ライフサイエンスコーパス: fumonisin

1 to contribute to pathologies associated with fumonisins.

2 resultant mutant lost the ability to produce fumonisins.

3 the role of Fum14p in the esterification of fumonisins.

4 FUM14 is required for the esterification of fumonisins.

5 method for the quantitative determination of fumonisins.

6 and 94.4% for all the mycotoxins, except for fumonisins.

7 nd FB2 contents in silage were due to hidden fumonisins.

8 lerable daily intake (PMTDI) recommended for fumonisins.

9 rates confirming exposure to aflatoxins and fumonisins.

10 Exposure to fumonisin alone or coexposure with aflatoxins may contri

11 HL-60 and the transfectants was abrogated by fumonisin, an inhibitor of ceramide generation, and by t

12 The effects of GEO on fumonisin and ergosterol production were evaluated at co

13 s, subsequently inhibiting the production of fumonisins and ergosterol.

14 flatoxins and ochratoxin, and 2.0ngL(-1) for fumonisins and neosolaniol.

15 Fusarium moniliforme toxins (fumonisins) and Alternaria alternata lycopersici (AAL) t

16 oor child health and development: aflatoxin, fumonisin, and deoxynivalenol.

17 Aflatoxin and fumonisin are toxic food contaminants.

18 Fumonisins are a family of carcinogenic secondary metabo

19 Fumonisins are a group of mycotoxins found in various fo

20 Fumonisins are a group of polyketide-derived mycotoxins

21 Fumonisins are mycotoxins produced by Fusarium species t

22 Fumonisins are polyketide-derived mycotoxins produced by

23 Fumonisins are secondary metabolites of the fungus Fusar

24 a Farber disease patient in the presence of fumonisin B (1), the conversion to NBD-ceramide was redu

25 A 2-h pretreatment of Jurkat cells with fumonisin B(1) (100 microm), a specific inhibitor of CoA

26 Fumonisin B(1) (FB(1)) is a mycotoxin that inhibits cera

27 C(6)-ceramide, fumonisin B(1) (FB(1)), or etoposide was used to initiat

28 sphorylation of SR proteins was inhibited by fumonisin B(1) and by overexpression of glucosylceramide

29 ns grown for 3 weeks in culture in 20 microM fumonisin B(1) develop dendrites, axons, and synaptic te

30 s of the sphingolipid biosynthesis inhibitor fumonisin B(1) has been achieved.

31 These data demonstrate that fumonisin B(1) protects against toxin-induced synaptic b

32 In this work the ability to predict fumonisin B(1)+B(2) contents in corn meal using an FT-NI

33 Fumonisin B(1), an inhibitor of ceramide synthase, and g

34 The increase in ceramide was inhibited by fumonisin B(1), an inhibitor of ceramide synthase, but n

35 tor of serine palmitoyltransferase (SPT), or fumonisin B(1), an inhibitor of ceramide synthase, retar

36 Fumonisin B(1), an inhibitor of ceramide synthesis, sign

37 cord cell cultures grown in the presence of fumonisin B(1), an inhibitor of ganglioside synthesis.

38 pressed by inhibitors of ceramide synthesis, fumonisin B(1), myriocin, and l-cycloserine, and 4-HPR t

39 When cells were treated with 5-50 microm fumonisin B(1), the cellular level of ceramide decreased

40 to control cultures, tetanus toxin added to fumonisin B(1)-treated cultures does not block potassium

41 Supplementing fumonisin B(1)-treated cultures with mixed brain ganglio

42 ent with the inhibitor of ceramide synthase, fumonisin B(1).

43 de synthase is inhibited by the fungal toxin fumonisin B(1).

44 expressing wild type PAK1 with sphingosine, fumonisin B, or sphingomyelinase, all of which are able

45 /kg), diacetoxyscirpenol (<LOQ - 91 mug/kg), fumonisin B1 (<LOQ - 95 mug/kg), fumonisin B2 (<LOQ), fu

46 The specific inhibitor of ceramide synthase, fumonisin B1 (50 microM), was able to suppress H(2)O(2)-

47 glycol-dimethacrylate), PA-EGDMA) to remove fumonisin B1 (FB1) and fumonisin B2 (FB2) from model sol

48 The inhibitory effect on fumonisin B1 (FB1) and fumonisin B2 (FB2) production was

49 eaf tissues with a PCD-inducing fungal toxin fumonisin B1 (FB1) and increased sensitivity to heat sho

50 essment of two highly concerning mycotoxins (fumonisin B1 (FB1) and ocratoxin A (OTA)) has successful

51 e report that PCD triggered by the mycotoxin fumonisin B1 (FB1) can be suppressed by PTI in Arabidops

52 In this study, fumonisin B1 (FB1) consumption was assessed through dete

53 n of sphingolipid synthesis by the mycotoxin fumonisin B1 (FB1) disrupts axonal growth in cultured hi

54 e of the mycotoxins deoxynivalenol (DON) and fumonisin B1 (FB1) in industrial beers.

55 The fungal toxin fumonisin B1 (FB1) induces apoptosis-like programmed cel

56 Fumonisin B1 (FB1) is a food-borne mycotoxin produced by

57 rabidopsis tissues but can be upregulated by fumonisin B1 (FB1) treatment and pathogen infection.

58 nd sensitivity to the PCD-inducing mycotoxin fumonisin B1 (FB1) were increased by ssSPTa overexpressi

59 we assessed GTP mitigation on biomarkers of fumonisin B1 (FB1), a class 2B carcinogen, in blood and

60 Fumonisin B1 (FB1), a programmed cell death-eliciting to

61 Interestingly, fumonisin B1 (FB1), an inhibitor of the salvage pathway,

62 hain ceramide levels, which was inhibited by fumonisin B1 (FB1), and not by myriocin (MYR).

63 are targets for inhibition by the mycotoxin fumonisin B1 (FB1).

64 induced by mycotoxins ochratoxin A (OTA) and fumonisin B1 (FB1).

65 ome immunoanalysis) for the detection of the fumonisin B1 (FmB1).

66 ne governing the production of the mycotoxin fumonisin B1 (fum1) among 121 random ascospore progeny f

67 in adducts (AF-alb) using ELISA, and urinary fumonisin B1 (UFB1) using liquid chromatography-mass spe

68 YPC1p suppressed the inhibition of growth by fumonisin B1 albeit more modestly.

69 nd AtORM2 displayed increased sensitivity to fumonisin B1 and an accompanying strong increase in LCBs

70 suitable screening tool for the analysis of Fumonisin B1 and B2 in food samples.

71 bition of the de novo biosynthesis of SLs by fumonisin B1 and beta-chloro-L-alanine completely abroga

72 Good specificity toward fumonisin B1 and its structural analog, fumonisin B2, wa

73 educed sensitivity to PCD-inducing mycotoxin fumonisin B1 as well as oxidative stress inducers, where

74 Although fumonisin B1 blocked ceramide production and increased s

75 as based on the following: 1) the ability of fumonisin B1 but not myriocin to inhibit ceramide format

76 Nevertheless, fumonisin B1 but not myriocin was able to protect from T

77 se findings suggest that dietary exposure to fumonisin B1 could adversely affect folate uptake and po

78 because inhibition of ceramide synthase with fumonisin B1 decreased apoptosis in lyase-overexpressing

79 The ceramide synthase inhibitor fumonisin B1 did not affect AA-induced ceramide producti

80 his is the first report of the occurrence of fumonisin B1 in commercial samples of polished rice from

81 preparation method for the determination of fumonisin B1 in rice was optimised using a strategy of s

82 pe microarray was applied to the analysis of fumonisin B1 in spiked maize and wheat samples.

83 Fumonisin B1 induced cell cycle arrest in the G1 phase i

84 Fumonisin B1 inhibited both the ceramide increase and th

85 ls basally and in response to UV-C, but only fumonisin B1 inhibited cell death, suggesting the presen

86 Ceramide analogues bypassed fumonisin B1 inhibition to initiate apoptosis directly.

87 The addition of fumonisin B1 or AAL toxin, TA, to CV-1 cells induced the

88 Inhibition of ceramide formation by fumonisin B1 or down-regulation of PKCdelta potentiated

89 lls treated with ceramide synthase inhibitor fumonisin B1 or glucosylceramide synthase inhibitor 1-ph

90 h ceramide synthesis inhibitors myriocin and fumonisin B1 or siRNA silencing of CerS6 prevented C16-c

91 Inhibition of ceramide synthesis by fumonisin B1 overcame the defect in PKC phosphorylation

92 paired kernel colonization, but the ratio of fumonisin B1 per unit growth was not significantly reduc

93 Inhibition of ceramide synthase with fumonisin B1 prevented p53 reactivation induced by GCS s

94 nd, inhibition of ceramide accumulation with fumonisin B1 restored the ability of PMA to induce trans

95 ition of de novo synthesis using myriocin or fumonisin B1 resulted in decreased overall cellular cera

96 gulation of CYP2C11 when added alone or with fumonisin B1 to block acylation of the exogenous sphingo

97 nor facilitative transport was inhibited by fumonisin B1 treatment, indicating that the effect of sp

98 array-based immunoassay for the detection of fumonisin B1 using a novel mimotope selected by phage di

99 was immobilized onto epoxy-glass slides, and fumonisin B1 was detected in a competitive binding inhib

100 is, since ceramide synthase inhibition (with fumonisin B1) had no effect.

101 sitive on-site quantification of fumonisins (fumonisin B1+fumonisin B2) in maize has been developed.

102 The inclusion of fumonisin B1, a ceramide synthase inhibitor, blocked PSC

103 in the ceramides was partially decreased by Fumonisin B1, a ceramide synthase inhibitor.

104 was dependent on ceramide synthesis, because fumonisin B1, a ceramide synthetase inhibitor, blocked t

105 amide without FFA induced DNA laddering, but fumonisin B1, a ceramide synthetase inhibitor, completel

106 de novo biosynthesis was similar to that of fumonisin B1, a classical inhibitor of ceramide synthase

107 Fumonisin B1, a dihydroceramide synthase inhibitor, exag

108 CS activation was obligatory, since fumonisin B1, a fungal pathogen that acts as a specific

109 ction was investigated in Caco-2 cells using fumonisin B1, a mycotoxin that inhibits the biosynthesis

110 However, addition of fumonisin B1, a selective ceramide synthase inhibitor, a

111 ed sphingosine by ceramide synthase, we used fumonisin B1, a specific inhibitor of ceramide synthase.

112 Treatment with fumonisin B1, a specific natural inhibitor of ceramide s

113 and that LASS1 in HeLa cells is sensitive to fumonisin B1, an in vitro inhibitor of (dihydro)ceramide

114 sphinganine by a second method (addition of fumonisin B1, an inhibitor of ceramide synthase) also re

115 Both fumonisin B1, an inhibitor of ceramide synthase, and ISP

116 ion induced by S1P was completely blocked by fumonisin B1, an inhibitor of ceramide synthase, but onl

117 Fumonisin B1, an inhibitor of ceramide synthase, prevent

118 16)-ceramide in SW480 cells was inhibited by fumonisin B1, an inhibitor of ceramide synthases (CerS).

119 in arachidonate signaling was detected since fumonisin B1, an inhibitor of de novo ceramide synthesis

120 y was not inhibited in vitro and in cells by fumonisin B1, an inhibitor of the CoA-dependent ceramide

121 nd okadaic acid, ceramide synthase inhibitor fumonisin B1, and ROS scavenger N-acetylcysteine (NAC).

122 gnificant variables for the determination of fumonisin B1, and then, a central composite rotatable de

123 termination of ten mycotoxins (ochratoxin A, fumonisin B1, fumonisin B2, deoxynivalenol, fusarenon-X,

124 of ceramide production by the fungal toxin, fumonisin B1, impaired TCR-induced interleukin (IL)-2 pr

125 sphingolipid biosynthesis, L-cycloserine and fumonisin B1, prevented the observed accumulation of the

126 Myriocin and fumonisin B1, specific inhibitors of key enzymes (serine

127 Fumonisin B1, the N-acyl-sphinganine dehydrogenase (e.g.

128 ivity is CoA-independent and is resistant to fumonisin B1, thus explaining why YPC1 was cloned as a f

129 presence of the ceramide synthase inhibitor fumonisin B1, which inhibited apoptosis by 18%-81% (medi

130 Conversely, fumonisin B1, which inhibits the biosynthesis of endogen

131 Conversely, fumonisin B1, which selectively inhibits ceramide syntha

132 the programmed cell death-inducing mycotoxin fumonisin B1, with an accompanying reduced accumulation

133 B1, thus explaining why YPC1 was cloned as a fumonisin B1-resistant gene.

134 ular ceramide levels and Abeta generation in fumonisin B1-treated cells.

135 s whose overexpression bestows resistance to fumonisin B1.

136 y of SL synthesis, beta-chloro-L-alanine and fumonisin B1.

137 competitive inhibitor of ceramide synthase, fumonisin B1.

138 wn risk factors may be caused by exposure to fumonisin B1.

139 bilization, which was blocked exclusively by fumonisin B1.

140 lead to cell death, which were inhibited by fumonisin B1.

141 de novo ceramide biosynthesis, myriocin and fumonisin B1.

142 im of this study was to evaluate the fate of fumonisins B1 (FB1) and B2 (FB2) during industrial dry-m

143 The stability of Fumonisins B1 and B2 (FB1, FB2) was studied and the effe

144 termined to be effective for quantitation of fumonisins B1 and B2 in feed.

145 simultaneous extraction and determination of fumonisins B1 and B2 in maize.

146 derivatization is a suitable alternative for fumonisins B1 and B2 quantitation in corn-based feeds.

147 nivalenol, zearalenone, sterigmatocystin and fumonisins B1, B2 and B3.

148 91 mug/kg), fumonisin B1 (<LOQ - 95 mug/kg), fumonisin B2 (<LOQ), fumonisin B3 (<LOQ), T2 (<LOQ) and

149 , PA-EGDMA) to remove fumonisin B1 (FB1) and fumonisin B2 (FB2) from model solutions and red wine.

150 inhibitory effect on fumonisin B1 (FB1) and fumonisin B2 (FB2) production was significant at GEO con

151 s with immobilised L-thyroxine, glucosamine, fumonisin B2 or biotin as template, can demonstrate comp

152 e quantification of fumonisins (fumonisin B1+fumonisin B2) in maize has been developed.

153 n B1) and 15mugL(-1) (for deoxynivalenol and fumonisin B2).

154 ten mycotoxins (ochratoxin A, fumonisin B1, fumonisin B2, deoxynivalenol, fusarenon-X, T-2 and HT-2

155 ward fumonisin B1 and its structural analog, fumonisin B2, was observed, together with negligible cro

156 B1 (<LOQ - 95 mug/kg), fumonisin B2 (<LOQ), fumonisin B3 (<LOQ), T2 (<LOQ) and zearalenone (<LOQ).

157 chratoxin A, diacetoxiscyrpenol (DAS), three fumonisins, beauvericin (BEA), deoxynivalenol (DON), 15-

158 In Fusarium, fumonisin biosynthetic genes (FUM) are clustered, and th

159 ied, as did the effects on the production of fumonisins, but at >/=300 mug/mL of REO, these processes

160 Whereas fungi damage plants, fumonisins cause disease both to cattle breedings and hu

161 However, the three forms of fumonisins collected in all fractions amounted to 183%,

162 Fumonisins contain a highly reduced, acyclic 18-carbon c

163 Fumonisins contain two tricarballylic esters that are cr

164 lation between cancer and food suggests that fumonisin contamination rather than aflatoxin is the mos

165 associated with a safer product in terms of fumonisin contamination.

166 ation between child growth and aflatoxin and fumonisin exposure in Tanzania.

167 B(4) to the tricarballylic esters-containing fumonisins, FB(3) and FB(4), respectively, when incubate

168 gbw/day for the sum of (DON+3-ADON+15-ADON), fumonisins (FB1+FB2+FB3), the sum of (T2+HT-2), NIV and

169 d the occurrence of deoxynivalenol (DON) and fumonisins (FBs) in malting barley.

170 effect of nixtamalization on the content of fumonisins (FBs), hydrolysed (HFBs) and partially hydrol

171 and ultrasensitive on-site quantification of fumonisins (fumonisin B1+fumonisin B2) in maize has been

172 allows a fast and reliable determination of Fumonisin in beer samples with recovery rate of 87-105%.

173 d is comparable to HPLC for the detection of fumonisins in corn, animal feeds, and human foods.

174 ysed (HFBs) and partially hydrolysed (PHFBs) fumonisins in maize was investigated at laboratory-scale

175 nd PHFBs reduction, due to the solubility of fumonisins in water during the steeping process, but did

176 ked by myriocin inhibition of SPT as well as fumonisin inhibition of the ceramide synthases, suggesti

177 HFB(4), which are biosynthetic precursors of fumonisins lacking the tricarballylic esters, were detec

178 In the endosperm, cornmeal and grits fumonisin levels decreased from 60 to 95%.

179 trial dry-milling can contribute to reducing fumonisin levels in corn products intended for human con

180 Fumonisin levels in cornmeal and grits were below the ma

181 robic conditions for 7days have shown higher fumonisin levels than those not exposed to air.

182 flatoxin promotes hepatocellular cancer, and fumonisin may promote esophageal cancer.

183 Fusarium verticillioides produces fumonisin mycotoxins during colonization of maize.

184 oduced by inhibition of ceramide synthase by fumonisins, mycotoxins produced by Fusarium moniliforme,

185 Thus, the inhibition of fungal biomass and fumonisin production was dependent on the concentration

186 growth of F. verticillioides and subsequent fumonisin production.

187 h) were tested, with all polymers exhibiting fumonisin removal capacities (monitored by LC-MS).

188 Fumonisin-specific antibody was used to isolate mimotope

189 are not frequently studied in milk, such as fumonisins, sterigmatocystin or ochratoxin B.

190 , ochratoxin A, zearalenone, deoxynivalenol, fumonisins, T-2 and HT-2 toxins, fusarenone X, diacetoxy

191 on made available forms of matrix-associated fumonisins that were then converted to their hydrolysed

192 Law limits set fumonisins tolerable daily intake with respect to severa

193 Moreover, blocking ORMDL induction with fumonisin treatment resulted in significantly greater in

194 A limit of detection of 2.5 mugL(-1) for fumonisins was achieved, with an analytical working rang

195 The occurrence of masked fumonisins was also investigated.

196 The recovery values for fumonisins were between 42.1% and 64.6%.

197 Fumonisins were concentrated in the germ and pericarp at

198 und in peanut, maize, rice, and cassava) and fumonisins, which occur primarily in maize.