but the importance of fucose metabolism for the parasite is unknown.

181 lly related carbohydrates such as arabinose, fucose, methyl galacturonate and N-acetylgalactosamine t

182 s with procainamide hydrochloride to inhibit fucose migration during tandem MS analysis.

183 tin and EGF domains of L-selectin bound to a fucose mimetic; that is, a terminal mannose on an N-glyc

184 O-Linked fucose modifications on Notch1 epidermal growth factor-l

185 sual N-glycans with a range of galactose and fucose modifications on the Man2-3GlcNAc2 core region.

186 ose-deficient murus1 mutant, AGPs lack these fucose modifications.

187 Both galactosylated fucose moieties were also found in two parasitic nematod

188 The fucose moiety of the blood group B trisaccharide Galalph

189 cosidase mutants could introduce an alpha1,6-fucose moiety specifically at the Asn-linked GlcNAc moie

190 ains 11-13 of hN1 modified with either the O-fucose monosaccharide or the GlcNAc-fucose disaccharide

191 erved varying degrees of elongation beyond O-fucose monosaccharide, indicating that Fringe preferenti

192 ed statistically lower action where alpha1-2 fucose neighbors the sialic acid or is on the opposing b

193 hated polysaccharide that consists mainly of fucose, normally found in brown seaweeds.

194 Removal of the core fucose of this glycan greatly increases the affinity for

195 t a disease-associated increase in outer arm fucose on both bi- and triantennary glycans at the N187

196 lian Notch receptors require modification by fucose on epidermal growth factor-like (EGF) repeats of

197 Our previous work indicated that fucose on human epithelia is a frequent target for lecti

198 Indeed, removal of fucose on myelin reduced DC-SIGN-dependent homeostatic c

199 COLEC11) recognizes an abnormal pattern of L-fucose on postischemic renal tubule cells and activates

200 has been demonstrated that lack of the core fucose on the Fc N-glycans leads to drastic enhancement

201 f C. elegans N-glycans and that the alpha1,3-fucose on the reducing terminus can be substituted by an

202 two N-acetylhexosamine, thirteen hexose, one fucose, one methyl, and two pentose residues; however, i

203 ggest that B. bifidum SC555 does not utilize fucose or sialic acid from HMO.

204 erns specific to those structures containing fucose or sialic acid residues.

205 ansporter that competes with Slc35c1 for GDP-fucose, or a factor that otherwise enhances the fucosyla

206 ve carbohydrate cleavage reactivity toward l-fucose over d-glucose.

207 how that GFT preferentially transports GDP-L-fucose over other nucleotide sugars in vitro, while GFT1

208 llowing key reactions were identified: (i) L-fucose oxidation to L-fuconate via a dehydrogenase, (ii)

209 ural symmetry motifs in the Escherichia coli fucose permease (FucP) results in remarkable homology to

210 ilms in the presence of fucose, although its fucose permease mutant (fucP) shows no change.

211 ting a mutation in fucP (encoding a putative fucose permease), one of the genes in the plasticity reg

212 similarity with the glycerol-3-phosphate and fucose permeases from Escherichia coli, respectively.

213 The fucose phenotype, shown in chemically defined medium, is

214 Thus, the GDP-fucose precursor is essential in a wide variety of organ

215 e diagnostic peak corresponding to [GlcNAc + Fucose + Procainamide + H](+) in the tandem MS data of f

216 is constructed by one bifunctional enzyme L-fucose pyrophosphorylase (FKP) via two reactions.

217 1-4) with and without core fucose (i.e., 20% fucose remaining).

218 structure of the complex of MsaFBP32 with l-fucose reported here shows a cylindrical 81-A-long and 6

219 or receptor binding is the embrace of an ABO fucose residue by a disulfide-clasped loop, which is ina

220 in proton migration, which in turn leads to fucose residue migration from the glycan core to the ant

221 ltrasferase (FUT)-catalyzed transfer of an L-fucose residue to carbohydrate acceptors.

222 ules with only one N-acetylglucosamine and a fucose residue was fully able to abolish the interaction

223 ducing terminal galactose, as well as of the fucose residue.

224 ical of many other eukaryotes; some of these fucose residues are capped with hexose residues as shown

225 The modification of alpha1,6-linked fucose residues attached to the proximal (reducing-termi

226 Up to three fucose residues can be present on the standard N,N'-diac

227 removal of alpha2,3-sialic acid and alpha1,3-fucose residues from host cell surfaces makes them less

228 /MS), we now reveal that actually up to five fucose residues modify the core region of C. elegans N-g

229 that modulate Notch activity by modifying O-fucose residues on epidermal growth factor-like (EGF) re

230 pha1,3-linked, but also core alpha1,6-linked fucose residues on their N-glycans.

231 onalized glycoclusters with galactose and/or fucose residues targeting both PA-IL and PA-IIL lectins

232 Previously, up to four fucose residues were detected on its N-glycans, despite

233 toid arthritis SF contained both sulfate and fucose residues, and SF lubricin was capable of binding

234 ted glycans, namely O-methylated mannose and fucose residues, as part of bacterial LPS and nematode c

235 olved in the incorporation and cleavage of L-fucose residues, respectively, represent captivating tar

236 ex type containing terminal sialic acids and fucose residues.

237 sists of N-glycans with core alpha1,3-linked fucose residues.

238 oligosaccharides that are deficient in "core fucose" residues and appear to be more effective than fu

239 f the aldehyde dehydrogenase enzyme from the fucose/rhamnose utilisation BMC with different short-cha

240 Homologues for enzymes involved in a fucose salvage pathway are apparently absent in the P. f

241 ct an Atfkgp mutant that is defective in the fucose salvage pathway indicates that 2F-Fuc must be con

242 This fucose-sensing system is required for robust EHEC coloni

243 ly, these antibodies with a low amount of Fc fucose showed enhanced phagocytosis of platelets using F

244 , similar to the type 2 LacNAc termini, with fucose, sialic acid, or sulfate.

245 ucose sites (N103 and N448) and one O-linked fucose site (T61) were fully glycosylated in both innova

246 The two N-linked fucose sites (N103 and N448) and one O-linked fucose sit

247 The majority of the O-fucose sites were modified to high stoichiometries.

248 ified peptides containing all 22 predicted O-fucose sites, all 18 predicted O-glucose sites, and all

249 SL2-1 belongs to a new group of bacterial fucose-specific lectins that have no similarity to known

250 ars was suggested by lectin blots, using the fucose-specific Lens culinaris agglutinin (LCA).

251 ssays reveal that addition of O-glucose or O-fucose stabilizes a single EGF repeat and that addition

252 t8-deficient (Fut8(-/-)) mice that lack core fucose structure die within 3 days after birth, but the

253 ting reports regarding the maximal number of fucose substitutions in C. elegans, which in part may be

254 e parasite is not known, the presence of GDP-fucose suggests that the metabolite may be used for furt

255 measurements of monosaccharide composition, fucose, sulfate, and uronic acid contents revealed that

256 GDP-mannose 4,6-dehydratase (GMD) and GDP-L-fucose synthase (FS), is conserved in the parasite genom

257 ues of GDP-mannose 4,6-dehydratase and GDP-L-fucose synthase enzymes that are active in vitro, indica

258 iparum GDP-mannose 4,6-dehydratase and GDP-L-fucose synthase expressed in transgenic 3D7 parasites sh

259 ck of fucosylation consequent to loss of GDP-fucose synthesis contributes to colon carcinogenesis.

260 solic protein required for the first step of fucose synthesis.

261 nzymes GDP-mannose dehydratase (GMD) and GDP-fucose synthetase (GMER) were expressed ectopically; fro

262 with Kdo-N3 and an alkynated derivative of L-fucose that incorporates into rhamnogalacturonan I, co-l

263 These results demonstrate that, like O-fucose, the O-glucose modifications of EGF repeats occur

264 proximal renal tubule in association with L-fucose, the potential binding ligand for CL-11.

265 at involved in recognizing the terminal HBGA fucose, the saccharide which forms the primary conserved

266 localization of mucin origin, with terminal fucose, the sialyl T-antigen, and N-linked oligosacchari

267 ucose derivatives that depleted cells of GDP-fucose, the substrate used by fucosyltransferases to inc

268 ly tert-butyldimethylsilyl (TBDMS) protected fucose thioglycosides as glycosyl donors for oligosaccha

269 T) catalyzes the transfer of fucose from GDP-fucose to asparagine-linked GlcNAc of the N-glycan core

270 osyltransferase-VI and guanosine diphosphate fucose to enhance the interaction of CD34(+) stem and ea

271 d-Arap, both proteins were able to salvage l-fucose to GDP-fucose.

272 We hypothesized that adding fucose to human Tregs, forming the Sialyl Lewis X moiety

273 Here, we show that addition of L-fucose to purified FucP in detergent induces approximate

274 T1 catalyzes the transfer of fucose from GDP-fucose to terminal galactosyl residues on xyloglucan sid

275 gy of Fx-/- mice was reversed by addition of fucose to the diet, which restored fucosylation via a sa

276 leucine in nac(1) flies, which abolishes GDP-fucose transport in vivo and in vitro.

277 This pathway as well as L-fucose transport shows interesting overlaps to the D-ara

278 cose, and significant inhibition of active L-fucose transport, indicating that the two residues are l

279 a conserved serine residue in the Golgi GDP-fucose transporter (GFR) is substituted by leucine in na

280 Here we identify GDP-fucose transporter 1 (GFT1), an Arabidopsis nucleotide s

281 he crystal structure of the Escherichia coli fucose transporter FucP and have identified four transme

282 results suggest that Slc35c2 is either a GDP-fucose transporter that competes with Slc35c1 for GDP-fu

283 ucosylation via over-expression of a key GDP-Fucose transporter, Slc35c1, in zebrafish.

284 The third position of the fucose unit is always linked to a rhamnose, which is a s

285 idue of the main chain, (ii) a hyperbranched fucose unit, and (iii) two rhamnose residues with opposi

286 thin the identified glycans, the position of fucose units was located to quantitate possible changes

287 of the NCTC11168 locus into 81-176 activated fucose uptake and chemotaxis.

288 now known to encode pathways for glucose and fucose uptake/metabolism.

289 was enzymatically synthesized from 4-deoxy-L-fucose using L-fucose dehydrogenase.

290 to this paradigm, we provide evidence for l-fucose utilization by C. jejuni.

291 Consistent with their function in fucose utilization, transcription of the genes in the lo

292 on, we found that this locus is required for fucose utilization.

293 this locus was consistently associated with fucose utilization.

294 ting from readily available l-rhamnose and l-fucose via highly regioselective, one-pot double serial

295 sII with the C4-epimer of TDP-quinovose (TDP-fucose) was examined.

296 maR), and whether the absence of the Fc core fucose (which increases binding to FcgammaRIIIa) increas

297 o a terminal xylose unit and a hyperbranched fucose, which is in turn substituted with a terminal gal

298 lammatory responses through recognition of L-fucose, which we confirmed by showing that fucosidase-tr

299 fucose, and the hydrophobic interaction of L-fucose with the beta-face of D-galactose), a nonconventi

300 X stands for different sulfation patterns of fucose (X = 3,4S (46%), 2,4S (39%), and 4S (15%)).

301 e whereas the acidic polysaccharides contain fucose, xylose and 4-O-methylglucuronic acid -residues.