ライフサイエンスコーパス: functional domain

1 ted power of sequence-based features in that functional domain.

2 eatly even if substitutions were in the same functional domain.

3 deficiency and identified a new antithrombin functional domain.

4 derlying "structure" modulating this central functional domain.

5 rium and that the loop 3 helix is a critical functional domain.

6 g coatomer subunit alpha) affecting the same functional domain.

7 leted forms of dystrophin, missing important functional domains.

8 dendritic cell (DC) migration to define its functional domains.

9 ents of RNA polymerase, contacting different functional domains.

10 sual ability overall (r = -0.42) and for all functional domains.

11 erent clonal origins that are organized into functional domains.

12 predominantly reside in CTCF/cohesin-limited functional domains.

13 significant independent effect on the other functional domains.

14 an residues distributed evenly over all four functional domains.

15 nal (3D) network with diverse structural and functional domains.

16 any different proteins where they bridge two functional domains.

17 ption and organizing eukaryotic genomes into functional domains.

18 T-boxes have two functional domains.

19 pathfinding through a non-overlapping set of functional domains.

20 s possess large N termini containing various functional domains.

21 ole of the structural rich club to interlink functional domains.

22 rovide evidence that CT694 contains multiple functional domains.

23 trabody efficacy via fusions to heterologous functional domains.

24 s of MAPT promoter deletions revealed unique functional domains.

25 ing proteins with substitutions in different functional domains.

26 on of the human MAPT promoter by mapping its functional domains.

27 ers the properties of an RNA guide, creating functional domains.

28 lly into at least three large structural and functional domains.

29 ACTOR1 (RAF1), which lacks any characterized functional domains.

30 regulation of the mTORC1 pathway through two functional domains.

31 The FlgJ proteins consist of two functional domains.

32 ng in two dimeric OMPDC and two dimeric OPRT functional domains.

33 SA complexes impairs accessibility to all FH functional domains.

34 pts coding for inactive proteins lacking key functional domains.

35 -frequency synchronous activity that crosses functional domains.

36 stributed throughout the protein in multiple functional domains.

37 henotypic innovation than changes in protein functional domains.

38 onventional building conditions for all nine functional domains.

39 cating NPHP5 at Leu87 and removing all known functional domains.

40 uct bound structures encompassing all of the functional domains.

41 biquitin substrate were located to different functional domains.

42 tRNA genes, and the occurrence of conserved functional domains.

43 nts, but they contain no known structural or functional domains.

44 s have orthologs in many species and contain functional domains.

45 are commonly viewed as membrane anchors for functional domains.

46 s that are mediated by each of the protein's functional domains.

47 entifying 4 acetylated lysines in 3 distinct functional domains.

48 or different constituents, forming specific, functional domains.

49 xtreme mutations giving rise to partial, but functional, domains.

50 4 months between the two treatment groups in functional domains 1 and 2 of the Motor Function Measure

51 The structure of the Slo1 channel has two functional domains, a core consisting of four voltage se

52 ng their essential roles in coupling the two functional domains, a hypothesis confirmed by mutational

53 ediate allosteric coupling between different functional domains, a model that has subsequently been v

54 which catalyze pilus assembly, contain five functional domains: a 24-stranded transmembrane beta-bar

55 argeting functionalities of chimera with two functional domains: a dsRNA binding domain (dsRBD) for s

56 Hsp70s contain two functional domains: a nucleotide binding domain and a su

57 al mRNAs, they are generally composed of two functional domains: a receptor (aptamer) domain that bin

58 The PapC usher contains five functional domains: a transmembrane beta-barrel, a beta-

59 d even lower activity, indicating that these functional domains accounted for most of the pro-chemota

60 hubs based on their participation in several functional domains across different networks and ability

61 emonstrates significant deficits in multiple functional domains across pediatric burn survivors compa

62 Furthermore, mutations in these functional domains acted as dominant negatives that affe

63 tion factor, ERalpha has two transactivating functional domains (AF), AF-1 and AF-2.

64 ns with amino acid substitutions in the same functional domain and between alleles encoding proteins

65 he identification of four genes that share a functional domain and modulate heterocyst commitment: he

66 motif that divided the protein into its two functional domains and activated SipA in a manner necess

67 Functional domains and amino acid motifs in the viral pr

68 ns clustered in recurrent hotspots affecting functional domains and caused defective RHOA signaling,

69 h the complementary sequences in the arms of functional domains and connector.

70 major sigma factor, sigma(70), have similar functional domains and contact similar regions of RNAP,

71 associated with, and interplay between, its functional domains and defining the requirement for its

72 Toxicity in yeast has been used to identify functional domains and elucidate the biochemical functio

73 ve localized all the PRC2 subunits and their functional domains and generated a detailed map of inter

74 Establishing causative links between protein functional domains and global gene regulation is critica

75 ignificant improvements in the EORTC QLQ-C30 functional domains and Global Health Status/QoL versus p

76 ful in both reconstructing the already known functional domains and in identifying the structural cou

77 ting boundaries that segregate chromatin and functional domains and in organizing higher-order chroma

78 is a plasma protein consisting of 6 distinct functional domains and is an important regulator of key

79 1 is a large protein that lacks well defined functional domains and is predicted to be largely intrin

80 By identifying functional domains and key amino acid residues in PinX1

81 bellum's contributions to a diverse array of functional domains and neuropsychiatric disorders.

82 nalysis of mutants, in vivo, that identifies functional domains and phosphorylation sites critical fo

83 nt and synergistic relationship of all three functional domains and provide an explanation for the de

84 SroHCN contains highly conserved functional domains and sequence motifs that are correlat

85 ncluding missense mutations within important functional domains and start-loss and splicing mutations

86 Although commonalities can be found in the functional domains and strategies used to carry out and

87 utations in 200 genes, highlighting specific functional domains and synaptic candidate genes importan

88 expressed different forms of EZH2 to analyze functional domains and used small interfering RNAs to re

89 structed based on common replication protein functional domains and, even within one replication doma

90 ates of heritability cluster strongly within functional domains, and across all traits the reported h

91 be located at the interface between the two functional domains, and Pro(485) induces flexible hinges

92 of the enzyme, the relative positions of its functional domains, and the mode of its interaction with

93 Little is known about the functional domain architecture of long noncoding RNAs (l

94 Genes with some functional domains are convergently restored to 'singlet

95 zed allelic murine mutants in which distinct functional domains are deleted.

96 ediction of conserved domains indicated that functional domains are preserved.

97 ll visual ability and in visual ability in 4 functional domains as measured by the Activity Inventory

98 Predictors of visual ability and functional domains as measured by the AI.

99 re measured physical, social, emotional, and functional domains as well as sexual function.

100 s to enable selective extraction of specific functional domain-based networks, whether it be by botto

101 oplasmic reticulum (ER) membranes (MAMs) are functional domains between both organelles involved in C

102 n domains provides new insight into defining functional domain boundaries and provides a framework fo

103 tip remodeling occurs in bursts and respects functional domain boundaries.

104 idal dendrites, inhibitory dendrites respect functional domain boundaries.

105 predicted protein of 24 kD with no annotated functional domains but containing domains that are highl

106 a caveolin-1 protein that contains all known functional domains but has a change in only the final 20

107 o caveolin-1 protein that contains all known functional domains but has a change only in the final 20

108 with one, two, three, or four copies of the functional domain by PCR and splice overlap.

109 Finally, the functional domain by which the toxin inhibits ASIC1a cha

110 ds are segregated into two morphological and functional domains called grana and stroma lamellae.

111 NA-resistant mutant p53 along with a mutated functional domain can be inducibly or stably expressed.

112 For deciphering them, functional domains can be overexpressed.

113 addition, we provide an understanding of how functional domains can evolve over time, resulting in su

114 uroclinical Assessment that incorporates key functional domains derived from the neurocircuitry of ad

115 mbinant EBOV carrying mutations disabling GP functional domains did not restore DC maturation.

116 modulates other binding states that require functional domains distal to the N-terminal binding site

117 he patient together with physician from four functional domains (dressing, hygiene, limb position, an

118 prostate cancer commonly had declines in all functional domains during 15 years of follow-up.

119 properties, phylogenetic analyses place all functional domains except the CTD squarely within a gyra

120 e further divided PiSLF into three potential Functional Domains (FDs), FD1-FD3, based on sequence com

121 The 3 functional domains for cases, their unaffected siblings,

122 at may reflect an optimal positioning of its functional domains for transcription.

123 ely studied; however, its full complement of functional domains has yet to be characterized.

124 elements upon which the more variable viral functional domains have evolved.

125 CTLs targeting Nef epitopes outside critical functional domains have little effect on the pathogenic

126 are organized into topologically constrained functional domains; however, the molecular mechanisms re

127 Both of RV-cyclin's functional domains, i.e., the cyclin box and the activat

128 the similarity of tyrosine- and lysine-rich functional domains identifies this protein as a new memb

129 In view of the observation that apoE and its functional domains impact extracellular matrix (ECM) rem

130 n the cytoplasmic domain of RyR1 in multiple functional domains implicated in RyR1 activity-regulatin

131 Within the protein, multiple functional domains important for uncoating, host cell me

132 We characterized the functional domain in AKR1B10 and found that helix 10 (am

133 y, the ectodomain, a region that carries the functional domain in GPI-APs, in Pd-resident proteins fu

134 Yet undiscovered functional domains in addition to the homeodomain and th

135 ature stop codons and have less identifiable functional domains in both the human and mouse.

136 lignancy and dissect the importance of these functional domains in cancer biology, metastatic potenti

137 and FANCI contribute to the organization of functional domains in chromatin, ensuring the coordinati

138 Finally, we have elucidated the functional domains in EGL-27/MTA that mediate its reprog

139 To dissect the roles of functional domains in Fli1, we recently generated mutant

140 itro transcription assays, we identified two functional domains in Gdown1.

141 ether, these results suggest how the size of functional domains in homeothermic cells may be regulate

142 rotein expression, the role of the protein's functional domains in host immunity is unknown.

143 abrogate the expression of all known VEGFR-1 functional domains in neonatal and adult mice and analyz

144 ll type-specific deletions of Nkx2.2 and its functional domains in order to characterize its role in

145 , transcriptional activation, as well as the functional domains in p44 related to its growth inhibiti

146 modular design with distinct structural and functional domains; in particular, a highly conserved po

147 ion of RyR1, which are clustered in multiple functional domains including those implicated in the act

148 CpsA has multiple functional domains, including a DNA-binding/transcriptio

149 ARAP2 contains multiple functional domains, including a GTPase-activating protei

150 KDM2B contains multiple functional domains, including a JmjC domain that catalyz

151 RK2 is a large complex protein with multiple functional domains, including a Roc-GTPase, protein kina

152 CPG proteins altogether contained 19 unique functional domains, including Kunitz and endostatin doma

153 e factors that contain a very similar set of functional domains, including N-terminal pleckstrin homo

154 can occur in the same molecular pathways and functional domains, including synaptic transmission, the

155 thogenic LRRK2 variants mapping to different functional domains increase phosphorylation of Rabs and

156 uced in Bacillus subtilis and encompassing a functional domain, induces antibodies that recognize the

157 functional domain(s) of a protein, where the functional domain information is generated through searc

158 tudies provide new information regarding the functional domains involved in transcriptional regulatio

159 l 1 (ASIC1) is homologous to ENaC, but a key functional domain is highly divergent.

160 nstrate that while the loop 3 helix is a key functional domain, its function does not exclusively rel

161 ression in the muscle, we confirmed that the functional domain lies within the VP3 portion of the cap

162 Functional domain mapping based on super-resolution imag

163 Functional domain mapping of CheZ(HP) determined the pol

164 Our results provide evidence that high-level functional domains may be mapped according to early rudi

165 ustrate that disruption of particular CEP290 functional domains may lead to particular disease phenot

166 We further found that the 8q24 functional domains more likely interacted with genomic r

167 ntials of mean force, and time dependence of functional domain motions in proteins.

168 s of p53 mutants share a common property and functional domains necessary for mutant p53 gain of func

169 The functional domain of Ag43a displays a twisted L-shaped b

170 We sought to analyze whether each functional domain of AIRE is critical for the activation

171 ole of BAI1 in apoptotic cell clearance, the functional domain of BAI1 was used as a competitive inhi

172 These data provide evidence for a functional domain of high CA activity around mitochondri

173 One very important functional domain of proteins is the protein-protein int

174 hat the conserved HMG box domain is the only functional domain of Sry, and highlight an evolutionary

175 dicted fungal AAPs revealed that the minimal functional domain of the N. crassa AAP corresponded clos

176 f IL-33 (amino acids 66-111) as an important functional domain of the protein and suggests that inter

177 efect associated with the loss of a specific functional domain of the transcription factor Fli1 and s

178 s human counterpart and that it mapped a key functional domain of TNPO3 to the carboxy-terminal cargo

179 ith the general structure and characteristic functional domains of a bacterial transcription factor.

180 et(249), Met(331), and Met(496) in important functional domains of ADAMTS13 were oxidized to methioni

181 e as a test bed for dissecting the different functional domains of BEACH (for beige and human Chediak

182 in of 90 kDa) is often found associated with functional domains of client proteins, including those f

183 Among them, macaques were shown to exhibit functional domains of color-selectivity, in areas V1 and

184 logical membranes segregate into specialized functional domains of distinct composition, which can pe

185 With further dissection of the functional domains of EXO1, we report that the PIN domai

186 ilisin cleavage sites reside within critical functional domains of FH, including the complement regul

187 Functional domains of GRK2/3 were stably expressed, or s

188 ing myeloid differentiation, but how the two functional domains of LBR support this role is currently

189 The functional domains of LR11 suggest that it can act as a

190 Various mutants of functional domains of MCPIP1 showed disruption of the RN

191 The functional domains of MEGF10 and drpr bear striking simi

192 Two functional domains of mortalin, the N-terminal ATPase do

193 To define the functional domains of myomaker required to direct fusion

194 We dissected the functional domains of p44 for protein interaction with t

195 biochemical and structural insights into the functional domains of PARP-2, which has restricted our u

196 In addition, mutational analyses identified functional domains of r129 resulting in recombinant prot

197 subjected to variation and demonstrate that functional domains of ribosomes are targets of 2'-O-Me p

198 ons of up to 900 residues, lacking all known functional domains of Sgs1, suppressed the hydroxyurea s

199 terminal truncation, could be gated by fused functional domains of STIM1.

200 Using point mutations, we identify the key functional domains of Talin that mediate its response to

201 ographic or modeled structures of individual functional domains of TcdB reveals for the first time th

202 ese data identify the critical intracellular functional domains of Thbs4, which was formerly thought

203 rticipate in synaptic plasticity in specific functional domains of the adult central nervous system,

204 tive PirAB(vp) heterodimer might emulate the functional domains of the Cry protein, and in particular

205 Mutations in functional domains of the fusion protein suppress the pr

206 within a 20-kb window that spans several key functional domains of the gene.

207 ntegration of information between segregated functional domains of the human cortex.

208 In this study, we have analyzed the functional domains of the KSHV NEC proteins and their in

209 Recent genetic analysis identified the functional domains of the lambda spanins, which are simi

210 ts to transmit information between different functional domains of the large subunit.

211 al consequence of these perturbations to key functional domains of the motor.

212 Different functional domains of the PC2 Cterm have been studied us

213 ny of these sites are localized in different functional domains of the protein, including the catalyt

214 Here, we have identified 4 functional domains of the protein.

215 cid variations were found at positions where functional domains of the proteins were identified.

216 This synergy is dependent on conserved functional domains of the proteins, as well as on a nove

217 tural motifs recognized by L7Ae, in distinct functional domains of the RPR and suggest testable mecha

218 Given these results, we describe the functional domains of the S. mutans SloR protein and pro

219 ansposition mutagenesis approach to identify functional domains of the triplex proteins.

220 The functional domains of these genes were conserved to a fa

221 gammaherpesvirus conserved residues revealed functional domains of these two proteins, which in many

222 the interaction, cellular localization, and functional domains of these two proteins.

223 Two isoforms of the C. sapidus TPS encode functional domains of TPS and trehalose-6-phosphorylase

224 Herein, we have identified the essential functional domains of TR from the basal eukaryotic speci

225 we report that the separated and coexpressed functional domains of UL16 are mutually responsive to ea

226 functional analysis of chimeras in which the functional domains of VILIP-2 are substituted in CaM.

227 Here we define functional domains of ZLD required for both DNA binding

228 n of SLC7A14 corresponding to the so-called "functional domain" of the hCAT proteins, a protein stret

229 es form mutation hotspots that disrupt their functional domains or active sites, leading to gain- or

230 membrane domains but with no other predicted functional domains or homology outside of nematodes.

231 alternative functionality by loss or gain of functional domains, or by acquiring alternative subcellu

232 Ig domains interact with each other forming functional domain pairs, where the interaction with sign

233 y-induced cell death, whereas mutated p62 at functional domains (PB1, UBA) failed to do so.

234 secretase activity assays, suggesting that a functional domain pertinent to gamma-secretase activity

235 tified a gene (Hs-Tyr) encoding a tyrosinase functional domain (PF00264).

236 intain secondary and tertiary structural and functional domains present in certain DNA sequences.

237 anticipated from the molar concentration of functional domains present in the constructs.

238 n increased concomitantly with the number of functional domains present.

239 posed that membranes contain small, dynamic, functional domains (rafts), which act as platforms for m

240 erall visual ability and visual ability in 4 functional domains (reading, mobility, visual motor func

241 erall visual ability and visual ability in 4 functional domains (reading, mobility, visual motor func

242 4 months) in overall visual ability and in 4 functional domains (reading, visual information, visual

243 4 months) in overall visual ability and in 4 functional domains (reading, visual information, visual

244 the plant databases and 45 contigs based on functional domains referencing to the Pfam database.

245 ue opportunity to detect the movement of the functional domains relative to the substrate-binding cat

246 ties required for tissue growth, as well the functional domains required for cell binding.

247 h residues 28 to 39 constituting the minimal functional domain responsible for chNHE1 binding of ALV-

248 HIV fusion inhibitors, containing different functional domains resulted in synergistic anti-HIV-1 ef

249 position, transmembrane domain(s) (TMDs) and functional domain(s) of a protein, where the functional

250 ith nine transmembrane regions and conserved functional domains similar to other flavonoid and isofla

251 n the viral life cycle and, depending on the functional domain targeted, either attenuated or amplifi

252 In summary, ORF2 has more than one functional domain that regulates its stability and funct

253 veal a previously uncharacterized C-terminal functional domain that uncouples ATP hydrolysis from str

254 ations as well as point substitutions in key functional domains that abrogate signaling in cell-based

255 A) envelope glycoproteins are organized into functional domains that allow changes in receptor choice

256 coronavirus genome, and it contains multiple functional domains that are required for coronavirus rep

257 ous polymorphism in the regions encoding the functional domains that are required for lysing parasite

258 xGxxIxW(89) and (171)EDRW(174) are two novel functional domains that are very critical for Vif functi

259 contain modular architectures with distinct functional domains that combine to send signals in respo

260 karyotic genome into distinct structural and functional domains that contribute to gene regulation an

261 RGS domain, which contain several additional functional domains that facilitate protein-protein (or p

262 Thus, Q-rich repeats are dynamic functional domains that modulate a regulator's innate fu

263 scription factor that is composed of several functional domains: the N-terminal transactivation domai

264 with Wilson disease that affected different functional domains; the gene products were expressed usi

265 Hsp70 inter-domain linker: coupling the two functional domains through V389 and L391 and mediating t

266 r truncating or affect conserved residues in functional domains, thus supporting a putative role for

267 In alpha, we narrowed down the functional domain to a 48-nt-long, highly conserved segm

268 hose sequences to feline CRM1, we mapped the functional domain to HEAT (Huntingtin, elongation factor

269 esses the non-genomic pathway via its unique functional domain to inactivate c-Src.

270 vities, we analyzed the contributions of its functional domains to its localization and function.

271 proteins can be modified to carry additional functional domains to regulate expression of genomic loc

272 2AR in ASM and the ability to exploit GRK2/3 functional domains to render ASM hyporesponsive to contr

273 and in subunits with mutations in predicted functional domains, to permit detection with the fluores

274 ions in the gene encoding the 330-kDa triple functional domain (TRIO) protein associated with neurode

275 otein folds and a lack of well-characterized functional domains typically result in a low discovery r

276 ion analysis of RID to determine the minimal functional domain, we have identified a subdomain at the

277 of and the coupling between these different functional domains, we analyzed the thermal unfolding of

278 ace its evolutionary history and to identify functional domains, we embarked on a computational seque

279 Based on crystal structures of three functional domains, we generated a computational structu

280 imaging of single synapses within identified functional domains, we have revealed unexpected and diff

281 Here, to dissect APP functional domains, we used APP mutant mice lacking the

282 RipA functional domains were identified by measuring the effe

283 y important differences in visual ability in functional domains were reading (44% [95% CI, 42%-48%]),

284 < .001) on overall visual ability and on all functional domains, whereas cognition had an effect on o

285 posed of modules that house repeated sets of functional domains, which select, activate and couple am

286 ws us to identify and characterize potential functional domains with feature patterns similar to cano

287 We find that 186 CII possesses two functional domains, with an independent activation epito

288 These data reveal a novel functional domain within SteC, raising the possibility t

289 nformation of CR1 and points to LHR-D as the functional domain within the CR1 protein that mediates t

290 Thus, we have identified a novel functional domain within the GPCR protein family, which

291 le fMRI networks and, by indicating multiple functional domains within a single voxel, present a new

292 Here, we searched for the functional domains within Ac45 by analyzing a set of del

293 ously described the presence of at least two functional domains within CT694.

294 f eIF2beta in start codon selection, and two functional domains within eIF2beta are likely involved,

295 cue assay in Drosophila S2 cells to identify functional domains within integrator subunit 12 (IntS12)

296 body and used it as a molecular probe to map functional domains within nicastrin ectodomain.

297 , in a completely un-biased manner, distinct functional domains within prefrontal and (pre)motor cort

298 ity to modulate circuit activity in discrete functional domains within the basal ganglia circuitry wi

299 To investigate functional domains within the gH/gL structure, we constr

300 This suggests that two different functional domains within the heparanase enzyme (the enz