ライフサイエンスコーパス: functional impairment

1 eas the other groups demonstrated persistent functional impairment.

2 e with PAD are associated with the degree of functional impairment.

3 on are at risk for developing depression and functional impairment.

4 thin complex III, causing its structural and functional impairment.

5 on, generalised anxiety, alcohol misuse, and functional impairment.

6 ners with serious mental health problems and functional impairment.

7 monitored and correlated with physiological functional impairment.

8 conditions are transient and do not lead to functional impairment.

9 ciation with other psychiatric disorders and functional impairment.

10 ent-reported measures of quality of life and functional impairment.

11 ent-reported measures of quality of life and functional impairment.

12 s) along with depressive symptoms and severe functional impairment.

13 tion in peripheral blood NK cells and marked functional impairment.

14 is associated with greater lesion burden and functional impairment.

15 of predominantly short-term memory loss and functional impairment.

16 Similar patterns were observed for PTSD and functional impairment.

17 th schizophrenia with greatest cognitive and functional impairment.

18 experience nursing home admission or severe functional impairment.

19 rate skeletal muscle wasting with associated functional impairment.

20 n intratumoral T cells that displayed marked functional impairment.

21 years with CFS and severe fatigue leading to functional impairment.

22 ecessary to determine the mechanisms of this functional impairment.

23 icipants continued to exhibit high levels of functional impairment.

24 apidly reexpressed PD-1 and exhibited severe functional impairment.

25 and proteins associated with structural and functional impairment.

26 nutritional support and leads to progressive functional impairment.

27 fit for patients with advanced cognitive and functional impairment.

28 rgan preservation but can be associated with functional impairment.

29 ion due to reduced chronic disease risks and functional impairment.

30 movement may appear normal despite residual functional impairment.

31 considered to help with quality of life and functional impairment.

32 tic transmission machinery, suggesting local functional impairment.

33 ansgenic KOs demonstrated significantly less functional impairment.

34 ory was associated with significantly higher functional impairment.

35 including assessment for likely etiology and functional impairment.

36 ients older than 60 years of age with severe functional impairment.

37 more likely to have preexisting cognitive or functional impairment.

38 resence of cholesterol in surfactant without functional impairment.

39 e endoplasmic reticulum (ER), leading to its functional impairment.

40 t and who continue to experience distress or functional impairment.

41 nsuccessful, accompanied by CTL deletion and functional impairment.

42 e mild cognitive decline and no, or limited, functional impairment.

43 oid bursitis, muscle or joint stiffness, and functional impairment.

44 ry (TBI) and a major driver of mortality and functional impairment.

45 low-risk procedure if the outcome was severe functional impairment.

46 etes and if overlooked may result in chronic functional impairment.

47 UR1 are retained in the ER and have variable functional impairment.

48 responsiveness to IL-2, contributes to Treg functional impairment.

49 he accuracy of predictability in post-stroke functional impairment.

50 fect translates into reductions in hind limb functional impairment.

51 l nitric oxide synthase (nNOSmu), leading to functional impairments.

52 in the artery wall that results in selective functional impairments.

53 k factor for a large number of disorders and functional impairments.

54 ssible underlying mechanism for the observed functional impairments.

55 to neuronal death, thus causing irreversible functional impairments.

56 5) for PTS, -0.42 (95% CI: -0.58, -0.27) for functional impairment, -0.48 (95% CI: -0.61, -0.34) for

57 aregivers in terms of emotional distress and functional impairment; 2) whether there were any differe

58 gh levels of both psychological distress and functional impairment according to the 12-item General H

59 ent report of poor general or mental health, functional impairment, activity limitation, or cancer-re

60 ent report of poor general or mental health, functional impairment, activity limitation, or cancer-re

61 s study aimed to identify an early marker of functional impairment after an implantable cardioverter-

62 ared for quantification of tissue injury and functional impairment after MI using murine models with

63 rence in the proportion of children with any functional impairment after prescription of erythromycin

64 higher dose of NP001 had significantly less functional impairment after the treatment period compare

65 n, and return to work and the development of functional impairments after injury.

66 erent case definitions and have not assessed functional impairment, alcohol misuse, or aggressive beh

67 stress (AMD, -5.86; 95% CI, -8.53 to -3.19), functional impairment (AMD, -4.17; 95% CI, -5.84 to -2.5

68 dysfunction is independently associated with functional impairment among acute lung injury survivors

69 mptoms and produced a smaller improvement in functional impairment among OVC having experienced high

70 membranes was associated with an increase in functional impairment among their children at 7 years of

71 unctional impairment on which 0 indicates no functional impairment and 24 indicates maximum impairmen

72 vaccinated with ATIV were older and had more functional impairment and comorbidities.

73 Functional impairment and decline are common in middle a

74 mine the epidemiology and clinical course of functional impairment and decline in middle age.

75 y are associated with marked symptom burden, functional impairment and decreased quality of life.

76 nic hepatitis B virus (HBV) infection is the functional impairment and depletion of antiviral T cells

77 actions, which in turn increases the risk of functional impairment and depression.

78 d on the basis of animal experiments showing functional impairment and electrophysiologic disturbance

79 rsistent exposure to cognate Ag leads to the functional impairment and exhaustion of HIV-specific CD8

80 Functional impairment and functional decline are common

81 The prevalence and extent of functional impairment and functional decline in PAD may

82 We examined functional impairment and impairment in activities of da

83 ions in this group also were associated with functional impairment and increased risk of incident dep

84 y of hepatic HDL biogenesis, suggesting that functional impairment and premature clearance of HDL imm

85 among young people, leading to cognitive and functional impairment and raised mortality, particularly

86 Aging is characterized by functional impairment and reduced capacity to respond ap

87 natural process characterized by progressive functional impairment and reduced capacity to respond ap

88 dr in nephrocytes led to dramatic nephrocyte functional impairment and shortened life span, as well a

89 ldren and adolescents and is associated with functional impairment and suicide.

90 varied as a function of both the severity of functional impairment and the temporal distance from str

91 obe the neurobiological mechanism underlying functional impairment and to longitudinally monitor prog

92 te in lung TCD8 characterized by progressive functional impairment and upregulation of numerous inhib

93 ic delivery of recombinant protein, reversed functional impairments and restored genomic integrity in

94 f benefit with regards to quality of life or functional impairment, and (3) the abundant evidence of

95 nxiety, 75% and 37% for PTS, 67% and 22% for functional impairment, and 71% and 32% for aggression.

96 Grief, functional impairment, and incident depression.

97 efractory gout have reduced quality of life, functional impairment, and joint destruction.

98 than selectively to the elderly, those with functional impairment, and those with certain chronic co

99 ic characteristics, psychiatric comorbidity, functional impairment, and treatment seeking.

100 valuating its relationship to the subsequent functional impairment, and understanding the underlying

101 Reduced neurocognitive performance, functional impairments, and nonpositive attenuated sympt

102 g unfavourable health behaviours, health and functional impairments, and social risk factors) and 4.3

103 of depression and PTS (primary outcomes) and functional impairment, anxiety symptoms, aggression, and

104 nality disorder, whereas negative affect and functional impairment are more stable features of the di

105 hese findings demonstrate that cognitive and functional impairments are detectable in patients at cli

106 Schwann cells, suggesting that the observed functional impairments are directly linked with choleste

107 paralysis and sensory disturbances, but such functional impairments are often short lived because of

108 t groups, such as the elderly and those with functional impairment, are denied access to potentially

109 locomotor muscle from the potentially severe functional impairment as a consequence of severe intramu

110 tion against left ventricular structural and functional impairment as assessed by echocardiography in

111 us visual field defects experience disabling functional impairments as a consequence of their visual

112 atients with ALS correlated with severity of functional impairment, as measured by total score on the

113 uestioned due to the absence of evidence for functional impairment associated with drug-induced devel

114 Carbonylation of MyBPC showed significant functional impairment associated with its actin binding

115 nces, including demonstrable symptomatic and functional impairment associated with persistent subclin

116 adial pulsation or occlusion, local pain, or functional impairment at 30 days.

117 adults aged 50 to 56 years who did not have functional impairment at enrollment.

118 pants with childhood ADHD, ADHD symptoms and functional impairment at follow-up were significantly co

119 ervention patients) with either cognitive or functional impairment at hospital discharge.

120 gher scores indicating worse symptoms]), and functional impairment (average score across 20 tasks [ra

121 09.98=2.66 [95% CI, 0.17-1.18]; P=.009), and functional impairment (B [SE], 0.24 [0.08]; t111.40=3.01

122 ld-type mice were investigated for reflexes, functional impairment (beam walking, pole climbing, wire

123 in which symptoms of dementia, cognitive and functional impairment become observable.

124 comorbidities, polypharmacy, and concomitant functional impairment, but there is a paucity of high-le

125 ion-induced exacerbation of brain injury and functional impairment caused by cerebral ischemia.

126 Alterations and functional impairment caused by jaundice increase the ri

127 ive perceptions are associated with reported functional impairment, chest pain and anxiety, but not i

128 st 5% developed clinical characteristics and functional impairment comparable to previously described

129 ffect on the proportion of children with any functional impairment, compared with receipt of no co-am

130 s and the insulin-secreting beta cells whose functional impairment contributes to diabetes mellitus.

131 This functional impairment corresponded to increased lung inf

132 Such functional impairment could be related to 1) the observe

133 7% in 2010, whereas the prevalence of severe functional impairment declined by 47.1% (P < 0.001), fro

134 n involvement is associated with significant functional impairment, distressing symptoms, and diminis

135 ese results indicate that PD-1 mediates TCD8 functional impairment during acute viral infection and m

136 ontributes to pulmonary CD8(+) T cell (TCD8) functional impairment during acute viral LRI, but the ro

137 Functional impairment during successful antiretroviral t

138 ups reported similar severity of fatigue and functional impairments during the study, but duration wa

139 g may be most beneficial among patients with functional impairment, elevated inflammatory markers, or

140 icated grief causes substantial distress and functional impairment even years after a loss, yet knowi

141 unique contributions to increased levels of functional impairment, even after controlling for the cl

142 mechanical ventilation, difficulty weaning, functional impairment, exercise limitation, and poor hea

143 ovariectomized mice displayed a significant functional impairment following ischaemia.

144 ion of the NF-kappaB pathway showed complete functional impairment for null mutations, whereas partia

145 ted with violence, an important indicator of functional impairment for these individuals.

146 ive pain coping behaviors, nonorganic signs, functional impairment, general health status, and presen

147 ly analyzed in the murine LCMV model, such a functional impairment has been validated in other chroni

148 Apathy has profound consequences, such as functional impairment, higher service utilization, highe

149 es hippocampal hyperactivity as a very early functional impairment in AD transgenic mice and provides

150 family-level variables were associated with functional impairment in adolescents with JPFS.

151 ctivation, and immunosenescence markers with functional impairment in aging human immunodeficiency vi

152 trans form, contributes to tau pathology and functional impairment in an animal model of severe TBI.

153 l sensitivity and their value to reflect the functional impairment in chronic CSC.

154 of intracerebral haemorrhage, mortality, and functional impairment in different types of patients.

155 el mice, that such defects may contribute to functional impairment in DS, and that these phenotypes,

156 de useful information in determining risk of functional impairment in glaucoma.

157 cation of critical illness leading to severe functional impairment in many intensive care unit surviv

158 e propose that this might be the result of a functional impairment in noradrenergic circuits associat

159 ent to which they share common features with functional impairment in older adults.

160 Functional impairment in people with serious mental illn

161 ial cognition is an important determinant of functional impairment in schizophrenia, but its relation

162 (VSM) and in genetic human syndromes causes functional impairment in some regional circulations, the

163 ng information on the risk of development of functional impairment in the disease.

164 common pathological hallmark associated with functional impairment in the elderly which has been mode

165 eral inflammation, giving rise to associated functional impairment in the form of reduced spatial mem

166 idative stress-induced cell death and severe functional impairment in TMJ chondrocytes, and warrant i

167 similar format in reducing OCD symptoms and functional impairment in young children (5-8 years of ag

168 h increased risk for psychiatric illness and functional impairment in youth.

169 latelet size with structural alterations and functional impairments in activation and aggregation.

170 Functional impairments in children with TBI were more pr

171 ment may also pertain to recovery from other functional impairments in chronic stroke.

172 dition to numerical decline, sepsis leads to functional impairments in DCs, diminishing their capacit

173 of cranial nerve VIII tumors correlates with functional impairments in hearing and balance, as measur

174 rmanently alter brain structures and produce functional impairments in many aspects of behavior, incl

175 that can aggravate neuronal degeneration and functional impairments in many neurological conditions,

176 ate and severe TBI were rated as having more functional impairments in multiple domains than those wi

177 At least some of these morphological and functional impairments in p73 null cells can be rescued

178 pment that contributes to the persistence of functional impairments in self-regulation in BN.

179 results indicate significant structural and functional impairments in the barrel cortex of the Bird

180 s, uninjured mutant mice have anatomical and functional impairments in the peripheral nervous system.

181 This patient population generally had severe functional impairment, including 1192 (24%) patients wit

182 Mice expressing KIM-1Deltamucin had greater functional impairment, inflammatory responses, and morta

183 Functional impairment is persistent in the year followin

184 hosphate, and reduced NAD phosphate, whereas functional impairment is reflected in reduced neutrophil

185 re adaptations to ageing-induced atrophy and functional impairment is still unsettled.

186 ch patients have mild neuropsychological and functional impairments, lack characteristic bvFTD brain

187 r health, as measured by the health indices (functional impairment, limitation of activities, repeate

188 These alleles leading to subtle functional impairment may contribute to complex, polygen

189 s examined with parent-reported symptoms and functional impairment measures using a categorical (DSM-

190 ange] LR, 0.39 [0.38-0.40]) and low baseline functional impairment (median [range] LR, 0.40 [0.10-0.5

191 an [range] LR, 2.5 [2.2-2.8]), high baseline functional impairment (median [range] LR, 2.1 [1.2-2.7])

192 AD: more severe PAD, greater lower extremity functional impairment, more adverse calf skeletal muscle

193 Biomarkers of functional impairment, neuronal loss, and protein deposi

194 onstrates that the CD4 T cell exhaustion and functional impairment observed in CVID patients is assoc

195 the neurosteroid allopregnanolone mitigated functional impairments observed in preCGG neurons in a r

196 ation, partial loss of oligodendrocytes, and functional impairment, occurred in the adult mice lackin

197 dy-mediated rejection that has progressed to functional impairment of a renal transplant have been de

198 s exofacial Asn(27) and Asn(28), resulted in functional impairment of approximately 70% of mutants, d

199 ponses in heart and kidneys, associated with functional impairment of both organs.

200 One reason for functional impairment of BSEP is systemic administration

201 We show that the functional impairment of CD4 T cells, including the redu

202 2 (AIH-2), are permitted by a numerical and functional impairment of CD4(pos) CD25(high) regulatory

203 2 (AIH-2), are permitted by a numerical and functional impairment of CD4(pos)CD25(high) regulatory T

204 ls of prebeta-1 HDL may serve as an index of functional impairment of cholesterol efflux or esterific

205 sponse and imply that the oxidation-mediated functional impairment of DJ-1 leads to gradual dysregula

206 ts a 50% change in CTD protein sequence, and functional impairment of exon 7 exclusion activity in a

207 aret gene led to ultrastructural changes and functional impairment of flight muscles, and transcripts

208 ammatory transcription factor NF-B, and thus functional impairment of force-generating capacity.

209 Ablation or functional impairment of Foxp3(+) Tregs in vivo at the s

210 uced GABA(A) receptor clustering, suggesting functional impairment of GABA signaling.

211 The reduced expression levels and functional impairment of global miRNAs are related to va

212 pe glutamate receptors, along with prominent functional impairment of glutamatergic synapses in the h

213 expression of Hsp72, GRP75, and Hsp25 and in functional impairment of Hsp60 and Hsp70 as determined u

214 apacities of MM HSPCs, which underlines that functional impairment of HSPCs depends on MM-related mic

215 The functional impairment of HSV-2-exposed DCs could be part

216 sentation of hematopoietic stem cells and in functional impairment of long-term hematopoietic repopul

217 everity showed a direct correlation with the functional impairment of MeCP2.

218 They also demonstrated functional impairment of medial temporal lobe (MTL) stru

219 te attenuator (BTLA) plays a similar role in functional impairment of MiHA-specific T cells after all

220 These processes led to a functional impairment of mitochondria, culminating in ce

221 accumulation leads to crystal formation and functional impairment of multiple organs.

222 cluding T-cell exhaustion, viral escape, and functional impairment of naive-like HCV-specific CD8(+)

223 Functional impairment of oxidative phosphorylation was t

224 Loss or functional impairment of p53 occurs in many human cancer

225 Persistent viruses often cause depletion or functional impairment of pDCs, but the role of pDCs in t

226 ain, may thus underlie the vulnerability and functional impairment of pivotal inhibitory circuits in

227 d to aberrant intracellular localization and functional impairment of promyelocytic leukemia zinc-fin

228 AGE-modification causes structural and functional impairment of proteins.

229 ge-related muscle decline is associated with functional impairment of satellite cells (SCs).

230 tive was to evaluate chronic pain states and functional impairment of septic and nonseptic patients 6

231 ion of the proline substitution in the helix functional impairment of Sgs1 function varied, gradually

232 Functional impairment of stress granules has been implic

233 rogrammed death-1 (PD-1) are involved in the functional impairment of T cells during infection.

234 lucose uptake and insulin resistance (IR) to functional impairment of the heart.

235 state of mPFC disinhibition resulting from a functional impairment of the local prefrontal GABAergic

236 regulation by HCV core protein coupled with functional impairment of the membrane attack complex und

237 nia, and cognitive aging may result from the functional impairment of the motivational salience signa

238 Background: Functional impairment of the orbital and medial prefront

239 Atrial fibrillation ablation results in functional impairment of the UGI system, including the e

240 ulsation loss or occlusion and local pain or functional impairment of the upper extremity.

241 These data show a functional impairment of Tregs in a proportion of patien

242 nflammatory environment, that exacerbate the functional impairment of Tregs, which are reduced in num

243 ing that this inflammatory milieu is key for functional impairment of Tregs.

244 We hypothesized that functional impairment of tumor-specific T cell responses

245 eptor specifically in T reg cells results in functional impairment of virus-specific CD8(+) and CD4(+

246 their splice variants may result in critical functional impairments of prefrontal cortex in the alcoh

247 ms that underlie the disparate cognitive and functional impairments of schizophrenia.

248 These results suggest that functional impairments of the prefrontal striatonigral c

249 ire commonly used to measure LBP and related functional impairment on which 0 indicates no functional

250 g-standing symptoms were not associated with functional impairment or a particular strain of B. burgd

251 Functional impairment or complete loss of type VII colla

252 rt, and ATP formation, eventually leading to functional impairment or death of cells, as well as up-r

253 Functional impairments or trafficking defects of inhibit

254 dize patency and lead to recurrent symptoms, functional impairment, or a threatened limb.

255 The risk of nursing home admission, severe functional impairment, or death was low (16%) for patien

256 latively mild early TBI experience long-term functional impairments, particularly in the context of l

257 disorder (OCD), and is associated with worse functional impairment, poorer quality of life, and poore

258 tal health (PR, 1.66; 95% CI, 1.52 to 1.80), functional impairment (PR, 4.53; 95% CI, 3.91 to 5.24),

259 Its functional impairment promotes autoimmunity and atherosc

260 1 values the best correlation with the later functional impairment (R(2) =0.94).

261 ce rates for PTSD or depression with serious functional impairment ranged between 8.5% and 14.0%, wit

262 s coordinated by a case manager who assessed functional impairments relating to mood symptoms.

263 ged from 9% to 31% depending on the level of functional impairment reported.

264 ul test for assessment and quantification of functional impairment resulting from cardiovascular dise

265 ailure with preserved ejection fraction have functional impairment resulting in reduced quality of li

266 teration of podocytes sets them in motion to functional impairment, resulting in proteinuria and glom

267 e (RR = 5.7, P < .01) conditions, as well as functional impairment (RR = 7.7, P < .01) and activity l

268 .01; multiple conditions: RR = 2.6, P < .01; functional impairment: RR = 3.5, P < .01; activity limit

269 sruption of the ELM, and significant macular functional impairment (RS decrease) vs SND-.

270 s, individuals with persistent ADHD had more functional impairment (school/work: OR, 3.30 [95% CI, 2.

271 was defined as the presence of any level of functional impairment (severe, moderate, or mild) derive

272 Patients with more severe functional impairment showed lower mean dMT network conn

273 exhibited inhibitory receptor expression and functional impairment similar to those of mice experienc

274 8 induced long-term neuroprotection, reduced functional impairment, stabilized blood-brain barrier th

275 ood or anxiety state is related to even more functional impairment, suggesting that prolonged fatigue

276 nter the peripheral repertoire in a state of functional impairment, termed anergy.

277 indicated that HcrtR antagonists cause less-functional impairment than BzRAs.

278 e inherently more active than WT channels, a functional impairment that cannot be reversed by dephosp

279 ilure by oligodendrocytes contributes to the functional impairment that characterizes the demyelinati

280 ompared with wild-type animals, resulting in functional impairments that affect in particular the sen

281 s ex vivo; virus-specific CD8(+) T cells had functional impairments that were temporally restricted t

282 ess Disorder Reaction Index (range, 0-4) and functional impairment using a locally developed measure

283 pulmonary CD8+ cytotoxic T lymphocyte (TCD8) functional impairment via programmed death-1/programmed

284 walpindi), age (<6 years or >/=6 years), and functional impairment (Vineland Adaptive Behaviour Scale

285 Functional impairment was a composite of poor academic p

286 This in vivo functional impairment was accompanied by dampened expres

287 Functional impairment was defined as the presence of any

288 This intrahepatic functional impairment was HCV-specific and directly asso

289 Physical and mental health status and functional impairment was measured by the Medical Outcom

290 es in tumor-related pain, disfigurement, and functional impairment was observed.

291 o identify the mechanisms underlying NK cell functional impairment, we characterized the distribution

292 atients show myocardial fibrosis well before functional impairment, we postulated that earlier treatm

293 ut in nearly all patients, both symptoms and functional impairment were mild and had resolved by 4 mo

294 ge, 11.1-11.8 years]), the combined rates of functional impairment were not significantly different b

295 Brain damage and functional impairment were reduced by IF in young and mi

296 Comorbidities with functional impairments were common.

297 These functional impairments were driven by rare Nef polymorph

298 radiographic knee OA may experience pain and functional impairment, which can diminish their health s

299 dicare decedents with advanced cognitive and functional impairment who were nursing home residents 12

300 umatic Stress Disorder Checklist for DSM-5), functional impairment (WHODAS 2.0), progress on problems