ライフサイエンスコーパス: fully functional

1 ing inactive and trimers and tetramers being fully functional.

2 RPE grafts until demonstrating that they are fully functional.

3 y ICCS, indicating that these iNKT cells are fully functional.

4 Nrdp1 for degradation is properly folded and fully functional.

5 ved keratinocytes, suggesting that they were fully functional.

6 ction, translation in the apicoplast must be fully functional.

7 recruited to the centromeres, which remained fully functional.

8 to evade the host immune response and remain fully functional.

9 Shortened H proteins were not fully functional.

10 humoral immunity before its immune system is fully functional.

11 asmic droplet for the spermatozoon to become fully functional.

12 d the hypothalamic-thyroid (HPT) axis is not fully functional.

13 indicating that the NK cell populations were fully functional.

14 ochondrial tRNAs must be processed to become fully functional.

15 We report fully functional, 3D integrated complementary metal-oxid

16 e a phosphodeficient mutant at this site was fully functional, a phosphomimetic mutant displayed impa

17 3D-wPAT has three layers of fully functional acoustic transducer arrays.

18 29L variants uncoupled from RhoGEFs (but not fully functional activated G alpha12Q229L) induced trans

19 Thus, the levels of the naturally expressed, fully functional, active cellular MT1-MMP enzyme are rou

20 It is increasingly apparent that fully functional adipose tissue can be cardioprotective

21 diac chamber is crucial for development of a fully functional adult heart.

22 s and the cells do not appear to mature into fully functional adult motor neurons.

23 opy to demonstrate that the rotary device is fully functional after insertion.

24 We conclude that the production of fully functional AID protein by U-CLL and M-CLL cells co

25 E(1) represents a fully functional allele with a coding DNA sequence (CDS)

26 Expression of normal, fully functional alphavbeta3 enabled tumor growth in bon

27 -infected mice during the priming phase were fully functional and able to clear Pneumocystis infectio

28 Under these conditions, both enzymes are fully functional and are bound to VhuD in substoichiomet

29 The eluted tubulin is fully functional and can be efficiently assembled into m

30 hCG-generated Tregs were fully functional and could confer tolerance when adoptiv

31 d that recycling of internalized nAChRs into fully functional and denervated synapses was promoted by

32 re selected for and lead to the formation of fully functional and diverse H chain-only antibodies in

33 ull-length RTKs require protein that is both fully functional and free from contaminating proteins.

34 The web server is fully functional and freely available at http://csb.stan

35 The recruited DCs were fully functional and in a more advanced stage of maturat

36 cient myotubes, derived from myoblasts, were fully functional and mirrored the pathological features

37 Peptide synthesis was used to create a fully functional and monomeric PLB mutant with a spin la

38 This cofactor was fully functional and reconstituted the catalytic activit

39 pses formed during early development are not fully functional and respond poorly to presynaptic actio

40 We found that the complex is fully functional and that the stoichiometry of Rho* to G

41 The induced APOBEC3B enzyme is fully functional and therefore may exert mutational effe

42 ion channel pores of the P2X receptors were fully functional and unaltered by the receptor interacti

43 Nanobodies are the smallest fully functional antigen-binding antibody fragments poss

44 Here, we show that a fully functional antiviral CD8(+) T-cell response can be

45 By whole cell recording, these fusions are fully functional as CRAC channels.

46 ocalized to the yeast plasma membrane and is fully functional as evidenced by ATPase activity measure

47 hannels formed from concatenated dimers were fully functional as indicated by agonist-induced Ca(2+)

48 The expanded population was fully functional as judged by IFN-gamma production and M

49 ontaining only one active site cysteine were fully functional as repressors and still responded, albe

50 Furthermore, the trimeric replicase is fully functional at a replication fork with helicase, pr

51 l stability of BN, the ionic conduits remain fully functional at temperatures up to 90 degrees C.

52 red at -47 and -59, respectively, and NAC is fully functional at these promoters.

53 hesized that optimal T cell priming requires fully functional B cells.

54 this effect was ablated in mice that lacked fully functional B cells.

55 erahertz (THz) electromagnetic spectrum as a fully-functional bandwidth, the development of a family

56 man-adapted Bordetella subspecies produces a fully functional BatB protein; nucleotide differences wi

57 -ATPase assembled in the absence of Pkr1p is fully functional because the mutant cells are able to we

58 in the deficient in vitro maturation towards fully functional beta-cells.

59 The presence of a fully functional beta-glycoform together with the activi

60 into a normally monocular brain structure, a fully functional binocular circuitry can be made to deve

61 This kinase is fully functional biochemically and in cells, and is rapi

62 ered, disulfide cross-linked ClpB hexamer is fully functional biochemically, suggesting that ClpB deo

63 ide the necessary tools to produce the first fully functional bioengineered livers for organ transpla

64 Their interactions not only serve to support fully functional blood vessels but also can regulate ves

65 We demonstrate fully functional blue light-emitting diodes (LEDs) by gr

66 This interaction requires fully functional BRCA1 as a mutant BRCA1 protein is unab

67 M16 and C/EBP-beta is sufficient to induce a fully functional brown fat program in naive fibroblastic

68 s a result, prostate cancer cells expressing fully functional but not dis-regulated alphavbeta3 integ

69 Second, the Calvin cycle is not fully functional, but RubisCO continues to fix CO2 and s

70 ; these nascent synapses subsequently become fully functional by 2 h after Sema4D treatment.

71 This reconstituted system was fully functional, capable of translating natural messeng

72 from prepubescent primates can maintain the fully functional capacity of spermatogonia to produce sp

73 these Wt1(+) precursors differentiated into fully functional cardiomyocytes.

74 Here we report the development of fully functional CaV2.2 constructs containing inserted s

75 Fully functional CD8(+) T cell memory is highly dependen

76 cell help is essential for the generation of fully functional CD8(+) T cells during the primary respo

77 nn at centrosomes has become synonymous with fully functional centrosomes in Drosophila melanogaster.

78 ransfer, but the relevance of avalanches for fully functional cerebral systems has been controversial

79 omerization but could not form a pore with a fully functional channel.

80 igate this hypothesis in a system containing fully functional channels in a native environment with a

81 ical measurements on these same samples show fully functional channels, even without the presence of

82 ot sufficient for root, or leaf, growth, but fully functional chloroplasts are necessary and sufficie

83 ore extensive role for RFX TFs in generating fully functional cilia.

84 l challenge as they integrate into a mature, fully functional circuit.

85 he fabrication, understanding and control of fully functional circuits at the single-molecule level c

86 prokaryotic tryptophan transporter TnaT to a fully functional Cl(-)-dependent form by a single point

87 ing fluorescently tagged beta3 subunits were fully functional compared with receptors with untagged b

88 associates with the viral DNA ends to form a fully functional concerted integration intermediate.

89 lytical ultracentrifugation, we found that a fully functional construct of caveolin-1 (Cav1(62-178))

90 D124V and H80R SOD1 proteins appear to have fully functional copper-binding sites, inductively coupl

91 d recall ability have less diAcH3 than their fully functional counterparts, indicating that the diAcH

92 thin the cell, resulting in the secretion of fully functional cytokines.

93 e differentiation of naive CD8+ T cells into fully functional cytolytic effector cells and mediated t

94 usively showed that dld-II and lldEFG encode fully functional d-and l-LDH enzymes, which catalyze the

95 on of CD41 and CD45 followed by emergence of fully functional definitive HSCs.

96 t accompany post-natal differentiation where fully functional differentiated cell types with limited

97 pression of a set of genes necessary for the fully functional, differentiated beta cell state, wherea

98 A fully functional DNA repair proteome for removing harmfu

99 ethylated CpG dyads in the DNA of cells with fully functional Dnmt and Tet proteins.

100 emissions trends emphasize the importance of fully functional DPFs.

101 She describes her health as good, is fully functional, drives, has had no falls, and provides

102 A fully functional, easy to set up server is provided as a

103 of physicians reported having an extensive, fully functional electronic-records system, and 13% repo

104 We show that a fully functional endocannabinoid system is present in pr

105 We show that the encoded protein is indeed a fully functional, endoplasmic reticulum-localized, singl

106 e presence of fabK, a gene encoding a second fully functional enoyl-ACP reductase.

107 the acinetobactin gene cluster, is the only fully functional entB ortholog present in ATCC 19606(T).

108 raphy in LSO-IC projections, suggesting that fully functional ephrin-B2 reverse signaling is required

109 ral and targeted to prevent the emergence of fully functional escape variants.

110 Microfluidic features remained fully functional even after prolonged exposure to nonpol

111 cles with a capacitance of 25 F g(-1) and is fully functional even at compressions up to 75%.

112 In contrast, a fully functional EWS/FLI mutant (Mut9, which retains app

113 Remarkably, such flexible MTJs are fully functional, exhibiting a TMR ratio as high as 190%

114 Thus, this work implicates a fully functional exocyst complex as a component of the c

115 an trigger AP activation in individuals with fully functional factor H.

116 hat then must 'decide' to differentiate into fully functional fat cells is critical to our understand

117 However, a fully functional FeS cluster was required for Elongator

118 Using a fully functional fluorescent version of Arabidopsis thal

119 e periplasm into aglycosylated IgGs that are fully functional for antigen binding.

120 P dephosphorylation, and gene looping but is fully functional for mRNA 3'-end processing.

121 teraction with Sm proteins or hnRNP C remain fully functional for telomere elongation.

122 cherichia coli was expressed and purified in fully functional form and demonstrated to bind Cu(I) wit

123 It does not achieve a fully functional form in the absence of the trigger fact

124 o Th17-like and Th1-like cells but also into fully functional Foxp3(+) induced regulatory T cell-like

125 the final product contains greater than 90% fully functional FOXP3(+) Tregs.

126 deficiency that results from the absence of fully functional Fpn1.

127 Here we describe fully functional GABAergic communication within rodent p

128 se (NIK) is essential for the formation of a fully functional gammadelta T cell compartment.

129 Human subjects with fully functional gastrointestinal tracts (n = 6) and ile

130 utive modules arising from an uninterrupted, fully functional gene in the entomopathogenic bacterium

131 tence in the B-cell system in the absence of fully functional germinal center activity and of a class

132 demonstrate that CD10 identifies a subset of fully functional germinal center TFH in normal secondary

133 Using a fully functional, GFP-tagged EGL-4, we show here that pr

134 heteromerize with another protein to form a fully functional glucose polymer receptor.

135 A fully functional Glut1 molecule lacking all 6 native cys

136 ts expression is needed for the formation of fully functional GSVs.

137 nt pK(a) for the self-cleavage reaction in a fully functional hairpin ribozyme with a unique 8azaA at

138 support for gene/metabolite annotation and a fully functional heatmap builder.

139 ly remodeled bone, mature vasculature, and a fully functional hematopoietic compartment.

140 st time that ClyA can be used to co-localize fully functional heterologous proteins directly in bacte

141 nits GABA(B1a), GABA(B1b), and GABA(B2) form fully functional heteromeric GABA(B(1a,2)) and GABA(B(1b

142 ed to the Fc region of human IgG, creating a fully functional homodimer (or "lysibody") with high-aff

143 it is the hope that the hurdle of obtaining fully functional HSCs in a laboratory setting will be ov

144 vertible to fully human antibodies) and have fully functional humoral immune systems indistinguishabl

145 use tumor cells arising in the presence of a fully functional immune system are less immunogenic than

146 However, existing HumAb mice do not have fully functional immune systems, perhaps because of the

147 fortunately, existing HumAb mice do not have fully functional immune systems, perhaps because of the

148 nt human MC line, ROSA(KIT WT), expressing a fully functional immunoglobulin E (IgE) receptor.

149 Q in bo(3) from E. coli has been shown to be fully functional, implying that the positive charge of t

150 enhancement of TFH and GC B cells is already fully functional in 3-wk-old infant mice, which were ful

151 we also finally prove that the BM in pigs is fully functional in adult animals and that B lymphogenes

152 ied TRPV1, however, was recently shown to be fully functional in artificial liposomes in the absence

153 Phospho-IIF is fully functional in binding to free pol II and is able t

154 gB cytodomain mutants and show that they are fully functional in cell-cell fusion at shorter coincuba

155 The ability to generate fully functional iN cells from aged organisms will be pa

156 existing in a latent state, this complex was fully functional in eliciting SMAD-dependent signaling.

157 While Bst-IF2 is fully functional in formation of E. coli 70SIC, relative

158 Interestingly, mouse SDC1 is also fully functional in mediating HCV attachment when expres

159 to a D173A active site mutant, Exo1-E109K is fully functional in mismatch-provoked excision and repai

160 ed, is transported to the sarcolemma, and is fully functional in mouse muscle.

161 Moreover, the IL-7-induced pathway was fully functional in naive T cells from elderly and young

162 Importantly, the mutated NDK5 that appeared fully functional in ndk5 cells elicited a dominant-negat

163 The LG3 domain from Marchantia polymorpha is fully functional in P. patens, whereas angiosperm sequen

164 eptor (MLA1) from monocotyledonous barley is fully functional in partially immunocompromised dicotyle

165 However, it is fully functional in regulated genes encoding iron uptake

166 form of a large protein precursor (P3) to be fully functional in replication; (ii) the replication co

167 ng synV derivative was constructed, which is fully functional in Saccharomyces cerevisiae under all c

168 way (as defined by studies in C. elegans) is fully functional in some parasitic nematodes.

169 terminal 24 amino acids (pHA-UL3825-331) was fully functional in suppressing cell death during infect

170 owed improved telomeric localization and was fully functional in terms of chromosome end protection b

171 The mutant protein is fully functional in that it can both stabilize PopB and

172 TRPV1 is fully functional in the absence of phosphoinositides, ar

173 ctivators is relatively intact, and they are fully functional in the Lhx3 complex and V2 interneuron

174 tly, membrane proteins have been shown to be fully functional in these fully hydrated, planar bilayer

175 clock, and many other peripheral clocks, are fully functional in this model allows the assignment of

176 resentation and activation signals to become fully functional in this model of Pneumocystis infection

177 and other nuclear gene groups appears to be fully functional in this mutant, indicating that a block

178 ion, human EBV-specific T lymphocytes seemed fully functional in vitro and also selectively accumulat

179 hich the order of the domains is reversed is fully functional in vitro and in vivo.

180 y, IL-10/IL-35 double-deficient T(regs) were fully functional in vitro and in vivo.

181 d by HemQ remains to be characterized, to be fully functional in vitro it requires the presence of a

182 ITPA-P32T is also fully functional in vivo in model organisms as determine

183 itionally, we show that Cbl-b(-/-) Tregs are fully functional in vivo, further suggesting that the re

184 lone (J6CF), which we previously found to be fully functional in vivo, was replication incompetent in

185 hway undergoes autocatalysis normally and is fully functional in vivo.

186 r, several nonconsensus sequences are almost fully functional, indicating that mechanistic requiremen

187 RP3 enhanced ASC speck formation, leading to fully functional inflammasomes and caspase-1 activation.

188 Thus, proper development of fully functional iNKT cells is constrained by a limited

189 tories had appropriate technical competency, fully functional instrumentation, and suitable reagents

190 We show that the purified protein is a fully functional ion channel with properties akin to the

191 he A. tumefaciens biotin protein ligase is a fully functional ligase that has no role in regulation o

192 cal, and other 3D shapes and integrated into fully functional light-trapping PV devices.

193 d PI-MECs displayed all of the properties of fully functional lobular progenitors including giving ri

194 t reconstitution using suboptimal numbers of fully functional LT-HSCs results in the generation of a

195 step toward the ultimate goal of generating fully functional lungs in vitro, these results suggest t

196 Here we report that a fully functional lysine-less mutant of an inner nuclear

197 telets are capable of generating and storing fully functional lysosomal enzymes and can also lead to

198 ologically relevant drug-binding site in the fully functional M2(21-61) is S31 in the TM pore.

199 o-EM can be used to investigate complete and fully functional macromolecular complexes in different f

200 the authors found activated Rho proteins in fully functional macrophages that hypersecreted inflamma

201 H, containing monohydroxylated betaTrp57, to fully functional MADH by catalyzing the insertion of a s

202 thelial cells were capable of establishing a fully functional mammary gland.

203 , indicating that processing is required for fully functional maturation of P30.

204 onserved endonuclease complex that generates fully functional mature tRNAs.

205 here the isolation and characterization of a fully functional megacomplex composed of a phycobilisome

206 cells are defective in differentiating into fully functional mesoderm-derived cardiomyocytes and adi

207 uring process to produce fully assembled and fully functional millimeter-scale tools.

208 ed mutation, alphaL260P, in the context of a fully functional mini-spectrin.

209 Platelets also contain fully functional miRNA machinery, and certain miRNA leve

210 t is subsequently processed to release three fully functional miRNAs.

211 rol efflux capacity, and anti-miR33 required fully functional mitochondria to enhance ABCA1-mediated

212 the earliest diverging eukaryotes that have fully functional mitochondria.

213 A fully functional model of hair reconstitution remains el

214 face beta-strand is sufficient to generate a fully functional monomer.

215 f the 21 amino acids in TM4 to cysteine on a fully functional, MTS-resistant C270A-hASBT template.

216 f extrinsic Ca(2+) to those cells containing fully functional NCX/GM1: differentiated NG108-15 and C6

217 melanocortinergic phenotype and maintains a fully functional neuronal POMC phenotype throughout adul

218 o reprogram human astrocytes in culture into fully functional neurons.

219 by apoptosis but is gradually replaced by a fully functional new growth plate from progenitor stem c

220 neurotransmitter acetylcholine bound to the fully functional nicotinic acetylcholine receptor embedd

221 nase mechanism and allow reconstruction of a fully functional nitrogenase from the "skeleton" enzyme,

222 plicable methods to produce large numbers of fully functional NK cells is a critical step to maximize

223 izes with the beta(1) subunit and produces a fully functional NO- and BAY41-2272-sensitive enzyme.

224 e last eukaryotic common ancestor (LECA) had fully functional NPCs.

225 ic phosphoproteins and the re-formation of a fully functional nuclear envelope.

226 tor, but it compromises the formation of the fully functional nucleoprotein complex.

227 Thus, a fully functional, ongoing, antigen-specific CTL response

228 NA regulatory network to specify and produce fully functional oocytes.

229 in the differentiation of preosteoblasts to fully functional osteoblasts.

230 mpared to control BALB/c mice, which express fully functional P2X(7) receptors.

231 In summary, a fully functional PA and a minimum of adenylate cyclase a

232 sive regulatory changes can rapidly assemble fully functional pathways in microbes.

233 itecture holds the key to the realization of fully functional photonic-integrated circuits.

234 Significantly, both isoforms form fully functional photopigments.

235 ate with anti-flu Ab responses, indicating a fully functional population.

236 expression of human Alix in the absence of a fully functional PPPY late domain partially rescued both

237 in budding is amplified in the absence of a fully functional PPPY motif.

238 proteins and one encoding a PR, generated a fully functional PR photosystem that enabled photophosph

239 However, fully functional practical thermoelectric coolers have n

240 We confirmed the involvement of MED25 for fully functional preinitiation complex recruitment and t

241 However, fully functional primary hepatocytes remain difficult to

242 This work presents the first fully functional, printed coils for 1.5- and 3-T clinica

243 Considerably larger fully functional promoters were required for maximum pro

244 Although 3CD is a fully functional protease, it lacks polymerase activity.

245 nteraction of p30 with a PA28gamma retaining fully functional proteasome activity is required for p30

246 bodies that are subsequently used to produce fully functional protein by an in vitro refolding proces

247 Fully functional protein microarrays, with monolayer arr

248 A number of fully functional proteins have been identified to exist

249 The delivery of fully functional proteins to infected cells upon virion

250 working bits were then configured to form a fully functional random access memory circuit for storin

251 the functional interaction with L to form a fully functional RdRP.

252 idelines for preparation and handling of the fully functional receptor suitable for a wide array of d

253 We have developed a fully functional recombinant PVM strain with a fluoresce

254 sphonate instead of the natural phosphate in fully functional, reconstituted bacterial ribosomes.

255 Fully functional RecQL5 requires both helicase activity

256 ely trafficked to the cell membrane and were fully functional; regulation was normal except when YFP

257 hese results describe a novel route by which fully functional regulatory elements can arise rapidly f

258 vitro and entirely from nonplant sources, a fully functional replicase complex of Tomato bushy stunt

259 vector stably expressed 17-77 mug ml(-1) of fully functional rhesus eCD4-Ig for more than 40 weeks,

260 Our results show that fully functional root amyloplasts are not sufficient for

261 iate complex (RPi) before the formation of a fully functional RPo.

262 cardiac precursors able to mature and form a fully functional SAN-like tissue.

263 tivity assays indicated that QUAD opsin is a fully functional scramblase.

264 In the present work, we show that fully functional self-organized TiO(2) nanotube layers c

265 culture system can generate large numbers of fully functional sensory cells which could be used to in

266 Remarkably, deletion of the leader yielded a fully functional SfIAP with dramatically increased prote

267 uch "eyeball" cameras, including examples of fully functional silicon devices capable of collecting r

268 combined with dA-dT and dG-dC, it provides a fully functional six-letter genetic alphabet.

269 ps that have been taken towards delivering a fully functional solar fuels generator, which have explo

270 e assembly process or upon completion of the fully functional structure.

271 stem to the chick embryo and find that it is fully functional, suggesting that this strategy is gener

272 The immediate availability of fully functional synapses upon formation supports an age

273 Fully functional T cells are necessary for the maintenan

274 rm-free (GF) mice, ablation of the otherwise fully functional T reg cells resulted in a systemic auto

275 This failure to prime a fully functional T(CD8(+)) response results from a reduc

276 ecreted by P. syringae and is required for a fully functional T3SS.

277 tability conferred by DnaK did not require a fully functional Tat signal as substrates bearing transl

278 or enhanced infant responses but induces few fully functional TFH cells, which are mostly follicular

279 Once blood circulation becomes fully functional, the embryonic head no longer produces

280 during germination, before photosynthesis is fully functional, the roles of PSVs in adult vegetative

281 nthesis and mutagenesis of UV radiation were fully functional, those of a site-specific 1,N(6)-etheno

282 ipheral IL-7 deficiency in the presence of a fully functional thymus, and we document a critical requ

283 behavior and development of thymocytes in a fully functional thymus, we developed transgenic reporte

284 l phosphoSH3C-SH3N unit in which the SH3N is fully functional to bind polyproline type II ligands and

285 g 72 h ambient storage, neutrophils remained fully functional to migrate towards chemical cues and ma

286 ces and discusses the challenges of creating fully functional transplantable liver grafts with this w

287 c (TrkB(F616A)) mice that express mutant but fully functional TrkB receptors.

288 he first multimixing stopped-flow study on a fully functional truncated variant of human peroxidasin

289 We demonstrate that the full-length PKS is fully functional upon rigidification of the ACP domain,

290 s library to in vitro selection and obtained fully functional variants with deletions of up to 18 ami

291 Establishment of a fully functional vasculature is complex and requires a n

292 ess that is essential for the formation of a fully functional vasculature.

293 Thus, the unusual V225d cag architecture was fully functional via conserved elements, but the natural

294 gmatic mutations-F45L, V209M and F220C-yield fully functional visual pigments that bind the 11-cis re

295 A fully functional vWFR is necessary for platelet attachme

296 ization enzymes from Citrobacter freundii is fully functional when cloned in Escherichia coli, both p

297 nce genes and the induction mechanism remain fully functional when transferred to heterologous bacter

298 The sensors were fully functional with excellent selectivity to interferi

299 ences that encode elements that appear to be fully functional with intact open reading frames and oth

300 Here we have reconstituted fully functional yeast Set1/COMPASS and human MLL/COMPAS