ライフサイエンスコーパス: fucosylated

1 or a subset, of the EGF repeats need to be O-fucosylated.

2 orm with higher affinity for heparin was not fucosylated.

3 trast to expectations, PSGL-1 is not heavily fucosylated; a majority of the O-glycans are disialylate

4 er membrane protein that mediates binding to fucosylated ABH antigens of the ABO blood group.

5 ino acid residues as critical for binding to fucosylated ABH antigens.

6 Normal plasma IgG contains approximately 94% fucosylated Abs, but alloantibodies against, for example

7 Hypo-fucosylated adalimumab increased the number of CD206(+)

8 When hypo-fucosylated adalimumab was added to PBMCs, a larger numb

9 Susceptibility of [(14)C]fucosylated AGPs to alpha(1,2)fucosidase, and not to alp

10 pha2-3 glycans, including alpha2-3GalNAc and fucosylated alpha2-3 glycans (including sialyl Lewis x),

11 (b), and Le(y) determinants carried by their fucosylated analogues.

12 n strategy to separate functionally relevant fucosylated and afucosylated glycans on mononclonal anti

13 results in a form of the protein that is not fucosylated and has substantially weaker activity in cel

14 e tandem mass spectrometry; these are highly fucosylated and have a novel core that contains internal

15 sed 20 monosialylated and nonsialylated, and fucosylated and nonfucosylated complex- and hybrid-type

16 The minor fucosylated and polylactosamine species were well separa

17 mannosamine (ManNAc), were incorporated into fucosylated and sialylated glycans in several cancer cel

18 Fucosylated and sialylated glycopeptides from human lact

19 samine-type structures were found to be core fucosylated and some of them contained one to three lact

20 A mixture of afucosylated, fucosylated, and high mannose oligosaccharides was separ

21 were poorly galactosylated, not processively fucosylated, and negligibly inhibitory, whereas the fuco

22 linkage determination of neutral, branched, fucosylated, and sialylated oligosaccharides.

23 glycans but is modified with hybrid, highly fucosylated, and sialylated sugars.

24 The ligands must be sialylated, fucosylated, and sulfated for optimal recognition by L-s

25 Most human milk oligosaccharides are fucosylated, and their production depends on enzymes enc

26 Furthermore, they proposed that the non-fucosylated antenna mediated adherence to a peridontal p

27 core structures can be decorated with novel fucosylated antennae composed of Fucalpha(1-3)GlcNAc.

28 on its N-glycans, despite these lacking the fucosylated antennae typical of many other eukaryotes; s

29 Hypo-fucosylated anti-TNF might be more effective in patients

30 In mice with colitis, hypo-fucosylated anti-TNF significantly increased the number

31 We produced hypo-fucosylated antibodies against mouse and human TNF (adal

32 esidues and appear to be more effective than fucosylated antibodies in promoting phagocytosis of anti

33 ose transporter, resulting in a reduction of fucosylated antigens on the cell surface.

34 e form with lower heparin affinity being 97% fucosylated at this position, whereas the form with high

35 en animals given NFb12 and those given fully fucosylated b12, indicating that FcgammaR-mediated activ

36 , together with the structures of another 12 fucosylated biantennary glycans.

37 ) and branched (sialylated, neutral and core fucosylated biantennary IgG glycans) carbohydrates.

38 A core fucosylated biantennary oligosaccharide was converted to

39 e Fv region have three characteristics (core-fucosylated biantennary oligosaccharides with one or two

40 AZT) and a significant accumulation of core-fucosylated biantennary oligosaccharides.

41 after surgery with the decrease of most core-fucosylated biantennary structures, as well as the incre

42 d a larger proportion of sialylated and core-fucosylated biantennary, triantennary and tetra-antennar

43 Fc region contained typical Fc glycans (core-fucosylated, biantennary oligosaccharides with zero to t

44 conferred by the elaboration of sialylated, fucosylated binding determinants on N-glycans.

45 ohydrates including high mannose structures, fucosylated blood group antigens, and glycans with termi

46 BabA adhesin of Helicobacter pylori binds to fucosylated blood group antigens, such as the Lewis(b) a

47 hilum infection of BMMCs depends on alpha1,3-fucosylated, but not sialylated, glycans.

48 that many proteins in human tissues are core-fucosylated, but their expression is localized to skin k

49 Both L-selectin ligands must be fucosylated by alpha(1,3)-fucosyltransferase (FucT)-IV o

50 Man5GlcNAc2 glycan could be efficiently core-fucosylated by FUT8 in an appropriate protein/peptide co

51 ary complex-type N-glycan also could be core-fucosylated by FUT8, albeit at much lower efficiency tha

52 The O-glycans and glycolipids were not fucosylated by the H-type alpha1, 2FT.

53 ggest that Sfrs proteins are responsible for fucosylated carbohydrate-dependent lung metastasis of ep

54 egulation and function of terminal alpha(1,2)fucosylated carbohydrates in these and other tissues, we

55 nteracts with several related sialylated and fucosylated carbohydrates.

56 t vaginitis, indicating a role for alpha(1,2)fucosylated cervical glycans in mucosal defense.

57 abundant glycoforms in HCC, including 3 core-fucosylated (CF) forms.

58 sulfation, some of which was located on the fucosylated chitobiose core.

59 Fucosylated chondroitin sulfate (fCS) extracted from the

60 zed holothurian glycosaminoglycan (DHG) is a fucosylated chondroitin sulfate with antithrombin-indepe

61 zed holothurian glycosaminoglycan (DHG) is a fucosylated chrondroitin sulfate that possesses antithro

62 a predominance of bi- and tri-antennary core-fucosylated complex type structures carrying one, two, a

63 ans in tACE to be mostly of the biantennary, fucosylated complex type.

64 abling a highly convergent synthesis of core-fucosylated, complex CD52 glycopeptide antigen.

65 the expression of sialyl Lewis X and sialyl-fucosylated core 2 O-glycan (CHO-131 antigen), respectiv

66 dified with tyrosine sulfate and sialylated, fucosylated, core-2 O-glycan(s).

67 ferases required to construct sialylated and fucosylated, core-2 O-glycans on PSGL-1.

68 finity binding epitope of SL2-1 was alpha1-6 fucosylated di-n-acetylchitobiose.

69 Six non-fucosylated diantennary complex type glycoforms were det

70 lycans are of the complex type with the core-fucosylated disialylated biantennary and trisialylated t

71 to be important for the recognition of an O-fucosylated EGF repeat by all three mammalian Fringes.

72 nants for the recognition of an individual O-fucosylated EGF repeat by the Fringe enzymes.

73 uences that will allow us to predict which O-fucosylated EGF repeats are modified by the Fringes.

74 laboratory have demonstrated that not all O-fucosylated EGF repeats of Notch are further modified by

75 It is probable that these highly fucosylated epitopes contribute to the immunosuppressive

76 , unexpected mucosal expression of alpha(1,2)fucosylated epitopes in nonsecretor individuals was freq

77 ression of Slc35c2 reduces expression of the fucosylated epitopes Lewis X and sialylated Lewis X in C

78 hat BambL could recognize a wide spectrum of fucosylated epitopes, albeit with a lower affinity for b

79 Fucosylated epitopes: the H-type-1 antigen and those rec

80 A hypo-fucosylated form of adalimumab bound human FcgammaRIIIa

81 A hypo-fucosylated form of anti-TNF binds FcgammaRIIIa with hig

82 N-glycans and milk oligosaccharides based on fucosylated fragment ions with characteristic CCSs.

83 ution structures of both nonglycosylated and fucosylated FVII EGF-1 in the presence of CaCl2.

84 The overall structure of fucosylated FVII EGF-1 is very similar to the nonfucosyl

85 on constants (Kd) for the nonfucosylated and fucosylated FVII EGF-1 were found to be 16.4 +/- 1.8 and

86 toward a variety of sulfated, sialylated, or fucosylated Gal beta 1,3/4GlcNAc beta- or Gal beta 1,3Ga

87 discerned with sulfated, sialylated, and/or fucosylated Gal beta 1,3/4GlcNAc beta-based acceptor moi

88 rum albumin coupled with a common glycoform (fucosylated glycan lacking the alpha1,3-linked mannose)

89 Selectin interactions with fucosylated glycan ligands mediate leukocyte rolling in

90 one or more alpha2,3-sialylated and alpha1,3-fucosylated glycan receptors that are unique from those

91 teract with alpha2,3-sialylated and alpha1,3-fucosylated glycan receptors, including 6-sulfo-sialyl L

92 lectively block the endogenous generation of fucosylated glycan structures.

93 orders was shown for twins with low level of fucosylated glycans and high level of non-fucosylated gl

94 that neither the FUT loci nor their cognate fucosylated glycans are essential to normal development.

95 CD43 lacks the fucosylated glycans found on PSGL-1 and is enriched for

96 f another locus that regulates production of fucosylated glycans in intestinal enterocytes.

97 DC-SIGN has high affinity for fucosylated glycans in several plant glycoproteins and p

98 The affinity of BambL for small fucosylated glycans is very high as demonstrated by micr

99 Fucosylated glycans on pathogens are known to shape the

100 Modeling of MsaFBP32 complexed with fucosylated glycans that are widely distributed in proka

101 etailed structures and roles of other highly fucosylated glycans that co-exist in the parotid gland a

102 Two fucosylated glycans were found to be up-regulated in hea

103 y that selectins and DC-SIGN bind to related fucosylated glycans, but the mechanism of the interactio

104 orhabditis elegans expresses a wide range of fucosylated glycans, including N-linked oligosaccharides

105 rTF(1-263) contain high mannose, hybrid, and fucosylated glycans.

106 (PSGL-1), as well as sialylated and alpha1,3-fucosylated glycans.

107 l tool to address functional questions about fucosylated glycans.

108 nants, including core beta-xylose and highly fucosylated glycans.

109 of fucosylated glycans and high level of non-fucosylated glycans.

110 eutrophils depend on sialylated and alpha1,3-fucosylated glycans.

111 as well as asymmetrically and symmetrically fucosylated, glycans were identified from HCCF in experi

112 m-free NMRI mice revealed that production of fucosylated glycoconjugates and an alpha1, 2-fucosyltran

113 The intracellular localization of fucosylated glycoconjugates was visualized by using fluo

114 resented as relative abundance of individual fucosylated glycoforms normalized to the level of their

115 line results in the production of fully core-fucosylated glycoforms of the oligomannose substrate Man

116 eported glycoforms of IgG1, including doubly fucosylated glycoforms.

117 utant animals are defective in production of fucosylated glycolipids and that bre-1 mutant animals ma

118 lular fucosylation and facilitate studies of fucosylated glycoproteins and glycolipids.

119 CTB-binding fucosylated glycoproteins are present in normal human in

120 n leukocyte CD11b/CD18 and basally expressed fucosylated glycoproteins followed by binding to desmoso

121 ttle is known about the distribution of core-fucosylated glycoproteins in mammalian tissues.

122 synthesis of structurally well-defined, core-fucosylated glycoproteins remains a challenging task due

123 The presence of fucosylated HBGAs in saliva and stomach biopsy specimens

124 th the defucosylated pentasaccharide and the fucosylated hexasaccharide without a significant differe

125 he first example of production of fully core-fucosylated high-mannose glycoforms.

126 The capability to preferentially consume fucosylated HMO suggests a competitive advantage for the

127 l gene cluster devoted to the utilization of fucosylated HMO, including genes for import of fucosylat

128 se, certain strains additionally metabolized fucosylated HMO.

129 ing revealed a preference for consumption of fucosylated HMO.

130 e fecal microbiota of Fut2(-) mice that lack fucosylated host glycans show decreased alpha diversity

131 These preclinical data indicate that fucosylated human Tregs is an effective strategy for pre

132 d galactosylation, decreased sialylation (of fucosylated IgG glycan structures) and increased bisecti

133 glycoforms, in which more than 50% were core-fucosylated, implicating a clear GnT I-independent core

134 e domain probes expressed nearly exclusively fucosylated LacdiNAc on bi-antennary complex-type chains

135 produce complex-type N-glycans with alpha1,3-fucosylated LDN (LDNF) GalNAcbeta1-4(Fucalpha1-3)GlcNAcb

136 hus, the HGE bacterium specifically bound to fucosylated leukocyte PSGL-1.

137 nts can be difficult, in particular terminal fucosylated Lewis and blood group antigens present on N-

138 an outer membrane protein that binds to the fucosylated Lewis b histo-blood group antigen on the sur

139 of human adenocarcinomas express sialylated, fucosylated Lewis blood group antigens on cell surface a

140 lly, that simultaneous DC-SIGN engagement by fucosylated ligands and TLR4 signaling was required for

141 participates in the generation of alpha(1,3)fucosylated ligands for L-selectin and provide further e

142 Thus, CD31 and fucosylated ligands of P-selectin seem to be the candida

143 ally could confer a distinct specificity for fucosylated ligands.

144 The production of the homogeneous core-fucosylated Man5GlcNAc2 glycoform of EPO in the FUT8-ove

145 ll surface oligosaccharides contain specific fucosylated moieties expressed in lineage- and/or tempor

146 Specific fucosylated moieties of oligosaccharides and related gly

147 1) and the alpha2,3-sialylated- and alpha1,3-fucosylated-moiety sialyl-Lewis x (sLe(x)), which modifi

148 a closely related sialylated and alpha-(1,3) fucosylated molecule, plays a key role in HGE infection,

149 ulations, confirmed by experiment, predicted fucosylated molecules that are restricted to librations

150 cosylated HMO, including genes for import of fucosylated molecules, fucose metabolism and two alpha-f

151 ter pylori, abnormal expression of alpha(1,2)fucosylated motifs and binding of GII.4 virus-like parti

152 al alterations include an increase in large, fucosylated, mucin-type glycoproteins, changes in the ty

153 udies indicate that expression of sialylated fucosylated mucins by human carcinomas portends a poor p

154 ant animals, although viable, show a lack of fucosylated N- and O-glycans, based on mass spectrometri

155 the glycosylation reveals that only a single fucosylated N-acetyl glucosamine on N54 is required for

156 We found that Endo-D preferred core-fucosylated N-glycan for hydrolysis but favored nonfucos

157 e possible functional significance of highly fucosylated N-glycans is discussed in relation to their

158 d for selective capture and analysis of core fucosylated N-glycans present in complex glycan mixtures

159 rocainamide + H](+) in the tandem MS data of fucosylated N-glycans rapidly verifies core fucosylation

160 Asn623 and Asn752) are occupied with highly fucosylated N-glycans that possess unusual difucosylated

161 healthy human myelin, MOG is decorated with fucosylated N-glycans that support recognition by the C-

162 selective and quantitative profiling of core fucosylated N-glycans using UPLC-HILIC-FLR analysis was

163 strated its ability to bind to core alpha1-6 fucosylated N-glycans, but not to core alpha1-3 fucosyla

164 osylated N-glycans, but not to core alpha1-3 fucosylated N-glycans, or other alpha1-2, alpha1-3 and a

165 venue to a wide variety of homogeneous, core-fucosylated N-glycopeptides and N-glycoproteins that are

166 Surprisingly, fucosylated N-linked glycans and glycolipids, previously

167 tivity is mediated by sialylated, alpha(1,3) fucosylated, N-linked glycans.

168 The structures of the fucosylated neoglycans in CHO(alpha1, 2)FT cells and the

169 teracting specifically with high mannose and fucosylated neutral carbohydrate structures, langerin ha

170 solated a nonfucosylated and three variously fucosylated neutral oligosaccharides from human milk tha

171 Fucosylated O- and N-linked glycans are essential recogn

172 ults demonstrate that PSGL-1 contains unique fucosylated O-glycans that are predicted to be critical

173 PSGL-1 requires sialylated, fucosylated O-linked glycans and tyrosine sulfate to bin

174 ressing cell line was found to be fully core-fucosylated oligomannose glycan (Man5GlcNAc2Fuc).

175 , agalacto, bisected biantennary, and a core-fucosylated oligosaccharide in the position of Asn B37 w

176 glycan moiety consisting of a sialylated and fucosylated oligosaccharide properly positioned on a cor

177 nsensus motif, was modified with biantennary fucosylated oligosaccharide structures.

178 Fucosylated oligosaccharides and glycoconjugates have be

179 gests that the N-CRD recognizes more complex fucosylated oligosaccharides and with a relatively highe

180 -dimensional structure and dynamics of three fucosylated oligosaccharides are investigated using a co

181 Fucosylated oligosaccharides have been proposed to be in

182 combinant Sfrs1 protein bound to a series of fucosylated oligosaccharides in glycan array and plate-b

183 The expression of specific fucosylated oligosaccharides in milk thus varies in rela

184 Determination of fucosylated oligosaccharides is particularly important d

185 alpha(1,3)Fucosylated oligosaccharides represent components of leu

186 Additionally, administration of fucosylated oligosaccharides to C. rodentium-challenged

187 ed recombinantly and demonstrated to bind to fucosylated oligosaccharides with a preference for alpha

188 is thus imperative for the synthesis of all fucosylated oligosaccharides.

189 ors but discriminates between differentially fucosylated oligosaccharides.

190 ns, or other alpha1-2, alpha1-3 and alpha1-4 fucosylated oligosaccharides.

191 fetal bovine serum acetylcholinesterase were fucosylated on the innermost N-acetylglucosamine residue

192 y oligosaccharides including structures with fucosylated or sialylated N, N'-diacetyllactosediamine (

193 Sf9 cells mainly processed the fucosylated paucomannosidic structure (GlcNAc)(2)(Mannos

194 appear to be caused by structural changes in fucosylated pectic components such as rhamnogalacturonan

195 d neutrophils, and a cell line devoid of the fucosylated platelet selectin glycoprotein ligand 1 (PSG

196 ls were co-administered with MSCs or ex vivo fucosylated prior to injection, respectively.

197 ccharides included sialylated, sulfated, and fucosylated products based on mass spectrometry.

198 Fucosylated proteins are shed into the lumen and fucose

199 oying CD11b/CD18 as a probe to blot T84 cell fucosylated proteins purified via fucose-specific lectin

200 on encodes an adhesin that binds an alpha1-2 fucosylated receptor(s) present in the cecal mucosa.

201 We showed that, compared to fully fucosylated (referred to as wild-type in the text) b12,

202 -Xaa(2)-(Ser/Thr)-Cys-Xaa-Xaa-Gly (where the fucosylated residue is underlined).

203 It is surprising that some of the fucosylated schistosome glycans contain the Lewis x (Le(

204 Fucosylated selectin ligands are essential for all inter

205 to express alpha2-3-sialylated and alpha1-3-fucosylated selectin ligands such as sialyl Lewis x (sLe

206 ed can allow rapid identification of various fucosylated, sialylated, sulfated glycotopes and definit

207 e chains - a key step in the biosynthesis of fucosylated sidechains of galactoxyloglucan.

208 Selectins bind to sialylated and fucosylated sLe(x) receptors, and two enzymes, fucosyltr

209 idase digestions, and co-chromatography with fucosylated standards, the product of the reaction with

210 ed nonfucosylated seed amyloid xyloglucan or fucosylated stem xyloglucan as a substrate with equal fa

211 glycans might be complicated by the partial fucosylated structure and the alpha-Gal (1-3)-beta-Gal o

212 Similar fucosylated structures are also commonly found in a vari

213 All fucosylated structures contained a core (alpha1-6-linked

214 Genetic deletion of these fucosylated structures in the mouse has been a powerful

215 The functional significance of these fucosylated structures is incompletely defined, although

216 We further show that fucosylated structures promote CTB entry into a colonic

217 mplying that as yet unidentified sialylated, fucosylated structures serve as physiologically relevant

218 es (10-15%) of extended SLex with internally fucosylated structures: NeuAc alpha 2-->3 Gal beta 1-->4

219 Enzymatic synthesis of fucosylated sugars in milligram scale was successfully p

220 C-type lectins that bind certain sialylated, fucosylated, sulfated glycoprotein ligands.

221 nd similarly to alpha3-sialylated and alpha2-fucosylated terminal LN, but not to alpha6-sialylated an

222 LN, but not to alpha6-sialylated and alpha3-fucosylated terminal LN.

223 ding many species with highly charged and/or fucosylated termini.

224 studies have suggested that the sialylated, fucosylated tetrasaccharide sialyl Lewis X (sLex) is an

225 -galactosyl-capped trisaccharide and the two fucosylated tetrasaccharides.

226 A minority of the O-glycans are alpha-1,3-fucosylated that occur as two major species containing t

227 clinical data suggesting that use of ex vivo fucosylated third-party human regulatory T cells (Tregs)

228 e 2 O-linked glycans that are sialylated and fucosylated to bind P- and E-selectin.

229 Selectin ligands must be alpha1-3 fucosylated to form glycan determinants such as sialyl L

230 The DG9-glycan index, which is the ratio of fucosylated to nonfucosylated triantennary glycans, prov

231 he untreated Tregs, the murine recipients of fucosylated Tregs maintained weight, had ameliorated cli

232 In a xenogenic GVHD mouse model, fucosylated Tregs showed prolonged periods of in vivo pe

233 MALDI-MS data revealed several fucosylated tri- and tetra-antennary glycans which were

234 The level of core-alpha-1,6-fucosylated triantennary glycan (NA3Fb) increased both o

235 Glycopeptide 1 with the fucosylated trisaccharide, beta-d-GlcNAc(1-->4)[alpha-l-

236 e pd-A1PI, most glycans on recA1P1 were core fucosylated via alpha(1-6) linkage.

237 ures, sometimes methylated and core alpha1,6-fucosylated, with terminal beta1,3-linked galactose; a r

238 These results suggest that fucosylated XyG is a suitable substrate for at least one

239 ble genotypes all had substantial amounts of fucosylated XyGs and weakly ME-HGs, but lacked heavily M

240 s of PD-resistant grapevine genotypes lacked fucosylated XyGs and weakly methyl-esterified HGs (ME-HG

241 upport the conclusion that weakly ME-HGs and fucosylated XyGs are substrates of the pathogen's CWDEs

242 s) seeds, which produce large amounts of non-fucosylated xyloglucan as a seed storage polymer.

243 tain less than 2% of the wild-type amount of fucosylated xyloglucan because of a point mutation in th

244 polymer, XTR9 has a clear preference for non-fucosylated xyloglucan polymer.