ライフサイエンスコーパス: functional conservation

1 logues in teleosts and tetrapods, suggesting functional conservation.

2 , little is known about their structural and functional conservation.

3 her in C. crescentus and E. coli, indicating functional conservation.

4 ect to strong purifying selection indicating functional conservation.

5 function in C. elegans, demonstrating their functional conservation.

6 totic centromeres, further highlighting this functional conservation.

7 ive regulator of telomere length, indicating functional conservation.

8 in the node and its derivatives, suggesting functional conservation.

9 of these divergent papillomaviruses exhibit functional conservation.

10 in, suggesting that there may be significant functional conservation.

11 otic genomes, present more complex issues in functional conservation.

12 ith clear thresholds for different levels of functional conservation.

13 activating transcription, which indicates a functional conservation.

14 mented the 4091-5-8 pth11 mutant, indicating functional conservation.

15 ats within each species, suggesting a strong functional conservation.

16 ating that the sequence similarities reflect functional conservation.

17 li FtsZ, suggesting a degree of interspecies functional conservation.

18 the structural basis for this difference in functional conservation.

19 the arginines does not translate into strict functional conservation.

20 in mouse and human CD4(+) T cells, revealing functional conservation.

21 ed apoptotic response representing 550 My of functional conservation.

22 rescued their phenotype, which demonstrates functional conservation.

23 ctively-does not necessarily predict lack of functional conservation.

24 use of sequence conservation as a proxy for functional conservation.

25 uman orthologue TMEM258 in Drosophila proved functional conservation.

26 degrade rhesus macaque APOBEC3G, indicating functional conservation.

27 amino acid sequence level, suggesting their functional conservation.

28 tain protein identity, suggesting additional functional conservation.

29 e nonprimate species compared with 67.5% for functional conservation.

30 uired for cell viability, the reason for its functional conservation across all strains of S. pneumon

31 SA share a moderate degree of structural and functional conservation across bacterial species, we sho

32 tly isolated from human cell lines, implying functional conservation across evolution.

33 dynamics both at protein and DNA levels and functional conservation across kingdoms still needs inve

34 of PAB is well conserved in eukaryotes, its functional conservation across species has not been exte

35 CR2 reduces respiration in worms, indicating functional conservation across species.

36 YBP mutant flies by mouse YAF2 demonstrating functional conservation across species.

37 s and paralogues thereafter, indicating that functional conservation after the radiation may also be

38 These results support structural and functional conservation among Rec12/Spo11/Top6A family m

39 eir homologues in mouse, suggesting a strong functional conservation among the individual isoforms, M

40 The high degree of sequence and functional conservation among the mammalian PLM proteins

41 ether, these results demonstrate significant functional conservation among the prokaryotic SecD and S

42 Thus, there is strong structural and functional conservation among the simian EBNA-LP homolog

43 The degree of functional conservation among the various B-class GATA f

44 Using structural and functional conservation analysis of yeast and Drosophila

45 These examples of functional conservation and convergent evolution emphasi

46 omplementation tests can be used to evaluate functional conservation and divergence of biological pat

47 from related organisms provide insight into functional conservation and diversification.

48 t model for understanding the structural and functional conservation and diversity of this enormous f

49 es can yield in-depth understanding of their functional conservation and evolutionary history.

50 of neutralization is paradoxical, given the functional conservation and exposure of receptor-binding

51 The structures shed new light on 14DM functional conservation and open an excellent opportunit

52 " properties of ESCs from the perspective of functional conservation and variation.

53 ued growth defects in irc6 cells, indicating functional conservation, and modeling predicted a simila

54 On the basis of the known functional conservation between a number of mammalian on

55 In this work we evaluated the level of functional conservation between AMP1 and its human homol

56 equired for Rec12(Spo11) removal, confirming functional conservation between Ctp1(CtIP) and the more

57 The structural and functional conservation between DET2 and human steroid 5

58 The functional conservation between DOG-1 and FANCJ suggests

59 oylation in P. falciparum, and the degree of functional conservation between enzymes of the human and

60 interspecies transgenesis approach, we find functional conservation between gnathostome Hoxd enhance

61 We found an intriguing functional conservation between human and mouse immune F

62 te for GON-1 in transgenic worms, suggesting functional conservation between human and nematode homol

63 escues the hok1 mutant phenotype, suggesting functional conservation between humans and fungi.

64 ptors in Arabidopsis, indicating substantial functional conservation between maize and Arabidopsis et

65 The observed functional conservation between mitochondrial import in

66 restore native TgADF activity, demonstrating functional conservation between parasites.

67 s confirming a high degree of structural and functional conservation between plant and mammalian SRP

68 Our data illustrate the extreme functional conservation between prokaryotic and eukaryot

69 The structural and functional conservation between Rcn1p and DSCR1 suggests

70 ation in early C. elegans embryos suggesting functional conservation between the adhesion-GPCRs Celsr

71 Our results demonstrate a high degree of functional conservation between the extra-embryonic tiss

72 me and Smith-McCort dysplasia, demonstrating functional conservation between the two species.

73 binds to both yeast and human Ran suggesting functional conservation between the yeast and human MOG1

74 utant deleted for the MMS19 gene, indicating functional conservation between the yeast and mammalian

75 unc-30 mutants, indicating a high degree of functional conservation between these evolutionarily rel

76 EOL-1 in learning regulation, demonstrating functional conservation between these homologs.

77 ssed the yeast pheromone pathway, indicating functional conservation between these human and plant ge

78 the myo7-null mutant, supporting fundamental functional conservation between these two distant myosin

79 HSF isoforms, and demonstrate the remarkable functional conservation between yeast and human HSFs, cr

80 The degree of functional conservation between yeast and human protein

81 This functional conservation emphasizes the fundamental impor

82 These commonalities suggest that there is functional conservation for spalt genes between vertebra

83 . crescentus and that of A. tumefaciens, the functional conservation for this presumptive control pat

84 mitochondrial polypeptide with sequence and functional conservation from human to yeast.

85 This evolutionary-developmental (evo-devo) functional conservation has been extended to morphogenes

86 Structural and functional conservation have been found between some of

87 onjecture" (or, more properly, the "ortholog functional conservation hypothesis").

88 These functional conservations imply that human MTO2 may act a

89 are highly conserved across phylogeny, their functional conservation in axon guidance is now being ri

90 odomain, has become a paradigm, illustrating functional conservation in developmental pathways.

91 ast Saccharomyces cerevisiae to assess their functional conservation in farnesylating Ras and a-facto

92 ize and tolerance to H(2)O(2), demonstrating functional conservation in filamentous ascomycete phytop

93 To investigate functional conservation in more detail, we focused on Ci

94 etion, correlation with gene expression, and functional conservation in NCC isolated from chicken emb

95 Importantly, several of these genes show functional conservation in regulating apoptosis in mamma

96 This functional conservation in the absence of precise molecu

97 present a striking example of structural and functional conservation in the almost complete absence o

98 y, the combined data indicate structural and functional conservation in the Tat systems of these thre

99 ose that within the N-terminal half of UL37, functional conservation is centered within the R2 surfac

100 al ACE-like genes, we also suggest that this functional conservation is reflected in an ancestral gen

101 sequence identity threshold above which 100% functional conservation is required, functional inferenc

102 These results provide evidence for the functional conservation of a DPE-dependent, general tran

103 Moreover, we demonstrate functional conservation of a homolog of Brachyury of the

104 between T. thermophilus and E. coli, and the functional conservation of a number of resurrected ancie

105 Functional conservation of AmiA implicates a role in cyt

106 To explore the structural and functional conservation of Cdc5 throughout evolution, we

107 /ELC attracted murine splenocytes suggesting functional conservation of CK beta-11/MIP-3 beta/ELC bet

108 s that there is a high degree of genetic and functional conservation of coagulation, portending futur

109 To investigate the functional conservation of cohesin in eukaryotes distant

110 Functional conservation of DME enzyme was confirmed by c

111 We herein study the functional conservation of enzymes and non-enzyme sequen

112 The results document functional conservation of eukaryotic mRNA guanylyltrans

113 Here we have studied the evolutionary and functional conservation of four T3SS proteins from the I

114 Given the functional conservation of Friend of GATA proteins and t

115 and highlighting the general structural and functional conservation of human Pol II and Pol III pre-

116 ongruent with those in the human, suggesting functional conservation of ICAM-2 across species.

117 emonstrate the high degree of structural and functional conservation of InsP3Rs from nematodes to mam

118 In order to explore the functional conservation of JAGGED, a key gene involved i

119 Here we demonstrate functional conservation of key UTP-binding and metal-ion

120 of receptor translocation and for structural-functional conservation of ligand binding domains broadl

121 tochondrial distribution, suggesting partial functional conservation of Mdm12p activity between buddi

122 Collectively, our results suggest functional conservation of MET1 and CMT families during

123 There is remarkable functional conservation of muSOX host shutoff activities

124 To explore the functional conservation of myomixer, we investigated the

125 e nicotine dependence in mammals, suggesting functional conservation of nAChRs in nicotine responses.

126 The high functional conservation of neprilysins and their substra

127 ontent is shared among the grasses; however, functional conservation of orthologous genes has yet to

128 genetic and functional analyses revealed the functional conservation of P450s despite belonging to di

129 The functional conservation of proteins that control the G1/

130 ion Scoring (RRS) model for the detection of functional conservation of regulatory sequences using pr

131 0 on both phagocytes and lymphocytes showing functional conservation of several properties of Il10.

132 Although we found extensive functional conservation of short-term learning between l

133 Additionally, functional conservation of SIE in diverse virus groups s

134 The results highlight structural and functional conservation of SRP assembly between archaea

135 These findings indicate functional conservation of Ssdp as a cofactor of Ldb1 du

136 king Slx8-Rfp, underscoring the evolutionary functional conservation of STUbLs.

137 Supporting functional conservation of T2S and T4P minor components,

138 It also provides information on functional conservation of target sequences, as well as

139 p1 defect in the Gap1 mutant, indicating the functional conservation of the accessory Sec complex.

140 These results sustain the functional conservation of the alpha-syn expression in c

141 Together, our results establish the functional conservation of the autorepressed conformatio

142 catalytic activity of yeast Ime4, indicating functional conservation of the catalytic domain.

143 The functional conservation of the CrPV-like IRES elements i

144 Functional conservation of the CTE was investigated in t

145 homologues in Escherichia coli demonstrated functional conservation of the encoded proteins.

146 This functional conservation of the epistatic relationship be

147 These studies reveal the functional conservation of the FA pathway and validate t

148 perm gene complementations(6), suggests deep functional conservation of the heterodimeric SMF1 and SC

149 ssion of the alpha-globin gene, suggesting a functional conservation of the homeodomain.

150 e etiology and treatment of bipolar illness, functional conservation of the key enzyme in inositol bi

151 Our findings demonstrate a functional conservation of the lab class homeo proteins

152 These findings strongly suggest functional conservation of the mechanisms used by the ac

153 These observations led us to test the functional conservation of the mouse Pitx2 and worm unc-

154 In this study, we demonstrate additional functional conservation of the NMD pathway through the i

155 through regulation of H3K36me3, and indicate functional conservation of the PAF1 complex from yeast t

156 Our study also directly demonstrates the functional conservation of the regulatory mechanisms gov

157 ss heat sensitivity of rat TRPV1, supporting functional conservation of the residues.

158 ved, as might be expected from the degree of functional conservation of the ribosome among kingdoms (

159 Here we provide further evidence for the functional conservation of the second step factors betwe

160 and complementation experiments to test the functional conservation of the sporopollenin-associated

161 The functional conservation of the tRNA core is correlated w

162 of ancient duplication, suggesting long-term functional conservation of the underlying genes.

163 residue and activates the enzyme, suggesting functional conservation of the upstream kinases between

164 ble of cleaving insulin, suggesting that the functional conservation of these enzymes may not be bidi

165 chanotransduction in invertebrates; however, functional conservation of these ion channels in mammali

166 e results demonstrate a remarkable degree of functional conservation of these myogenic factors despit

167 Drosophila gos28 mutants, demonstrating the functional conservation of these proteins.

168 re1 and adaptation to hypoxia, demonstrating functional conservation of this cleavage recognition mot

169 expressed from the ARR1 promoter, indicating functional conservation of this divergent family member.

170 Furthermore, we demonstrate the functional conservation of this factor, as depletion of

171 the developing retina and limbs, suggesting functional conservation of this gene.

172 owth in lats mutant flies, demonstrating the functional conservation of this gene.

173 (+) from tryptophan via QA, highlighting the functional conservation of this important biosynthetic a

174 regions of these two proteins, demonstrating functional conservation of this important stress protein

175 Functional conservation of this protein is supported by

176 Functional conservation of this protein is supported by

177 her, these results demonstrate the exquisite functional conservation of this protein throughout evolu

178 The results imply a highly functional conservation of type III secretion between P.

179 escued by human ubiquilin 1 or 2, suggesting functional conservation of ubiquilin proteins.

180 on development, and provide evidence for the functional conservation of Vg1 activity in mice.

181 immunity, and they highlight structural and functional conservation of X-type lectins among chordate

182 he data presented here provide support for a functional conservation of XyG structure in higher plant

183 rescues the Zfrp8 phenotype, underlining the functional conservation of Zfrp8/PDCD2.

184 Taken together, these results demonstrate a functional conservation of Zic3 in L-R patterning and un

185 The phylogenetic and functional conservations of SmedOB1 provide one mechanis

186 riable and is correlated with the effects of functional conservation on gene sequences.

187 e expression) and suggest a higher degree of functional conservation than implied by previous studies

188 ulti-domain proteins have significantly less functional conservation than single-domain ones, except

189 nt identity is more effective at quantifying functional conservation than the more modern scores (e.g

190 are striking in light of the structural and functional conservation that typifies other imprinted do

191 To gain insight into its functional conservation, the organization of the functio

192 ell documented aspects of Hox structural and functional conservation, there are mechanistic differenc

193 rol biosynthetic intermediate, demonstrating functional conservation to human C14SR.

194 timizes both the protein and the interaction functional conservations, using a novel alignment search

195 Functional conservation was demonstrated by the ability

196 In light of this functional conservation, we examined the potential role

197 Consistent with functional conservation, we found that roX RNAs of dista

198 h atonal and its mouse homolog Math1 exhibit functional conservation, we inserted (beta)-galactosidas

199 hans show similar evolutionary signatures of functional conservation, we propose that orphan loss is

200 sequence conservation is presumed to reflect functional conservation, which indeed has been demonstra

201 ore of conserved residues that could reflect functional conservation, while allowing for immune evasi

202 these systems have revealed a high degree of functional conservation, while also uncovering features

203 n mammals and Drosophila shows molecular and functional conservation with C. elegans sleep.

204 scent myotubes, thus establishing a possible functional conservation with Drosophila Sns.

205 binds stretches of poly(dG)/poly(dC) showing functional conservation with plant AP2/ERF proteins.

206 e that hUBC9 retains striking structural and functional conservation with yUBC9 and suggest a possibl

207 o the central region of the gene, suggesting functional conservation within the amino and carboxy ter

208 Lastly, we provide evidence of functional conservation within the PLAA family by showin