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1 h C3 cyclizing the chain when it reaches the full length.
2 tter disease classification, suggesting that full-length 16S gene assemblies are a powerful alternati
3 Dirichlet process clustering to reconstruct full-length 16S gene sequences from metagenomic sequenci
5 ems for the Baselines Initiative (6,177 near full-length 16S rRNA gene sequences and 9.4 million high
7 strains revealed that FplA is expressed as a full-length 85-kDa outer membrane-embedded protein or as
12 rmations of the active and inactive forms of full-length AfGcHK in solution, we investigated the intr
13 ails of photoactivation, we investigated the full-length Agp1 bacteriophytochrome from the soil bacte
15 was added to the CS-AMEL hydrogel to cleave full-length amelogenin during the growth of enamel-like
17 le N-terminally truncated amyloid-beta40 and full-length amyloid-beta40 accumulation showed an almost
18 red to pathological ageing, whereas cortical full-length amyloid-beta42 accumulation was comparable b
19 at N-terminally truncated amyloid-beta42 and full-length amyloid-beta42 accumulations distributed dif
20 n areas, especially some limbic areas, while full-length amyloid-beta42 tended to accumulate more in
21 tercellular adhesion molecule-1 and endocan [full-length and cleaved p14 fragment]) were obtained bef
22 ractions from metastatic IECs contained both full-length and cleaved TLR3, demonstrating surface expr
24 ons (R565W and L640R) in the context of both full-length and N-terminally truncated (DeltaNT) G1.
28 R with the molecular structure of an intact, full-length, and functional receptor.ligand complex.
29 gth proteins into constant region loops of a full-length antibody or an antigen-binding fragment (Fab
32 tely 23- to 24-kDa protein diminish, and the full-length, approximately 45-kDa K15P protein accumulat
34 clinical CRPC, the expression levels of the full-length AR (twofold, P < 0.05) and the AR splice var
37 Here we expanded the number of available full-length baboon STLV-1 sequences from one to three an
38 ivatable unnatural amino acids, we show that full-length BACE1, independently of its subcellular loca
39 report that BH3-only proteins bind inactive full-length BAK at mitochondria and then dissociate foll
42 topological investigations of membrane-bound full-length bitopic protein complexes under physiologica
43 To validate its activity, a small amount of full-length BoNT/X was assembled by linking two non-toxi
46 stingly, the expression of CD40LG and active full-length CD40 was increased in the disease tissues, w
50 rapid amplification of cDNA ends (RACE) and full-length cDNA sequencing, revealed four independent p
51 tudy, we have isolated and characterized the full-length cDNA, gDNA and a putative promoter of a RIOK
53 ina RNA-seq and Pacific Biosciences (PacBio) full-length cDNAs to identify 104,091 high-confidence pr
55 we recombinantly expressed murine and human full-length CLEC3As as well as truncated forms of CLEC3A
56 ile birds, using a lentivirus containing the full-length coding sequence of the human NR2B subunit.
58 the sporozoites, combined with the flexible full-length conformations of CSP, may provide the sporoz
60 nstrated that cytoplasmic LANA isoforms were full length, containing the N-terminal nuclear localizat
62 emical interrogation of the structure of the full length CTD of Drosophila melanogaster, which we con
63 tein Alpha 1- 20 kDa), which is required for full-length Cx43 trafficking, but by an unknown mechanis
64 mparisons of spectra of IL-8 (1-66) bound to full-length CXCR1 (1-350) and to N-terminal truncated co
67 ese two proteins were generated from (i) the full-length dbpA gene combined with the invariable regio
68 InsP7 kinase/InsP8 phosphatase activities of full-length diphosphoinositol pentakisphosphate kinases
69 po11 protein to various DNA-binding modules: full-length DNA binding proteins, zinc fingers (ZFs), tr
71 of the truncated RRM2 domain compared to the full-length domain, consistent with previous experimenta
72 ritical for relieving the auto-inhibition of full-length Drs2p, whereas the 1-104 N-terminal residues
73 that lentiviruses can be used for permanent full-length dystrophin gene therapy, which presents a si
74 optimising foamy virus vectors carrying the full-length dystrophin open-reading frame for transducti
75 a4beta2 nicotinic receptors in vitro, as did full length ectodomain of the rabies virus glycoprotein.
76 65kDa truncated protein isoform that opposes full-length eIF2Bepsilon to inhibit global translation.
77 s were superior to Apelin-13, likely because full-length ELA enabled a distinctive regulation of pitu
79 o prevent proteolytic processing generated a full-length enzyme that is active in vitro toward a solu
80 An electron microscopy structural model of full-length ERdj3 shows that these tetramers are arrange
81 Here, we report the crystal structures of full length Escherichia coli RapZ at 3.40 A and 3.25 A,
82 ogen-deuterium (H/D) exchange MS (HDX-MS) of full-length Escherichia coli DXPS to provide a snapshot
85 Lumacaftor partially stabilized purified full-length F508del-CFTR and slightly delayed deactivati
86 Compared with purified wild-type CFTR, the full-length F508del-CFTR was about 10 degrees C less the
89 were derived from 128 667 intron-containing full-length FLNC reads, including a large number of AS e
92 lalanine (azF) into N-terminal residues of a full-length functional human GLP-1R in mammalian cells.
93 ases of the Clk family control the supply of full-length, functional mRNAs coding for a variety of pr
94 ne-anchored FZD4 CRDs and oligomerization of full-length FZD4, which requires the integrity of CRD pa
96 Results of in vitro and in vivo assays using full-length GabR support the conclusion that AFPA is an
100 ere we report the 3.0 A crystal structure of full-length GCGR containing both the extracellular domai
105 recapitulate the genetics of HD, having two full-length, genomic human HTT transgenes heterozygous f
108 ictions about the functional behavior of the full-length GluK2/K5 receptor, which we confirmed via el
109 CA45, while exhibiting negligible binding to full-length GP, bound a proteolytically remodeled GP wit
113 separate quantitation of non-phosphorylated full-length guide strands from 5-phosphorylated forms th
114 equencing technology can be used to generate full-length HCV envelope sequences at the single-molecul
115 gle cells, the unique task of assembling the full-length heavy and light chain sequences from single
116 le human B cells to scRNA-seq, assembled the full-length heavy and the light chains, and experimental
118 ated by normal mode analysis from one of the full-length HiLpoA molecules but even better agreement w
119 pture strategy for purification of unspliced full-length HIV RNA-protein complexes preserved in vivo
120 were not measurably different from those of full-length HjLPMO9A, indicating that the presence of th
122 y of a CD3 T cell-dependent bispecific (TDB) full-length human IgG1 therapeutic antibody targeting CL
124 rms, we overexpressed and purified the three full-length human isoforms from suspension-adapted HEK c
125 ntroduction of equivalent stop codons in the full-length human L1 sequence leads to the expression of
127 t two electron cryo-microscopy structures of full-length human TRPML1: a 3.72-A apo structure at pH 7
131 Perivascular access and distribution of full-length IgG could be enhanced by intrathecal co-infu
132 n hippocampal neurons, the overexpression of full-length IL1RAPL1 and mutants lacking part of C-termi
134 tes, are retrotranslocated to the cytosol as full-length intermediates during ERAD, and we have inves
135 le real-time sequencing, characterization of full-length JCPyV genomes in urine and plasma samples fr
138 We also solved the crystal structure of full-length KGA and present a small-angle X-ray scatteri
139 ta, proteolysis experiments performed on the full length KpOmpA as well as on its membrane domain, re
140 ports the expression and purification of the full-length L protein of RABV and the characterization o
141 2 can selectively bind evolutionarily young, full-length L1s located within transcriptionally permiss
142 We now report the crystal structure of a full-length lipid A phosphoethanolamine transferase from
146 dies on a pathogenic mutation that generates full-length M1 and M87 proteins, truncated M1 was notabl
151 , blocking Nix-mediated mitophagy stabilizes full-length MAVS, which aggregates spontaneously and ind
154 binding constants of GCAP1 and GCAP2 to the full-length membrane-bound guanylate cyclase type 1.
157 this site selectively impair proteolysis of full-length MKKs yet have no impact on cleavage of short
158 Starting from a sequence, it first generates full-length models using I-TASSER by iterative structura
159 uctural insight into chemical degradation in full-length monoclonal antibodies and the high-resolutio
163 usion-based transfer mechanism, we find that full-length mRNAs undergo direct cell-cell transfer via
164 ence, this work supports the hypothesis that full-length mRNAs undergo transfer between cells through
165 bstitutions, which lead to the expression of full-length mutant proteins that accumulate in cancer ce
167 we studied the single molecule movement of a full-length myosin-X construct with leucine zipper at th
168 These results suggest that the lever-arm of full-length myosin-X is flexible enough to processively
169 nad5 rather than nad5T1 causing loss of the full-length nad5 transcript, and degradation of nad5 los
170 we perform electrophysiological analysis of full-length NMDARs with a glycosylation-preventing GluN1
172 Here we report the crystal structures of full-length NS5 and its polymerase domain at 3.0 A resol
173 ibril interface residues in viruses encoding full-length NSs completely abrogated intranuclear filame
174 rs otherwise tightly bound carotenoid to the full-length OCP apoprotein, resulting in formation of ph
177 es the binding activity, suggesting that the full length of the alpha-helical regions of Hic is requi
180 Full structural characterization of the full-length oligomeric p53 is challenging because of its
181 ting the thermodynamics of hybridization for full-length oligonucleotide-template alignments - thermo
182 s African trypanosomiasis and contains three full-length oligosaccharyltransferase (OST) genes; two o
183 ressed in Arabidopsis, the overexpression of full-length OsbZIP48 in rice transgenics reduced the pla
185 f isoprostanoid moieties that are present in full-length oxygenated PAPC species, we used an inhibito
186 oding sequence has been replaced with either full-length P. vivax VK210 or the allelic VK247 csp that
188 els with available crystal structures of the full-length p53 (fl-p53) tetramer bound to three differe
191 in adult pancreatic acinar cells by using a full-length pancreatic elastase promoter-driven Cre.
194 n codon (PTC) that prevents synthesis of the full-length peptide are considered more likely to mount
195 507) phosphorylation (that does not apply to full-length PKCdelta) in structurally organizing diverse
199 ing NS cleavage increased association of the full-length prodomain with Gbb15, resulting in a concomi
201 alleles responded to treatment and produced full length protein, in some cases more than 50% relativ
202 as they are likely less immunogenic than the full-length protein and more convenient to produce.
203 the arrangements of the PCM subunits in the full-length protein dimer in solution differ significant
204 hese results demonstrate that insertion of a full-length protein into non-CDR loops of antibodies pro
205 N-P gene position of the rHPIV1 vector as a full-length protein or as a chimeric form with its TMCT
206 rom the first or second gene position as the full-length protein or as a chimeric protein with its tr
207 as codon optimized and expressed either as a full-length protein or as an engineered chimeric form in
208 atalyzed deacetylation of singly-acetylated, full-length protein substrates, revealing that HDAC8 sub
209 cated form of this enzyme suggested that the full-length protein was required for correct lipid subst
210 mulated higher ATP hydrolysis rates than the full-length protein, indicating that binding to MinD is
212 ite for GCAP1 with similar affinities as the full-length protein, whereas GCAP2 did not bind to this
218 generate bifunctional antibodies by grafting full-length proteins into constant region loops of a ful
219 g post-translational modifications (PTMs) in full-length proteins is a challenge, especially in the c
220 HDAC8 substrate selectivity for peptides and full-length proteins suggest that HDAC8 substrate prefer
221 rate selectivity in the context of peptides, full-length proteins, and protein-nucleic acid complexes
223 dentified multiple sets of independent, near-full-length proviral sequences from cART-treated individ
224 ificant expression originating from 15 HML-2 full-length proviruses, through four modes of transcript
226 on of the PTEN C2 domain mimicked effects of full-length PTEN but a membrane-binding defective mutant
227 was used to reconstruct the assembly of the full-length RagA(GTP):RagC(GDP) dimer bound to Ragulator
229 l isoforms based on the number of supporting full-length reads with those of annotated isoforms and e
233 gen synthase kinase 3beta (GSK3beta) via the full-length receptor] and its congener 3-(1H-imidazol-4-
236 fragments N-R2 and N-R6 bind to L1 and that full-length Reelin and its N-terminal fragment N-R6 prot
239 high resolution in Saccharomyces cerevisiae Full-length resection requires Exo1 exonuclease and the
241 and purification system for isolation of the full-length RhoGC protein expressed in HEK293 cells in d
244 esulting synthetic nucleocapsids package one full-length RNA genome for every 11 icosahedral assembli
245 s possessed more sialidase activity than did full-length rNanI, further supporting the proteolytic ac
247 aden hydrogel pulp-like tissue constructs in full-length root canals for dental pulp regeneration.
251 , we demonstrate that the NADase activity of full-length SARM1 is required in axons to promote axonal
254 7S has SUMO isopeptidase activity but unlike full-length SENP7L, SENP7S is localized in the cytosol.
255 have been reported, the atomic structures of full-length separase and especially the complex with sec
259 n the CID/UVPD data, UVnovo assigned correct full-length sequences to 83% of the spectral pairs of do
260 INB7 cDNA carrying the mutation and promoted full-length SERPINB7 protein synthesis in NPPK keratinoc
261 ptic peptides, cleavable SIL peptides, and a full-length SIL protein were compared for internal calib
262 the cryo-electron microscopy structure of a full-length Slo1 channel from Aplysia californica in the
264 SMNDelta7 protein, but from which functional full length SMN protein is produced at very low levels (
267 igand ectodysplasin A (EDA) is produced as 2 full-length splice variants, EDA1 and EDA2, that bind to
270 O have been solved, efforts to elucidate the full-length structure of NEMO have proved difficult due
273 on but also inhibit the ability of exogenous full-length tau fibrils to seed intracellular tau in HEK
275 e pseudoknot does not form in the context of full-length TER in the absence of TERT, due to formation
279 tome annotation and generates manual-quality full-length transcript models at high-throughput scales.
280 Gene annotations were updated using 111,000 full-length transcripts obtained by single-molecule real
285 electron microscopy (cryo-EM) structure of a full-length TRPML3 channel from the common marmoset (Cal
286 In vitro reconstitution of TSP1 with either full-length TSP1 or 3TSR, an anti-angiogenic TSP1 fragme
291 the cytoplasmic abundance or distribution of full-length viral RNAs on Gag trafficking and assembly i
292 in trans In contrast, artificially tethering full-length viral RNAs or surrogate gag-pol mRNAs compet
295 chroism spectroscopy confirmed that purified full-length wild-type CFTR is folded and structurally re
296 more than three orders of magnitude for the full-length wild-type KcsA, a pH-gated bacterial channel
298 ein [VSVm] versions) that express either the full length ZIKV envelope protein (ZENV) alone or includ
300 rt the cryo-electron microscopy structure of full-length ZntB from Escherichia coli together with the
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