ライフサイエンスコーパス: functional activity

1 found between regional diffusion metrics and functional activity.

2 individuals and controls in conflict-related functional activity.

3 mice and to characterize their phenotype and functional activity.

4 close to residue 24 were also important for functional activity.

5 ydrolyze protein, peptide separation and its functional activity.

6 ghest affinities were investigated for their functional activity.

7 was model-derived steady-state trough C1-INH functional activity.

8 dendrimers can enhance binding affinity and functional activity.

9 lls that display enhanced antibody-dependent functional activity.

10 , we examined the role of NBS1 in macrophage functional activity.

11 r cognitive control and increased prefrontal functional activity.

12 ly cleaved protein with no ligand binding or functional activity.

13 s associated with a considerable increase in functional activity.

14 tle is known about their receptors and their functional activity.

15 ined three-dimensional structures to acquire functional activity.

16 in expression and a substantial decrease in functional activity.

17 t, to date, very little is known about their functional activity.

18 of great importance for characterizing their functional activity.

19 ibatidine determined that all mutants retain functional activity.

20 ATF-1 required phosphorylation for full functional activity.

21 ctured substrate prime the chaperone for its functional activity.

22 antibodies that interfered with each other's functional activity.

23 the role of human IgG subclasses on antibody functional activity.

24 ll lines, and this was related with a higher functional activity.

25 al scaffold and display receptor binding and functional activity.

26 cellular signaling events with NMDA-mediated functional activity.

27 ives was prepared and assayed for their PPAR functional activity.

28 s, thereby disrupting protein expression and functional activity.

29 soluble intracellular receptor fragment with functional activity.

30 eins that require ubiquitin binding for full functional activity.

31 e RNA-binding protein motif that retains its functional activity.

32 directly to protein synthesis and downstream functional activity.

33 ly correlated with an impairment in MBL-MASP functional activity.

34 with heterogeneity to predict areas of true functional activity.

35 ther increased in patients with lower C1-INH functional activity.

36 whole blood, sera from immunized mice showed functional activity.

37 reported to exhibit bio-functional or techno-functional activities.

38 g expression, activation, proliferation, and functional activities.

39 he wealth of information in terms of defined functional activities.

40 sfected cells, we noted disparities in their functional activities.

41 hich are important for substrate binding and functional activities.

42 STAT1 might affect NK cell proliferation and functional activities.

43 epitope specificity, antibody affinity, and functional activities.

44 mpared 2F5 IgA2 and IgG binding affinity and functional activities.

45 rs or older who were evaluated monthly in 13 functional activities (1998-2012).

46 ence of blockade does not predict absence of functional activity; 2) neutralizing mAbs bind spatially

47 ffinity (1.41 and 1.35 nM, respectively) and functional activity (23 and 44 nM), which correspond to

48 In the search for opioid ligands with mixed functional activity, a series of 5'-(4-chlorophenyl)-4,5

49 c and sensitive enough to reveal directional functional activity across layers.

50 hat mGluR5 coordinates a reduction in mGluR1 functional activity after cocaine treatment.

51 tration in humans; however, its clinical and functional activity after longer-term administration has

52 all three CD4-based CARs displayed specific functional activities against HIV-1 Env-expressing targe

53 In conclusion, mAb 2C7 showed functional activity against all gonococcal HepI LOS stru

54 esidents in malaria endemic areas have shown functional activity against blood-stage parasites as jud

55 affinity, and the reduction in differential functional activity against the sensitive and Pgp overex

56 ed a high-resolution MEMRI protocol to image functional activities among different layers of the reti

57 Functional activity analyses indicated that mutant LRP5

58 ing their distribution, morphology, density, functional activities and inflammatory phenotype.

59 induced antibodies with opsonophagocytic and functional activities and provided consistent protection

60 nse to several cytokines, we studied NK cell functional activities and STAT1 signaling in 8 patients

61 bs against different epitopes have different functional activities and that the binding of one MAb ca

62 predicted to encode proteins that differ in functional activity and could represent novel determinan

63 tistical threshold in order to maximize true functional activity and eliminate false positives.

64 n bone marrow-derived mononuclear cell (BMC) functional activity and homing capacity.

65 IFNalpha protein correlated well with functional activity and IFN-stimulated gene expression.

66 on therapy (CCRT) would modify resting brain functional activity and improve cognitive function in pa

67 domains, yielding receptors with heightened functional activity and more amenable to assessment of e

68 Dopamine-induced lateralization of functional activity and networks during speaking is not

69 studies using slice cultures, indicate that functional activity and perhaps functional upregulation

70 isomerization as a mechanism modulating AF1 functional activity and provide insight into the role of

71 omeprazole in fundic organoids and indicated functional activity and regulation of parietal cells.

72 ease patients have an impairment in MBL-MASP functional activity and that this defect is associated w

73 y: compared to wild type, one (R175P) had no functional activity and the other (C192F) had decreased

74 by changes in cortical structure as well as functional activity and variable degrees of cognitive de

75 st format because it had overall the highest functional activity and was very stable in vitro in both

76 The KC number, functional activity, and maturational status are directl

77 relation between M1 PAM binding affinity and functional activity, and that [(3)H]PT-1284 can serve as

78 ranslational modifications are essential for functional activity, and the ability to identify them wi

79 he nature and location of DCLRE1C mutations, functional activity, and the clinical phenotype has been

80 may allow for determination of areas of true functional activity, and thus eliminate clinician bias.

81 Although P450 functional activities are known to be affected by lipids

82 ders, central dopaminergic and overall brain functional activity are altered to different degrees, ca

83 mpair both mitochondrial energetics and BSEP functional activity are more sensitive to more severe ma

84 These shifts in functional activity are often accompanied by negligible

85 on allows for ligand binding and appropriate functional activity are said to be in an active state.

86 idual compounds were characterized for their functional activities as agonists or antagonists with th

87 Their in vitro functional activity as inverse agonists was confirmed in

88 cal blood-oxygenation-level-dependent (BOLD) functional activity as well as behavioral performance du

89 r organs and long-term preservation of miRNA functional activity, as assessed by monitoring the expre

90 The in vitro functional activity assays, performed by using cyclic AM

91 4, and 21 days, with mRNA/protein levels and functional activity assessed by: 1) real-time polymerase

92 omatic units and evaluated their binding and functional activities at the D3 and D2 receptors.

93 und 39 exhibited potent in vitro binding and functional activities at the H(3) receptor, good selecti

94 antagonists in order to achieve the intended functional activity at a GPCR of therapeutic interest.

95 Changes in functional activity at functional MR imaging during the

96 8 was evaluated for its binding affinity and functional activity at rodent and primate TAAR1 receptor

97 essed for binding affinity, selectivity, and functional activity at the 5-HT1AR.

98 ds as high affinity ligands with conflicting functional activity at the alpha2-adrenoceptor, a G-prot

99 Five compounds were evaluated for their functional activity at the AT(2) receptor, applying a ne

100 re no differences in peanut IgG(4) levels or functional activity at the end of the study.

101 exhibits good potency but not the preferred functional activity at the GPCR of choice.

102 novel series behaved as agonists, exhibiting functional activity at the human CB(2) receptor.

103 We identified 9 which retained functional activity at the target M1 mAChR and D2R and d

104 Consistent with these functional activities, BBA70 is located on the borrelial

105 ivity against ROCK and strong differences of functional activity between parent compounds and expecte

106 ing region of an antibody), yet it maintains functional activity, binding to p40 and p19 specific rea

107 rovements in solubility while retaining good functional activity but displayed new liabilities associ

108 asigin interaction in vitro is predictive of functional activity, but absence of blockade does not pr

109 ons between gene expression in the brain and functional activity by comparing fractional amplitude of

110 the O:4-specific antibodies provided in vivo functional activity by decreasing the bacterial load in

111 Immune sera were also tested for functional activity by in vitro opsonophagocytic-killing

112 C1-INH concentration and functional activity (C1-INHc+f ), C1(q,r,s), C3, C4, C3a

113 The mean trough plasma levels of C1-INH functional activity, C1-INH and C4 antigen levels during

114 Following spinal transection, functional activity can be regained, to a degree, follow

115 Identifying key miRNAs, defined by their functional activities, can provide a deeper understandin

116 ve identified subsets of ILCs with differing functional activities, capacities to produce cytokines a

117 ges to improve biological target affinity or functional activity, change physical properties, enhance

118 or only slightly reduced ligand binding and functional activity compared with the most common polymo

119 ed ligands leading to major changes in their functional activity, converting agonists into antagonist

120 that ligands with MOR agonist/DOR antagonist functional activity could emerge as novel analgesics dev

121 evaluated for their binding affinities, and functional activity data are presented at MOR, KOR, and

122 ough HSCs numerically expand with age, their functional activity declines over time, resulting in deg

123 of metabolic pathways and networks, predict functional activity directly from spectral feature table

124 for pollen development, and defines distinct functional activities during early and late pollen devel

125 ic diseases, the progressive loss of certain functional activities during Trypanosoma cruzi infection

126 ed for multiple comparisons) as well as with functional activity during a sexual cue-reactivity parad

127 stical parametric maps tested differences in functional activity during the AX-CPT, and vertexwise ma

128 nal connectivity patterns to measurements of functional activity during two independent tasks.

129 -derived glycans represent the most abundant functional activities encoded by genes unique to the hum

130 and did not show any significant decrease in functional activity for six months.

131 istinct pathologic patterns in overall brain functional activity for various parkinsonian disorders.

132 From the database, we identified functional activity groups of burster (isolated neuron)

133 f IL-2 to expand T cells with maintenance of functional activity has been translated into the first r

134 moderate to severe pain that interfered with functional activity; however, emotional distress to pain

135 rent understanding of key microbial taxa and functional activities in both natural and restored ecosy

136 SSC demonstrated functional activity in 100% of cancer patients and healt

137 ection, and m169 expression inhibited miR-27 functional activity in a reporter assay.

138 We report studies that show 16 has functional activity in cellular assays by modulation of

139 annose-associated serine protease (MBL-MASP) functional activity in Crohn's disease patients.

140 single domain is sufficient to provide Brh2 functional activity in HR, but to enable HU-induced kill

141 ane analogues, namely 1 and 2, showed potent functional activity in in vitro and in vivo models.

142 Herein, we report the measurement of MRP1 functional activity in individual cancer cells using sca

143 memory reactivation are supported by altered functional activity in key cognitive and motor networks,

144 iciency leads to increased TF expression and functional activity in macrophages after challenge with

145 The results showed higher functional activity in the RFIC to own versus other infa

146 romatin state, indicative of their selective functional activity in the transcriptional regulatory ne

147 rejection rarely occurs, suggesting limited functional activity in the tumor microenvironment.

148 by the assay and are demonstrated to support functional activity in vitro and in plants.

149 ort a novel BK channel-targeted peptide with functional activity in vitro and in vivo.

150 ype-switched IgGs in mice and pigs, yielding functional activity in vitro and protection against a le

151 ple input signals that are both required for functional activity in vivo.

152 ntagonist (>1000x over Kv1.1) with picomolar functional activity in whole blood and a pharmacokinetic

153 Equally cross-reactive Fc receptor-mediated functional activities, including ADCC and antibody-depen

154 adapt to the underlying surface, while MRP1 functional activity increases once the dimensions of the

155 y overlooked property of antibodies is their functional activity inside cells.

156 Furthermore, we found that their functional activity is controlled by the presence of the

157 ectious diseases, but dysregulation of their functional activity leads to the development of inflamma

158 ase (nNOS) and the receptor NK1, express the functional activity marker Fos selectively during sleep.

159 on CD4 and CD8 expression that have distinct functional activities may differentially affect B cell f

160 TTP regulation provides a clue as to how its functional activity may be used in a physiologic pathway

161 This suggests that functional activity may represent a powerful indicator o

162 This enhanced functional activity may thus critically contribute to th

163 nnose-binding lectin, mannose-binding lectin functional activity, MBL2 and NOD2 polymorphisms, anti-S

164 their origin and processes for development, functional activity, migratory pattern, and activation s

165 he extent of editing correlates with 5-HT2CR functional activity: more highly edited isoforms exhibit

166 tRNA increases LARP4 levels and reveals its functional activity, net lengthening of the PATs of hete

167 er assay (lentiMPRA) to directly compare the functional activities of 2236 candidate liver enhancers

168 These compounds efficiently restored functional activities of apoE4-expressing cells in secon

169 Therefore, understanding the functional activities of each genomic aberration to be t

170 The functional activities of endogenous PGE2-sensitive recep

171 ets and suggest that strategies to influence functional activities of inflammatory cells may benefit

172 cs can provide invaluable information on the functional activities of intestinal microbiota and on ho

173 The functional activities of key miRNAs were further demonst

174 BDL mice show altered functional activities of Kupffer cells compared with sha

175 t inhibiting homotrimerization of MIF or the functional activities of MIF homotrimers could have ther

176 Gene regulatory networks controlling functional activities of spatially and temporally distin

177 Here we have investigated functional activities of the AS-SRO, the element necessa

178 We evaluated the functional activities of the compounds at all three mono

179 We analyzed the functional activities of the hemagglutinin-neuraminidase

180 tory cells with or without modulation of the functional activities of the MIF/CD74 complex.

181 The functional activities of the tumor suppressor promyelocy

182 ss the effect that the human body has on the functional activities of VRC01 as measured by several in

183 l modifications that are likely to alter the functional activity of a GPCR ligand may be of use to re

184 We validated the functional activity of a PCRM associated with joint-rela

185 Here, we characterize the functional activity of a putative tfs4-encoded VirD2-lik

186 he Pregnancy Malaria Initiative compared the functional activity of antiadhesion antibodies elicited

187 herapeutic strategies aimed at mimicking the functional activity of BCL-3 may be effective in the tre

188 lycosylated dimeric protein that retains the functional activity of both cytokine moieties.

189 A cell proliferation assay revealed potent functional activity of both FGF2 and IGF1, suggesting th

190 The functional activity of brain areas (network nodes) were

191 etween JNK and PP2A pathways determining the functional activity of c-Jun/AP-1 in tumour cells.

192 The residual functional activity of C5 can be screened using a 50% he

193 We assessed the functional activity of CAIX in two colorectal tumor mode

194 The number and functional activity of circulating progenitor cells (CPC

195 al role of the Hsp90 chaperone in regulating functional activity of diverse protein clients is essent

196 ce package Basset to apply CNNs to learn the functional activity of DNA sequences from genomics data.

197 U-251 MG glioblastoma multiforme cells, and functional activity of each mutant in conditioned media

198 We also assessed the existence and functional activity of ecto-ATPase for extracellular ATP

199 Thus, IL-7R signaling on Treg supports the functional activity of effector Treg by increasing their

200 CD8(+) T cells, on the yield, phenotype, and functional activity of expanded CD8(+) T cells during th

201 ariants, suggesting that CFH variants affect functional activity of FH rather than serum levels.

202 Upon nanoconjugation functional activity of gemcitabine was retained as teste

203 erative stress, leading to a decrease in the functional activity of HSCs.

204 he IL-18BP promoter is of importance for the functional activity of IL-27.

205 ive also in mammals, where it stimulates the functional activity of innate immune cells, of mesenchym

206 lucosylation gene from C. bombicola, and the functional activity of its gene product.

207 Interestingly, SUMOylation regulates the functional activity of many of the transcription factors

208 emature ovarian failure (POF) diminishes the functional activity of MCM8.

209 Expression and functional activity of MRP1 were determined using flow c

210 compound myoVin-1 inhibits the enzymatic and functional activity of myosin-5B in vitro Partial inhibi

211 P3 peptide, which specifically inhibits the functional activity of PfCDPK1, blocks microneme dischar

212 JD (F363A/I364A, L356A, and F350A) abrogates functional activity of PfCDPK1, demonstrating the import

213 k between FPR1 and CCR1 was dependent on the functional activity of protein kinase Cbeta.

214 ates for single-molecule (sm) studies of the functional activity of protein-DNA complexes.

215 The abundance and functional activity of proteins involved in the formatio

216 However, how the functional activity of PrP(C) is subverted to deliver ne

217 auto-inhibitory mechanism that regulates the functional activity of PrP(C).

218 Functional activity of selected compounds in stimulating

219 ments in an enhancer reporter assay indicate functional activity of several of de novo H3K4me1-marked

220 ng, on a quantitative level, between lack of functional activity of sinusoidal uptake versus that of

221 fter-hyperpolarization and a decrease in the functional activity of SK channels.

222 Functional activity of soluble PfTopoII from the transla

223 microanatomy of the intact tongue mucosa and functional activity of taste cells in response to topica

224 omain and C region structure on the in vitro functional activity of TGN1412 was investigated using F(

225 ng basic molecular mechanisms underlying the functional activity of the AhR.

226 st reaction target organs, but decreased the functional activity of the alloreactive T cells.

227 which antibodies that can interfere with the functional activity of the antigen are more likely to co

228 but also for regulating the organization and functional activity of the apical cytoskeleton, particul

229 How the functional activity of the brain is altered during aging

230 nomethylfumarate (MMF) on the expression and functional activity of the cystine/glutamate exchanger S

231 tantly, both drugs rescue DAT maturation and functional activity of the DTDS-associated mutations A31

232 action with the Trp residues involved in the functional activity of the enzyme as demonstrated by adv

233 several BCRP probe substrates confirmed the functional activity of the human transporter in these mi

234 may help to explain the generally increased functional activity of the immunoproteasome.

235 In this series, the affinity and functional activity of the ligands were found to be infl

236 ctrophysiology measurements demonstrated the functional activity of the microsomes harboring KcsA sho

237 We tested the hypothesis that high functional activity of the mineralocorticoid endocrine p

238 ht into the synthesis reaction and potential functional activity of the product.

239 NA recognition and therefore may control the functional activity of the protein-DNA complex.

240 h hampers progress toward enhancing yield or functional activity of the target protein.

241 cell identity and (ii) interfering with the functional activity of the transcription factor Blimp1.

242 cogenic methyltransferase that represses the functional activity of the tumor suppressor proteins p53

243 ed after a spinal cord lesion by re-engaging functional activity of the upper limbs?

244 rough physico-chemical characterization, the functional activity of these novel agents was establishe

245 MRP1) is prevalent in many cancer types, the functional activity of this efflux pump is more difficul

246 rain areas quantified at rest relates to the functional activity of those areas during task.

247 as activators of TRPML3, thus confirming the functional activity of TRPML2 at the plasma membrane and

248 We investigated the functional activity of truncated TSLP using a PBMC-based

249 Posttranslational modifications control the functional activity of TSLP in humans and overproduction

250 y illustrating a molecular mechanism linking functional activity of VGSCs to transcriptional activati

251 clear phagocytes and exerts immunoregulatory functional activities on lymphocytic and nonlymphocytic

252 able alternative to proteins with respect to functional activity on membranes.

253 targets and suitable antibodies that exert a functional activity or deliver a payload to the tumor si

254 ms, histologic features, plasminogen levels (functional activity, plasma antigen), genetic features,

255 ing the allosteric site display a variety of functional activity profiles, where behavior of at least

256 ni-Mental Status Examination (MMSE), and the Functional Activities Questionnaire (FAQ).

257 or the ICU, Katz activities of daily living, Functional Activities Questionnaire (measuring instrumen

258 equently used measures of functional status (Functional Activities Questionnaire at 3 months vs. cont

259 ons (for Katz activities of daily living and Functional Activities Questionnaire scores) or via gener

260 (activities of daily living scales, Pfeffer Functional Activities Questionnaire, and Katz Activities

261 identified so far, in particular because its functional activities remain far from clear.

262 re, the reasons underlying its low levels of functional activity remain unclear.

263 sporter (DAT) availability and overall brain functional activity, respectively.

264 r (p < .005 vs. control on days 2, 3, and 5) functional activity, resulted in higher C3 levels (p < .

265 l magnetic resonance imaging to evaluate the functional activity resulting from the stimulation of in

266 x with two mixed profile PR modulators whose functional activity results from two differing molecular

267 the identification of 7 by a high-throughput functional activity screen using mouse embryonic stem (m

268 orrelates of inhibitory response control, as functional activity serves as a more dynamic measure tha

269 For the resting brain functional activity, significant group x time interactio

270 or occupancy assay corresponds with in vitro functional activity, suggesting a direct correlation.

271 em cell-derived astrocytes have demonstrated functional activities that are equivalent to those obser

272 nd provide a more direct measure of regional functional activity that is less dependent on nonlineari

273 ning options for multidimensional control of functional activities through combinations of orthogonal

274 hese sequences contribute a diverse array of functional activities to the life cycle of their viruses

275 e CTL clones also severely compromised their functional activities toward autologous tumor cells.

276 nthesized and examined for their binding and functional activities toward melanocortin receptor subty

277 to maintain high affinity, selectivity, and functional activity toward the mu-opioid receptor.

278 n paxillin (Pxn) in downstream signaling and functional activities triggered through alphaE/CD103 cha

279 and displayed cytochrome P450 activities and functional activities typical of mature primary hepatocy

280 inal homing/retention by Tregs nor a lack of functional activities typically associated with CD103(+)

281 broadly shared as well as cell type-specific functional activities unique to the trophoblast lineage.

282 omewhat lower for appraisal of overall brain functional activity using (123)I-FP-CIT and (18)F-FDG im

283 th R and/or R-induced alterations in Ikaros' functional activities via cellular signaling pathways.

284 losteric regulation triggering the protein's functional activity via conformational changes is an int

285 sion/injection serum VRC01 retained expected functional activity (virus neutralization, antibody-depe

286 C1-INH functional activity was assessed by EIA.

287 Functional activity was assessed using allergen-induced

288 d CD200L was measured by flow cytometry, and functional activity was assessed using blocking antibodi

289 Plasma-purified plasmin(ogen) functional activity was evaluated by chromogenic, turbid

290 the basal ganglia, whereas the overall brain functional activity was examined using VOIs across the b

291 Antibody functional activity was quantified by Opsonophagocytic K

292 Affinities and functional activities were determined at recombinant hHx

293 erozoites, IE surface antigens, and antibody functional activities were quantified.

294 cytosis, virus inhibition, and degranulation functional activity were also observed.

295 MTBI-induced differences in working memory functional activity were observed even though difference

296 omes use HSPGs for their internalization and functional activity, which significantly extends the eme

297 -weighted structural MRI scans and drive its functional activity with a dual phase-encoded stimulus.

298 onabant (rimonabant TPSA = 50) and excellent functional activity with limited CNS penetration were id

299 that discriminated between E and NE areas of functional activity, with a cross-validation AUC and suc

300 t human NK cells are able to terminate their functional activity without the aid of other immune cell