ライフサイエンスコーパス: functional importance

1 stabilizing selection, suggesting potential functional importance.

2 fluenced by its expression level rather than functional importance.

3 d, raising the question of the extent of its functional importance.

4 ation, inhibition, or ablation to test their functional importance.

5 e during the course of NTN, indicating their functional importance.

6 l intermediates or hidden states that are of functional importance.

7 tination of Hsc70 in vitro, highlighting its functional importance.

8 n of residues comprising this pocket suggest functional importance.

9 species than the other parts, implying their functional importance.

10 al organization of chromosomal elements with functional importance.

11 PA3 revealed PAK1 signaling to be of primary functional importance.

12 interpreted in terms of the vague concept of functional importance.

13 ome pols achieve medium or low fidelity with functional importance.

14 our understanding of bacterial shape and its functional importance.

15 tuberculosis is unusual in its composition, functional importance and activation mechanism.

16 These data underscore the functional importance and cell type specificity of many

17 This strongly indicates that isomiRs are of functional importance and have contributed to the evolut

18 of AGO proteins with profound structural and functional importance and provide the first hints at str

19 N variability and provides evidence both for functional importance and redundancy of G-CSF receptor-m

20 preservation of this feature highlights its functional importance and suggests that this highly cons

21 several surface-exposed regions of potential functional importance and test their importance using mu

22 Functional importance and the molecular mechanism of CDK

23 Because of their functional importance and well-characterized differentia

24 though hard to detect, can potentially be of functional importance, and may also give insight into th

25 main TMs, identified pore-lining residues of functional importance, and provided evidence of an emerg

26 site regulation of expression and breadth of functional importance as the immediate early gene produc

27 ts on nucleoporin localization are likely of functional importance as we have defined specific geneti

28 ventral surface of the disc lamellae implies functional importance associated with the adhesive mecha

29 Their functional importance at a clinical level, however, rema

30 tered in our structure, and we confirmed its functional importance by mutagenesis.

31 Due to its functional importance, DBP is considered a prime vaccine

32 experimental tools to map detour circuits of functional importance, directing circuit rewiring to pro

33 mechanistic studies that demonstrated their functional importance during inflammation, autoimmune di

34 under tight control by arginase 1 and is of functional importance during ischemia-reperfusion.

35 However, their functional importance during the priming phase of an org

36 se different annotations into one measure of functional importance (Eigen) that, unlike most existing

37 eurons of the locomotor circuits, with known functional importance for coordinated movement.

38 Although a functional importance for cysteines localized to the N-t

39 ntricular neuronal masses, demonstrating its functional importance for normal cortical development.

40 the perspective on allostery and implicates functional importance for the directionality of alloster

41 the TMD of IFNAR1 is low, suggesting limited functional importance for this region.

42 l biological roles, but their prevalence and functional importance has remained elusive because they

43 ts of such brain rhythms, particularly their functional importance, have been unclear.

44 Despite the functional importance, how DRG neurons function at a pop

45 to rafts in the plasma membrane, which is of functional importance in a wide range of cellular proces

46 directed mutagenesis, and we demonstrate its functional importance in activating the SV40 primosome i

47 To address their functional importance in angiogenic processes, several e

48 traints reveal hitherto unseen structures of functional importance in apparently disordered proteins.

49 tant eye movement behavior or whether it has functional importance in basic perceptual tasks.

50 utations in cancer cells, underscoring their functional importance in cellular regulation.

51 that mechanically gated ion channels are of functional importance in chondrocyte mechanotransduction

52 s that control PGC-1alpha turnover and their functional importance in energy metabolism are largely u

53 ive immune responses; however, their in vivo functional importance in hepatic ischemia/reperfusion (I

54 as an acetyl-lysine-binding module, but its functional importance in human cancer remains unknown.

55 le challenge for now-we cannot establish its functional importance in human health, disease and new t

56 lesions in multiple sclerosis (MS), but its functional importance in pathogenesis is unclear.

57 e the mechanisms of STAT3 activation and its functional importance in PDAC pathogenesis.

58 Such alleles are likely to be of functional importance in population based studies of rar

59 ectional selection that correlate with their functional importance in prey capture.

60 expression of these genes, supporting their functional importance in promoting proliferation.

61 onal modifications in eukaryotic cells, with functional importance in protein degradation, subcellula

62 e discussion of the potential structural and functional importance in proteins of the related anion-a

63 sly expressed transcriptional regulator with functional importance in the central nervous system.

64 The functional importance in the disease was corroborated by

65 n define a novel cluster of amino acids with functional importance in the regulation of type I interf

66 emains unknown and we aimed to determine its functional importance in these tissues.

67 ween agrin and alpha3-Na(+)K(+)-ATPase is of functional importance in this system.

68 Despite its functional importance in various fundamental bioprocesse

69 Despite its functional importance in vascular development, the physi

70 mouse mast cell responses in vitro and their functional importance in vivo.

71 selection on specific codons, supporting its functional importance in widow venom.

72 This functional importance is because of three novel cellular

73 , but the consistent decline of invertebrate functional importance is indicative of a human-induced s

74 f the water pathway in the protein nor their functional importance is known.

75 fully conserved among ABC proteins and whose functional importance is unknown.

76 Despite their functional importance, little is known about their origi

77 To identify regions of functional importance, M proteins from a variety of VHSV

78 Yet, despite their presumed functional importance, M. mulatta Ab receptors are large

79 Uniformity is of both practical and functional importance, necessary to increase structural

80 Despite this functional importance, no large-scale neuroimaging genet

81 To explore the functional importance of 5hmU, we develop a method for t

82 ular studies define the structural basis and functional importance of a form of LIMP-2 for lipid traf

83 ic algorithm to estimate the topological and functional importance of a protein from the global netwo

84 e NSS transport mechanism that emphasize the functional importance of a second substrate (S2) binding

85 port current models of regions of particular functional importance of AGO proteins.

86 The functional importance of amblyopia at an individual leve

87 Altogether, our observations describe the functional importance of amino acid 375H in CRF01_AE env

88 nt studies, however, question the extent and functional importance of apoA-I Tyr(166) nitration based

89 The functional importance of approximately 50% of the ORF2p

90 We tested the functional importance of Arg-1203 by incubating sialylat

91 y breaking perfect six-fold symmetry implies functional importance of asymmetric association of p97 s

92 equirements for p29 and p48 cleavage and the functional importance of autoproteolysis in the context

93 O and abolished by diclofenac indicating the functional importance of B2R-induced activation of endot

94 In view of the functional importance of bacterial communities in the ph

95 In this study, the functional importance of beta1 integrin in lung epitheli

96 pecies does not necessarily translate to the functional importance of biodiversity measured in whole

97 These findings highlight the functional importance of cancer cell O-glycans and relat

98 eavage, recent studies have demonstrated the functional importance of carboxyl terminal fragments of

99 Exchanging exonic regions revealed the functional importance of CCK1R exon 3, extending from th

100 In this study, we investigated the functional importance of CD82 expression in melanoma-med

101 We investigated the mechanism and functional importance of Cdk for this interaction using

102 ng RNA-mediated depletion, demonstrating the functional importance of cellular proteins in the biolog

103 Overall, our results show the structural and functional importance of conserved extracellular cystein

104 promoters, provided further evidence of the functional importance of coordinated transcription facto

105 Our work offers a proof of the functional importance of CSCs in breast cancer, and it e

106 by demethylation of pluripotency genes, the functional importance of de novo DNA methylation has not

107 One relates to the functional importance of dehydroascorbate reductases (DH

108 rk of lung mesenchymal niches and reveal the functional importance of developmental pathways in promo

109 , rich resources and novel hypotheses on the functional importance of diploidy.

110 ken together, these results demonstrated the functional importance of distinct domains in the SMYD fa

111 We tested the functional importance of DnaN-mediated mismatch detectio

112 The functional importance of dual- (or multi-) transmitter n

113 gulates the IKS channel, thus confirming the functional importance of E3-ligase autoinhibition.

114 osin XV result in deafness, highlighting the functional importance of each domain.

115 ip residues in cardiomyocytes shows that the functional importance of each skip residue is associated

116 omal DNA (ecDNA), although the frequency and functional importance of ecDNA are not understood.

117 ecular tools will be poised to elucidate the functional importance of endophytes in natural plant pat

118 ons of craniofacial shape, demonstrating the functional importance of enhancers in defining face and

119 appaBalphaSR transgenic mice to evaluate the functional importance of epithelial NF-kappaB in respons

120 These studies confirm the functional importance of ER mutations in endocrine resis

121 ) exhibit vast structural diversity, but the functional importance of FA variations and the mechanism

122 at may lead to a deeper understanding of the functional importance of facilitation.

123 The functional importance of fast gating subthreshold erg ch

124 hanisms of Wnt signalling activation and the functional importance of FZD subtypes, and the use of Wn

125 n wild-type cells did not correlate with the functional importance of gammaH2Ax.

126 The functional importance of gene enhancers in regulated gen

127 nsights into molecular underpinnings and the functional importance of genetic pathways governing vari

128 However, the functional importance of glycosylation of the TRPV1 rece

129 n increased survival, and we demonstrate the functional importance of GRIN2A mutations in melanoma an

130 Together, these data demonstrate the functional importance of H3K9me3 in hypoxia, and they pr

131 proteins under ambient conditions belies the functional importance of higher-energy conformational st

132 lin function, also shedding new light on the functional importance of hormone's B-chain C-terminus fo

133 Together, our findings highlight the functional importance of IKBKE in pancreatic cancer, sup

134 In this study, we have examined the functional importance of IL-27 receptor (IL-27R) signali

135 While early studies identified the functional importance of individual EDC genes, the recog

136 negative selection can be used to infer the functional importance of individual protein domains of i

137 However, the functional importance of individual species does not nec

138 re locations, time spans, and functions, the functional importance of individual species is becoming

139 While the functional importance of inflammasomes in blood-derived

140 To address the functional importance of inhibitory signaling in DA neur

141 pathophysiology of CRSwNP demonstrating the functional importance of innate lymphoid cells in Th2-me

142 To demonstrate the functional importance of integrin beta3 in promoting end

143 Despite the functional importance of its homopolymers, no structural

144 The functional importance of KCa3.1 channels in the regulati

145 basal layer of Krt5-null mice to assess the functional importance of keratin IF self-organization in

146 The ability to test the functional importance of LC-derived TGF-beta1 is complic

147 k provides a road-map for deconstructing the functional importance of local interactions in communiti

148 To test the functional importance of Lp-PLA2, we generated chimeric

149 n spatial learning and memory, revealing the functional importance of LSD1n in neuronal activity-regu

150 The functional importance of MAGE-11 was indicated by decrea

151 this approach, we provide an overview of the functional importance of many Hippo pathway components a

152 provide new insight into the development and functional importance of medullary microenvironments dur

153 E2 domain, but unresolved is the nature and functional importance of metal ion binding to APLP1 and

154 er cell migration and invasion, suggesting a functional importance of mitochondria in breast cancer m

155 Thus, our study reveals the functional importance of mitophagy during the dynamic re

156 We demonstrated the functional importance of NCC in this response by showing

157 Emerging evidence has highlighted the functional importance of non-coding RNAs, particularly m

158 and the repair of the DSB, demonstrating the functional importance of nucleosome disruption in DSB re

159 we investigated the potential existence and functional importance of nuocytes in experimental allerg

160 However, the functional importance of O-mannosylation in these tissue

161 To assess the functional importance of OPN and CLU, peripheral nerve r

162 Other experiments have tested the functional importance of oscillations and their coupling

163 In support of the functional importance of our findings, oral administrati

164 The functional importance of palmitoylation results in part

165 ommunity by providing detailed clues for the functional importance of particular mutations, as well a

166 ial for seed and pollen development, but the functional importance of PDAT in vegetative tissues rema

167 by increased PDLIM5 levels, underscoring the functional importance of PDLIM5 for proper kAE1 membrane

168 To determine the functional importance of phosphatases that control the P

169 g miRNAs can arise infrequently and that the functional importance of polyomaviral miRNAs is context

170 Collectively, these studies highlight the functional importance of promoter DNA methylation in con

171 Despite the greater functional importance of protein levels, our knowledge o

172 The functional importance of protein-protein interactions in

173 To investigate the functional importance of Proton Gradient Regulation5-Lik

174 odeling guided electrophysiology reveals the functional importance of radial tuning of the S6 segment

175 Our results demonstrate the functional importance of radial tuning of the sodium cha

176 Our results provided new insights into the functional importance of RBPs in coordinating the expres

177 However, firm evidence for the existence and functional importance of resident microbiomes in larval

178 KEY POINTS: The functional importance of residues in loop G of the GABAA

179 ctivated T cell expansion, demonstrating the functional importance of RyR in T cells.

180 But how this occurs, and the functional importance of S-nitrosation sites across the

181 In summary, our study illustrates the functional importance of SID-1 ECD as a dsRNA binding do

182 While much is known about the functional importance of signaling centers, relatively l

183 These findings underscore the functional importance of simultaneous interactions and p

184 To reliably predict the functional importance of single isolated UMCs across the

185 Here, we provide data demonstrating the functional importance of SLO fibroblasts during Notch-me

186 t is active in this model, to illustrate the functional importance of spatially regulated RhoA.

187 s that indirect relationships homogenize the functional importance of species in ecosystems.

188 We hypothesized that the functional importance of species would tend to be concen

189 To further explore the functional importance of specific AREG domains, we stabl

190 al consequences of neurodegeneration and the functional importance of specific connectivity within a

191 In addition, the functional importance of specific MPK features could be

192 sitivity alpha2beta2 nAChR and validated the functional importance of specific residues in alpha2 and

193 This regulation shows the functional importance of splicing-regulated miRNA and su

194 These results together show that the functional importance of sterol superlattice formation i

195 The functional importance of stromal Tenascin-C and S100A4(+

196 The functional importance of such correlations in vivo was c

197 organization is consistent with the emerging functional importance of synaptically and extrasynaptica

198 In vitro kinase assays revealed the functional importance of T207 and Y210, but not T198, in

199 Our results demonstrate the functional importance of TADs for orchestrating gene exp

200 cal PI(3)P binding domain, demonstrating the functional importance of targeting PTEN to endosomal mem

201 Moreover, the functional importance of the 19H variant on intestinal A

202 The functional importance of the asymmetry is not fully clea

203 xtensive reporter analysis, we confirmed the functional importance of the ATTA co-motif in primary he

204 ested in the intron, indicating the possible functional importance of the bindin intron variability.

205 To determine the functional importance of the binding of CTCF and cohesin

206 In vivo screens confirmed the functional importance of the conserved "TTnnnG" motif re

207 To determine the structural-functional importance of the conserved cysteines and the

208 mised the formation of dimer, indicating the functional importance of the dimer.

209 The results suggest functional importance of the dimerization interfaces in

210 d lipogenesis in COS-7 cells, indicating the functional importance of the dimerization.

211 gic killing of Citrobacter, attesting to the functional importance of the H. polygyrus-mediated downr

212 ogical studies to define and distinguish the functional importance of the HCN/TRIP8b interaction site

213 As further evidence for the functional importance of the HR complex, RAD51C mutants

214 of the 90-kDa palladin isoform revealed the functional importance of the interaction with MT1-MMP in

215 of each other on FLC chromatin, showing the functional importance of the interaction.

216 growth, but we also provide evidence for the functional importance of the local PIF-induced response.

217 Collectively, our study demonstrates the functional importance of the m(6)A methylation and the c

218 the pen2 mutant phenotype, corroborating the functional importance of the mitochondrial PEN2 protein

219 esence of two identical targets enhances the functional importance of the mode of binding.

220 ses fusion and viral entry, highlighting the functional importance of the MPER/TM-FL interaction in E

221 Finally, to confirm the functional importance of the NAc-S to VP-m pathway we us

222 can trigger distinct signaling cascades, the functional importance of the PAR(2)-biased agonism is un

223 s show strong conservation, highlighting the functional importance of the physical activities that th

224 f post-Paleozoic crinoids suggests a general functional importance of the pigments, contributing to t

225 signature' and provides new insight into the functional importance of the plasticity of RNA.

226 These results not only demonstrate the functional importance of the pseudoknot but also reveal

227 The findings highlight the special functional importance of the right frontoinsular cortex-

228 assembly reactions provided evidence for the functional importance of the S&lrarr2;D equilibrium.

229 his shape change are now well described, the functional importance of the spherical mitotic cell for

230 yme catalysis and regulation, indicating the functional importance of the tetramer.

231 c mode of UCPH-101 inhibition underlines the functional importance of the trimerization domain of the

232 These findings highlight the functional importance of the tVTA/RMTg as a major GABA b

233 X proteins through their direct binding, the functional importance of their interaction in leukemogen

234 -based mutations of these factors reveal the functional importance of their interactions for ribosome

235 ippo signalling components and establish the functional importance of their localization to Warts act

236 The functional importance of these bridges remains largely u

237 t roles in normal and disease cells, but the functional importance of these clustered enhancer elemen

238 ious studies in arid zones have demonstrated functional importance of these communities in reducing s

239 both candidate genes revealed evidence for a functional importance of these genes by influencing diff

240 amine (DA) receptors ex vivo; the nature and functional importance of these interactions in vivo rema

241 mediated through multi-SIM modules, and the functional importance of these interactions is demonstra

242 However, the functional importance of these intricate inter-connectio

243 uture experiments aimed at understanding the functional importance of these kinetoplastid-specific ri

244 To determine the functional importance of these observations, we first ex

245 ng evolutionary constraint, highlighting the functional importance of these regions.

246 -forming segments of NALCN, highlighting the functional importance of these segments.

247 methylator phenotype (G-CIMP), although the functional importance of this altered epigenetic state r

248 The mechanism and functional importance of this arrangement of chromosomes

249 g future in vitro and in vivo studies on the functional importance of this association.

250 Characterization of the functional importance of this conserved aspartate, relat

251 We provide evidence for the functional importance of this conserved intragenic eleme

252 ith good surface complementarity, suggesting functional importance of this crystallographic dimer.

253 subsequent mitotic events, underscoring the functional importance of this feedback.

254 e actin-remodeling protein gelsolin, but the functional importance of this gelsolin modification has

255 ance (MCM) plays a role, but the details and functional importance of this interaction have not been

256 e floral quartet model, but evidence for the functional importance of this interaction is scarce outs

257 Here we demonstrate the functional importance of this interaction through the an

258 defective APP processing, demonstrating the functional importance of this interaction.

259 Finally, we show the functional importance of this latter phenomenon, demonst

260 cNAc during T cell activation to address the functional importance of this modification and to identi

261 A new study highlights the functional importance of this neurophysiological phenome

262 The functional importance of this NLRP1-binding motif was fu

263 To test the functional importance of this observation, LNK was eithe

264 ling and recruitment in vivo demonstrate the functional importance of this pathway.

265 ffect T cell cytotoxicity, demonstrating the functional importance of this pathway.

266 We also suggest that the functional importance of this region is significantly di

267 1's first hydrophilic loop suggests critical functional importance of this region.

268 ed tuning of Ras and Rap and underscores the functional importance of this regulation in homeostatic

269 And yet quantification of the functional importance of this response heterogeneity rem

270 ligands and the studies that underscore the functional importance of this signaling pathway in physi

271 In addition, we assessed the functional importance of three target genes, Vitamin C 2

272 r-associated biofilm infection to assess the functional importance of TLR2 and TLR9 in the host immun

273 srupting conditions allows us to analyze the functional importance of TNTs in an ex vivo model.

274 The functional importance of tumor expression of versican in

275 on of a UV-inducible gene, demonstrating the functional importance of variant expression.

276 The functional importance of VEGF-C was investigated by aden

277 teract with the Cys-rich domain revealed the functional importance of VWF residues Ile1642, Trp1644,

278 Our results highlight the functional importance of weak interactions, typically a

279 To understand the functional importance of Wnt signalling in oocytes, we d

280 el acetyllysine-binding module; however, the functional importance of YEATS domain-containing protein

281 were undertaken to define the regulation and functional importance of zinc-dependent histone deacetyl

282 ansitional nature of such boundary areas has functional importance, of which the precise nature will

283 However, its extent and functional importance remain a subject of intense invest

284 ull-length (FL) SIRT3 in the nucleus and its functional importance remain controversial.

285 Despite their functional importance, several questions remain about ho

286 Genes with high expression and functional importance, such as the kai genes, are usuall

287 significance to identify candidate genes of functional importance that would otherwise be overlooked

288 However, despite its functional importance, the mechanism of how R7 RGS forms

289 Despite their functional importance, the molecular mechanisms of funct

290 his region is relatively conserved, implying functional importance, the origins of which are not well

291 However, despite its prevalence and functional importance, the pathophysiology of post-traum

292 hagy receptors and autophagy machinery is of functional importance to execute selective autophagy.

293 rovide compelling evidence that MUC1-C is of functional importance to induction of DNMT1 and DNMT3b a

294 Here, we demonstrate such a complex and its functional importance to modulate signaling.

295 orus (Pi) acquisition, implying some type of functional importance to the metabolism of As, Pi or bot

296 Hence, our data attributed a functional importance to the temporal development of Vga

297 The functional importance was tested in an ex vivo model of

298 d contacts mRNA via conserved residues whose functional importance was unknown.

299 To uncover its functional importance, we developed a MALAT1 knockout mo

300 Condel were used to predict each mutation's functional importance, whereas the actual effect was mea