ライフサイエンスコーパス: functional

1 imaging of beating cardiomyocytes provides a functional 3D map of active ECC couplons (on average, 17

2 clear phagocytes and exerts immunoregulatory functional activities on lymphocytic and nonlymphocytic

3 affinity, and the reduction in differential functional activity against the sensitive and Pgp overex

4 Herein, we report the measurement of MRP1 functional activity in individual cancer cells using sca

5 -invariant synaptic transmission delays as a functional adaptation for input timing adjustment in a b

6 en SCs become myelinating, they downregulate functional AMPARs.

7 Moreover, the study demonstrates that functional analyses of genes carrying DNMs are warranted

8 The functional analyses showed that the mutation results in

9 Functional analysis found that the RNA structure in MYB3

10 Functional analysis showed that such a reduced respirato

11 Functional analysis with miRNA mimics in cellular models

12 As such, functional and anatomical measures provide independent a

13 timated myeloarchitecture, indicating shared functional and anatomical organization that may underlie

14 discuss recent progress made in the field of functional and artificial amyloids and highlight connect

15 Confocal microscopy was used to study functional and bioenergetic parameters in cardiomyocytes

16 er, or a regulator of Ctr1 activity, but its functional and evolutionary relationship to Ctr1 is uncl

17 ng a combination of first-principles density-functional and many-body calculations.

18 est as these cells may possess a coordinated functional and molecular phenotype which can be targeted

19 e determined that chrysophanol inhibited the functional and morphological features of MNU-induced ret

20 This combined functional and mutational pathway assessment of a single

21 The development of functional and personalized holographic devices in the v

22 he dermis and epidermis and control both the functional and reparative capacity of the skin.

23 protein biophysics for sample manipulation, functional and structural studies, detection and materia

24 indicate that recently acquired BGCs can be functional and that complex evolutionary processes shape

25 sm underlying the response at an anatomical, functional, and behavioral level.

26 These applications include functional annotation, disease gene prioritization, comp

27 nt allele advantage hypothesis, we show that functional aspects of allelic diversity help to elucidat

28 therefore, recommend studying structural and functional aspects of ligand interactions with purified

29 n H2S signaling that affects mechanistic and functional aspects of several biological processes such

30 Here we utilize a functional assay to assess the ex vivo drug sensitivity

31 In a functional assay, 1b displayed full antagonist activity

32 Radioligand binding studies and functional assays that use human receptors expressed in

33 hotspot residues, in silico predictions, and functional assays were all informative in distinguishing

34 nt Health Questionnaire, PTSD checklist, and Functional Assessment of Cancer Therapy-Bone Marrow Tran

35 species) to test six possible morphological-functional associations between FF volume and ecological

36 thin individual genes that have differential functional associations: these include PTEN, FUBP1, and

37 emerging Vss subfamilies displayed a higher functional avidity for their cognate antigen than Vss su

38 minant response to the Gag293 epitope with a functional avidity intermediate between that of controll

39 ented granule cell dysmaturation, restored a functional balance of gamma-band network oscillations, a

40 of other tissues-suggests the existence of a functional basis.

41 Systems chemistry aims to emulate the functional behavior observed in living systems by constr

42 Functional, biochemical, and morphological characterizat

43 fold more interactions (>500,000) and better functional biological relevance than comparable resource

44 ng Independent Components Analysis to obtain functional brain components from 98 healthy participants

45 in function that underlies hemodynamic-based functional brain imaging techniques.

46 nce of identifying normative trajectories of functional brain maturation.SIGNIFICANCE STATEMENT Altho

47 cluding 9 low-frequency variants pointing to functional candidates.

48 composites exhibiting unique structural and functional capabilities.

49 ents a valuable opportunity to replenish the functional cells to the heart.

50 Here, we report the first functional characterization of PRX17 (At2g22420), one of

51 Functional cholangiocyte differentiation was demonstrate

52 I enables network-wide, tunable, all-optical functional circuit mapping that captures supra- and subt

53 ere comparatively appraised in terms of both functional cohesion and intra-subnetwork association str

54 These mechanisms are vital to the functional competence of the eye, a fact underscored by

55 exclusion chromatography (SEC) demonstrated functional complexation with human growth hormone bindin

56 s study provides prospective validation that functional connectivity between an individual's rTMS cor

57 mantic prediction and enhanced resting-state functional connectivity between hubs of the reading/lang

58 the anterior cingulate cortex showed weaker functional connectivity in at-risk than control particip

59 Seed-based analyses demonstrated reduced functional connectivity in frontal brain regions and inc

60 ivity in frontal brain regions and increased functional connectivity in posterior brain regions of po

61 ttempters, reductions in amygdala-prefrontal functional connectivity may be associated with severity

62 Functional connectivity metrics have been widely used to

63 etween Tau-PET imaging with F(18)-AV1451 and functional connectivity MRI (fcMRI) in the context of am

64 Obesity is linked to alterations in the functional connectivity of dorsal striatal networks rele

65 Additionally, interhemispheric functional connectivity of the bilateral precentral gyri

66 The resting-state functional connectivity of the following three regions w

67 s. slow) genotype individuals showed greater functional connectivity strength among smokers but not n

68 in utero and found that systems-level neural functional connectivity was diminished in fetuses that w

69 Functional connectivity was examined by cross-correlatin

70 ome based on that lesion's unique pattern of functional connectivity, without the need for pre-existi

71 Here, we outline a novel concept of functional connectome-wide alterations that are linked t

72 associated with increased modularity of the functional connectome.

73 These modifications have significant functional consequences as indicated by profoundly highe

74 M1056I, and R1150Q/R1150W) and investigated functional consequences using macroscopic rubidium ((86)

75 Functional consequences were investigated by RNA studies

76 EADD mouse lines to further characterize the functional contributions of Cre defined populations.

77 es identified by our screen, we compared the functional contributions of P. simiae genes to growth in

78 However, the interchangeability, functional cooperation and relative contributions of Wnt

79 humans, tolerance of the loss of one or both functional copies of a gene is related to the gene's cau

80 ic progression depends on tight physical and functional coupling of recombination steps at the DNA le

81 Functional CREB signatures were extracted from the trans

82 HBV functional cure is sustained hepatitis B surface antigen

83 e activation, primarily due to numerical and functional deficiencies of Treg cells in the periphery.

84 tment at P15 despite the profound vestibular functional deficits that persist with treatment at this

85 To investigate the structural and functional determinants of pattern separation we built m

86 Little is known about the functional development of individual neurons in vivo.

87 patients (88%) were alive and free of major functional disability, with minimal clinical symptoms.

88 This novel functional dissociation of pain processing within the in

89 The implications of this functional diversity for the regulation of neuronal proc

90 vertebrates and exhibit some of the greatest functional diversity of all vertebrates.

91 al 'silent code' mechanism that controls the functional diversity of protein isoforms.

92 factor expression with CD4(+) Th2 cells, but functional diversity of the ILC2 lineage has yet to be f

93 neous lymphocyte-associated antigen (CLA), a functional E-selectin ligand (ESL), is selectively expre

94 ternative cell sources capable of generating functional ECs.

95 lecular interactions and the organization of functional elements in order to gain control over the sp

96 l EPOS control criteria at 3-5 years after a functional endoscopic sinus surgery (FESS) and correlate

97 Overall, our findings offer functional evidence that complement activation serves as

98 cells lacking mitochondrial DNA (mtDNA) with functional exogenous mitochondria and selection in a res

99 Biochemical as well as functional experiments revealed that Spt6 could compete

100 Our results demonstrate that CATH functional families can be used to identify drug-target

101 Using a fully functional fluorescent version of Arabidopsis thaliana F

102 natural antioxidative and anti-inflammatory functional food ingredients was demonstrated in the pres

103 Honey is a functional food widely consumed.

104 results reinforce that strawberry fruits are functional foods that can act as an adjuvant in the trea

105 r conditions for which growth has a specific functional form.

106 f a family of nonempirical semilocal density functionals, from the basic local density approximation

107 perform gene set analysis using data-defined functional gene signatures.

108 Functional genome annotation predicts that at least 66 p

109 Expanded data content is mostly genomic and functional genomic data while new data types include pro

110 ries of variable size and coverage depth for functional genomics application.

111 ese two species and their comparisons at the functional genomics level to support tailor-designed bre

112 Here, we show using functional GFP reconstitution experiments that Kenyon ce

113 nctionalized with the most electron donating functional group (p-(CH3CH2)2NPh-MoS2) is the most effic

114 , the first polymer to contain the ladderane functional group, was synthesized from a gemini monomer

115 d with the electron donating strength of the functional group.

116 carbon center bearing a C(sp(3)) organoboron functional group.

117 e derivatives can be prepared with excellent functional-group compatibility.

118 stal and geometric relationships between the functional groups and C-H bonds of a substrate has been

119 S) that provides proteins with two different functional groups for post-translational labeling at the

120 For secondary amino ozonides, additional functional groups had variable effects on metabolic stab

121 t Fe(II) was complexed primarily by carboxyl functional groups in reduced NOM.

122 ad understanding of the impact of individual functional groups on the success of a transformation und

123 l double bonds, number of methyl- and ethyl- functional groups, molecular weight, and number of ring

124 ing new conditions that tolerate challenging functional groups.

125 eraction with the negatively charged surface functional groups.

126 the Xi and found 30 genes clustered in seven functional groups.

127 s compatible with a range of redox-sensitive functional groups.

128 termediates enable the reduction of multiple functional groups.

129 the Fc region of human IgG, creating a fully functional homodimer (or "lysibody") with high-affinity

130 terest for the development of III-V/graphene functional hybrid heterostructures.

131 t animal model for this syndrome, displaying functional hyperdopaminergia and neurodegenerative pheno

132 Here we report on functional identification and characterization of a nove

133 bstitution degree up to four NOTAs was still functional; (iii) circular dichroism (CD) analysis confi

134 Functional imaging and gene expression studies both impl

135 Here, we use in vivo functional imaging to identify a class of cutaneous sens

136 ing events are defined in the mouse, yet the functional impact of most is unknown.

137 mutation imparts subtle if any structural or functional impact on RNAP in the absence of RIF.

138 elligence quotients, supporting their strong functional impact.

139 sruption of the ELM, and significant macular functional impairment (RS decrease) vs SND-.

140 We examined functional impairment and impairment in activities of da

141 el mice, that such defects may contribute to functional impairment in DS, and that these phenotypes,

142 re adaptations to ageing-induced atrophy and functional impairment is still unsettled.

143 ients older than 60 years of age with severe functional impairment.

144 n define a novel cluster of amino acids with functional importance in the regulation of type I interf

145 But how this occurs, and the functional importance of S-nitrosation sites across the

146 To reliably predict the functional importance of single isolated UMCs across the

147 pulsatility on treatment are associated with functional improvement in patients with HF and reduced e

148 The lack of functional improvement post-TAVR was predicted by a mix

149 ta demonstrated that ASP might be a valuable functional ingredient to create a reducing environment i

150 viously unknown co-associations and provides functional insights into hundreds of poorly characterize

151 of this critical cytokine and we reveal its functional interaction interface with high-affinity liga

152 wall composition is further supported by its functional interaction with BasA (sphingolipid biosynthe

153 d a stable Rca hexamer ring and analyzed its functional interaction with Rubisco.

154 Investigations of putative functional interactions between these regions are compli

155 Functional interplay between tumour cells and their neop

156 3'UTR 16-mer sequences for the generation of functional levels of VSG expression in bloodstream form

157 iceosomal association of Cactin/Cay1, with a functional link between Sde2 and Cactin further supporte

158 tic search for post-mortem, pharmacological, functional magnetic resonance and molecular imaging stud

159 reversal learning task during acquisition of functional magnetic resonance imaging (fMRI) in a 2-drug

160 We measured brain activity with functional magnetic resonance imaging (fMRI) in voluntee

161 ion of real-life sounds from high-resolution functional magnetic resonance imaging (fMRI) response pa

162 st amisulpride] in humans with resting-state functional magnetic resonance imaging and clustering met

163 s, psychiatric assessment, and resting-state functional magnetic resonance imaging in a cross-section

164 Functional magnetic resonance imaging included a resting

165 aracter that impacts the development of many functional materials and systems.

166 By investigating a wide variety of functional materials, general criteria for solid-state e

167 at promise for the tailor-made design of new functional materials.

168 structural patterning goes hand-in-hand with functional maturation of the entire heart.

169 many miRNAs is dramatically regulated during functional maturation of the mouse visual cortex with mi

170 ted timing of human neuron specification and functional maturation remains a key challenge that hampe

171 Molecular dynamics simulations and density-functional methods were then used to explore solvation s

172 Knock-out mice without functional mGluR5 exhibit severe dysregulation of sleep-

173 nd progenitor compartments with emergence of functional mIDH2 neutrophils were observed.

174 al post-transcriptional process that creates functional mitochondrial mRNAs in Kinetoplastids.

175 learning, perception, or production of song, functional models of HVC activity may need revision to a

176 As a result, such conserved functional modules can be identified through comparative

177 There are mainly five functional modules in TFBSbank aimed at characterizing C

178 The boroxole functional monomer bound the sugar templates through cis

179 h Parkinson's disease using an event-related functional MRI (fMRI) experiment design.

180 essment for simultaneous PET scanning during functional MRI studies was performed with a spiral in-an

181 We applied novel fetal resting-state functional MRI to measure brain function in 32 human fet

182 e, then verbally described the events during functional MRI, producing unguided detailed descriptions

183 functions, galectin-3 is monomeric, and its functional multivalency therefore is somewhat of a myste

184 The plethora of methods for functional neural imaging can be daunting to the nonexpe

185 Functional neuroimaging data showed that amygdala respon

186 Modern functional neurosurgery for movement disorders such as P

187 Overexpression of functional NMDAR in non-neuronal cells results in cell d

188 flow cytometry to show that ICAP1 contains a functional nuclear localization signal and that nuclear

189 we prioritized approximately 100 putatively functional ones located in neuronal OCRs, including rs11

190 sed to enhance charge transfer efficiency in functional organic electronic materials.

191 vide independent and converging evidence for functional organization into striped-based subdivisions

192 pinal cord preparation, here we identify the functional organization of muscle and cutaneous afferent

193 year was independently associated with poor functional outcome (P = 0.04), poor cognitive outcome (P

194 t a model in which EAP deficits lead to poor functional outcome via impaired cognition and increased

195 tically augmenting efferocytosis may improve functional outcomes by both reducing tissue injury and p

196 specific activation of Smad3 has contrasting functional outcomes that may involve activation of an in

197 ible to identify network motifs that lead to functional outputs such as bistability or oscillations.

198 involved in reversible exchange processes as functional paramagnetic probes.

199 Change in these functional parameters was compared between the 2 arms as

200 efer to as colloidal fusion, for fabricating functional patchy particles in a tunable and scalable ma

201 intratumoral CD8(+) T cells acquired a more functional phenotype characterized by downregulation of

202 ty, as they have the ability to switch their functional phenotypes during inflammation and recovery.

203 rogramming, manipulate the genome, or select functional phenotypes.

204 cently introduced silicon chip coated with a functional polymer named copoly(DMA-NAS-MAPS) to the sim

205 ubunits play pivotal roles in assembling the functional polymerase complex, which is essential for th

206 Functional prediction was used to investigate the effect

207 and temperature during grain storage on the functional properties and isoflavone profile of soy prot

208 y demonstrates a novel route to the enhanced functional properties in the material system with reduce

209 ytokines, and growth factors (GFs) influence functional properties of key cells in RA, especially syn

210 response to sodium channel blockers and the functional properties of mutations in children with SCN2

211 ve limitations in providing insight into the functional properties of particular nucleosomes in their

212 yzanol recovery followed by improving of the functional properties of rice bran.

213 SF is a feasible alternative to increase the functional properties of yogurts.

214 content, yerba mate beverages maintain their functional properties such as antioxidant, antibacterial

215 e protein arrays (RPPA) represent a powerful functional proteomic approach to elucidate cancer-relate

216 ular levels were now applied to assess their functional quality: (i) size exclusion chromatography (S

217 spite significant improvement, molecular and functional readouts were not completely reversed by ammo

218 on improves coordinated locomotion, and this functional recovery is accompanied by preservation of my

219 are more stringently required, likely due to functional redundancy in the latter.

220 sly marginal species can achieve a degree of functional redundancy, and that their compensatory herbi

221 lts show that erosion of X. laevis genes and functional regulatory elements is associated with repeat

222 Determining the functional relationship between Tau phosphorylation and

223 However, the regulatory and functional relationships between Twist1 and Foxa1 in bre

224 ematically derive rules governing structural-functional relationships.

225 The functional relevance of the gut mycobiome was confirmed

226 thways are active in the basal state and the functional relevance of the observed tonic signaling het

227 the polyanionic substrate, and confirmed the functional relevance of these amino acids using a target

228 However, the functional relevance of this strong collecting duct epit

229 bset of genetic variants more likely to have functional relevance.

230 ed hCPCs antagonizes senescence and improves functional responses.

231 The functional role of IL-27 and CD301b(+) cells is demonstr

232 Here, we evaluated the biological and functional role of p21-activated kinase 4 (PAK4) and its

233 sly identified HS binding site, suggesting a functional role.

234 many different cell types that have distinct functional roles and are subject to different evolutiona

235 rotrusions but the underlying mechanisms and functional roles are not known.

236 AtBAG7 has functional roles in both the ER and the nucleus.

237 egion on HA is severely constrained by their functional roles in engaging the host receptor and in me

238 (RBPs) is important for understanding their functional roles in gene expression regulation.

239 e their patterns of connectivity and ascribe functional roles in reinforcement.

240 In this study, we identify new functional roles of RASSF4.

241 NAs is the initial step in determining their functional significance in ageing and osteoarthritis, an

242 As debates continue over the functional significance of many specific lncRNAs, suppor

243 re likely to be of value in interpreting the functional significance of mutations in the CTLA-4 pathw

244 However, the detailed functional significance of the vast majority of them rem

245 promoters, and alternative splicing, but the functional significance of this evolutionary conserved d

246 d with distributed cortical regions, yet the functional significance of this extensive thalamocortica

247 mplex containing beta-catenin and HMGA1 have functional significance.

248 ion regulation on cellular stress and reveal functional similarities to the mammalian system.

249 features, and divisive, to split groups when functional site features suggest distinct functionally-r

250 erative, to add sequences containing similar functional site features, and divisive, to split groups

251 ctions can greatly expand the structural and functional space of supramolecular nanostructures.

252 ng of fine-grained memory detail, supporting functional specialization of hippocampal-cortical networ

253 The results demonstrate functional specialization of the left dHb-IPN pathway in

254 sensory deprivation relates to the original functional specialization of the reorganized brain regio

255 ue called 'sieve analysis', one can identify functional specificities of vaccine-induced immune respo

256 activity, and interaction contribute to PIN functional specificity.

257 R provided a promoter and the 5' exon with a functional start codon while the bulk of the protein-cod

258 Here, we demonstrate that hamsters devoid of functional STAT2 are highly susceptible to as few as 10

259 at home, managed by dialysis staff, improves functional status in adult patients on dialysis.

260 ere receiving long-term opioids had multiple functional status markers that were modestly poorer even

261 justed odds ratio, 1.9; 95% CI, 1.4-2.6); no functional status markers were improved by long-term use

262 profiling, integrative network analysis, and functional studies define landscapes of the T cell prote

263 The availability of probes for functional studies of mammalian Nav is limited.

264 In addition, functional studies reveal reduced force generation and a

265 Functional studies revealed that SLC25A46 may play an im

266 d prioritizing clinically relevant genes for functional studies, developing reference variant-phenoty

267 e serotonergic neuronal system, borne out in functional studies, for the modulation of distinct facet

268 These include enhanced functional studies, generation of oncolytic virus vector

269 assification of effectors as well as for the functional study of effector uptake mechanism not only i

270 t ICP monitoring is associated with improved functional survival of children with severe TBI.

271 uncovers Vangl2-Dvl interaction as a key bi-functional switch that underlies the central logic of PC

272 -mediated DNA damage response that occurs on functional telomeres following replication in G2.

273 ary computed tomography angiography (CTA) or functional testing (exercise electrocardiography or nucl

274 Density functional theory (DFT) calculations on these reactions,

275 ur combined experimental results and density functional theory (DFT) calculations reveal that the sur

276 Density functional theory (DFT) is used to calculate the energy

277 ein ChoX, as revealed by crystal and density functional theory (DFT)-optimized structures, which bind

278 rved KIE for three isotopologues and density functional theory calculations reveal that a stepwise tr

279 Density functional theory calculations yielded vibrational modes

280 studies, in tandem with theoretical density functional theory calculations, demonstrate that the non

281 al measurements, in combination with density functional theory calculations, show distinct layer-depe

282 )H solid-state NMR spectroscopy with density functional theory calculations, we show that, for ringwo

283 cal models developed with the aid of density functional theory calculations, which account for the ob

284 s simulations and quantum-mechanical density functional theory calculations.

285 magnetic resonance spectroscopy and density functional theory, that a six-porphyrin nanoring templat

286 es, and uses tools and concepts from density functional theory.

287 lower prices of the test; (3) strengthening functional tiered laboratory networks and systems to exp

288 rrelations between species sensitivities and functional trait values can thus help to identify when e

289 demonstrating that different combinations of functional traits can act to maximize ANPP in a given en

290 We found that the functional traits characterizing Arctic fish communities

291 mation should spur the search for additional functional traits or other processes underlying communit

292 ents that lead to the replacement of single, functional tumor suppressor genes by the mutant alleles.

293 Here, we describe functional units, at a cellular level, of a compound eye

294 s exclusively on statistical association, so functional validation is necessary to make strong claims

295 al's genetic architecture, thus enabling the functional validation of known genetic risk factors and

296 Identification and functional validation of oncogenic drivers are essential

297 Functional validation of this transporter gene revealed

298 significant associations were found for rare functional variants in BBS1, BBS9, GNAS, MKKS, CLOCK and

299 Altogether, our results provide a functional view of the Bam35 viral proteome, with a focu

300 eneral-purpose nature of the class of vdW-DF functionals, with particular consequences for predicting