ライフサイエンスコーパス: full-length protein

1 ATPase and motor activities compared to the full length protein.

2 s of the kinase domain in the context of the full length protein.

3 with substantially weaker affinity than the full-length protein.

4 than by altering the coding sequence of the full-length protein.

5 conditions should ideally be done using the full-length protein.

6 her substrates with the same affinity as the full-length protein.

7 omain that inhibits adhesion mediated by the full-length protein.

8 ng to derive distance constraints across the full-length protein.

9 thereby permitting expression of functional full-length protein.

10 red to be stable fragments of their original full-length protein.

11 wo short protein isoforms in addition to the full-length protein.

12 on may contribute to light activation of the full-length protein.

13 nctional, despite SCRC encoding a functional full-length protein.

14 n that has the same membrane topology as the full-length protein.

15 hin the conserved TNF-homology domain of the full-length protein.

16 regulatory functions similar to those of the full-length protein.

17 restrict the conformational landscape of the full-length protein.

18 nts appear to be proteolytic products of the full-length protein.

19 ndividual transmembrane (TM) domains and the full-length protein.

20 K1 and NK1 were more stable than the native, full-length protein.

21 (or are likely to bind) the ligand within a full-length protein.

22 allosteric interaction studies that use the full-length protein.

23 port similar to that of cells expressing the full-length protein.

24 he stability and DNA binding affinity of the full-length protein.

25 spliced isoform of ACTN4 than it does in the full-length protein.

26 hagocytosis, which was not a property of the full-length protein.

27 gher enzymatic activity as compared with the full-length protein.

28 -angle X-ray scattering experiments with the full-length protein.

29 ion of the affected gene and production of a full-length protein.

30 ated mass shifts consistent with that of the full-length protein.

31 i3 fragment that opposes the activity of the full-length protein.

32 he interactions of NmerA and the Core in the full-length protein.

33 y beta-catenin binding domain present in the full-length protein.

34 intractable to X-ray crystallography in the full-length protein.

35 cal for GAG-dependent oligomerization of the full-length protein.

36 ion by BAK in the membrane without using the full-length protein.

37 me rearrangements in the cytoskeleton as the full-length protein.

38 niquely to the structure and function of the full-length protein.

39 ion codon (PTC) and prevent the formation of full-length protein.

40 inding and redox properties exhibited by the full-length protein.

41 ctin with essentially the same properties as full-length protein.

42 esult from nuclear activity of overexpressed full-length protein.

43 zation in solution and in the context of the full-length protein.

44 ave weaker transcription activities than the full-length protein.

45 iants in M. acetivorans and equal amounts of full-length protein.

46 pecific activity within a factor of 2 of the full-length protein.

47 dherence compared with immunization with the full-length protein.

48 he PAS domains are isolated or are part of a full-length protein.

49 rmination at a PTC to restore synthesis of a full-length protein.

50 fication influences a disordered region of a full-length protein.

51 model for the regulation of activity in the full-length protein.

52 e to the lack of a complete structure of the full-length protein.

53 tute the presumed biological function of the full-length protein.

54 and nuclear localization, compared with the full-length protein.

55 on, trimerization, and porin function by the full-length protein.

56 (NB2a) cells, as well as the structure of a full-length protein.

57 counts for over half of the stability of the full-length protein.

58 gene that controls expression of soluble and full-length protein.

59 eutralizing properties in the order of CCL26 full-length protein.

60 al frameshift required for production of the full-length protein.

61 lain altered properties of the corresponding full-length proteins.

62 the double mutant cycle data obtained on the full-length proteins.

63 es remained limited, as is the case for many full-length proteins.

64 egy that allows for mapping the interface of full-length proteins.

65 ct the substrate selectivity of HDAC8 toward full-length proteins.

66 ally for high affinity association of intact full-length proteins.

67 escues from misfolding a large repertoire of full-length proteins.

68 nteract with polyubiquitin in the context of full-length proteins.

69 osphorylated and non-phosphorylated forms of full-length proteins.

70 eight C-terminal deletion constructs and the full length protein (1-81, 1-92, 1-99, 1-105, 1-110, 1-1

71 DPCs containing full-length proteins (11-28 kDa) or a 23-mer peptide blo

72 g exon 8 (Traf3DE8) that, in contrast to the full-length protein, activates ncNFkappaB signaling.

73 Tetrameric full-length protein aggregated at similar rates and kine

74 1 RRM domain specifically binds poly(A), the full-length protein also binds poly(U).

75 A low-resolution crystal structure of the full-length protein also revealed that the sheet is inse

76 NCX1 full-length protein and a 75-kDa NCX1 fragment along wit

77 asma membrane and endosomes that exists as a full-length protein and a truncated form of Ctr1 lacking

78 tyricum, consisting of a complex between the full-length protein and an N-terminally truncated C-term

79 t subcellular distribution compared with the full-length protein and enhanced deISGylation activity i

80 r bacterial species that are targeted by the full-length protein and in addition was able to lyse som

81 ni were intrinsically disordered in both the full-length protein and its complex with a 20-residue sp

82 We show that the full-length protein and its DNA-binding domain (DBD) inh

83 result in the final localization of both the full-length protein and its major Deltapsi-dependent cle

84 solution structure and activity of both the full-length protein and its Ntd-truncated mutant (RapADe

85 as they are likely less immunogenic than the full-length protein and more convenient to produce.

86 Zn(2+)/Cd(2+)-ATPase could be isolated as a full-length protein and the ATPase activity was increase

87 n overexpressed in HeLa cells, both the MST1 full-length protein and the MST1 kinase domain (MST1-NT)

88 conformational and kinetic behaviors of the full-length protein and, even in absence of the pilin do

89 ttering to obtain solution structures of the full-length proteins and a series of deletion mutants.

90 onnexin mutants were translated into stable, full-length proteins and assembled into GJs when express

91 Purified recombinant full-length proteins and kinase domain constructs differ

92 Sufu into the MEFs stabilizes Gli2 and Gli3 full-length proteins and rescues Gli3 processing.

93 However, 15% of LARPs were full-length proteins and we confirmed several candidates

94 mational sampling properties of the DNA-free full-length protein, and in particular about the bHLH do

95 n structure with the periplasmic part of the full-length protein, and is capable of binding substrate

96 (C5-C10) had effects similar to those of the full-length protein, and it bound actin more tightly tha

97 membrane conductance regulator mRNA, restore full-length protein, and reestablish functional chloride

98 ased levels of LXR-independent SREBP-2 mRNA, full-length protein, and SREBP-2 active cleavage product

99 rate selectivity in the context of peptides, full-length proteins, and protein-nucleic acid complexes

100 al of this technology is to employ peptides, full-length proteins, antibodies, and small molecules to

101 An alternative method is presented in which full-length proteins are produced recombinantly with a p

102 veals the existence of approximately 140-kDa full-length protein as well as truncated forms of BAT3 w

103 Use of stable isotope-labeled full-length proteins as an internal standard prior to mu

104 y we determined the crystal structure of the full-length protein at 2.05 A resolution.

105 e but was expressed in mdx3cv mice as a near full-length protein at approximately 5% of normal levels

106 t interact with the C-terminal domain in the full-length protein at pH 4.

107 rite growth also rely on APP's presence as a full-length protein at the cell surface, implying that A

108 ing natural messenger RNA (mRNA) into active full-length proteins at temperatures up to 65 degrees C

109 revealed that the mutant AR aggregates as a full-length protein, becoming proteolyzed to a smaller f

110 Mosaics and Con-S Envs expressed as full-length proteins bound well to a number of neutraliz

111 expressed HERV-K envelopes not only makes a full-length protein but also specifically interacts with

112 esterol increased levels of SREBP-1 mRNA and full-length protein but did not change levels of cleaved

113 a mutation in GATA1, which leads to loss of full-length protein but expression of the GATA-1s isofor

114 ow that both Dnmt3L(s) and Dnmt3L(o) produce full-length proteins but that the Dnmt3L(at) transcripts

115 lize the fragment in a manner similar to the full-length protein, but some other fragments lacking th

116 d HrcA from chlamydiae, we only detected the full-length protein, but we found that endogenous HrcA h

117 EFs) can restore the levels of Gli2 and Gli3 full-length proteins, but not those of their repressors,

118 ome of the isolated MeCP2 domains and in the full-length protein by binding to DNA.

119 e stop codons resulting in the production of full-length protein by interfering with ribosomal proofr

120 target is the ribosome and that it produces full-length protein by promoting insertion of near-cogna

121 A recognition and structural analysis of the full-length protein by X-ray crystallography and small a

122 foundation for understanding recognition of full-length proteins by HDACs.

123 antibiotics have been proposed for restoring full-length proteins by readthrough of PTC.

124 These data suggest that the AR is toxic as a full-length protein, challenging the notion of polygluta

125 onstruction methods merely identified 21% of full-length protein-coding transcripts from H. sapiens.

126 ences in the lipid binding properties of the full-length protein compared to its PH domain.

127 53) impaired nucleation and fibril growth of full-length protein, confirming that these segments part

128 C1 domain alone (Kd = 8.2 +/- 1.1 nm for the full-length protein containing all four mutations), and

129 domains, originally selected from Pfam, and full-length proteins containing their homologous domains

130 elements that lead to the production of the full-length protein, CsoS2B, and a truncated protein, Cs

131 Thus, in the context of the full-length protein, DeltaF508 mutation causes detectabl

132 ductance but a similar gating pattern as the full-length protein, demonstrating the ability of the la

133 nhibited MMTV infection better than a cloned full-length protein derived from 129/Ola RNA when packag

134 the arrangements of the PCM subunits in the full-length protein dimer in solution differ significant

135 been no published structural studies on the full-length protein due to proteolysis of its C-terminal

136 0-aa sequence derived from SPARC that mimics full-length protein effects.

137 e unbiased discovery of interactions between full-length proteins encoded by a library of 'prey' ORFs

138 To answer these questions, we studied 16 full-length protein equivalents of pseudogenes.

139 chaperone activity comparable to that of the full-length protein, even when monomer dissociation is r

140 r crystal structures show that, although the full-length protein exclusively forms nine-subunit assem

141 ividual domains of Hop, no structure for the full-length protein exists, nor is it clear exactly how

142 to mRNA defects and to a strong reduction in full-length protein expression.

143 The full-length protein forms trimers and larger complexes,

144 RTC to effectively restore the expression of full-length protein from a nonsense-mutant allele.

145 near-cognate tRNA, leading to synthesis of a full-length protein from otherwise defective mRNA.

146 terations also result in dissociation of the full-length protein from the ribosome.

147 n suppressing drugs that allow expression of full-length proteins from mutated genes with premature i

148 clear localization sequence had no effect on full-length protein function or localization.

149 ssay reveals that this glycine mutant of the full-length protein greatly reduced NADPH oxidase activi

150 mains of PutA are known, a structure for the full-length protein has not previously been solved.

151 n of each histidine to copper binding in the full-length protein has not.

152 /2 are autoinhibited such that the purified, full-length proteins have significantly less Rab35 bindi

153 protocols indicate alternate interactions of full-length proteins; HCN1 can interact with protocadher

154 ion of the peroxidase-like domain or, in the full-length protein, heterodimeric interactions with a m

155 P15) nearly recapitulate the features of the full-length protein (i.e., partition constants, molecula

156 precise informations on binding surfaces of full-length proteins, identifying sequential (linear) or

157 can be used as part of a strategy to restore full-length protein in a variety of genetic diseases.

158 entified retroviral envelope gene encoding a full-length protein in all simians under purifying selec

159 d 6D isoforms, inhibit polymerization of the full-length protein in an in vitro filament formation as

160 sors required the biosynthesis of the entire full-length protein in continuity, as it did not occur w

161 ondary structures of the 3 fragments and the full-length protein in the presence and absence of Ca2+

162 inal third of BLAP75 is just as adept as the full-length protein in the promotion of dHJ dissolution

163 tations also impeded self-interaction of the full-length protein in vivo, as measured by yeast-two hy

164 ing sites in vitro than are regulated by the full-length protein in vivo, regions outside the homeodo

165 metry by measuring the binding curves of the full-length proteins in living cells.

166 in vitro-transcribed/translated peptides and full-length proteins in mammalian cell lysates coimmunop

167 to investigate the dynamic properties of the full-length proteins in solution during the various asse

168 alidated the interface in the context of the full-length proteins in solution.

169 ed and employed biophysical approaches using full-length proteins in the budding yeast system.

170 ificity characteristics of the corresponding full-length proteins in their native cellular context.

171 The advantages of BRET include expressing full-length proteins in their native environment that ha

172 ydrolyzable thioacetyl-lysine (ThioAcK) into full-length proteins in vitro, mediated by flexizyme.

173 alleles responded to treatment and produced full length protein, in some cases more than 50% relativ

174 g the first 40 N-terminal amino acids of the full-length protein including the transactivation and Md

175 designs can disrupt the fibril formation of full-length proteins, including those, such as tau prote

176 mulated higher ATP hydrolysis rates than the full-length protein, indicating that binding to MinD is

177 e loosely associated with chromatin than the full-length proteins, indicating a conserved function fo

178 igosaccharide binding fold recapitulates the full-length protein interaction specificity for the TERT

179 hese results demonstrate that insertion of a full-length protein into non-CDR loops of antibodies pro

180 generate bifunctional antibodies by grafting full-length proteins into constant region loops of a ful

181 es are processive, meaning that they degrade full-length proteins into small peptide products without

182 isolation are known to be inactive, and the full length protein is required for its function.

183 Parkin R42P full length protein is trafficked poorly to ER and stabl

184 show that a misfolding lesion in NBD1 of the full-length protein is a prerequisite for functional res

185 ross-linker glutaraldehyde revealed that the full-length protein is also a monomer in vitro.

186 re cleaved in the endolysosome, such that no full-length protein is detectable in the compartment whe

187 rnative translation initiation, but only the full-length protein is essential for gene variation.

188 eyond intradomain misfolding, folding of the full-length protein is further slowed by the formation o

189 Accordingly, the full-length protein is now classified as isoform Pirh2A.

190 VirB4 domain purifies as a monomer, but the full-length protein is observed in a monomer-dimer equil

191 The results show that the full-length protein is predominantly monomeric, whereas

192 nctional AQP4, the surface expression of the full-length protein is reduced.

193 into its stable native structure before the full-length protein is released from the ribosome.

194 he capsule operon with similar affinity, and full-length protein is required for specificity.

195 reverse transcription-PCR, reveals that the full-length protein is required for translational repres

196 The full-length protein is toxic to bacteria when taken up t

197 g post-translational modifications (PTMs) in full-length proteins is a challenge, especially in the c

198 -terminal regions or the architecture of the full-length proteins is available.

199 d of associating ontological terms only with full-length proteins, it sometimes makes more sense to a

200 The crystal structure of full-length protein kinase C betaII was determined at 4.

201 f N. crassa DGAT2 were tested: the predicted full-length protein (L-NcDGAT2) and a shorter form (S-Nc

202 nt prematurely terminates translation of the full-length protein, leaving the identity of the "enhanc

203 inity and salt dependence as compared to the full-length protein, likely indicative of a more suitabl

204 studies revealed that the N terminus and the full-length protein localized to both the nuclear and cy

205 is, which also suggested that binding by the full-length protein may involve both monomers and small

206 cular-weight protein, a vaccine based on the full-length protein may not be feasible.

207 CDD incorporates several protein domain and full-length protein model collections, and maintains an

208 s that N- and C-terminal interactions in the full-length protein modulate its lipid binding propertie

209 mRNA containing a premature stop codon, the full length protein negatively regulates its production

210 their homologue from Naegleria gruberi, the full-length protein NgTET1, are distributive in both che

211 eptide, 47YGRKKRRQRRR57, which can transduce full-length proteins not only across the cell membrane b

212 under conditions in which the binding of the full-length protein occurred.

213 domains by 44 and 51 residues, which yields full-length proteins of 147 and 221 residues, respective

214 cting models from electron microscopy of the full-length protein, one of which proposes that the doma

215 stinct forms of ICP34.5 in infected cells: a full-length protein, one shorter form sharing the N term

216 the influenza virus C/Johannesburg/1/66 HEF full-length protein or a chimeric protein HEF-Ecto, whic

217 N-P gene position of the rHPIV1 vector as a full-length protein or as a chimeric form with its TMCT

218 rom the first or second gene position as the full-length protein or as a chimeric protein with its tr

219 as codon optimized and expressed either as a full-length protein or as an engineered chimeric form in

220 rotein and that overexpression of either the full-length protein or either of two centrosome localiza

221 ransposase MuA, which is not observed in the full-length protein or in the assembled transpososome in

222 ular dynamics simulations performed with the full-length protein or with the transmembrane segments w

223 We demonstrate that, like the full-length protein, overexpression of Hfe proteins lack

224 conformation, helping to rationalize how the full-length protein participates in multiple steps of DN

225 For the full-length protein, prephenate, the product of the CM r

226 as a dominant negative to block secretion of full-length protein produced from unaffected alleles.

227 sulted in nearly complete proteolysis of the full-length protein, producing stable breakdown products

228 hat the UL117 open reading frame encoded the full-length protein pUL117 (45 kDa) and the shorter isof

229 The wild-type, full-length protein, purified from bacteria, binds duple

230 Rather, the full-length protein rapidly samples many different confo

231 we quantitatively compare the binding of the full-length protein (Redbeta(FL)) and the N-terminal dom

232 carry the biological information encoded in full-length proteins remain underdeveloped.

233 Interestingly, full-length protein remained inactive in E. coli peripla

234 ; however, the molecular architecture of the full-length protein remains unknown.

235 he phosphodegron, when incorporated into the full-length protein, result in increased levels of const

236 ve PINK1, and the consequent accumulation of full-length protein, results in mitochondrial abnormalit

237 Our measurements on the full-length protein reveal a distinct role of the C-term

238 diverse ubiquitin-binding domains (UBDs) in full-length proteins, selective recognition of chains wi

239 Mutation of these interface positions in the full-length proteins showed that these interactions were

240 lagging edge membrane when coexpressed with full-length protein, showing that CynA clustering is med

241 Data analysis revealed that full length protein standards have the broadest quantita

242 a fluorophore as well as the purified native full-length protein substrates p53 and acetyl-CoA synthe

243 ClpA, the protease subunit ClpP can degrade full-length protein substrates processively, albeit at a

244 atalyzed deacetylation of singly-acetylated, full-length protein substrates, revealing that HDAC8 sub

245 t activation of SIRT1 with native peptide or full-length protein substrates, whereas they do activate

246 to be required for processive proteolysis of full-length protein substrates.

247 HDAC8 substrate selectivity for peptides and full-length proteins suggest that HDAC8 substrate prefer

248 L, is more resistant to degradation than the full length protein, suggesting that sites on the C-term

249 viral large envelope protein but not to the full-length protein, suggesting a need for proteolytic c

250 ulation was suppressed in the context of the full-length protein, suggesting that Pacsin is autoinhib

251 erence band was absent in the spectra of the full-length protein, suggesting that the isolated sensor

252 free protein synthesis kit that is active in full-length protein synthesis and (ii) the relative acti

253 ts quantitative estimation of the effects on full-length protein synthesis of various additions, subt

254 but requires a conformational change in the full-length protein that is promoted by autophosphorylat

255 rm lacking the transactivation domain of the full-length protein that modulates total p53 activity an

256 After validating their ability to produce full-length proteins that localize to photoreceptor conn

257 Compared with the activity of the full-length protein, the C-terminal helicase domain had

258 is highly dynamic, but in the context of the full-length protein, the dynamics is lost when the PDZ d

259 real-time monitoring of the expression of a full-length protein, the green fluorescent protein varia

260 In the full-length protein, the N-terminal helix is aligned nea

261 c finger (TZF) domain, in the ability of the full-length protein to bind to AREs within the tumor nec

262 Hit peptides are tested against the full-length protein to identify the best binder.

263 olecular mechanism for the adaptation of the full-length protein to increasing lipid load during chol

264 n isolation as well as in the context of the full-length protein to reveal that the Ub binding proper

265 oth the DBL domains and the parasite-derived full-length proteins to erythrocytes, which has implicat

266 MP correlated with that of the corresponding full-length proteins to induce apoptosis in the absence

267 me marker LC3 in osteoblasts, but unlike the full-length protein, trNbr1 fails to complex with activa

268 In contrast with full-length protein, truncated ASCC1 did not reduce the

269 Like the full-length protein, truncated langerin exists as a stab

270 in Ultrabithorax Ia (UbxHD), whereas for the full-length protein (UbxIa) affinity differs by more tha

271 2+ and HA determined by FTIR showed that the full-length protein undergoes slight conformational chan

272 ies cannot replicate the key features of the full-length proteins used in cellular studies.

273 eta conformational transition of RfaH in the full-length protein using a dual-basin structure-based m

274 acterize the structural architecture of both full-length proteins utilizing negative stain electron m

275 cus immunodominance compared to the case for full-length protein vaccination.

276 al production of a non-glycosylated, soluble full-length protein vaccine immunogen.

277 that of full-length HB-EGF, even though the full-length protein was efficiently cleaved, thus produc

278 indicating that another APP fragment or the full-length protein was likely responsible for maintaini

279 e specificity of palmitoylation seen for the full-length protein was lost, and the SH4 domain was pal

280 cated form of this enzyme suggested that the full-length protein was required for correct lipid subst

281 GFP and MCT12:214Delta-GFP revealed that the full-length protein was trafficked to the plasma membran

282 SH3 domain including a linker region of the full length protein), we observe a large temperature dep

283 In studying the full-length protein, we also have uncovered that IpaH fa

284 cific truncation and partial cleavage of the full-length protein were employed to further characteriz

285 s amino-acid-specific-labeled samples of the full-length protein were prepared and mixed, so that onl

286 separate domains of both species and of the full-length proteins were modeled.

287 dies indicated that interactions between the full-length proteins were more extensive than the contac

288 s residues critical for the stabilization of full-length proteins when the PAS domain is present.

289 ite for GCAP1 with similar affinities as the full-length protein, whereas GCAP2 did not bind to this

290 e initially produced as approximately 45-kDa full-length proteins, which undergo an intramolecular cl

291 he established biochemical activities of the full-length protein, while the carboxy-terminal 143 resi

292 bset of PPI interfaces without depleting the full-length protein will be valuable for structure-funct

293 acterize the enzymatic activity of NS4B, the full-length protein with a C-terminal His tag was expres

294 been complicated by the coexpression of the full-length protein with an in-frame, C-terminus-specifi

295 amined the interaction of Puma BH3 domain or full-length protein with Bak by surface plasmon resonanc

296 ransported to the cell surface via T9SS as a full-length protein with its CTD intact, independently o

297 The crystal structure of the full-length protein with prephenate bound and the accomp

298 hieve reversible immobilization of bioactive full-length proteins with good spatial and temporal cont

299 d TprI are highly thermostable, endowing the full-length proteins with impressive conformational stab

300 Furthermore, full-length proteins with these mutations decrease SID-1