ライフサイエンスコーパス: function of @2 in

1 To probe the function of CG feedback in a causal manner, we selective

2 tistical study of the cracking behavior as a function of crystal orientation in a laser 3D-printed DL

3 We now report pacemaker function of iPSC-CMs in a canine model.

4 domains were constructed to demonstrate the function of light harvesting in a polymeric nanostructur

5 as significant implications for the proposed function of the IP in a variety of behaviors, including

6 Our results reveal a synaptogenic function of TRPV1 in a specific interneuron population i

7 athological aggregation could compromise the function of LSD1 in AD and FTD."LSD1 is a histone demeth

8 al of the present study was to elucidate the function of FXR1P in adult neurogenesis.

9 However, expression and function of Sema3E in allergic asthma has not been exten

10 sh and elucidate the unanticipated oncogenic function of RUNX1 in AML.

11 To test function of CLEC12A in an animal model of multiple scler

12 efore, we investigated the tumor-suppressive function of PTPN23 in an orthotopic transplantation mous

13 45) is solely responsible for the incomplete functioning of BdTGD1 in Arabidopsis tgd1-1 Coevolutiona

14 owever, it is unclear what the physiological functions of AhR in B cells are.

15 f CTD auto-inhibition predicts the chaperone function of Hfq in bacterial genera and illuminates how

16 We demonstrate a novel function of Id1 in BAT thermogenesis and programming of

17 -induced tumorigenesis, while the regulatory functions of FGF19 in bile acid, glucose and energy meta

18 y, systematically increase in amplitude as a function of irradiance in both anesthetized and awake, f

19 eered hydrogels could support the growth and function of primary cardiomyocytes in both two dimentina

20 binding suggests reduced numbers or altered function of immune cells in brain in early-stage schizop

21 thus further elucidate the tumor-suppressive function of FBXO32 in breast cancer.

22 genes of miR-221 and reversing the oncogenic function of miR-221 in breast cancer cells.

23 echanistic analysis of the tumor-suppressive function of PTPN23 in breast cancer supports the identif

24 These oncogenic functions of PHF8 in breast cancer confer its candidacy

25 Pigment regeneration is critical for the function of cone photoreceptors in bright and rapidly-ch

26 Recent work has begun to explore the function of autophagy in cancer metastasis, which is of

27 , these findings highlight a novel oncogenic function of circRNA in cancer progression and metastasis

28 dates for reactivating the tumor suppression function of p53 in cancer by dual targeting of the negat

29 Ventura explores the biological functions of noncoding RNAs in cancer and development.

30 The genomic functions of signaling kinases in cancer cells are manif

31 The aim of this study was to investigate the function of TNC in cardiac hypertrophy in response to pr

32 s provide additional evidence for a critical function of fibronectin in cartilage and bone.

33 Here, we investigated the function of ZapA in Caulobacter crescentus.

34 Although many studies have described the function of IRF4 in CD4(+) T cells, few have focused on

35 is thus plausible that the additional repair function of NONO, revealed in cell-based assays, could i

36 Our study uncovers a function of SRC in cell-cell communication, supported by

37 rt circuiting also may serve to restrict the function of host E3s in cells.

38 our electrophilic quinazolines modulate the function of V-ATPase in cells.

39 ther verified the inhibitory and stimulatory functions of UbVs in cells.

40 is a prerequisite for the proposed transport function of myosin-5B in cellular recycling pathways.

41 Gain and loss of function of PAPC in chicken embryos disrupted somite seg

42 This is the first report about the function of TLR3 in chicken T-cell lymphoma, especially

43 y may contribute to aberrant development and function of the amygdala in children with ASD.

44 Here, we investigate the function of TSPO in cholesterol efflux from the RPE cell

45 Beyond defining the functions of CTCF in chromosome folding, these results p

46 To investigate the function of GalNAc-T6 in colon cancer, we used precise g

47 irst time identifies a progression-promoting function of GM-CSF in colon cancer by inducing EMT.

48 rein, we report a novel chromatin-associated function of PTEN in complex with the histone chaperone D

49 e manufacturing, and drop tower testing, the function of hierarchy in conch shell's multiscale microa

50 f the hypofucosylated IgGs enhanced effector function of macrophages, which, in contrast to NK cells,

51 However, the in vivo functions of specific microRNAs in controlling mammary s

52 Our study demonstrates a critical function of NCoR1 in coordinated positive and negative s

53 conditions, while little is known about the function of DM in corneal endothelial wound healing proc

54 ithelium revealed pelage hair-type-dependent functions of NF-kappaB in cycling HFs.

55 ITIM) of Ly49A that abolished the inhibitory function of Ly49A in cytotoxicity assays.

56 onal methods investigated the expression and functions of lncRNAs, resulting in deeper appreciation f

57 nd Hoxd3 In this study, we have analyzed the function of Hoxd genes in delayed growth trajectories by

58 lpha-synuclein may disrupt the structure and function of the synapse in dementia with Lewy bodies.

59 ration of autoreactive T cells; however, the function of Smad7 in dendritic cells (DCs) remains elusi

60 med to investigate the potential therapeutic function of miR-96 in developing rats with SE.

61 s can now be defined, and the regulation and function of adipose plasticity in development and physio

62 providing a new foundation to understand the function of EWS in development and disease.

63 The in vivo function of microRNAs (miRs) in diabetic retinopathy (DR

64 w GRIN2A mutations affect the expression and function of the receptor in different ways.

65 an important role in the various beneficial functions of vaspin in different tissues.

66 provides valuable information to clarify the functions of SPIs in digestion, development, reproductio

67 capability of 8-oxoG to affect structure and function of RNA, resulting in distinct outcomes as a fun

68 The function of ABA in dormancy is rather well understood, b

69 n how these two activities contribute to the function of Pent in Drosophila wing development and SMOC

70 Here, we report the novel functions of PHF8 in EMT (epithelial to mesenchymal tran

71 scribing the histologic and noncardiomyocyte function of human myocardium in end-stage heart failure

72 However, the functions of SAM domains in Eph receptors remain elusive

73 h this stem cell factor, linking MUC1-C with function of the PRC1 in epigenetic gene silencing.

74 covered that BI1 attenuates the pro-survival function of bZIP28 in ER stress resolution and, differen

75 anges in genomic DNA methylation levels as a function of growth phase in Escherichia coli.

76 ere we characterize, for the first time, the functions of PPP1R1A in Ewing sarcoma (ES) pathogenesis.

77 Our work reveals the molecular function of Hh signaling in extrinsic sheath tissues for

78 stimate water yield and water consumption as functions of land use in Fresno County, a key farming re

79 Therefore, this study reveals a function of Aub in GSCs and their progeny, which promote

80 an improved framework for investigating the function of ion transport in health and disease.

81 However the function of PLA2R in health and in disease remains uncle

82 scovered, but much remains unknown about the functions of enteric glia in health and disease.

83 We show that the input-output function of MNCs in heart failure (HF) rats is enhanced.

84 (GFP-La(SD)), suggesting a proproliferative function of La in HEK293 cells.

85 ide an overview of the normal regulation and function of Runx factors in hematopoiesis and focus part

86 However, the function of MOF in hematopoietic stem cell (HSC) develop

87 Our findings establish a function of Nup98 in hematopoietic gene activation and p

88 Here we examined the function of these stores in hippocampal pyramidal neuron

89 We found that the functions of BRCA1 in homologous recombination (HR) and

90 wever, how L1 activity is controlled and the function of L1s in host gene regulation are not complete

91 In plants, however, the functions of autophagy in host immunity and viral pathog

92 red recruitment of MRX to the DSB, and other functions of MRX in HR including the recruitment of long

93 halography to investigate the expression and function of hippocampal oscillations in human anxiety.

94 suppression experiments indicated a similar function of PAX6 in human beta cells.

95 Heterozygous loss of function of PTEN in human subjects has a significant eff

96 establish that MRPS34 is required for normal function of the mitoribosome in humans and furthermore d

97 tic performance has been used to discern the functions of these clocks in humans outside of controlle

98 Little is known about the functions of miRNAs in IL-22/IL-17-producing T cells.

99 sion of a constitutively active PI3K rescued function of B cells in infected mice.

100 Here, we review the broad functions of histone modifications in initiating cell fa

101 in the mammalian immune response, the immune function of Cactin in insects has not been described yet

102 (IBDs), herein we investigate expression and functions of SPM in intestinal inflammation.

103 section of both conserved and virus-specific functions of UL37 in intracellular capsid trafficking.

104 ) in diabetic islets, and to investigate the function of DMRs in islet biology.

105 In the present study, we uncovered a novel function of tau in its ability to regulate brain insulin

106 er, whether dendritic morphology varies as a function of sex in juvenile mice or primary neuronal cel

107 utions provides a powerful strategy to probe functions of conserved nucleobases in large RNAs.

108 To directly demonstrate the function of LdSar1 in Ldgp63 trafficking, we coexpressed

109 In metaphase, p37 negatively regulates this function of PP1, resulting in lower cortical NuMA levels

110 llectively, we identify the lineage-specific function of CDC42 in lung tumorigenesis potentially thro

111 titutes a unique resource to further explore functions of TRPC3 in macrophage biology.

112 un-deleted macrophages highlight the central function of c-Jun in macrophages, in particular for immu

113 , our data point to a biologically important function of ALCAM in maintaining BBB integrity.

114 Whether the function of CUL9 in maintaining genomic integrity and su

115 Our findings delineate a critical function of Pten in maintaining SC quiescence and reveal

116 egmental area (VTA), supporting an important function of tau in maintaining the survival of midbrain

117 Here, to understand the function of CD36 in malaria immunity, we studied parasit

118 al a novel mechanism of EBV in diverting the functions of MYC in malignant transformation and provide

119 Here, we review the crucial functions of KLFs in mammalian embryogenesis, stem cell

120 Although the function of ANKZF1 in mammals had not been previously ev

121 The in vivo function of GAS2L3 in mammals remains unknown.

122 Many biological functions of ABA in mammals are mediated by its binding

123 This mechanism may shed light on analogous functions of POMT genes in mammals and help to elucidate

124 A primary function of 5' regions in many secretory protein mRNAs i

125 Together, these results shed light on the function of CPSF in mediating PAS-dependent RNA cleavage

126 Understanding the function of PNN components in memory processes may lead

127 it highlights some of the critical roles and functions of anodes in MFCs, strategies available for im

128 Surprisingly, and despite the antiviral functions of ISG15 described in mice, humans born with i

129 Although much is known about the functions of the kinases in mitosis, less is known about

130 disease progression remains elusive, and the function of AR in mitotically active cells is not well u

131 This work unveils a noncanonical function of ErbB2 in modulating autophagy and establishe

132 Our study reveals an isoform-specific function of gamma2-AMPK in modulating ribosome biosynthe

133 One of the functions of the cerebellum in motor learning is to pred

134 we set out to gain further insights into the function of SMARCAD1 in mouse ESCs.

135 Electrophysiological data indicate that the function of ppk29 in muscle is necessary for normal post

136 ation of a second strong allele confirms the function of PPR78 in nad5 mRNA accumulation and maize se

137 ur findings demonstrate critical and diverse functions of WDR62 in neocortical development and provid

138 To characterize in vivo the function of ZFP423 in neurogenesis, we analyzed allelic

139 The function of NKG2D signaling in NK cells has largely been

140 and NOG1-2 in Arabidopsis revealed the novel function of these genes in nonhost resistance and stomat

141 We investigated the function of G9a in normal and stressed cardiomyocytes wi

142 t specifically the role of the non-chaperone function of Hsp90alpha in normal wound closure.

143 gy targeting this complex, understanding the function of LEDGF/p75 in normal hematopoiesis is crucial

144 Entropy was a logarithmic function of ROI area in normal control tissues (aorta, p

145 Little is known about the function of TRIM14 protein in normal or disease states.

146 Thus, our results reveal a potential function of mTORC1 in nutrient-dependent regulation of g

147 We demonstrate striking functions of Orco in odorant perception, reproductive ph

148 suggesting that a common variation impacting function of genes involved in OGID influences height at

149 These findings both define a physiological function of Hedgehog signaling in olfaction and provide

150 us important to understand the structure and function of A6 in order to solve the long-standing myste

151 T5 targets have been identified, the overall function of SIRT5 in organismal metabolic homeostasis re

152 However, little is known about the function of 5-HTT in other arteries.

153 ill likely also be useful for studies of the functions of Rap1 in other biological pathways.

154 alization is essential for the stability and function of MS in P. pastoris.

155 In order to study the function of Mig-6 in P4 resistance, we generated a mouse

156 The expression and function of NMDARs in pancreatic beta-cells, by contrast

157 Although the functions of CD36 in parasite sequestration and phagocyt

158 udy a broad spectrum of issues involving the function of skin catalase in particular, and the native

159 We evaluated the function of CD55 in patients' cells, which we confirmed

160 r pattern of return of BPND to baseline as a function of time in patients with SZ and HC, suggesting

161 dge about the development, organization, and function of the omentum in peritoneal immunity.

162 These results suggest that the disrupted function of AMPARs in PFC may underlie the behavioral de

163 aims to compile the current knowledge on the functions of ErbB receptors in physiology and physiopath

164 AHisGUG was required, revealing an important function of BmThg1l in piRNA biogenesis.

165 information on their detailed structure, the function of these glycans in planta, and the mechanisms

166 To gain insight into the function of LDs in plants, we have characterized the Ara

167 PK, PrMPK9-1 Rather few data relating to the function of TDY MAPKs in plants currently exist.

168 summarizes our current understanding of the function of the cytoskeleton in podocytes and the associ

169 nancy complications associated with PTL, the functions of B cells in pregnancy are not well known.

170 ectively, our findings shed new light on the function of Bcl11b in priming lineage-specifying genes t

171 reated oocytes showed decreased quality as a function of significant enhancement in production of rea

172 Our results reveal a novel function of HDAC3 inhibitor in promoting functional reco

173 In conclusion, we report a novel function of IL-17A in promoting CD8(+) T cell cytotoxici

174 s pronounced phenotype, suggesting a loss of function of these mutants in promoting NMJ remodeling.

175 Together, our results indicate additional functions of IL-35 in promoting PDAC metastasis through

176 Here we uncover timely new functions of the SASP in promoting a proregenerative res

177 enhance the understanding of the mechanistic functions of ERG in prostate tumor biology and towards d

178 of S. aureus and enhancing the antimicrobial function of macrophages in protection against S. aureus

179 hese results suggest that PI3P regulates the functioning of Vps13, both in protein trafficking and ac

180 ue makes it possible to explicate regulatory functions of this modification in proteins.

181 This previously uncharacterized function of NuMA in rDNA transcription and p53-independe

182 ve DA fibers, supporting a regional specific function of ALDH1A1 in regulating dopamine availability/

183 Consistent with the function of C/EBPalpha in regulating the balance between

184 We demonstrate a new function of DRP1 in regulating collagen secretion and ca

185 These data unravel the novel function of FANCJ helicase in regulating SCR and SCR ass

186 This study not only reveals an important function of NAC1 in regulating glycolysis, but also iden

187 entification of this previously unrecognized function of the CSN in regulating EGFR neddylation has b

188 These results corroborate the suggested function of these neurons in regulating the gain of thal

189 These results demonstrate that the functions of CUL9 in regulating cell proliferation and m

190 Together, these results reveal important functions of DDX5 in regulating reprogramming and highli

191 Here we demonstrate new functions of Naf1 in regulating HIV-1 persistence.

192 ct PPARdelta target gene and suggest a novel function of PPARdelta in regulation of phospholipid meta

193 Together these findings highlight the function of PRDM13 in repressing the activity of bHLH tr

194 Previous studies have revealed an oncogenic function of YAP in reprogramming glucose metabolism, whi

195 hese predictions have revealed the dynamical function of GRNs in response to environmental variation.

196 aluate orientation decoding performance as a function of stimulus location in retinotopic cortex.

197 ining evolutionarily conserved and divergent functions of LANA homologs in Rhadinovirus infection and

198 ingle-atom and abasic substitutions to probe functions of conserved nucleobases in ribonuclease P (RN

199 taminylation is not essential for the normal functions of eEF1A in S. cerevisiae However, eEF1A gluta

200 in this study provide new insights into the function of SlCBL10 in salt stress tolerance.

201 erase (GmSHMT08); however, the novel gain of function of GmSHMT08 in SCN resistance remains to be cha

202 However, the function of hRetn in sepsis, or whether hRetn influences

203 and FHR-B proteins antagonize the protective function of FH in sheep erythrocyte hemolytic assays and

204 BPN1, which could provide insight into novel functions of PABPN1 in skeletal muscle and identify prot

205 ors strongly suppress the enhanced enzymatic function of mutant EZH2 in some lymphomas.

206 Essential functions of nitrogen transporters in source and sink or

207 PTMs), creating a PTM code that controls the function of proteins in space and time.

208 Understanding functions of proteins in specific human tissues is essen

209 esults provide a comprehensive survey of the functions of Huwe1 in spermatogenesis and reveal Huwe1's

210 To further understand the function of myospryn in striated muscle, we searched for

211 Thus, inhibition of the coactivation-function of Stat3 resulted in suppression of expression

212 We report an unexpected function of Plk1 in sustaining cardiovascular homeostasi

213 We propose that an auxiliary function of Swc5 in SWR is to assist H2A ejection as H2A

214 etes and obesity are well characterized, the function of D-mannose in T cell immune responses remains

215 unctions are attributed to its products, the function of 5-LO in the tumor microenvironment remains u

216 ty to metabolic stress and uncover a pivotal function of BAP1 in the regulation of the ER stress gene

217 Our data reveal a new noncanonical function of DGCR8 in the modulation of the alternative s

218 NF plays an important role in regulating the function of dopamine transporters in the striatum.SIGNIF

219 harmacology, expression pattern, and in vivo function of ELA peptides in the adult cardiovascular sys

220 jor goal of biomedicine is to understand the function of every gene in the human genome.

221 d zebrafish as a model organism to study the function of EYS in the retina.

222 Loss of function of FBXW7 results in the stabilization of numero

223 However, neither the region-specific function of FOXP2 in the brain, in particular the cerebe

224 However, the function of HBc in the occurrence and development of liv

225 However, the immunoregulatory function of ILC2s in the inflamed liver remains elusive.

226 prolactone) scaffold maintains viability and function of islets in the subcutaneous site.

227 The function of KCTD13 in the mammalian brain, however, rema

228 Interestingly, the synaptic regulatory function of leptin in the LHA-to-VTA neuronal pathway is

229 rk, we demonstrate an alternative inhibitory function of lipids in the prion conversion process as as

230 In summary, we describe an anti-inflammatory function of miR-100 in the vascular response to injury a

231 te immune cells in vitro Here, we assess the function of ML exosomes in the development of T/HS-induc

232 In this study, the function of MMP9 in the tooth development was examined b

233 ss of this protein affects the structure and function of neurons in the hippocampus.

234 erium tuberculosis Here, we describe a novel function of P27 in the interaction of M. bovis with its

235 oteins can help in elucidating the molecular function of proteins encoded in the organellar genomes.

236 xport signals, but little is known about the function of Prp40 in the export process.

237 haracterize the subcellular distribution and function of PS in the rod-shaped, polarized fission yeas

238 and proposed a tentative explanation of the function of PsbQ' subunit in the PSII complex.

239 In the past several years, the function of PXR in the regulation of xenobiotic metaboli

240 In filamentous fungi, the protective function of RNAi in the maintenance of genome integrity

241 us, elucidating the chemical composition and function of specialized metabolites in the rhizosphere i

242 hat GLYX-13 rapidly increases the number and function of spine synapses in the apical dendritic tuft

243 agnostic marker, and further analysis of the function of TAp63 in the mammary gland is critical for i

244 tic insight, there is a need to identify the function of TCF4 in the brain.

245 53/Y155 regulates a previously unappreciated function of TDP-43 in the processing of nucleolar-associ

246 2+) transient that have implications for the function of the atrial in the elderly.

247 lls in inflammatory diseases, we studied the function of these cells in the nephrotoxic nephritis (NT

248 ence, and further study of the structure and function of these elements in the genome of mosquitoes m

249 The speculative function of this CDP in the carbohydrate metabolism of T

250 However, the location and function of TRPV1 in the hippocampus is debated.

251 ed the inducible Cre-lox system to study the function of TSC in the remyelination of a focal, lysolec

252 These studies reveal a novel function of ubiquitination in the regulation of group I

253 Thus, the lesion search function of XPC in the genomic context is controlled by

254 eir chaperone activity in vitro, the in vivo functions of alphaB-crystallin in the maintenance of bot

255 The functions of blood flow in the morphogenesis of mammalia

256 However, the functions of GLIS3 in the thyroid gland and the mechanis

257 We review here sentinel functions of IELs in the maintenance of the mucosal barr

258 Specific functions of JAK1 in the context of hematopoiesis, and s

259 Overall, we conclude that the different functions of Mss116 in the biogenesis and functioning of

260 In the years since, the known functions of Reelin signaling in the brain have expanded

261 In contrast, little is known about the functions of SmgGDS in the nucleus, or how these nuclear

262 In this review, we describe the functions of this molecule in the context of cancer immu

263 tures, thus demonstrating nonbarrier-related functions of TJ proteins in the skin.

264 ted to chronic progressive fibrosis, but the function of PLD4 in this process is unknown.

265 The functions of cortactin phosphorylation in this process,

266 performed a complete characterization of the functions of Huwe1 in this process by examining the effe

267 Our studies suggest a critical function of REEP6 in trafficking of cargo via a subset o

268 To assess the generality of the observed function of Clp1 in transcription, we tested the effect

269 Furthermore, we demonstrate that the function of LKB1 in Tregs is largely independent of the

270 In vivo interrogation of the function of genes implicated in tumorigenesis is limited

271 transcriptional regulators that mediate the function of SEMA3s in vascular growth are poorly underst

272 Evidence suggests a physiological function of alphaS in vesicle trafficking and release.

273 ells blocks exocytosis without affecting the function of Sec3 in vesicle tethering.

274 reciated for a decade, the equally important functions of cellular lipids in virus replication have b

275 ynaptic connectivity toward appreciating the function of telodendria in visual signal processing.

276 bl2 domain is not required for the catalytic function of MERS PLpro in vitro.

277 n-chips, that recapitulate the structure and function of native tissues in vitro, have emerged as a p

278 nd were required for the differentiation and function of Tr1 cells in vitro and in vivo.

279 PSC-derived EVs can influence the biological functions of cardiac cells in vitro and to compare the s

280 w animal models are needed to understand the function of APOL1 in vivo We generated transgenic Drosop

281 Current investigations into the function of CLEC-2 in vivo have focused on knockout (KO)

282 at interest for further investigation of the function of KARs in vivo and may prove useful for pharma

283 To specifically study the function of LCs in vivo, without altering the DC subset

284 e, which provide insight into defects in the function of neural circuits in vivo and provide an appro

285 ng of the effect of disease pathology on the function of neural circuits in vivo This work describes

286 These results shed new light on the function of Parkin in vivo.

287 To better understand the function of PR3 in vivo, we generated a human PR3 transg

288 signal transduction in vitro To explore the function of Ric-8b in vivo, we generated a tissue specif

289 enerated mouse serves as a tool to study the function of ZC3H14 in vivo.

290 While IVM had no major impact on the functions of dendritic cells in vivo and in vitro, IVM i

291 he plus-end localisation and cargo transport functions of dynein in vivo.

292 DNA polymerases and indicates potential new functions of hpol eta in vivo.

293 pment and provide key tools for defining the functions of Myo10 in vivo.

294 , providing both a model to study the normal functions of these cells in vivo and mutants to explore

295 However, regulation of the pathologic functions of these cells in vivo is poorly understood.

296 gineering while preserving the viability and functions of these cells in vivo.

297 More animal models are needed to assess the functions of these genes in vivo, and to determine how t

298 kout (Mll1(f/f)Lyz2(Cre+) ) to determine the function of MLL1 in wound healing.

299 at the interaction with Skp1 is an essential function of Sgt1 in yeast.

300 smic CR domains are required for the in vivo function of Pcdh15a in zebrafish hair cells.SIGNIFICANCE