ライフサイエンスコーパス: function

1 2, a positive regulator of unknown molecular function.

2 f murine B-ALL cells with compromised Ikaros function.

3 ctin is required for effective thin filament function.

4 e 5-mg dose in patients with preserved renal function.

5 gain valuable insights into their potential function.

6 r changes in adipose tissue distribution and function.

7 and caffeine, which may also affect vascular function.

8 new avenues for optically controlling enzyme function.

9 own function, have been ascribed anti-CRISPR function.

10 ls is important for understanding biological function.

11 acts in a negative feedback loop to block AR function.

12 s necessary to make strong claims about gene function.

13 pathy, whereas CB1R blockade improves kidney function.

14 6.5 +/- 3.4 years (range: 1 to 13 years) in function.

15 ow biophysical characteristics contribute to function.

16 rizing early-born neurons in central complex function.

17 ed hexasaccharides will help understand HCII function.

18 on (DBS) within circuits that modulate motor function.

19 ellar, sensory, cranial nerve, and autonomic function.

20 f loop conformations, each essential for one function.

21 improved predictions of future reef form and function.

22 x metabolic processes to achieve this normal function.

23 rly all mRNAs is strongly dependent on TFIID function.

24 rmance status of 0-2, and adequate pulmonary function.

25 ontributing to fibrosis and decline in organ function.

26 t the N-terminus is required for optimal SWR function.

27 spike timing actually plays a role in brain function.

28 mediated mainly by modulation of KCNQ1 pore function.

29 n the regulation of T cell proliferation and function.

30 aturally acquire mutations that restore this function.

31 nding of proteasome assembly, structure, and function.

32 ny tectiviral proteins are ORFans of unknown function.

33 (OCD) are caused by impaired frontostriatal function.

34 strates a potent ability to restore effector functions.

35 he creation of new organisms with customized functions.

36 ding, its interactions with ligands, and its functions.

37 ng in enhanced FcgammaRIII-mediated effector functions.

38 s are widely involved in numerous biological functions.

39 me play important roles in numerous cellular functions.

40 ize molecular signals or manipulate cellular functions.

41 S on lipid mediators in affecting testicular functions.

42 ing these cell types for investigating brain functions.

43 ns that serve as hubs for essential cellular functions.

44 which most likely are involved in different functions.

45 tivation could be dissociated from its other functions.

46 al other reflexes regulating discrete immune functions.

47 is was associated with improved sensorimotor functions.

48 , is Mena(INV) involved in TMEM assembly and function?

49 motor pathways involved in recovery of hand function after injury.

50 amatically altered community composition and function after tooth loss, with smaller alterations in c

51 onstrates that PGI2 can reverse key platelet functions after their initial activation and identifies

52 H3N2 led to prolonged deterioration of lung function, aggravated mucus production, peri-vascular, pe

53 ion between organelles, which allows them to function and adapt to changing cellular environments.

54 p62 with Keap1, which further decreases Nrf2 function and antioxidative responses to S Typhimurium in

55 As knowledge of immune function and appreciation of immunodeficiency has develo

56 acterized by altered or inappropriate neural function and behaviour.

57 sordered proteins are important for cellular function and common in all organisms.

58 e human genome was believed to regulate cell function and development.

59 at, through adverse effects on mitochondrial function and endoplasmic reticulum stress, could have co

60 ty and invasion, including potassium channel function and EPH receptor signaling.

61 Renal function and histologic morphology were evaluated.

62 n IFITM3 on the basis of putative biological function and identified rs34481144 in the 5' UTR.

63 We reveal that neuronal function and integrity decline rapidly with age, culmina

64 ease (COPD) is characterized by reduced lung function and is the third leading cause of death globall

65 -glial communication and is required for the function and maturation of OLs to promote myelination.Ax

66 improvement in skeletal muscle phenotype and function and molecular perturbations of hyperammonemia;

67 M association and is important for F protein function and pre-fusion stability.

68 The function and regulation of these domains remain largely

69 poietic stem cells (HSCs) undergo changes in function and structure, including skewing to myeloid lin

70 th documented normal auditory and vestibular function and surgical specimens from patients with intra

71 al, and cellular contributions to islet (dys)function and T2DM pathogenesis.

72 -positive viremic patients with normal liver function and the incorporation of new biomarkers to help

73 KRIT1 leads to decreased microvessel barrier function and to the development of the vascular disorder

74 kine overactivity that act directly on brain function and/or treatment in early-stage psychosis popul

75 nology should facilitate revealing novel RNA functions and their genomic target regions.

76 eostatic plasticity to maintain normal brain functions and to prevent abnormal activity.

77 l for CNS homeostasis and innate neuroimmune function, and play important roles in neurodegeneration

78 fect of RDN on mean arterial pressure, renal function, and the reflex response to hemorrhage in sheep

79 These functions are differentially regulated by individual iso

80 These functions are served by distinct subtypes of mesodiencep

81 Hechtian Hypothesis translates classical AGP function as a Ca(2+) capacitor, pollen tube guide and wa

82 ) gene affect CFTR protein biogenesis or its function as a chloride channel, resulting in dysregulati

83 mologous protein, Ctr2, has been proposed to function as a low-affinity Cu transporter, a lysosomal C

84 ance pattern and causative mutation; retinal function as assessed by VA, visual fields, and electrore

85 is a hallmark of bacterial compartments that function as counterparts to eukaryotic organelles.

86 urthermore, we discovered that DLX1 and DLX2 function as direct transcriptional activators of Brn3b e

87 ses, and showed that 95.6% of tested TEs can function as either transcriptional activators or repress

88 Although mammalian Ctr1 functions as a Cu(+) transporter for Cu acquisition and

89 The transmembrane glycoprotein dystroglycan functions as a receptor for multiple extracellular matri

90 ur results suggest that MoVps17 specifically functions as a retromer component with CSC and also play

91 In particular, the C terminus functions as a toggle switch, which affects access of th

92 by RB-TnSeq, highlighting specific metabolic functions associated with root colonization genes.

93 controls, identifying microbial strains and functions associated with the disease.

94 h neonatal caffeine had improved respiratory function at 11 years of age compared with children treat

95 herapy during the newborn period and in lung function at 8 years of age in children whose birth was e

96 d breast milk with allergic disease and lung function at ages 12 and 18 years.

97 hat the yeast family members Ltc1 and Ltc3/4 function at the vacuole and plasma membrane, respectivel

98 versus distal sites may improve median nerve function at the wrist by somatotopically distinct neurop

99 the effects of mutant p53 oncogenic gain of function but also on the mechanisms underlying nonmutati

100 al energy levels are critical for proper CNS function, but the relative roles for the two main source

101 trait-based approach to predicting ecosystem function by demonstrating that different combinations of

102 cal role in endothelial cell maintenance and function by regulating eNOS activity.

103 ation of neural glycan biosynthesis and thus function can be achieved in vivo.

104 However, how living cell functions can be modulated via opsins by modifying funda

105 Severe loss-of-function cases were incompatible with life, whereas thos

106 he challenge with an alternative to the wave function-centered interpretations: instead of a quantum

107 r domain resulted in either gain- or loss-of-function changes, part of which was attributable to cyst

108 pairment of trophoblast-specific GATA2/GATA3 function could lead to early pregnancy failure.

109 This gain-of-function CRY1 variant causes reduced expression of key t

110 The pairing of both loss- and gain-of-function datasets reveals complex gene networks which co

111 requency dependence of the neuron's transfer function determine whether synchronous spikes possess a

112 ents (acute rejection [AR] and delayed graft function [DGF] before day 90) were recorded; serum creat

113 , anxiety/depressive symptoms, and executive function (differences of 0.6-0.7 SD; P=1.2x10(-3)-2.4x10

114 ches in the study of cellular and organismal functions, discuss current challenges, and present our o

115 Loss of THAP1 function disrupts a core set of OL maturation genes and

116 7 receptor function on retinal structure and function during aging.

117 study changes in both retinal structure and function during the first month following iatrogenic mac

118 ardial region-specific heterogeneity in cell function emerges during early development and how struct

119 celerated our understanding of its assembly, function, evolution, and its role in human disease.

120 Finally, gain-of-function experiments show that Pth4 can alter calcium/ph

121 her FW correlated with better neurocognitive functioning following 12 weeks of antipsychotic treatmen

122 e latter findings support a tumor suppressor function for KIND1, and identify c-Jun N-terminal kinase

123 Our data thus reveal a novel function for Nesprin-1alpha/Nesprin-1 in nuclear positio

124 o disruption of axonal transport, a critical function for neuronal survival.

125 ous gene expression in E. coli confirmed its functions for hydrolysis of AHLs, and the gene was desig

126 ledge, this is the first report of nucleolar functions for NSs within the Bunyaviridae family.

127 ic knockout further revealed Aire's critical functions for spindle assembly in preimplantation embryo

128 cts could allow PMd and PMv to play distinct functions for the control of hand movements and predispo

129 dissociating innate differences in cognitive function from cannabis-induced deficits is challenging.

130 ins have evolved to perform diverse cellular functions, from serving as reaction catalysts to coordin

131 eated CRDs enabling multivalency for various functions, galectin-3 is monomeric, and its functional m

132 gi, are phytotoxic to host plants, but their functions have not been well defined to date.

133 n 20 protein families, previously of unknown function, have been ascribed anti-CRISPR function.

134 ntermediate, and nonclassical) with distinct functions, however, the recruitment order of these subpo

135 PD) patients experience loss of normal motor function (hypokinesia), but can develop uncontrollable m

136 f excitatory synaptic transmission and their function impacts learning, cognition and behaviour.

137 esting-state functional MRI to measure brain function in 32 human fetuses in utero and found that sys

138 tated the recovery of blood vessel perfusion function in a murine hindlimb ischemia model.

139 The LTRs function in a stage-specific manner during the oocyte-to

140 t, genes associated with abdominal adiposity function in adipose tissue.

141 has been implicated in testicular and sperm function in adult males via interaction with relaxin/ins

142 ce and molecular imaging studies of dopamine function in bipolar disorder.

143 our results indicate that in addition to its function in caveolae biogenesis, Cavin-2 plays a critica

144 ost of these differentially methylated genes function in cell adhesion and communication pathways.

145 rowth factor (VEGF) regulates PRKCB promoter function in CLL cells, stimulating PKCbeta gene transcri

146 Yet, the exact molecular mechanisms of their function in complexes are largely unknown.

147 vity, here monitored on genes with a pivotal function in epithelial and hepatic morphogenesis, differ

148 that contributes to the MHC-B downregulation function in HIV-1 subtype C and show that carriage of Ne

149 ry dysplasia, but its effects on respiratory function in later childhood are unknown.

150 ecture that is fundamentally linked to their function in maintaining the kidney filtration barrier.

151 Sleep is essential for proper brain function in mammals and insects.

152 otic plaques, we examined its regulation and function in murine macrophages, compared it to the LD ad

153 nal morphogenesis and may shed light on MAP7 function in neurological disorders.SIGNIFICANCE STATEMEN

154 y come from, where they reside, and how they function in normal homeostasis and wound repair.

155 lycemic control is associated with cognitive function in older patients with type 2 diabetes who are

156 a comprehensive picture of SBT structure and function in plants.

157 Recovery of cardiac function in response to mechanical unloading was assesse

158 nel blocker apamin enhanced the input-output function in sham, although not in HF rats.

159 antipsychotic medications may affect neural function in studies of animals, healthy volunteers, and

160 rs suggests that NOD plays a cell-autonomous function in the leaf.

161 murine ortholog of LRTOMT, has an unexpected function in the regulation of mechanotransduction by hai

162 Confirmation that Sites 1 and 2 function in trans was demonstrated by examining the effe

163 tive phosphorylation, in fueling presynaptic function in unclear.

164 lutionary cooption of a morphogen-responsive function in wound repair.

165 to be at odds with the notion of lateralized functions in cerebral cortex.

166 h improved verbal memory and other cognitive functions in older men with low testosterone and age-ass

167 phosphate, and pyruvate and provides diverse functions in plants.

168 We further find that this G-actin pool functions in spine development and its modification duri

169 albicans, and it may have novel moonlighting functions in the nucleus.

170 with the extractability of GIPCs, and their functions in the plant remain poorly characterized.

171 They perform activation and repressive functions in the regulation of gene expression.

172 ulates CRPC through Twist-mediated oncogenic functions including epithelial-mesenchymal transition (E

173 wal is associated with deficits in cognitive function, including attention, working memory, and episo

174 impairments in clinically relevant cognitive functions, including general intelligence, executive fun

175 c chromosomal locus, and maintain centromere function indefinitely.

176 Our results altogether suggest that MSRB8 function is required for ETI and containment of stress-i

177 me, but direct evidence for their biological function is scarce.

178 major factor in the variation of SUMO-target function is the balance between the conjugated/de-conjug

179 his work establishes the relevance of thymic function, measured by sj/beta-TREC ratio, in HIV disease

180 sis for the signaling and pathophysiological functions mediated by 20-HETE in hypertension and cardio

181 isorder mucolipidosis type IV, and a gain-of-function mutation (Ala419Pro) in TRPML3 gives rise to th

182 by Salmonella Typhimurium because of loss-of-function mutations in Nramp1 (SLC11A1), a phagosomal mem

183 Loss-of-function mutations in the MCOLN1 gene, which encodes TRP

184 s included five de novo heterozygous loss of function mutations/deletions in the PBX homeobox 1 gene

185 riable bacterial communities to maintain the functions necessary for their nutrition.

186 Finally, we report that BEC-1/BECN1/Beclin1 functions non-cell-autonomously to facilitate cell-cycle

187 njugates without affecting the structure and function of biologically relevant proteins.

188 are known that produce proteins to block the function of class 1 CRISPR-Cas systems.

189 To test function of CLEC12A in an animal model of multiple scler

190 ox consensus sites and enhances the vascular function of converted cells.

191 t interchangeable, although the sequence and function of Domain 2 are highly conserved.

192 NF plays an important role in regulating the function of dopamine transporters in the striatum.SIGNIF

193 As the strength of this gradient is a function of extracellular solution pH, the pH-dependence

194 Loss-of-function of FRS7 and FRS12 results in early flowering pl

195 ygosity can help us relate the structure and function of gene regulatory networks.

196 To systematically study the expression and function of H1 subtypes, we generated knockin mouse line

197 and hole relaxation times are observed as a function of hot carrier energies.

198 o (trans/cis) of each stereoisomer pair as a function of intensity.

199 ulfide (Mo-S) compounds are important in the function of materials for various applications from elec

200 Hence, all the data for variance as a function of mean expression collapse onto a single maste

201 Here, we investigate the function of P. berghei P47 in Anopheles gambiae mosquito

202 dates for reactivating the tumor suppression function of p53 in cancer by dual targeting of the negat

203 mechanism that promotes the proinflammatory function of PGE2 We showed previously that PGE2 inhibits

204 changes in oxidative/nitrative stress are a function of prenatal exposure to NP/BPA and inflammation

205 y W972 within WT Arkadia is critical for the function of RING and that it depends on the nature of th

206 , Marciniak et al. identify a putative novel function of tau protein as a regulator of insulin signal

207 53/Y155 regulates a previously unappreciated function of TDP-43 in the processing of nucleolar-associ

208 We develop a mathematical model of the function of the 1,2-propanediol utilization microcompart

209 of texture indices and how they changed as a function of the activity distribution were assessed and

210 ngly dynamic systems, where the geometry and function of the device is not fixed at the point of fabr

211 lowed by dramatic deformations linked to the function of the Erythrocyte binding antigen family and P

212 The normal function of the human myocardium requires the proper gen

213 of the frequency generation performance as a function of the input pump power, the linear and nonline

214 rates that FAEE content can be inferred as a function of the intensity of organoleptic defects for sa

215 almonella enterica and use it to analyze the function of the microcompartment organelles in detail.

216 est due to their unique tunable bandgap as a function of the number of layers.

217 Significant shifts in composition and function of the oral microbiome were observed with poor

218 properties of smallest exogenous shocks as a function of the parameters that determine the endogenous

219 ert and MORM syndromes, is essential for the function of the primary cilium and maintenance of phosph

220 SRp55-mediated splicing changes modulate the function of the proapoptotic proteins BIM and BAX, JNK s

221 m pathways that compromise the integrity and function of the RPE.

222 park renewed investigation in modulating the function of these cells and developing novel strategies

223 iew, we outline the structure, evolution and function of these FASTK proteins and discuss the individ

224 din-1 may also be relevant to the biological function of these molecules.

225 ypothesis that the dorsal-ventral patterning function of Toll arose from the evolutionary cooption of

226 We showed that Mig-6 has an important function of tumor suppressor via inhibition of STAT3 pho

227 at have determined the cellular or enzymatic function of UBE3B.

228 reciated for a decade, the equally important functions of cellular lipids in virus replication have b

229 Beyond defining the functions of CTCF in chromosome folding, these results p

230 ess new areas of lncRNA biology, such as the functions of enhancer RNAs, circular RNAs and chemical m

231 Here, we review the crucial functions of KLFs in mammalian embryogenesis, stem cell

232 The functions of many RBR E3s are poorly defined, and their

233 nterleukin-27 promotes the tissue-protecting functions of neutrophils via, at least partly, the induc

234 es, are the basis for the various biological functions of O2-utilizing metalloproteins.

235 w insights into understanding the regulatory functions of RBPs, including the binding effects of the

236 Biological functions of RNA molecules are dependent upon sustained

237 However, the in vivo functions of specific microRNAs in controlling mammary s

238 cell interaction partners, and physiological functions of SPI-2 T3SS effectors in the context of the

239 probes to examine the unique and overlapping functions of the ALDH1/2 isoenzymes.

240 elopment, little is known about the specific functions of the different MLL lysine methyltransferases

241 However, the exact functions of the N-Srcs are unknown and it is likely tha

242 he DNA-binding activities and the biological functions of these proteins have been largely unexplored

243 an important role in the various beneficial functions of vaspin in different tissues.

244 estigate the effect of loss of P2X7 receptor function on retinal structure and function during aging.

245 coding protein products that regulate immune function or cell adhesion and tumor cell metastasis.

246 Genetic ablation of circadian clock function or environmental CRD in mice increased suscepti

247 acute, Koch phenomenon-like reactions), lung function, or radiology attributable to vaccine were obse

248 uced significant changes in VO2 peak, kidney function, or urine albumin-to-creatinine ratio.

249 ications built upon diverse membrane protein functions, or involved with drug targeting and delivery.

250 patient and graft survival, and stable renal function over 4 years.

251 ived neurotrophic factor (GDNF) promotes the function, plasticity, and survival of midbrain dopaminer

252 s, including general intelligence, executive function, processing speed, memory, perceptual reasoning

253 ations, implant-related complications, basic function/programming, common pacemaker-related issues, a

254 To gain insight into spanin function, pseudorevertant alleles that restored plaque f

255 most histone chaperones perform these common functions, recent structural studies of many different h

256 promoting axonal regeneration and locomotor function recovery.

257 t encounters complexes dedicated to opposing functions: recycling and degradation.

258 on parameter and the assessment of structure-function relationships of drugs using IM-MS.

259 conserved in eukaryotes, but their molecular function remains unknown.

260 The nonlinear input-output transfer function requires strong optical nonlinearity, e.g. self

261 Dysregulated Foxp3(+) Treg functions result in uncontrolled immune activation and a

262 nthesis and folding essential for riboswitch function, revealing the importance of metastable states

263 f participant's oscillatory impulse response function reverberating in alpha.

264 uggest that its aggregation and possibly its function(s) are controlled by regulatory mechanisms invo

265 ry, quantification of ventricular volume and function, stress imaging, shunt quantification, and tiss

266 cyclization products enabled stereochemistry-function studies of a series of bioactive indolines.

267 d the ability to conduct a careful structure-function study.

268 e 0.83 and 0.89 for the Local Eye and Visual Function subscales, respectively, and remained stable ov

269 RNA components have demonstrated a range of functions such as bistability, oscillation, feedback, an

270 interleukins, hemogram, and liver and renal function tests were performed at days 0 and 5.

271 the DNA demethylation cycle by promoting TDG function, TET1 nuclear localization, and TET/TDG associa

272 or binding sites using an integrative energy function that combines a knowledge-based multibody poten

273 We present a model for RecN function that includes presynaptic stimulation of the ba

274 mammals, Cks1 and Cks2, share an overlapping function that is essential for early development.

275 ne perturbation data, to incorporate logical functions that describe interactions between regulators

276 The core system is completed by additional functions that might be assumed by non-orthologous genes

277 innate-like subset of T cells with cytotoxic function, the role of which in lung immunity is unclear.

278 r NOTCH1 directly regulates vascular barrier function through a non-canonical, transcription-independ

279 Robustness of function through homeostasis may be ensured in any syste

280 sight into the mechanistic details of hm(5)C function to be obtained, the availability of RNAs contai

281 nels) in cardiac myocytes adjust contractile function to compensate for the level of available energy

282 PTTP can also efficiently function to generate singlet oxygen in situ (PhiDelta ap

283 role of linagliptin in modulating alpha cell function to restore normoglycemia.

284 Here, we introduce this dynamic utility function to several games.

285 g the brain's chronic signaling systems that function to slowly degrade molecular and cellular memory

286 R) and mannose receptor C-type 1 (MR), which functions to clear endogenous mannosylated proteins, a p

287 implicate YAP1 as a fluid mechanosensor that functions to regulate genes that promote metastasis.

288 ration of barcode primer bias by integrating functions to run digital PCR.

289 ), and CD49b, and exert strongly suppressive functions toward allergic responses induced by naive and

290 ceptor-dependent regulation of mitochondrial function via AMPK.

291 Results ERalpha transcriptional function was abolished in the mutated 231 G521R ER cells

292 Greatest impact on liver function was found in animals with polymicrobial sepsis

293 INTERPRETATION: Decline in cognitive function was more frequent with WBRT than with SRS and t

294 st for cis genetic elements required for Pxr function, we deleted the entire pxr gene from a developm

295 d sweet-taste perception system on cognition functions were examined by analyzing synaptic integrity

296 , suggesting that their innate antimicrobial functions were preserved.

297 We hypothesized that neurological function, which also depends on intracellular Ca(2+) tra

298 country, we estimate a common dose-response function, which we use to compute national electricity l

299 ignaling and plays important roles in immune function, while abnormal JAK1 activity has been linked t

300 contributes to our understanding of protein function within different Norovirus genogroups and expan