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2 cells absorb nutrients, respond to microbes, function as a barrier and help to coordinate immune resp
3 ers covering the endodermal cells and likely function as a barrier to limit transmembrane movement of
5 Hechtian Hypothesis translates classical AGP function as a Ca(2+) capacitor, pollen tube guide and wa
6 trate that NiPd-NG-Si (Si=silicon wafer) can function as a catalyst and show maximum NiPd catalysis f
8 f Sde2 into a short-lived activated form may function as a checkpoint to ensure proper splicing of ce
9 signaling molecules, the ascarosides, which function as a chemical language in this model organism.
10 ) gene affect CFTR protein biogenesis or its function as a chloride channel, resulting in dysregulati
11 in the absence of CHD1, suggesting that CHD1 function as a chromatin remodeler could indirectly affec
12 gnosed bleeding disorders, and therefore may function as a clinical diagnostic biophysical biomarker.
13 r area with corticospinal neurons that could function as a command apparatus for operation of the han
16 s etiologies, yet its role in altering brain function as a consequence of neuroinfectious disease rem
17 ut the capacity to integrate information and function as a coordinated individual is also a ubiquitou
18 firing rate showed that dopaminergic neurons function as a coupled oscillator whose frequency of disc
20 family microRNAs act in the early embryo to function as a developmental timer that preserves naivete
21 ediate, thereby demonstrating that prFMN can function as a dipole in a 1,3 dipolar cyclo-addition rea
23 ted to BDNF biology, as well as how BDNF may function as a downstream mediator of newer pharmacologic
24 cobaltochelatases, has evolved CbiK(P) a new function as a haem binding protein permitting it to act
25 by T cells and further suggest miR-24 could function as a key upstream molecule regulating TCF1-medi
26 mologous protein, Ctr2, has been proposed to function as a low-affinity Cu transporter, a lysosomal C
27 o demonstrate an important role for amygdala function as a mediator of this relationship at a very ea
28 ur observations implicate disruption in ZnT2 function as a modifier of secretory capacity and lactati
33 tify zinc as the first inorganic molecule to function as a physiological ligand for a nuclear recepto
36 e results suggest that multimeric KhpA/B may function as a pleiotropic RNA chaperone controlling pneu
37 ion of adult NSCs and identify mitochondrial function as a potential target to ameliorate neurogenesi
39 Thr(567) in the MT1-MMP cytoplasmic tail may function as a regulatory mechanism to impact ovarian can
40 These studies illustrate that Dicer1 can function as a traditional loss-of-function tumor suppres
41 tentially explaining a subsequent failure to function as a transcriptional activator of Il1a expressi
50 activate TMEM16F (or Anoctamin 6), a protein functioning as a Ca(2+)-dependent phospholipid scramblas
51 39 is upregulated in archival NSCLC samples, functioning as a decoy RNA for miR-339-3p, -663b-3p, and
52 ldhood acute B-lymphoblastic leukemia (cALL) functioning as a first-hit mutation that initiates a cli
53 he level of viral replication, as opposed to functioning as a mechanism that restricts viral entry/eg
54 of a three-dimensional (3D) anisotropic SRR functioning as a microscale inclinometer enabling it to
55 s for the perception of different EPFs, thus functioning as a specificity switch for the regulation o
56 ke) options in the prehospital setting, thus functioning as a tool for research on prehospital stroke
58 rough the SERCA2b pathway; beige fat thereby functions as a 'glucose sink' and improves glucose toler
59 e propose that GPCR signaling from endosomes functions as a biologic noise filter to enhance reliabil
62 we demonstrate that the human 7SK snRNP also functions as a canonical transcription factor that, in c
64 sed that the cellular prion protein (PrP(C)) functions as a cell-surface receptor, which binds to Abe
65 ken together, these data indicate that KHSRP functions as a checkpoint regulator of the innate immune
66 and the immunostimulatory molecule CD80 and functions as a checkpoint to regulate immune responses.
67 d call into question whether retromer indeed functions as a complex of SNX-BAR proteins and the VPS26
69 l nutrient for most life on Earth because it functions as a crucial redox catalyst in many cellular p
70 ding Cassette subfamily C2 (ABCC2) gene that functions as a Cry1Fa receptor in susceptible insects.
72 -type (WT) CAV1 in Cav1(-/-) MEFs, CAV1-P158 functions as a dominant negative by partially disrupting
73 rs, raising the possibility of whether TRPC3 functions as a downstream channel in the MRGPRD signalin
74 the mitochondrion-specific lipid cardiolipin functions as a first contact site for Bax during its tra
76 TAZ/YAP and Galphas-protein feedback circuit functions as a fulcrum balancing SC proliferation and di
77 domain has limited substrate flexibility and functions as a gatekeeper in the processing of unnatural
78 vitro assays further showed that this intron functions as a genomic enhancer where glucocorticoid rec
79 protein 13b (ARL13b) is a small GTPase that functions as a guanosine nucleotide exchange factor (GEF
80 strate that a major T. brucei PRMT, TbPRMT1, functions as a heterotetrameric enzyme-prozyme pair.
81 n by interferon beta (IFN-beta) in vitro and functions as a highly efficacious experimental vaccine.
82 nteraction network analysis reveal that CPH1 functions as a hub linking key motor and structural prot
84 that the phosphatase regulator, GADD34, also functions as a kinase scaffold in response to chronic ox
89 component of this contractile process, which functions as a membrane ratchet to ensure unidirectional
90 Scap is a polytopic membrane protein that functions as a molecular machine to control the choleste
91 consistent with the view that the C-terminus functions as a molecular sieve and stabilizer of the oli
92 of the actomyosin ring, although whether it functions as a motor or as an actin cross-linker to exer
93 7) has broad antiinflammatory properties and functions as a natural suppressor of innate inflammation
96 Under nonpathological conditions, d-serine functions as a neurotransmitter and coagonist for NMDA r
98 ence that the DDB1-CUL4A ubiquitin E3 ligase functions as a novel metabolic regulator that promotes F
99 Taken together, our data indicate that OTG functions as a novel negative regulator of Wnt signaling
101 e antischistosomal eutomer - (R)-PZQ - which functions as a partial agonist of the human serotoninerg
105 ombined structural model shows how Ragulator functions as a platform for the presentation of active R
106 at the flexible, N-terminal domain of PrP(C) functions as a powerful toxicity-transducing effector wh
111 The transmembrane glycoprotein dystroglycan functions as a receptor for multiple extracellular matri
112 ur results suggest that MoVps17 specifically functions as a retromer component with CSC and also play
113 cGAS catalyzes the synthesis of cGAMP, which functions as a second messenger that binds and activates
114 Buildup of hydrogen sulfide (H2S), which functions as a signaling molecule but is toxic at high c
116 and flow of spinal dynorphin/KOR signaling, functions as a switch, preventing or promoting, respecti
117 induces Dot1L expression, and Dot1L in turn functions as a T3 receptor (TR) coactivator to promote v
123 contributing to our understanding of how CSL functions as a transcriptional repressor of Notch target
124 -death suppressors revealed that necroptosis functions as a trap door to eliminate virally infected c
126 ific miRNA, regulates hepatic metabolism and functions as a tumor suppressor, yet systematic and dire
133 ike receptor 9 (TLR9) agonist, MGN1703-could function as an enhancer of innate immunity and an LRA in
136 on drug-seeking behavior and establish OCT3 function as an important determinant of susceptibility t
137 etion in the CF bronchial epithelium with KL functioning as an endocrine and local anti-inflammatory
138 with a multifaceted role in prostate cancer, functioning as an enhancer of the oncogenic AR signaling
140 flammatory cytokine production in microglia, functioning as an important neuroprotective factor.
141 e is indispensable for BTX actions, probably functioning as an integral part of the BTX receptor.
142 ow that BEX1 is a heart failure-induced gene functioning as an mRNA-associated protein that enhances
143 otein that encapsidates the viral genome and functions as an adapter between the virus and the host c
144 GDU1 cytosolic domain, suggesting that GDU1 functions as an adaptor or coactivator of amino acid exp
145 ne eukaryotic organism, encapsulated into Lp functions as an adjuvant to induce a robust specific CTL
146 the presence of ICP8, an HSV-1 protein that functions as an annealase, a protein that binds compleme
147 of the multi-domain REC protein, PhyR, which functions as an anti-anti-sigma factor and regulates tra
148 Once in the circulation, activated protein C functions as an anticoagulant, anti-inflammatory and reg
149 nalyses reveal that, in this context, Drosha functions as an antiviral clamp, conferring steric hindr
150 rpretation of these results is that Mediator functions as an assembly factor that facilitates PIC mat
151 b-interacting protein (TRIP8b), binds to and functions as an auxiliary subunit of hyperpolarization-a
153 known as a toxic gas, the electron-rich H2 S functions as an energy source and electron donor for che
155 that the early postnatal mammalian intestine functions as an environmental sensor of nutritional cond
157 4 is a cell surface receptor on T cells that functions as an immune checkpoint molecule to enforce to
159 emonstrate that the T4P assembly ATPase PilB functions as an intermediary in the EPS regulatory pathw
161 s in adult Drosophila melanogaster, where it functions as an obligatory allatotropin to promote juven
162 as a neuroblastoma susceptibility gene that functions as an oncogene in high-risk neuroblastoma.
163 findings offer direct evidence that Cyp24a1 functions as an oncogene in PTC, where its overexpressio
164 MP secreting mesenchymal cells (the cumulus) functions as an organizer of the dorsoventral axis.
165 17 contributes to persistent pain in EAE and functions as an upstream regulator of CaMKIIalpha signal
167 lymphocytes, in addition to their well-known function as antibody producing cells, participate in the
168 ata demonstrate that neutrophils can adapt a function as APCs and, in combination with their abundanc
169 rmation of monolayers with decreased barrier function (as assessed by transendothelial electrical res
170 ance pattern and causative mutation; retinal function as assessed by VA, visual fields, and electrore
171 ous repair cassettes that both edit loci and function as barcodes to track genotype-phenotype relatio
172 in the snoRNA, adjacent to the guide region, function as binding sites for the snoRNP proteins includ
173 sue engineering and regenerative medicine by functioning as biomimetic substrates to manipulate cellu
175 ssium channels are critical for normal brain function, as both loss-of-function and gain-of-function
176 the transcriptome of a bacterial pathogen by functioning as both a degradative enzyme and an RNA matu
177 ll other species groups that drive ecosystem functioning, as brown and green diversity components in
180 n in mural cells plays a key role in barrier function, as CRISPR-mediated knockout of N-cadherin in t
181 d the hypothesis that bone matrix components function as DAMPs for the NLRP3 inflammasome and regulat
182 s2 in a further 11 species and confirmed the function as Delta4 desaturases of Fads2 from medaka and
183 y to interfere with mSTAT3 and mitochondrial function, as demonstrated by site-directed mutagenesis a
185 urthermore, we discovered that DLX1 and DLX2 function as direct transcriptional activators of Brn3b e
187 e that plants encode proteins that appear to function as effector proteins that may regulate symbioti
188 hosphates to unwind helices, oligomerizes to function as efficient RNA helicase, and does not unwind
189 ses, and showed that 95.6% of tested TEs can function as either transcriptional activators or repress
191 results, targeting MUC1-C downregulates EZH2 function as evidenced by (i) global and promoter-specifi
192 UMBL inhibits osteoclast differentiation and function as evident by reduction in all hallmarks of ost
194 our understanding of how small molecules can function as fusion inhibitors and guides the development
196 Single band-edge states can trap light and function as high-quality optical feedback for microscale
200 seases and cancer, with such chemicals often functioning as inhibitors of key metabolic pathways or a
203 critical for the development of normal brain function, as KCNQ2 variants could lead to epileptic ence
205 d with each other, and MSI and BRAF mutation functioned as key molecular characteristics during the c
206 icates a positive role of LjNPF8.6 on nodule functioning, as knockout mutants display N-fixation defi
209 tures, such as wide continental shelves, can function as marine refugia for pelagic fauna, whereas of
212 atistically significant improvements in lung function, as measured by LCI2.5 and ppFEV1, versus place
214 teria, tRNAs with 8/4 and 9/3 structures may function as missense and nonsense suppressor tRNAs and/o
215 ogic to remind how these seven key molecules function as mobile packets of cellular currencies for ph
217 synaptic ionotropic glutamate receptors that function as molecular coincidence detectors, have critic
218 ing specific lipids from source membranes to function as molecular solubilizers that envelope their i
220 expand disability of physical and cognitive functioning as more frail, elderly individuals survive w
221 that lysenin channels have the potential to function as nano-sensing devices capable of single pepti
222 The TATAA-like, Sp1BS, and Inr elements all function as negative regulators of transcription, and ea
224 he prevailing view considered neutrophils to function as nonspecific effector cells that die quickly
228 In cancer, it exerts an immunosuppressive function as part of an acquired mechanism of immune esca
229 ation group I and D2 (FANCI and FANCD2) that function as part of the FA I-D2 complex, indicating that
231 RBA1 demonstrates that "truncated" NLRs can function as pathogen sensors, expanding our understandin
232 rrently distributed across East Africa could function as persistent groundwater hydro-refugia through
235 iscoveries include the cellular subsets that function as potential sources of alloantigens, the cross
237 tinoic acid, were further analyzed for their function as putative regulators of retinotectal map form
238 y-5-phenyl dipyrromethane derivatives, which function as ready precursors of ortho-substituted 8-aryl
239 ysosome or vacuole for degradation, can also function as recycling signal to sort a SNARE into COPI v
240 4A7 expression level, NBCn1 availability and function as reflected in elevated steady-state pHi and a
243 d angiogenesis via cytokine production; (ii) functioning as regulatory T (Treg)/T helper 2 (Th2)-like
248 f cel-mir-237 and its homolog, hsa-miR-125b, functions as sensitizers to gamma-irradiation in both a
251 stricted heterogeneous MaSC populations that function as single equipotent pools in the long term.
252 ttransplantation cyclophosphamide (PTCy) can function as single-agent GVHD prophylaxis after myeloabl
253 perience, demonstrating that these behaviors function as social environment-constructing traits.
254 erse class of essential cellular lipids that function as structural membrane components and as signal
255 ngle lineage and presumably perform the same functions as symbionts that have not undergone splitting
256 on the biologically active aziridine do not function as TbNTR or TbCPR-activated prodrugs and do not
258 ompartments of eukaryotic cells because they function as the cellular power plant and play a central
259 thelial development and homeostasis, YAP/TAZ function as the critical molecular switch to coordinate
260 50 enzymes, SbCYP82D1.1 and SbCYP82D2, which function as the flavone 6-hydroxylase (F6H) and flavone
261 he subtypes of reward-prediction errors that function as the key computational signatures of two dist
262 uropeptide and its cognate receptor, NPR-22, function as the ligand-receptor pair that defines the ne
264 ological consequences for lung stability and function as the morphological transition occurs at alveo
265 nce sections of TatC proposed to concertedly function as the primary docking site for twin-arginine s
268 t during differentiation, Set1A but not Mll2 functions as the H3K4 methylase on bivalent genes and is
269 mary driver of Treg proliferation and CTLA-4 functions as the main brake but is likely dependent on T
271 set of mouse non-peptidergic nociceptors and functions as the molecular receptor for the itch-inducin
273 tromal interaction molecule-1 (STIM1), which functions as the SR Ca(2+) sensor, and Orai1, the Ca(2+)
274 Apart from being a G2/M cyclin, cyclin F functions as the substrate-binding subunit of SCF(cyclin
275 of cell layers is essential for epithelia to function as tissue barriers and to control active tissue
277 he testis-specific isoform BRDT-that largely function as transcriptional coactivators and play critic
278 s into monomers, which enter the nucleus and function as transcriptional coactivators of plant defens
282 s) is involved in a wide class of ecological functions, as VOCs play a crucial role in plants interac
284 ults in clinical abnormalities in neurologic function as well as in skeletal and cardiac muscle defec
285 this molecule plays in normal physiological function as well as in the progression of PD and other n
286 h has implications both in understanding tau function as well as its role in disease, is underexplore
290 have altered central serotonin (5-HT) system function, as well as elevated peripheral blood 5-HT leve
291 data from synapses with normal and perturbed function, as well as for modeling the dynamics of short-
294 regulate cardiac metabolism and contractile function, as well as promoting anticontractile, anti-inf
295 n our rapidly expanding understanding of the function, as well as the dysfunction, of microglia in di
296 ains including angina frequency and physical function, as well as the role physical and role emotiona
297 0 g total fat) meal on postprandial vascular function, as well as triglyceride, glucose, and insulin
298 related with improved neurological and motor function, as well as with preservation of neuronal archi
299 l to mapping proteoforms to their biological functions as well as discovering novel proteoforms and n
300 the DROSHA repertoire of non-miRNA dependent functions as well as implicating RNA in regulating DNMT1
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